Motif ID: GTF2I.p2

Z-value: 2.355


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i



Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_17714070 5.132 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chrX_+_144707022 4.001 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr15_-_86600658 3.518 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr2_+_45022540 3.366 NM_005413
SIX3
SIX homeobox 3
chr12_+_6800950 3.023 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr18_-_28606839 2.911 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr14_-_60185659 2.898 NM_005982
SIX1
SIX homeobox 1
chr13_+_99431417 2.868


chrX_+_136476353 2.865 ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr18_-_21184824 2.813


chr12_+_93066370 2.713 NM_005761
PLXNC1
plexin C1
chr13_+_57103944 2.668 PCDH17
protocadherin 17
chr17_-_44047299 2.666 NM_024016
HOXB8
homeobox B8
chr13_+_57103789 2.665 NM_001040429
PCDH17
protocadherin 17
chr1_+_26609893 2.599 LIN28A
lin-28 homolog A (C. elegans)
chr8_+_104582151 2.510 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_36058648 2.501 NM_003317
NKX2-1
NK2 homeobox 1
chr14_-_23117614 2.496 JPH4
junctophilin 4
chr2_-_200030944 2.419 NM_001172509
SATB2
SATB homeobox 2
chr11_-_27697768 2.372 NM_001143807
BDNF
brain-derived neurotrophic factor
chr1_-_29322993 2.293 NM_001003682
TMEM200B
transmembrane protein 200B
chr10_+_102495327 2.288 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr3_+_54131731 2.276 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_+_104837004 2.272


chr3_-_193609531 2.263 NM_021032
FGF12
fibroblast growth factor 12
chr14_-_23117833 2.176 NM_001146028
NM_032452
JPH4

junctophilin 4

chr7_+_128218685 2.157 CCDC136
coiled-coil domain containing 136
chr10_+_94823636 2.132 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr4_-_122213018 2.083 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr12_-_56418295 2.033 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_26609819 2.015 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr13_+_87122778 1.999 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr3_+_54131613 1.905 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr3_+_11009436 1.904 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr19_-_55763091 1.885 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr11_-_30564338 1.880 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr20_-_22512893 1.826 FOXA2
forkhead box A2
chr19_-_52666886 1.791 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_-_53841064 1.774 NM_001217
CA11
carbonic anhydrase XI
chr7_+_86111803 1.753 GRM3
glutamate receptor, metabotropic 3
chr11_-_44288188 1.744 NM_021926
ALX4
ALX homeobox 4
chr11_-_62445308 1.739 CHRM1
cholinergic receptor, muscarinic 1
chr4_+_109308126 1.734 LOC641518
hypothetical LOC641518
chrX_+_136475979 1.703 NM_003413
ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr16_-_10184111 1.695 NM_000833
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr16_-_10183616 1.692 NM_001134407
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr6_+_1335067 1.689 NM_001452
FOXF2
forkhead box F2
chr9_-_34579679 1.688 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr4_-_5940893 1.649 CRMP1
collapsin response mediator protein 1
chr19_-_11452439 1.642 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr4_-_46690197 1.628 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr2_+_200031333 1.628


chr2_-_200030412 1.619 SATB2
SATB homeobox 2
chr13_-_27441290 1.616 NM_001265
CDX2
caudal type homeobox 2
chr5_-_134397470 1.601 PITX1
paired-like homeodomain 1
chr17_+_35036936 1.587 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_-_62334229 1.585 NM_018008
FEZF2
FEZ family zinc finger 2
chr4_-_1156959 1.561 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr13_-_27441143 1.554 CDX2
caudal type homeobox 2
chr4_+_147779492 1.550 NM_004575
POU4F2
POU class 4 homeobox 2
chr13_-_27441423 1.543 CDX2
caudal type homeobox 2
chr18_+_44319365 1.528 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chrX_-_74062005 1.527 NM_001008537
KIAA2022
KIAA2022
chr11_-_18769703 1.526 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr17_-_72045218 1.521 NM_134268
CYGB
cytoglobin
chr16_-_2776606 1.519 NM_152891
PRSS33
protease, serine, 33
chr19_-_52667056 1.502 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr11_-_72063059 1.491 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr9_+_8848130 1.473


chr5_-_134397740 1.469 NM_002653
PITX1
paired-like homeodomain 1
chr8_-_21702273 1.469 NM_001165038
NM_001165039
NM_001495
GFRA2


