Motif ID: HIF1A.p2

Z-value: 1.303


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)



Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_12046020 1.266 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr10_-_60606195 1.216


chr5_-_176760242 1.066 NM_001029886
PFN3
profilin 3
chr11_+_32808045 1.041 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr3_-_71916877 1.000 NM_001126128
NM_021935
PROK2

prokineticin 2

chr6_-_144427340 0.959 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr2_+_222997456 0.919 SGPP2
sphingosine-1-phosphate phosphatase 2
chr4_+_107036042 0.895 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr1_+_181025494 0.889 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr17_+_32380287 0.865 NM_012138
AATF
apoptosis antagonizing transcription factor
chr20_+_48781457 0.863 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_+_222997529 0.859 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr16_+_166678 0.797 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr17_-_3814334 0.782 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr2_+_32142083 0.782 NM_014946
NM_199436
SPAST

spastin

chr22_+_38720881 0.772 NM_138435
FAM83F
family with sequence similarity 83, member F
chr11_+_69602055 0.756 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr2_+_190981257 0.746 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr3_-_123223658 0.734 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr2_-_213724577 0.729 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_+_107036076 0.713 NPNT
nephronectin
chr1_+_67546143 0.709 IL12RB2
interleukin 12 receptor, beta 2
chr16_+_162845 0.684 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr4_+_89597257 0.669 NM_016323
HERC5
hect domain and RLD 5
chr3_+_127743868 0.655 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr20_-_538909 0.644 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr13_-_99422163 0.640 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr1_+_231816372 0.633 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr1_-_146543102 0.627


chr18_+_42167904 0.619 RNF165
ring finger protein 165
chr10_+_60606352 0.607 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr19_+_1022208 0.603 HMHA1
histocompatibility (minor) HA-1
chr1_+_222870573 0.597 CNIH3
cornichon homolog 3 (Drosophila)
chr4_-_90251571 0.595 FAM13A
family with sequence similarity 13, member A
chr6_+_73388713 0.592 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr13_-_95503566 0.587 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr17_-_64834780 0.582 NM_172232
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr6_-_28663045 0.574 NM_052923
SCAND3
SCAN domain containing 3
chr3_+_77171938 0.562 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr8_+_95722448 0.552 ESRP1
epithelial splicing regulatory protein 1
chr5_+_49998677 0.551 PARP8
poly (ADP-ribose) polymerase family, member 8
chr12_+_56299959 0.540 NM_133489
SLC26A10
solute carrier family 26, member 10
chr11_+_65311104 0.539 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr4_+_183302105 0.523 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr11_+_75157414 0.520 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr8_+_69405510 0.517 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr14_-_70345485 0.511 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr9_+_34948171 0.508 NM_015297
KIAA1045
KIAA1045
chr21_-_38954433 0.505 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr1_-_142536082 0.502


chr13_+_24152548 0.500 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr17_-_8643163 0.500 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr7_-_22363036 0.493 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_40431678 0.493 LSR
lipolysis stimulated lipoprotein receptor
chr11_-_74819165 0.492 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr4_-_119493322 0.491 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr4_+_48180033 0.489 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr19_+_60283571 0.487 NM_017729
EPS8L1
EPS8-like 1
chr19_-_19599973 0.487 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr10_+_112247614 0.482 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_-_233060774 0.482 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr13_-_19704533 0.475 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr1_+_67545634 0.467 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chr7_+_48041632 0.466 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr11_-_19219720 0.462 E2F8
E2F transcription factor 8
chr2_+_111594921 0.461 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr1_-_173428455 0.454 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr11_+_125279481 0.450 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr9_-_21965131 0.443 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chr13_+_97426713 0.443 IPO5
importin 5
chr1_+_65385799 0.441 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr11_+_65311142 0.439 OVOL1
ovo-like 1(Drosophila)
chr7_-_72077805 0.434 NM_198853
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr2_-_6923215 0.434 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_+_566482 0.428 NM_020901
PHRF1
PHD and ring finger domains 1
chr9_-_111300350 0.428 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_88922424 0.427 NM_006256
PKN2
protein kinase N2
chr13_-_19633182 0.423 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr1_+_231816540 0.421 KCNK1
potassium channel, subfamily K, member 1
chr4_-_17392232 0.421 NM_015688
FAM184B
family with sequence similarity 184, member B
chr1_+_222870798 0.418 NM_152495
CNIH3
cornichon homolog 3 (Drosophila)
chr13_+_78068246 0.417 LOC780529
hypothetical LOC780529
chr20_+_18516541 0.414 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr5_+_3649167 0.413 NM_024337
IRX1
iroquois homeobox 1
chr5_+_89890366 0.406 NM_032119
GPR98
G protein-coupled receptor 98
chr11_-_73149705 0.406 NM_002869
NM_198896
RAB6A

