Motif ID: HES1.p2

Z-value: 1.128


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)



Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_149895274 1.017 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr7_+_116099648 0.903 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr2_-_204108151 0.816 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr20_+_36810510 0.730 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr12_+_8741746 0.671 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr1_-_45924770 0.659 NM_021639
GPBP1L1
GC-rich promoter binding protein 1-like 1
chr16_+_55199978 0.657 NM_005953
MT2A
metallothionein 2A
chr15_+_94674849 0.626 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_+_234372454 0.623 NM_003272
GPR137B
G protein-coupled receptor 137B
chr11_-_2907169 0.615 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr2_-_127580975 0.603 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr6_-_86445138 0.581 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr5_+_14196287 0.580 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr1_-_223907283 0.574 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_+_11819364 0.571 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr20_+_254205 0.569 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr2_-_172458970 0.554 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr2_+_182464910 0.537 SSFA2
sperm specific antigen 2
chr1_-_45444812 0.527 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr15_-_53667800 0.524 PYGO1
pygopus homolog 1 (Drosophila)
chr8_+_120955080 0.522 NM_022783
DEPTOR
DEP domain containing MTOR-interacting protein
chr2_+_122229590 0.508 NM_004622
TSN
translin
chr2_+_85619802 0.500 MAT2A
methionine adenosyltransferase II, alpha
chr6_-_137407504 0.493 IL20RA
interleukin 20 receptor, alpha
chr2_-_85969527 0.490 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr17_-_77129802 0.489 NM_025161
C17orf70
chromosome 17 open reading frame 70
chr7_-_525336 0.487 PDGFA
platelet-derived growth factor alpha polypeptide
chr2_+_101680594 0.476 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr9_+_91115924 0.474 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr2_+_203901160 0.469 NM_005759
ABI2
abl-interactor 2
chr1_-_9111674 0.464 NM_024980
GPR157
G protein-coupled receptor 157
chr8_-_142080169 0.461 NM_005607
NM_153831
PTK2

PTK2 protein tyrosine kinase 2

chr12_+_92295738 0.458 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr8_+_66719441 0.458 NM_001145839
NM_014637
MTFR1

mitochondrial fission regulator 1

chr1_+_21639146 0.455 NM_032264
NBPF3
neuroblastoma breakpoint family, member 3
chr5_+_63497408 0.451 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr1_-_203557379 0.440 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr20_-_32877029 0.434 NM_014071
NCOA6
nuclear receptor coactivator 6
chr12_+_2939250 0.430 TEAD4
TEA domain family member 4
chr20_-_3336219 0.429 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr2_-_101291483 0.425 NM_173647
RNF149
ring finger protein 149
chr6_+_157722467 0.423 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr11_+_8660913 0.418 RPL27A
ribosomal protein L27a
chr3_+_37878647 0.417 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr16_-_84342129 0.410 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr1_-_209818342 0.409 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr17_-_76985538 0.405


chr1_-_52791309 0.397 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr6_-_163754903 0.397 LOC100526820
hypothetical LOC100526820
chr16_+_30617962 0.395 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr16_-_4341266 0.393 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr14_+_76634323 0.392 NM_033426
KIAA1737
KIAA1737
chr17_-_39757660 0.389 SLC25A39
solute carrier family 25, member 39
chr2_-_175741096 0.386 NM_001880
ATF2
activating transcription factor 2
chr2_-_218865451 0.383 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr9_-_83493415 0.381 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr16_+_2593351 0.376 LOC652276
hypothetical LOC652276
chr12_-_105057940 0.376 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr20_+_30410447 0.376 ASXL1
additional sex combs like 1 (Drosophila)
chr15_+_78858763 0.374 NM_018689
KIAA1199
KIAA1199
chr17_-_17435631 0.372 NM_148172
PEMT
phosphatidylethanolamine N-methyltransferase
chr8_-_96350575 0.372 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr2_+_113119985 0.367 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr16_+_23560187 0.364 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr1_-_239869826 0.362 NM_014322
OPN3
opsin 3
chr1_-_62926533 0.360 NM_033407
DOCK7
dedicator of cytokinesis 7
chr22_-_27405708 0.353 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr7_+_106472243 0.351 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr13_+_20175481 0.349 NM_138284
IL17D
interleukin 17D
chr15_+_38013559 0.349 NM_001013703
EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr1_+_93317374 0.347 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr16_-_69880591 0.347 NM_001099642
NM_018348
FTSJD1