GDNF family receptor alpha 2


chrX_-_111970662 1.457 NM_133265
AMOT
angiomotin
chr5_+_175231210 1.448 CPLX2
complexin 2
chr12_+_56291484 1.447 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr14_+_28306633 1.444 FOXG1
forkhead box G1
chr2_-_219558517 1.433 NM_017521
FEV
FEV (ETS oncogene family)
chr20_+_21634293 1.428 NM_006192
PAX1
paired box 1
chr17_+_35036704 1.407 NM_032192
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr5_+_139008667 1.405 CXXC5
CXXC finger protein 5
chr1_-_155095289 1.403 NM_014215
INSRR
insulin receptor-related receptor
chr5_+_175231170 1.390


chr15_-_24569201 1.372 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr9_-_85342868 1.370 NM_174938
FRMD3
FERM domain containing 3
chrX_-_137621060 1.369 FGF13
fibroblast growth factor 13
chr8_+_26427378 1.367 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr12_-_21818881 1.358 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr17_+_35036728 1.357 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr19_-_53706644 1.354


chr20_-_61755145 1.354 NM_015894
STMN3
stathmin-like 3
chr15_-_24569309 1.346 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr12_-_43556338 1.345 NELL2
NEL-like 2 (chicken)
chr19_-_44503328 1.345


chr1_+_109458247 1.341 KIAA1324
KIAA1324
chr2_-_144994038 1.336 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_5289079 1.331 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr15_-_24569253 1.330 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr19_+_3175734 1.323 CELF5
CUGBP, Elav-like family member 5
chr7_+_86112012 1.321 GRM3
glutamate receptor, metabotropic 3
chr12_-_43556424 1.296 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr3_+_53504070 1.293 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr1_-_202921103 1.292 NM_006338
NM_201630
LRRN2