RAB6A, member RAS oncogene family

chr8_+_28407613 0.404 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr10_-_43390014 0.404 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr18_+_53253775 0.400 NM_004852
ONECUT2
one cut homeobox 2
chr22_-_29231597 0.397 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr10_+_104394185 0.396 NM_030912
TRIM8
tripartite motif containing 8
chr5_+_63497408 0.393 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr5_+_110587546 0.389 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr11_+_133706977 0.384 NM_138342
GLB1L2
galactosidase, beta 1-like 2
chr1_-_146543016 0.383


chr7_+_26298018 0.380 NM_013322
SNX10
sorting nexin 10
chr10_-_98470164 0.379 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr1_-_180840016 0.378 NM_002928
RGS16
regulator of G-protein signaling 16
chr20_+_41519882 0.377 NM_006275
SRSF6
serine/arginine-rich splicing factor 6
chr7_+_115637795 0.377 NM_015641
TES
testis derived transcript (3 LIM domains)
chr16_-_66571863 0.375 NM_001129758
NM_022357
DPEP3

dipeptidase 3

chr8_+_31616809 0.374 NM_013962
NRG1
neuregulin 1
chr2_-_96174865 0.371 NM_004418
DUSP2
dual specificity phosphatase 2
chr8_-_30635112 0.370 GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr5_+_176951802 0.362 NM_017510
TMED9
transmembrane emp24 protein transport domain containing 9
chr1_+_20385164 0.359 NM_152376
UBXN10
UBX domain protein 10
chr9_+_34948320 0.358 KIAA1045
KIAA1045
chr8_+_75050930 0.357 NM_001040613
NM_017866
TMEM70

transmembrane protein 70

chr17_-_34084682 0.357 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr17_-_42924828 0.354 MRPL45P2
mitochondrial ribosomal protein L45 pseudogene 2
chr2_+_17585462 0.353 VSNL1
visinin-like 1
chr6_+_111515341 0.352 SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr16_-_18845223 0.352 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chrX_-_131919896 0.351 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr8_-_9046460 0.349 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr2_-_60633908 0.349 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr11_-_65895640 0.347 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr17_+_50697319 0.347 NM_002126
HLF
hepatic leukemia factor
chr1_+_191357906 0.346 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr10_+_52420936 0.341 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr17_+_50697355 0.340 HLF
hepatic leukemia factor
chr11_+_104986620 0.338 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr9_+_129199204 0.338 NM_014580
SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr2_+_17585287 0.337 NM_003385
VSNL1
visinin-like 1
chr10_+_105334704 0.337 NEURL
neuralized homolog (Drosophila)
chr22_+_24290738 0.336 NM_005160
ADRBK2
adrenergic, beta, receptor kinase 2
chr6_+_111515473 0.336 NM_018593
SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr11_+_75157450 0.335 DGAT2
diacylglycerol O-acyltransferase 2
chr2_-_101370291 0.334 CREG2
cellular repressor of E1A-stimulated genes 2
chr11_+_133707107 0.332 GLB1L2
galactosidase, beta 1-like 2
chr19_-_55999677 0.331 NM_199250
NM_199249
C19orf48

