Motif ID: FOSL2.p2

Z-value: 1.028


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2



Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_56445653 1.267 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr13_+_112746908 1.110 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_17719405 1.069 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_118571793 1.027 NM_001145018
CCDC153
coiled-coil domain containing 153
chr11_-_116199145 1.023 NM_000482
APOA4
apolipoprotein A-IV
chr10_-_31328426 0.981 NM_001143769
ZNF438
zinc finger protein 438
chr1_-_117554999 0.944 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr22_+_20899155 0.918


chr15_-_40089736 0.878 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr6_+_37360144 0.818 TBC1D22B
TBC1 domain family, member 22B
chr7_+_30927439 0.803 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr1_+_207995999 0.790 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr19_+_43971689 0.786 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr3_-_58175437 0.781 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_+_17507276 0.778 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr17_+_41424665 0.750 MAPT
microtubule-associated protein tau
chr18_+_19706979 0.747 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr17_+_77910411 0.741 NM_207459
TEX19
testis expressed 19
chr15_+_65245546 0.722 NM_001145104
SMAD3
SMAD family member 3
chr10_-_128199986 0.721 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr19_+_4180494 0.717 NM_005755
EBI3
Epstein-Barr virus induced 3
chr2_+_74595073 0.702 NM_016170
TLX2
T-cell leukemia homeobox 2
chr5_+_177473071 0.695 NM_015111
N4BP3
NEDD4 binding protein 3
chr19_-_40673185 0.693 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr19_+_40895669 0.684 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr19_-_40684638 0.637 NM_001035516
DMKN
dermokine
chr22_+_36549334 0.632 NM_003614
GALR3
galanin receptor 3
chr12_+_6292077 0.616 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr17_+_22823151 0.596 NM_014238
KSR1
kinase suppressor of ras 1
chr16_+_2023279 0.594 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_+_190147633 0.594 TPRG1
tumor protein p63 regulated 1
chr1_-_43523825 0.585 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr17_+_65582981 0.564 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_102505180 0.556 NM_017564
STAB2
stabilin 2
chr11_+_48194937 0.551 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr1_-_202432165 0.543 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr22_+_23921072 0.538 KIAA1671
KIAA1671
chr1_-_110414756 0.524 NM_006492
ALX3
ALX homeobox 3
chr5_-_75954807 0.521 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr3_+_134976965 0.520 TF
transferrin
chr6_-_30236667 0.517 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr1_+_40508336 0.514 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr7_+_128367961 0.508 NM_001098627
IRF5
interferon regulatory factor 5
chr10_+_134751398 0.490 NM_001083909
GPR123
G protein-coupled receptor 123
chr8_+_87180248 0.490 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr11_-_47502115 0.488 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr7_-_128330615 0.485 KCP
kielin/chordin-like protein
chr3_-_49812257 0.482 NM_001007540
CDHR4
cadherin-related family member 4
chr1_-_108032645 0.479 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_187840842 0.478 NM_014375
FETUB
fetuin B
chr1_+_148747208 0.476 ECM1
extracellular matrix protein 1
chr11_+_120966280 0.462 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr9_-_86173232 0.461 NM_022127
SLC28A3
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
chr11_-_65186790 0.460 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr1_-_221919982 0.456 CAPN8
calpain 8
chr7_-_76667045 0.447 NM_006682
FGL2
fibrinogen-like 2
chr22_+_21393107 0.446 IGLJ3
immunoglobulin lambda joining 3
chr20_+_35266581 0.443 RPN2
ribophorin II
chr3_-_197549640 0.440 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr12_+_55018925 0.439 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr20_+_10147455 0.438 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr6_-_41781655 0.430 TFEB
transcription factor EB
chrX_-_15593074 0.424 NM_020665
TMEM27
transmembrane protein 27
chr1_-_93030538 0.423 NM_005665
EVI5
ecotropic viral integration site 5
chr3_+_185377341 0.423 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr19_-_11549441 0.422 ACP5
acid phosphatase 5, tartrate resistant
chr5_+_147562531 0.420 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr19_-_11549484 0.417 ACP5
acid phosphatase 5, tartrate resistant
chr15_-_88023576 0.415 NM_001145311
NM_002666
PLIN1