leucine rich repeat neuronal 2

chr3_-_42282665 1.288 NM_000729
CCK
cholecystokinin
chr8_-_93184629 1.288 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr8_-_26427304 1.285 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_+_26742767 1.282 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr5_+_175231144 1.282 CPLX2
complexin 2
chr10_-_88116181 1.273 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr2_+_219432789 1.267 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr15_-_51839129 1.262 NM_182758
WDR72
WD repeat domain 72
chr2_+_176665694 1.245 NM_000523
HOXD13
homeobox D13
chr7_+_68702516 1.239 AUTS2
autism susceptibility candidate 2
chr12_+_84198015 1.235 NM_006982
ALX1
ALX homeobox 1
chr4_-_1156533 1.231 NM_012445
SPON2
spondin 2, extracellular matrix protein
chr2_-_192767494 1.224 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr15_+_64782468 1.222 SMAD6
SMAD family member 6
chr20_+_21634515 1.216 PAX1
paired box 1
chr7_+_30917939 1.214 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr16_+_85101605 1.210 NM_001451
FOXF1
forkhead box F1
chr12_-_43556220 1.209 NELL2
NEL-like 2 (chicken)
chr20_+_20296744 1.209 NM_002196
INSM1
insulinoma-associated 1
chr20_-_61462960 1.205 NM_000744
CHRNA4
cholinergic receptor, nicotinic, alpha 4
chr8_-_89408832 1.204 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr4_-_168392266 1.203 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_5941043 1.200 CRMP1
collapsin response mediator protein 1
chr13_-_71339313 1.196 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr15_-_49174107 1.193 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr7_+_68702252 1.193 AUTS2
autism susceptibility candidate 2
chr4_-_105635499 1.181 CXXC4
CXXC finger protein 4
chr1_-_40555413 1.180 COL9A2
collagen, type IX, alpha 2
chr2_-_227371698 1.179 NM_005544
IRS1
insulin receptor substrate 1
chr15_+_41597097 1.179 NM_002373
MAP1A
microtubule-associated protein 1A
chr20_-_55274497 1.175 BMP7
bone morphogenetic protein 7
chr2_+_74594093 1.170 TLX2
T-cell leukemia homeobox 2
chr8_-_111056099 1.164 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr2_+_176680251 1.160 NM_021192
HOXD11
homeobox D11
chr1_+_109458299 1.158 KIAA1324
KIAA1324
chr1_-_175400441 1.153 ASTN1
astrotactin 1
chrX_+_104953215 1.141 NRK
Nik related kinase
chr2_-_241408296 1.138 NM_004321
KIF1A
kinesin family member 1A
chr7_-_78920806 1.133 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_+_62391216 1.128 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr6_+_96570565 1.125 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr7_-_23476497 1.125 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr10_+_94823221 1.125 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr5_+_170779664 1.124 FGF18
fibroblast growth factor 18
chr15_+_90738108 1.119 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chrX_+_150095713 1.119 NM_004224
GPR50
G protein-coupled receptor 50
chr19_-_13478037 1.111 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr9_-_129557373 1.106 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr2_-_144994349 1.097 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr17_+_1906262 1.096 NM_001098202
HIC1
hypermethylated in cancer 1
chr1_-_37272295 1.093 NM_000831
GRIK3
glutamate receptor, ionotropic, kainate 3
chr3_-_159306532 1.093 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr19_-_14177980 1.092 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr2_-_200028977 1.090 SATB2
SATB homeobox 2
chr6_-_33268177 1.089 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chrX_-_137621492 1.087 NM_004114
FGF13
fibroblast growth factor 13
chr10_+_124885556 1.083 NM_001105574
HMX3
H6 family homeobox 3
chr13_+_99432258 1.082 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr1_+_2975590 1.080 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr4_+_61749540 1.078 LPHN3
latrophilin 3
chrX_+_104953187 1.076 NM_198465
NRK
Nik related kinase
chr17_-_34014390 1.072 SRCIN1
SRC kinase signaling inhibitor 1
chr1_+_145479805 1.070 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr4_-_46086528 1.069 NM_000807
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr4_+_7245218 1.058 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr7_-_15692551 1.053 MEOX2
mesenchyme homeobox 2
chr9_-_16860719 1.052 NM_017637
BNC2
basonuclin 2
chr4_-_168392307 1.051 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr18_+_53170718 1.049 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr3_+_148610516 1.039 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr17_-_44058612 1.035 NM_024017
HOXB9
homeobox B9
chr19_+_51059357 1.033 NM_004497
FOXA3
forkhead box A3
chr12_-_33483847 1.027 NM_198992
SYT10
synaptotagmin X
chr11_-_35398077 1.025 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_-_75711785 1.022 LINGO1
leucine rich repeat and Ig domain containing 1
chr19_-_40325194 1.021 LGI4
leucine-rich repeat LGI family, member 4
chr10_+_106390848 1.015 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr4_-_96689373 1.014 NM_003728
UNC5C
unc-5 homolog C (C. elegans)
chr5_+_92944680 1.010 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr3_-_135097111 1.006 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr2_+_5750229 1.001 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr12_-_16650687 1.001 LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_2116775 1.000 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_-_168392151 0.997 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr7_+_73080387 0.992 ELN
elastin
chr18_-_33399997 0.992 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr7_+_73080362 0.988 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr6_+_108593907 0.981 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr17_-_47591123 0.980 NM_020178
CA10
carbonic anhydrase X
chr2_-_163403485 0.979 NM_033272
NM_173162
KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_+_19164973 0.976 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr22_+_24895424 0.974 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chrX_+_90920915 0.974 NM_032967
PCDH11X
PCDH11Y
protocadherin 11 X-linked
protocadherin 11 Y-linked
chr12_+_56140184 0.973 NM_001160045
NM_001167609
NM_005269
GLI1


