Motif ID: HMGA1,2.p2

Z-value: 3.308


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2



Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150353179 4.500 NM_007113
TCHH
trichohyalin
chr12_-_94469357 3.771 NM_032147
USP44
ubiquitin specific peptidase 44
chr10_-_62002672 3.602 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_205344200 3.164 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr3_-_152529999 3.156 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr9_-_111253484 3.149 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr3_+_39346200 3.106 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr2_+_165860528 3.089 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr13_+_107753764 3.078


chr3_-_114176401 3.041 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr12_-_9976173 2.968 NM_001130711
CLEC2A
C-type lectin domain family 2, member A
chr6_-_132987106 2.888 NM_001033080
TAAR2
trace amine associated receptor 2
chr11_-_18214891 2.782 NM_006512
SAA4
serum amyloid A4, constitutive
chr8_-_20084892 2.689 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr11_+_113280727 2.638 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_+_143824955 2.455 NM_002670
PLS1
plastin 1
chr15_-_41195994 2.421 RPS3A
ribosomal protein S3A
chr11_-_40271086 2.409 LRRC4C
leucine rich repeat containing 4C
chr12_-_10850845 2.382 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr11_-_85146691 2.342 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr13_-_45577144 2.335 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr12_+_8557402 2.316 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr11_+_110890719 2.297 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr5_+_57823017 2.266 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr3_-_150993299 2.230 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr7_-_16888121 2.221 NM_176813
AGR3
anterior gradient homolog 3 (Xenopus laevis)
chr8_-_110762409 2.145 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr17_-_30909219 2.104 NM_001129820
SLFN14
schlafen family member 14
chr9_-_21295311 2.097 NM_002169
IFNA5
interferon, alpha 5
chr11_-_123695302 2.083 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr8_-_17787342 2.060 FGL1
fibrinogen-like 1
chr11_-_113971681 2.037 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr12_-_66905802 1.988 NM_018402
IL26
interleukin 26
chr12_+_10054492 1.965 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr1_+_171871283 1.957 NM_001195190
LOC730159
hypothetical protein LOC730159
chr11_-_102081654 1.949 NM_022122
MMP27
matrix metallopeptidase 27
chr2_+_158666627 1.929 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_203657803 1.921 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr13_-_38462857 1.886 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr7_-_92693716 1.881 NM_001039372
HEPACAM2
HEPACAM family member 2
chr3_-_152173475 1.858 NM_001195794
NM_174878
CLRN1