perilipin 1

chr15_+_38923914 0.414 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr11_+_44026106 0.407 NM_001031854
ACCSL
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
chr1_-_221920023 0.405 NM_001143962
CAPN8
calpain 8
chr3_+_52325374 0.404 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr11_+_57123927 0.400 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_-_65359019 0.400 GRIP1
glutamate receptor interacting protein 1
chr9_+_102231616 0.399 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr3_+_192529567 0.399 NM_174908
NM_178335
CCDC50

coiled-coil domain containing 50

chr6_-_24985432 0.398 NM_015864
FAM65B
family with sequence similarity 65, member B
chr3_-_197549588 0.393 TM4SF19
transmembrane 4 L six family member 19
chr1_+_153232685 0.392 NM_018655
LENEP
lens epithelial protein
chr1_+_203740306 0.392 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr8_+_11599119 0.390 NM_002052
GATA4
GATA binding protein 4
chr12_-_68291208 0.386 NM_201550
LRRC10
leucine rich repeat containing 10
chr1_+_205105776 0.384 NM_018724
IL20
interleukin 20
chr1_-_36589744 0.383


chr22_-_37214480 0.382 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr2_-_85494639 0.379 CAPG
capping protein (actin filament), gelsolin-like
chr7_-_98305599 0.379 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr9_+_4829763 0.378 RCL1
RNA terminal phosphate cyclase-like 1
chr16_+_56219802 0.375 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr22_+_21053972 0.374


chr22_+_21407066 0.374


chr12_-_47545816 0.373 NM_014470
RND1
Rho family GTPase 1
chr14_+_54291255 0.372 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr9_-_139068269 0.371 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr7_-_98305551 0.370 TMEM130
transmembrane protein 130
chr5_+_145297490 0.369 SH3RF2
SH3 domain containing ring finger 2
chr1_-_92725017 0.369 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr17_-_70480385 0.368 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr1_+_148747110 0.368 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chrX_-_10761729 0.365 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_26298136 0.365 SNX10
sorting nexin 10
chr4_+_76700281 0.362 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr8_+_10567556 0.359 NM_001040032
C8orf74
chromosome 8 open reading frame 74
chr10_+_82268433 0.359 TSPAN14
tetraspanin 14
chr11_-_62213946 0.353 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr15_+_57691382 0.347 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_-_156876798 0.347 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr1_+_110494654 0.346 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr9_-_68492023 0.345 NM_001085476
FOXD4L6
forkhead box D4-like 6
chr11_+_72660894 0.340 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_-_59223074 0.339


chr9_-_27287106 0.337 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr22_+_21116283 0.336