GLI family zinc finger 1


chr7_+_8440541 0.973 NXPH1
neurexophilin 1
chr7_-_32077504 0.970 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr15_-_71448194 0.970 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr1_+_168898898 0.969 PRRX1
paired related homeobox 1
chr16_+_85101734 0.966 FOXF1
forkhead box F1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.81 5.00e-20 GO:0007399 nervous system development
3.27 2.05e-18 GO:0048731 system development
2.78 1.86e-17 GO:0032502 developmental process
3.03 3.38e-17 GO:0048856 anatomical structure development
2.89 3.98e-17 GO:0007275 multicellular organismal development
9.31 7.47e-14 GO:0007389 pattern specification process
2.20 1.45e-13 GO:0032501 multicellular organismal process
4.03 2.49e-13 GO:0009653 anatomical structure morphogenesis
3.35 2.10e-12 GO:0030154 cell differentiation
3.26 6.43e-12 GO:0048869 cellular developmental process
10.49 1.76e-11 GO:0003002 regionalization
4.78 7.18e-11 GO:0022008 neurogenesis
4.75 5.72e-10 GO:0048699 generation of neurons
4.58 5.83e-10 GO:0048468 cell development
3.19 1.06e-09 GO:0048513 organ development
5.09 5.57e-09 GO:0009790 embryo development
5.84 2.00e-08 GO:0007417 central nervous system development
11.14 2.50e-08 GO:0009952 anterior/posterior pattern formation
6.97 2.54e-08 GO:0007420 brain development
4.88 3.59e-08 GO:0030182 neuron differentiation
6.83 3.63e-08 GO:0048598 embryonic morphogenesis
5.75 7.98e-08 GO:0031175 neuron projection development
5.69 9.79e-08 GO:0000904 cell morphogenesis involved in differentiation
5.84 5.22e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
5.74 6.98e-07 GO:0048812 neuron projection morphogenesis
1.69 7.83e-07 GO:0050794 regulation of cellular process
3.76 8.83e-07 GO:0007154 cell communication
4.73 1.08e-06 GO:0032989 cellular component morphogenesis
4.96 1.16e-06 GO:0048666 neuron development
8.02 1.97e-06 GO:0002009 morphogenesis of an epithelium
5.73 2.05e-06 GO:0007409 axonogenesis
4.77 2.35e-06 GO:0000902 cell morphogenesis
1.63 2.82e-06 GO:0050789 regulation of biological process
5.10 4.90e-06 GO:0048858 cell projection morphogenesis
5.06 5.64e-06 GO:0032990 cell part morphogenesis
1.58 6.06e-06 GO:0065007 biological regulation
4.10 6.77e-06 GO:0007267 cell-cell signaling
6.62 7.15e-06 GO:0048729 tissue morphogenesis
4.46 7.77e-06 GO:0030030 cell projection organization
4.53 1.41e-05 GO:0009887 organ morphogenesis
3.78 1.49e-05 GO:0040011 locomotion
6.24 1.58e-05 GO:0001501 skeletal system development
3.44 4.70e-05 GO:0009605 response to external stimulus
4.83 7.32e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.83 1.05e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
5.33 1.24e-04 GO:0009792 embryo development ending in birth or egg hatching
4.14 1.34e-04 GO:0045893 positive regulation of transcription, DNA-dependent
7.75 1.56e-04 GO:0035239 tube morphogenesis
3.43 1.74e-04 GO:0050793 regulation of developmental process
5.59 1.85e-04 GO:0007411 axon guidance
8.57 2.26e-04 GO:0060562 epithelial tube morphogenesis
3.48 2.72e-04 GO:0009888 tissue development
1.94 3.04e-04 GO:0023052 signaling
3.86 3.94e-04 GO:0051254 positive regulation of RNA metabolic process
3.82 4.57e-04 GO:0010628 positive regulation of gene expression
3.80 5.04e-04 GO:0045595 regulation of cell differentiation
5.59 5.12e-04 GO:0022603 regulation of anatomical structure morphogenesis
5.04 6.57e-04 GO:0043009 chordate embryonic development
3.40 7.24e-04 GO:0031328 positive regulation of cellular biosynthetic process