FtsJ methyltransferase domain containing 1

chr16_-_23559978 0.346 NM_024675
PALB2
partner and localizer of BRCA2
chr2_-_177836773 0.344 NM_001145412
NM_001145413
NFE2L2

nuclear factor (erythroid-derived 2)-like 2

chr20_-_20641122 0.340 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr2_-_179837490 0.339 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr6_-_119712596 0.338 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr18_-_53621277 0.338 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr16_-_85974810 0.335 NM_024735
FBXO31
F-box protein 31
chr7_-_33068699 0.328 NM_001002010
NT5C3
5'-nucleotidase, cytosolic III
chr4_-_10068055 0.328 NM_053042
ZNF518B
zinc finger protein 518B
chr11_+_12088639 0.326 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr6_-_143307976 0.326 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr17_+_42023353 0.318 NM_006178
NSF
N-ethylmaleimide-sensitive factor
chr20_-_49818306 0.318 NM_006045
ATP9A
ATPase, class II, type 9A
chr9_+_130354490 0.318 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr5_+_90711887 0.317 LOC100129716
hypothetical LOC100129716
chr2_+_177785667 0.317 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr7_-_139987044 0.316 DENND2A
DENN/MADD domain containing 2A
chr18_+_9465528 0.316 NM_006788
RALBP1
ralA binding protein 1
chr6_-_138470160 0.315 NM_022121
PERP
PERP, TP53 apoptosis effector
chr17_+_78070853 0.314 NM_004514
FOXK2
forkhead box K2
chr12_-_105165805 0.313 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr10_+_73393998 0.310 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr2_-_200424140 0.310 LOC348751
hypothetical LOC348751
chr20_+_6696744 0.309 NM_001200
BMP2
bone morphogenetic protein 2
chr20_-_49818268 0.307 ATP9A
ATPase, class II, type 9A
chr2_-_54051290 0.307 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr11_-_93114155 0.306 NM_024116
TAF1D
TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
chr17_-_33043514 0.306 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr19_+_4353658 0.305 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr1_+_25629968 0.304 NM_018202
TMEM57
transmembrane protein 57
chr7_+_93977267 0.303 CASD1
CAS1 domain containing 1
chr14_-_24588916 0.302 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr16_+_66484671 0.301 NM_006742
PSKH1
protein serine kinase H1
chr11_+_76171780 0.301 NM_015516
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr3_-_88190737 0.301 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chrX_-_9693916 0.298 NM_000273
GPR143
G protein-coupled receptor 143
chr2_+_85619797 0.298 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr9_-_21549696 0.294 LOC554202
hypothetical LOC554202
chr17_-_27210330 0.294 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr20_-_42373151 0.292 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr2_+_170363573 0.291 NM_003142
SSB
Sjogren syndrome antigen B (autoantigen La)
chr11_+_63883192 0.288 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr8_+_41554823 0.287 NM_178819
AGPAT6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
chr1_-_16812274 0.283 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr13_+_26723689 0.281 NM_000982
RPL21
ribosomal protein L21
chr6_-_44333002 0.280 NM_178148
SLC35B2
solute carrier family 35, member B2
chr6_-_150431864 0.280 NM_024518
ULBP3
UL16 binding protein 3
chr1_-_150232900 0.276 S100A10
S100 calcium binding protein A10
chr7_+_24579239 0.274 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr16_+_8799170 0.272 NM_000303
PMM2
phosphomannomutase 2
chr3_-_187025501 0.271 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr6_+_131498540 0.270 AKAP7
A kinase (PRKA) anchor protein 7
chr16_+_56038837 0.270 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr6_-_160599779 0.269 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr19_-_1603325 0.268 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr11_-_63770716 0.267 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_1814546 0.267 NM_031918
KLF16
Kruppel-like factor 16
chr3_-_187025438 0.266 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_92124064 0.262 TGFBR3
transforming growth factor, beta receptor III
chr12_-_46499834 0.261 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr11_+_35922106 0.259 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr17_+_69939806 0.257 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr15_+_83092854 0.256 ZNF592
zinc finger protein 592
chr9_+_137511448 0.255 NM_014811
KIAA0649
KIAA0649
chr11_+_10283171 0.255 NM_001124
ADM
adrenomedullin
chr6_-_84994032 0.255 NM_014895
KIAA1009
KIAA1009
chr16_-_21439195 0.253 SLC7A5P2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 pseudogene 2
chr12_-_41269679 0.252 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr13_-_78131259 0.252 NM_024546
RNF219
ring finger protein 219
chr1_+_26310854 0.250 NM_152835
PDIK1L
PDLIM1 interacting kinase 1 like
chr11_-_17055763 0.250 NM_001017
RPS13
ribosomal protein S13
chr9_-_129370954 0.249 FAM129B
family with sequence similarity 129, member B
chr7_-_86686754 0.247 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr1_+_25999245 0.247 NM_020451
NM_206926
SEPN1