chr4_+_78172966 0.335 SEPT11
septin 11
chr1_-_178100204 0.334


chr12_+_6903886 0.334 NM_001007026
ATN1
atrophin 1
chr8_+_120289735 0.332 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr8_-_13018123 0.331 NM_001164271
DLC1
deleted in liver cancer 1
chr10_+_35575958 0.331 NM_181698
CCNY
cyclin Y
chr19_-_43955984 0.330 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr18_+_59726183 0.329 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr20_+_30480848 0.329 ASXL1
additional sex combs like 1 (Drosophila)
chr22_+_20316968 0.328 NM_152612
CCDC116
coiled-coil domain containing 116
chr16_-_30032330 0.328 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr15_+_38923470 0.327 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr7_+_101978777 0.326 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr14_-_93919305 0.325 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_42777419 0.324 WISP2
WNT1 inducible signaling pathway protein 2
chr19_+_40242634 0.324 HPN
hepsin
chr1_+_160618143 0.322 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr15_+_39918302 0.322 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr19_+_55123770 0.322 NM_012068
ATF5
activating transcription factor 5
chr3_+_185377430 0.321 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_-_177378801 0.320 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr19_-_43926953 0.319 NM_144691
CAPN12
calpain 12
chr1_-_151804929 0.319 NM_005978
S100A2
S100 calcium binding protein A2
chr12_+_32546243 0.319 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_+_176170041 0.318 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr19_-_19599973 0.316 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr9_+_5500544 0.316 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_27700180 0.315 NM_170731
BDNF
brain-derived neurotrophic factor
chr3_-_11585264 0.314 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr19_-_11549508 0.312 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr1_+_203740391 0.311 CDK18
cyclin-dependent kinase 18
chr11_-_72057755 0.311 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr17_+_7225088 0.310 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr4_-_151990061 0.310 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr22_+_25347927 0.308 NM_001886
CRYBA4
crystallin, beta A4
chr4_-_171161486 0.307 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr9_-_108416 0.307 NM_207305
FOXD4
forkhead box D4
chr11_+_74548472 0.305 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr13_-_99983945 0.305 NM_033110
A2LD1
AIG2-like domain 1
chr17_-_24069299 0.304 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr6_-_112001590 0.303 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr3_+_125586241 0.303 KALRN
kalirin, RhoGEF kinase
chr12_-_101396459 0.303 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_-_20098929 0.303 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr8_-_125649926 0.300 MTSS1
metastasis suppressor 1
chr8_-_25338472 0.299 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr1_+_151223180 0.299 NM_005987
SPRR1A
small proline-rich protein 1A
chr15_-_53996597 0.297 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr1_-_26070330 0.297 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr3_+_189413414 0.297 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr16_-_1369613 0.296 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr15_-_68781662 0.296 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_-_49152918 0.296 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr12_-_10173947 0.295 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr8_+_22266256 0.295 PIWIL2
piwi-like 2 (Drosophila)
chr8_+_75899326 0.293 NM_015886
PI15
peptidase inhibitor 15
chr19_-_63177713 0.292 NM_152474
C19orf18
chromosome 19 open reading frame 18
chr1_-_151333624 0.291 NM_001024209
SPRR2E
small proline-rich protein 2E
chr22_+_21359175 0.288 IGLV3-25
immunoglobulin lambda variable 3-25
chr4_-_5879488 0.286 CRMP1
collapsin response mediator protein 1
chr11_-_64133908 0.285


chr11_+_117903357 0.283 NM_001080441
TTC36
tetratricopeptide repeat domain 36
chr15_+_49421004 0.282 NM_181789
GLDN
gliomedin
chr13_+_77007809 0.281 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr19_-_6621078 0.280 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr14_+_104218487 0.278


chr11_+_58146721 0.278 NM_000614
CNTF
ciliary neurotrophic factor
chr4_+_661710 0.276 NM_002477
MYL5
myosin, light chain 5, regulatory
chr10_+_47867667 0.276 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr17_+_7423662 0.273 CD68
CD68 molecule
chr2_+_218833982 0.273 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr6_+_41118214 0.272 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr5_-_149446182 0.270 CSF1R
colony stimulating factor 1 receptor
chr8_-_11748330 0.268


chr18_-_42590989 0.266 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr11_-_62213577 0.265 LRRN4CL
LRRN4 C-terminal like
chr22_+_21484240 0.265


chr17_+_7423685 0.264 CD68
CD68 molecule
chr5_-_86739683 0.264 CCNH
cyclin H
chr22_-_44751671 0.264 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr3_+_122794859 0.262 NM_016298
FBXO40
F-box protein 40
chr22_+_43451600 0.260 PRR5
proline rich 5 (renal)
chr21_-_30836051 0.259 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr19_-_40939756 0.258 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr20_+_3000838 0.258 OXT
oxytocin, prepropeptide
chr13_+_32488477 0.258 NM_004795
KL
klotho

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
93.49 1.32e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
75.04 2.05e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
43.03 6.25e-03 GO:0005085 guanyl-nucleotide exchange factor activity
11.63 6.79e-03 GO:0030234 enzyme regulator activity
24.09 1.99e-02 GO:0005083 small GTPase regulator activity
15.54 4.78e-02 GO:0030695 GTPase regulator activity