chromosome 19 open reading frame 48

chr15_-_76700563 0.327 NM_000743
NM_001166694
CHRNA3

cholinergic receptor, nicotinic, alpha 3

chr1_-_146398501 0.325 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr12_+_56230073 0.324 KIF5A
kinesin family member 5A
chr12_-_123965099 0.324 UBC
ubiquitin C
chr7_+_43118721 0.324 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr19_+_2427122 0.322 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_-_565848 0.322 LOC143666
hypothetical LOC143666
chr8_-_30635207 0.321 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr19_+_40431618 0.318 LSR
lipolysis stimulated lipoprotein receptor
chr10_-_95350949 0.317 NM_006744
RBP4
retinol binding protein 4, plasma
chrX_+_150614385 0.315 NM_024082
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr1_-_142535878 0.314 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr9_-_135847106 0.312 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr16_+_73739890 0.312 NM_153688
ZFP1
zinc finger protein 1 homolog (mouse)
chr19_-_54267690 0.312 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr8_+_24827173 0.311 NM_005382
NEFM
neurofilament, medium polypeptide
chr7_+_26298136 0.310 SNX10
sorting nexin 10
chr19_+_40431359 0.309 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr2_+_219432789 0.309 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr2_-_60634271 0.307 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_+_122229590 0.306 NM_004622
TSN
translin
chr11_-_47620590 0.306 NM_014342
MTCH2
mitochondrial carrier homolog 2 (C. elegans)
chr13_-_40604587 0.303 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr17_-_69151821 0.303 NM_001144952
SDK2
sidekick homolog 2 (chicken)
chr2_-_112729072 0.302 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr8_+_24827181 0.302 NEFM
neurofilament, medium polypeptide
chr2_+_84986273 0.301 NM_021103
TMSB10
thymosin beta 10
chr3_-_88190737 0.301 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr2_-_27195401 0.301 NM_001166240
NM_006569
CGREF1

cell growth regulator with EF-hand domain 1

chr4_+_119419354 0.300 SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr3_+_53503626 0.299 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr8_-_110726201 0.299 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr3_-_159306532 0.299 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr2_-_88533167 0.297 NM_001135649
FOXI3
forkhead box I3
chr19_-_54267932 0.296 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr4_+_158361185 0.296 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr6_-_153346283 0.295 NM_001142522
FBXO5
F-box protein 5
chr3_+_173240983 0.295 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr12_-_123965539 0.295 NM_021009
UBC
ubiquitin C
chr6_+_1336077 0.294


chr5_-_43432969 0.293 CCL28
chemokine (C-C motif) ligand 28
chr20_-_24986501 0.290 ACSS1
acyl-CoA synthetase short-chain family member 1
chr17_+_45778381 0.290 NM_022167
XYLT2
xylosyltransferase II
chr12_-_56111054 0.290 R3HDM2
R3H domain containing 2
chr8_-_81246215 0.289 NM_001025253
NM_005079
TPD52

tumor protein D52

chr10_-_101935777 0.289 NM_001100626
ERLIN1
ER lipid raft associated 1
chr7_+_23603495 0.289 NM_138771
CCDC126
coiled-coil domain containing 126
chr21_+_33364316 0.288 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr16_+_716936 0.288 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr3_+_128830656 0.288 NM_015720
PODXL2
podocalyxin-like 2
chr12_+_120810982 0.287 NM_002813
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr10_-_101935676 0.286 NM_006459
ERLIN1
ER lipid raft associated 1
chr1_-_143232275 0.285 LOC728855
hypothetical LOC728855
chr19_-_44386731 0.284 NM_001080468
SYCN
syncollin
chr9_-_126573349 0.284 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr22_+_24895623 0.284 SEZ6L
seizure related 6 homolog (mouse)-like
chr3_-_107070400 0.283 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr3_+_52694975 0.283 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr10_+_105716925 0.282 SLK
STE20-like kinase
chr1_-_90955365 0.282 NM_020063
BARHL2
BarH-like homeobox 2
chr8_+_85259654 0.280 NM_001100391
RALYL
RALY RNA binding protein-like
chr20_+_3399615 0.279 NM_139321
NM_139322
ATRN

attractin

chr20_-_50241930 0.279 NM_018197
NM_022088
NM_199426
NM_199427
ZFP64



zinc finger protein 64 homolog (mouse)



chr17_-_33043514 0.279 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr12_+_56230110 0.279 NM_004984
KIF5A
kinesin family member 5A
chr16_-_27982277 0.279 NM_001109763
GSG1L
GSG1-like
chr10_+_60606514 0.278 PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr11_-_74119833 0.277 NM_015424
CHRDL2
chordin-like 2
chr6_-_139737042 0.277 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.