4.95 8.08e-04 GO:0060429 epithelium development
7.43 8.48e-04 GO:0030900 forebrain development
3.35 9.52e-04 GO:0009891 positive regulation of biosynthetic process
4.19 1.17e-03 GO:0006935 chemotaxis
4.19 1.17e-03 GO:0042330 taxis
5.68 1.20e-03 GO:0035295 tube development
16.71 1.22e-03 GO:0060021 palate development
3.26 1.43e-03 GO:0006351 transcription, DNA-dependent
6.13 1.61e-03 GO:0048568 embryonic organ development
9.52 1.67e-03 GO:0061138 morphogenesis of a branching epithelium
1.30 1.90e-03 GO:0009987 cellular process
3.44 2.20e-03 GO:2000026 regulation of multicellular organismal development
3.40 2.55e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
6.45 3.04e-03 GO:0045664 regulation of neuron differentiation
10.86 3.10e-03 GO:0048706 embryonic skeletal system development
2.13 3.15e-03 GO:0048522 positive regulation of cellular process
4.12 3.20e-03 GO:0019226 transmission of nerve impulse
4.12 3.20e-03 GO:0035637 multicellular organismal signaling
3.30 3.95e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
4.32 4.01e-03 GO:0007268 synaptic transmission
2.05 4.28e-03 GO:0031326 regulation of cellular biosynthetic process
5.01 4.45e-03 GO:0060284 regulation of cell development
1.86 5.26e-03 GO:0080090 regulation of primary metabolic process
2.65 5.54e-03 GO:0051239 regulation of multicellular organismal process
2.02 5.63e-03 GO:0009889 regulation of biosynthetic process
8.04 5.95e-03 GO:0001763 morphogenesis of a branching structure
12.68 6.37e-03 GO:0048704 embryonic skeletal system morphogenesis
2.09 6.79e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
7.85 7.13e-03 GO:0048705 skeletal system morphogenesis
2.94 7.15e-03 GO:0032774 RNA biosynthetic process
9.53 7.41e-03 GO:0021537 telencephalon development
4.38 7.57e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.83 7.74e-03 GO:0031323 regulation of cellular metabolic process
2.93 7.80e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
4.07 7.81e-03 GO:0048646 anatomical structure formation involved in morphogenesis
9.43 7.97e-03 GO:0051216 cartilage development
2.71 9.60e-03 GO:0010604 positive regulation of macromolecule metabolic process
9.03 1.06e-02 GO:0048754 branching morphogenesis of a tube
2.00 1.08e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.13 1.19e-02 GO:0006355 regulation of transcription, DNA-dependent
2.04 1.24e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.53 1.24e-02 GO:0050896 response to stimulus
1.97 1.45e-02 GO:0048518 positive regulation of biological process
10.98 1.48e-02 GO:0009953 dorsal/ventral pattern formation
2.64 1.54e-02 GO:0031325 positive regulation of cellular metabolic process
5.33 1.62e-02 GO:0050767 regulation of neurogenesis
7.01 1.63e-02 GO:0001655 urogenital system development
8.41 1.69e-02 GO:0001822 kidney development
6.91 1.81e-02 GO:0045165 cell fate commitment
8.17 2.04e-02 GO:0048736 appendage development
8.17 2.04e-02 GO:0060173 limb development
1.94 2.16e-02 GO:0051171 regulation of nitrogen compound metabolic process
8.10 2.17e-02 GO:0072001 renal system development
4.65 2.20e-02 GO:0007610 behavior
13.93 2.38e-02 GO:0009880 embryonic pattern specification
2.03 2.41e-02 GO:0048519 negative regulation of biological process
6.58 2.56e-02 GO:0048562 embryonic organ morphogenesis
3.90 2.58e-02 GO:0051094 positive regulation of developmental process
2.05 2.65e-02 GO:0051252 regulation of RNA metabolic process
5.01 2.79e-02 GO:0045596 negative regulation of cell differentiation
2.77 2.89e-02 GO:0009892 negative regulation of metabolic process