selenoprotein N, 1

chr15_-_53668341 0.247 NM_015617
PYGO1
pygopus homolog 1 (Drosophila)
chr7_-_97719372 0.245 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr6_+_111911226 0.245 LOC643749
hypothetical LOC643749
chr17_-_73867748 0.243 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr19_-_15351523 0.241 NM_005858
AKAP8
A kinase (PRKA) anchor protein 8
chr2_-_38457934 0.241 NM_001135673
NM_022374
ATL2

atlastin GTPase 2

chr16_-_56038771 0.241 NM_020313
CIAPIN1
cytokine induced apoptosis inhibitor 1
chr4_-_141896920 0.241 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr6_-_112682038 0.239 LAMA4
laminin, alpha 4
chr15_-_78003059 0.239 NM_001100880
ST20
suppressor of tumorigenicity 20
chr7_-_27136876 0.239 NM_002141
HOXA4
homeobox A4
chr16_-_11852862 0.238 NM_015659
RSL1D1
ribosomal L1 domain containing 1
chr13_-_105985313 0.238 NM_004093
EFNB2
ephrin-B2
chr2_-_20413838 0.238 PUM2
pumilio homolog 2 (Drosophila)
chr1_+_52380633 0.237 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr2_-_177837540 0.236 NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr9_+_132700462 0.236 ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr1_+_164063684 0.236 UCK2
uridine-cytidine kinase 2
chr2_+_182464713 0.232 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr2_+_11804190 0.232 NM_145693
LPIN1
lipin 1
chr2_+_10360471 0.231 NM_002149
HPCAL1
hippocalcin-like 1
chr2_+_187059277 0.231 ZC3H15
zinc finger CCCH-type containing 15
chr6_+_10855977 0.231 NM_001127711
NM_030969
TMEM14B

transmembrane protein 14B

chr1_-_154290112 0.230 NM_020131
UBQLN4
ubiquilin 4
chr4_-_140696740 0.230 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr19_-_17217022 0.229 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr1_+_165456572 0.229 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr3_-_189354510 0.228 LOC339929
hypothetical LOC339929
chr16_+_24459173 0.227 RBBP6
retinoblastoma binding protein 6
chr4_+_39734902 0.226 NM_018177
N4BP2
NEDD4 binding protein 2
chr20_-_48980858 0.226 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr19_+_40451626 0.225 USF2
upstream transcription factor 2, c-fos interacting
chr3_-_17759100 0.225 NM_001134380
TBC1D5
TBC1 domain family, member 5
chr12_+_26003218 0.225 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr1_+_153846602 0.225 NM_018116
MSTO1
misato homolog 1 (Drosophila)
chr7_-_525556 0.225 PDGFA
platelet-derived growth factor alpha polypeptide
chr1_+_32251988 0.225 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr21_+_34367747 0.223 MRPS6
mitochondrial ribosomal protein S6
chr20_-_61317891 0.223 NM_017798
YTHDF1
YTH domain family, member 1
chr7_+_73226538 0.222 EIF4H
eukaryotic translation initiation factor 4H
chr17_-_19206475 0.222 NM_015681
B9D1
B9 protein domain 1
chr1_+_109963982 0.221 AMPD2
adenosine monophosphate deaminase 2
chr3_-_127558747 0.221 NM_014079
KLF15
Kruppel-like factor 15
chr5_-_159730196 0.221 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr1_+_109963950 0.220 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr11_-_101828563 0.220 NM_052932
TMEM123
transmembrane protein 123
chr17_-_45562112 0.219 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr2_-_99472910 0.219 NM_001037872
NM_016316
REV1

REV1 homolog (S. cerevisiae)

chr2_+_36436873 0.219 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr18_+_19337437 0.218 NM_013326
C18orf8
chromosome 18 open reading frame 8
chr2_-_175255717 0.218 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr9_-_129371171 0.218 NM_022833
FAM129B
family with sequence similarity 129, member B
chr18_+_32131628 0.216 NM_025135
FHOD3
formin homology 2 domain containing 3
chr11_-_10272256 0.215 NM_030962
SBF2
SET binding factor 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.