Motif ID: HAND1,2.p2

Z-value: 1.881


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2



Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_557269 2.008


chr5_+_150008030 1.542 SYNPO
synaptopodin
chr1_+_556968 1.478


chr7_+_142270634 1.469 EPHB6
EPH receptor B6
chr6_-_31196174 1.313 NM_001264
CDSN
corneodesmosin
chr1_+_199519202 1.296 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr1_+_200358594 1.281 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr14_-_87806913 1.237 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr8_-_19584373 1.211 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr11_+_118463906 1.204 NM_001024382
HMBS
hydroxymethylbilane synthase
chr22_+_21053972 1.203


chr1_-_199348316 1.174 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_-_23393808 1.146 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr11_-_119504726 1.138 TRIM29
tripartite motif containing 29
chr20_-_55718982 1.138 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr20_+_29420081 1.123 NM_054112
DEFB118
defensin, beta 118
chr19_-_59542197 1.115 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr20_-_29441946 1.108 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr11_+_18244383 1.106 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr1_+_17404206 1.043 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr12_+_27511009 1.029 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr6_+_167445284 1.028 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr17_+_71235324 1.025 ITGB4
integrin, beta 4
chr7_+_104539548 1.021 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr6_-_21631992 1.002


chr8_-_18585721 0.994 PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_124893875 0.984 MYLK
myosin light chain kinase
chr15_+_66695932 0.977 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr22_+_21393107 0.975 IGLJ3
immunoglobulin lambda joining 3
chr1_+_151035850 0.966 NM_178352
LCE1D
late cornified envelope 1D
chr6_+_29732736 0.960 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr4_+_76700281 0.954 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr8_-_28403652 0.939 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr17_-_36899641 0.938 NM_003771
KRT36
keratin 36
chr22_+_23329113 0.928 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr15_-_50316996 0.924 MYO5C
myosin VC
chr1_+_26358097 0.923 NM_024869
GRRP1
glycine/arginine rich protein 1
chr4_+_40032146 0.916 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr6_+_31016755 0.907 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr11_-_4893468 0.901 NM_001005238
OR51G2
olfactory receptor, family 51, subfamily G, member 2
chr5_-_121842680 0.896


chr20_+_36643251 0.883 NM_001018082
ADIG
adipogenin
chr1_-_166149867 0.866 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_+_28134090 0.864 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr3_+_196933422 0.835 NM_152673
MUC20
mucin 20, cell surface associated
chr10_-_70846573 0.823 NM_001057
TACR2
tachykinin receptor 2
chr5_-_149304475 0.819 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr8_-_38577891 0.800


chr22_-_16127520 0.800 CECR3
cat eye syndrome chromosome region, candidate 3
chr3_-_33675484 0.796 CLASP2
cytoplasmic linker associated protein 2
chr7_+_99654806 0.794 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr9_-_135074364 0.793 NM_014581
OBP2B
OBP2A
odorant binding protein 2B
odorant binding protein 2A
chr19_+_50144267 0.781 APOC2
apolipoprotein C-II
chr3_+_46894239 0.777 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr6_-_39180390 0.755 C6orf64
chromosome 6 open reading frame 64
chr3_+_153499883 0.753 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr14_+_70209807 0.750 TTC9
tetratricopeptide repeat domain 9
chr12_+_26096757 0.745 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr2_-_128155829 0.745 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr1_+_228949752 0.745 NM_006615
NM_016452
CAPN9