4.50 3.00e-02 GO:0051093 negative regulation of developmental process
2.85 3.20e-02 GO:0010605 negative regulation of macromolecule metabolic process
3.38 3.24e-02 GO:0010629 negative regulation of gene expression
3.20 3.42e-02 GO:0031327 negative regulation of cellular biosynthetic process
3.56 3.48e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.79 3.75e-02 GO:0060255 regulation of macromolecule metabolic process
2.49 3.76e-02 GO:0009893 positive regulation of metabolic process
9.19 4.08e-02 GO:0060485 mesenchyme development
3.49 4.35e-02 GO:0051253 negative regulation of RNA metabolic process
3.14 4.39e-02 GO:0009890 negative regulation of biosynthetic process
4.74 4.46e-02 GO:0051960 regulation of nervous system development
12.26 4.47e-02 GO:0001764 neuron migration
18.85 4.65e-02 GO:0031128 developmental induction
18.85 4.65e-02 GO:0045168 cell-cell signaling involved in cell fate commitment
3.28 4.70e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.78 4.71e-02 GO:0007165 signal transduction
1.70 4.93e-02 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
7.26 2.62e-08 GO:0044456 synapse part
6.02 5.09e-08 GO:0045202 synapse
8.28 5.07e-05 GO:0045211 postsynaptic membrane
7.14 5.85e-05 GO:0030425 dendrite
5.57 6.57e-04 GO:0005667 transcription factor complex
16.56 1.63e-03 GO:0042734 presynaptic membrane
15.32 2.41e-03 GO:0043679 axon terminus
14.59 3.08e-03 GO:0044306 neuron projection terminus
9.68 4.97e-03 GO:0033267 axon part
20.42 5.45e-03 GO:0043195 terminal button
5.31 7.25e-03 GO:0034702 ion channel complex
5.54 1.41e-02 GO:0030424 axon
3.02 3.19e-02 GO:0030054 cell junction
3.52 4.31e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.11 4.31e-10 GO:0043565 sequence-specific DNA binding
4.07 2.98e-09 GO:0001071 nucleic acid binding transcription factor activity
4.07 2.98e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
3.48 2.29e-06 GO:0030528 transcription regulator activity
6.11 4.85e-06 GO:0022836 gated channel activity
4.83 1.03e-04 GO:0005216 ion channel activity
4.75 1.26e-04 GO:0022838 substrate-specific channel activity
8.83 1.67e-04 GO:0015276 ligand-gated ion channel activity
8.83 1.67e-04 GO:0022834 ligand-gated channel activity
4.61 1.85e-04 GO:0015267 channel activity
4.60 1.90e-04 GO:0022803 passive transmembrane transporter activity
5.14 3.08e-04 GO:0016563 transcription activator activity
11.92 3.86e-04 GO:0005230 extracellular ligand-gated ion channel activity
2.14 6.69e-04 GO:0003677 DNA binding
10.72 7.89e-04 GO:0042165 neurotransmitter binding
10.21 1.10e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
9.53 1.73e-03 GO:0003704 specific RNA polymerase II transcription factor activity
9.23 2.16e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
3.12 3.63e-03 GO:0015075 ion transmembrane transporter activity
6.91 4.24e-03 GO:0022843 voltage-gated cation channel activity
10.36 4.84e-03 GO:0030594 neurotransmitter receptor activity
2.82 8.41e-03 GO:0022891 substrate-specific transmembrane transporter activity
18.85 1.09e-02 GO:0005245 voltage-gated calcium channel activity
4.65 1.23e-02 GO:0005261 cation channel activity
17.50 1.47e-02 GO:0008066 glutamate receptor activity
11.14 1.66e-02 GO:0008301 DNA bending activity
2.55 2.11e-02 GO:0022892 substrate-specific transporter activity
2.62 2.30e-02 GO:0022857 transmembrane transporter activity
5.25 2.96e-02 GO:0005244 voltage-gated ion channel activity
5.25 2.96e-02 GO:0022832 voltage-gated channel activity
5.06 3.81e-02 GO:0010843 promoter binding