calpain 9

chr21_+_34112456 0.736 ITSN1
intersectin 1 (SH3 domain protein)
chr8_+_134272463 0.730 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr10_+_82287637 0.730 NM_207372
SH2D4B
SH2 domain containing 4B
chr10_-_76529253 0.725 NM_016364
DUSP13
dual specificity phosphatase 13
chr2_-_73781974 0.711 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr11_-_63087430 0.706 NM_017878
HRASLS2
HRAS-like suppressor 2
chr1_-_41722883 0.705 NM_001956
EDN2
endothelin 2
chr1_+_46418786 0.703 TSPAN1
tetraspanin 1
chr8_-_93099040 0.700 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_53121540 0.699 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_-_181540631 0.698 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr3_-_15357878 0.696 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr12_-_108755588 0.694 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr2_+_128119908 0.691 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr2_+_231569082 0.691 NM_139073
SPATA3
spermatogenesis associated 3
chr19_+_52113772 0.687 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr2_-_219404755 0.678 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr11_+_118332217 0.677 NM_006760
UPK2
uroplakin 2
chr19_+_60850765 0.672 NM_013301
CCDC106
coiled-coil domain containing 106
chr15_+_42815851 0.663 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr10_-_121286034 0.659 NM_002925
RGS10
regulator of G-protein signaling 10
chr22_-_21814208 0.657 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr11_-_2517390 0.657


chr7_-_142293382 0.656 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr5_+_36644187 0.653 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_10074332 0.652 NM_031917
ANGPTL6
angiopoietin-like 6
chr1_+_148511806 0.647 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr10_-_73149505 0.643 NM_001164375
C10orf105
chromosome 10 open reading frame 105
chr1_-_53972464 0.642 NM_147193
GLIS1
GLIS family zinc finger 1
chr5_+_73145098 0.642 RGNEF
190 kDa guanine nucleotide exchange factor
chr3_-_15515382 0.639 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr15_+_37330176 0.631 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr16_+_55612125 0.630 NLRC5
NLR family, CARD domain containing 5
chr19_+_41085221 0.625 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr16_-_3089253 0.618 ZSCAN10
zinc finger and SCAN domain containing 10
chr21_+_29439768 0.617 C21orf7
chromosome 21 open reading frame 7
chr7_+_102078007 0.613 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr12_-_108755565 0.613 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr21_-_45165204 0.612 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_+_71232370 0.608 NM_001005619
ITGB4
integrin, beta 4
chrX_+_2680092 0.608 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr6_+_37081387 0.603 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr2_-_27571532 0.599 FNDC4
fibronectin type III domain containing 4
chr6_+_88026338 0.594 ZNF292
zinc finger protein 292
chr6_-_31215089 0.592 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr3_-_126215069 0.592 HEG1
HEG homolog 1 (zebrafish)
chr2_+_95621492 0.580 NM_138800
TRIM43
tripartite motif containing 43
chr20_+_34937928 0.578 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr5_-_41906459 0.572 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr6_+_6533932 0.571 NM_004271
LY86
lymphocyte antigen 86
chr9_-_131555111 0.570 NM_004878
PTGES
prostaglandin E synthase
chr1_+_15858950 0.569 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr5_-_171814026 0.564 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr15_+_72687765 0.563 NM_003992
CLK3
CDC-like kinase 3
chr6_-_167491305 0.562 NM_005299
GPR31
G protein-coupled receptor 31
chr1_+_245646080 0.558 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr11_-_5494391 0.557 NM_145053
UBQLNL
ubiquilin-like
chr14_-_64508547 0.557 NM_198686
RAB15
RAB15, member RAS onocogene family
chrX_-_69396241 0.555 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr6_-_3665308 0.554


chr21_-_45165249 0.547 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_136849104 0.545 RPL41P5
ribosomal protein L41 pseudogene 5
chr14_-_30927931 0.544 NM_015473
HEATR5A
HEAT repeat containing 5A
chr20_-_41788975 0.543 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr2_-_138762909 0.532


chr9_+_71848316 0.532 NM_153267
MAMDC2
MAM domain containing 2
chr5_-_39400319 0.530 NM_001737
C9
complement component 9
chr4_+_14985272 0.528 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr5_+_179065282 0.521 CANX
calnexin
chr3_+_38322430 0.513 NM_004803
SLC22A14
solute carrier family 22, member 14
chr1_+_205038837 0.513 NM_153758
IL19
interleukin 19
chr6_-_33822659 0.510 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr12_+_107797985 0.509 NM_001917
DAO
D-amino-acid oxidase
chr17_-_24426752 0.503 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_+_116744992 0.502 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_151804929 0.499 NM_005978
S100A2
S100 calcium binding protein A2
chr7_+_101978777 0.493 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr1_+_45251007 0.491 UROD
uroporphyrinogen decarboxylase
chr8_-_125649926 0.491 MTSS1
metastasis suppressor 1
chr1_-_120413542 0.489 NOTCH2
notch 2
chr20_+_764710 0.487 NM_207121
FAM110A
family with sequence similarity 110, member A
chr1_+_11171967 0.486 NM_021146
ANGPTL7
angiopoietin-like 7
chr12_+_119617060 0.477


chr10_-_45350804 0.477 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr15_+_40484249 0.476 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr3_+_196933481 0.473 MUC20
mucin 20, cell surface associated
chr1_+_154178103 0.473 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr1_+_184636326 0.470 NM_022375
OCLM
oculomedin
chr21_-_35153664 0.469 RUNX1
runt-related transcription factor 1
chr11_-_19180092 0.468 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chrX_+_1415508 0.466 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr17_+_65582981 0.463 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr21_-_42644138 0.463 NM_005423
TFF2
trefoil factor 2
chr10_-_75071498 0.462 NM_021245
MYOZ1
myozenin 1
chr3_+_150675117 0.461 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr16_+_55553262 0.461 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr21_+_43024936 0.460 PDE9A
phosphodiesterase 9A
chr16_+_76613912 0.458 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr8_-_27906287 0.457 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr20_+_19815075 0.456 RIN2
Ras and Rab interactor 2
chr6_+_37030186 0.454 NM_153370
PI16
peptidase inhibitor 16
chr17_-_36587965 0.453 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr1_+_226404037 0.450 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr19_+_54238913 0.450 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr12_+_111900650 0.446 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr2_-_27571602 0.446 NM_022823
FNDC4
fibronectin type III domain containing 4
chr18_+_19826734 0.443 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr11_+_5558682 0.441 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr3_+_113534604 0.440 NM_001004196
NM_005944
CD200

CD200 molecule

chr18_+_41659542 0.438 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr11_-_111636792 0.438 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr12_-_55134692 0.437 NM_012064
MIP
major intrinsic protein of lens fiber
chr11_+_66927976 0.436 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_-_40996040 0.435 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_3697328 0.435


chr15_+_67393795 0.434 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr2_+_113533155 0.434 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr18_-_58946858 0.433 BCL2
B-cell CLL/lymphoma 2
chr1_+_44217435 0.432 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr17_+_45617676 0.431


chr14_-_105392671 0.426


chr6_-_25940247 0.422 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr10_+_18669619 0.421 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_69418746 0.418 NM_001032726
RAB41
RAB41, member RAS oncogene family
chr19_-_47586259 0.415 NM_032488
CNFN
cornifelin
chr1_+_33003847 0.414 KIAA1522
KIAA1522
chr17_+_74531873 0.414 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr2_+_228386800 0.411 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_-_22947320 0.405 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr1_+_33003814 0.404 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr5_-_179004610 0.404 NM_001142306
C5orf60
chromosome 5 open reading frame 60
chr6_-_46997579 0.402 NM_001098518
GPR116
G protein-coupled receptor 116
chr12_-_108736983 0.401 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr13_-_59485299 0.400 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr3_+_150675169 0.400 TM4SF4
transmembrane 4 L six family member 4
chr5_-_41906257 0.399 OXCT1
3-oxoacid CoA transferase 1
chr5_-_41906216 0.397 OXCT1
3-oxoacid CoA transferase 1
chr3_-_46761248 0.396 NM_199183
PRSS45
protease, serine, 45
chr5_-_137099361 0.394 KLHL3
kelch-like 3 (Drosophila)
chr1_-_41398126 0.394 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.