clarin 1

chr7_-_48035169 1.851 NM_001030019
NM_152782
SUN3

Sad1 and UNC84 domain containing 3

chr11_-_8921155 1.837 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr10_+_115514567 1.825 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr3_+_46386636 1.818 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr1_+_195123766 1.814 NM_006684
CFHR4
complement factor H-related 4
chr9_-_21218132 1.795 NM_021268
IFNA17
interferon, alpha 17
chr8_+_24297742 1.791 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr14_-_57030227 1.774 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr4_-_77547481 1.766 NM_001042784
CCDC158
coiled-coil domain containing 158
chr6_+_132915522 1.736 NM_053278
TAAR8
trace amine associated receptor 8
chr4_+_14950657 1.733 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr14_+_61532293 1.704 NM_031914
SYT16
synaptotagmin XVI
chr3_-_99236520 1.690 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr5_+_36644187 1.689 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_191650291 1.685 NM_207316
TMEM207
transmembrane protein 207
chr10_+_63950212 1.680 NM_199452
ZNF365
zinc finger protein 365
chr8_+_7332600 1.670 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr1_-_161380562 1.657 RGS5
regulator of G-protein signaling 5
chr12_+_18305740 1.656 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr8_-_93181091 1.653 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_127940011 1.637 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr8_-_30121741 1.635 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr5_-_135259403 1.625 NM_000590
IL9
interleukin 9
chr8_-_18710575 1.612 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_40945315 1.610 NM_000587
C7
complement component 7
chr15_+_57696200 1.602 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr1_-_110863319 1.601 NM_005549
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr3_+_122769467 1.599 NM_001012659
ARGFX
arginine-fifty homeobox
chr8_+_62363078 1.598 NM_173519
CLVS1
clavesin 1
chr1_-_245988330 1.595 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr5_+_40945374 1.590 C7
complement component 7
chr12_-_45506001 1.587 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr3_+_120375053 1.576 NM_006952
UPK1B
uroplakin 1B
chr11_-_113971607 1.567 FAM55D
family with sequence similarity 55, member D
chr6_-_52217185 1.567 NM_052872
IL17F
interleukin 17F
chr5_-_177140071 1.560 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr1_-_205272619 1.544 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr15_-_74091817 1.541 NM_138573
NRG4
neuregulin 4
chr6_+_47857733 1.533 NM_181744
OPN5
opsin 5
chr4_-_77147625 1.512 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr3_-_139333813 1.492 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr11_-_102250876 1.488 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr11_-_57792206 1.476 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr11_-_5835507 1.471 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chr6_-_117256890 1.461 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr18_-_3864252 1.455 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr8_-_120720200 1.455 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr3_-_152403636 1.443 NM_013308
GPR171
G protein-coupled receptor 171
chr11_-_102001259 1.438 NM_004771
MMP20
matrix metallopeptidase 20
chr12_-_101396459 1.431 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_-_107087943 1.430 NM_003063
SLN
sarcolipin
chr13_+_48178620 1.428 NM_020377
CYSLTR2
cysteinyl leukotriene receptor 2
chr3_-_148604760 1.421 NM_001168378
ZIC4
Zic family member 4
chr12_+_10015274 1.421 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr11_-_76676110 1.419 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr9_-_106705780 1.418 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr8_-_7718769 1.413 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr4_+_100714995 1.411 MTTP
microsomal triglyceride transfer protein
chr4_-_100575313 1.393 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr12_-_25692754 1.393 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr7_+_123036312 1.389 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr3_+_108578877 1.383 NM_032600
CCDC54
coiled-coil domain containing 54
chr14_+_95792299 1.382 NM_000710
BDKRB1
bradykinin receptor B1
chr1_+_78888064 1.371 NM_006417
IFI44
interferon-induced protein 44
chr18_+_59726183 1.366 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr10_+_5228756 1.356 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr5_-_95794416 1.355 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_+_207944807 1.351 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_-_53121540 1.348 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr4_+_187227302 1.339 NM_003265
TLR3
toll-like receptor 3
chr12_-_49708279 1.333 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr4_-_88669625 1.329 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr8_+_12847521 1.327 NM_020844
KIAA1456
KIAA1456
chr11_-_104399104 1.317 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr4_-_10295412 1.311 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr10_-_100985548 1.300 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr9_-_21177529 1.298 NM_021068
IFNA4
interferon, alpha 4
chr6_+_50789215 1.294 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr6_+_50894397 1.289 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr9_+_21399132 1.285 NM_002170
IFNA8
interferon, alpha 8
chr15_+_83467295 1.282 PDE8A
phosphodiesterase 8A
chr7_+_121300446 1.282 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr2_-_157892391 1.281 NM_001009959
ERMN
ermin, ERM-like protein
chr2_-_218739891 1.276 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr12_+_9871343 1.276 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr3_+_171112053 1.275 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr1_+_116455898 1.260 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr9_-_106705867 1.258 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr11_-_62753574 1.245 NM_199352
SLC22A25
solute carrier family 22, member 25
chr9_-_14900992 1.242 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr11_+_26310253 1.241 NM_031418
ANO3
anoctamin 3
chr9_-_21192201 1.231 NM_021057
IFNA7
interferon, alpha 7
chr1_-_151296611 1.231 NM_005988
SPRR2A
small proline-rich protein 2A
chr7_-_91632525 1.230 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr19_-_13478037 1.230 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr4_+_157044296 1.229 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr7_-_16471817 1.228 NM_015464
SOSTDC1
sclerostin domain containing 1
chr7_-_101783608 1.227 NM_001146210
SPDYE6
speedy homolog E6 (Xenopus laevis)
chr5_-_20024050 1.225 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr11_-_117305277 1.225 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr18_-_65766068 1.223 CD226
CD226 molecule
chr1_+_200698493 1.222 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr13_+_42253685 1.214 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr1_-_202726068 1.211 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr15_-_48198697 1.205 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr6_+_123142344 1.200 NM_001446
FABP7
fatty acid binding protein 7, brain
chr2_+_166034402 1.190 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr5_+_140146059 1.184 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr3_-_140879463 1.183 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr11_-_32772731 1.182 NM_001008391
CCDC73
coiled-coil domain containing 73
chr2_-_21084077 1.167 APOB
apolipoprotein B (including Ag(x) antigen)
chr7_-_93027057 1.167 NM_001164738
CALCR
calcitonin receptor
chr10_+_77212524 1.165 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr4_+_15038726 1.164 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr10_+_124141808 1.162 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_+_99555387 1.150 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr6_+_24465109 1.146 NM_181337
KAAG1
kidney associated antigen 1
chr10_-_85975263 1.145 NM_001017924
LRIT2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr3_-_120761092 1.142 NM_005191
CD80
CD80 molecule
chr1_+_146824811 1.139 NM_001170755
NBPF15
neuroblastoma breakpoint family, member 15
chr6_+_97117144 1.137 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr5_+_147238466 1.128 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr5_+_140207540 1.120 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr10_+_123744131 1.118 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_141054621 1.115 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr12_+_76749199 1.112 NM_014903
NAV3
neuron navigator 3
chr10_+_114033403 1.109 NM_058222
TECTB
tectorin beta
chr9_-_112139908 1.106 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr12_-_10846435 1.104 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_-_127559841 1.101 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr1_+_78858675 1.092 NM_006820
IFI44L
interferon-induced protein 44-like
chr7_+_20653490 1.088 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr1_-_150599105 1.085 NM_001014342
FLG2
filaggrin family member 2
chr12_+_39372456 1.069 NM_001843
NM_175038
CNTN1

contactin 1

chr12_+_53927248 1.067 NM_001005490
OR6C74
olfactory receptor, family 6, subfamily C, member 74
chr4_+_114190233 1.065 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr4_+_74499651 1.064 ALB
albumin
chr19_+_53656317 1.063 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr1_-_89414310 1.060 NM_207398
GBP7
guanylate binding protein 7
chr4_+_71283383 1.059 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr11_-_64484184 1.057 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr20_+_12937616 1.056 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr12_+_100512877 1.054 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr6_+_153113624 1.052 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr6_-_52060327 1.048 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr1_+_50344550 1.042 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_21570457 1.040 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr2_-_135498716 1.038 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr2_+_161701711 1.026 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr16_+_52037186 1.023 RBL2
retinoblastoma-like 2 (p130)
chr1_-_150564302 1.023 NM_002016
FLG
filaggrin
chr14_+_20319049 1.016 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr3_+_99699137 1.006 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr20_+_9442995 1.003 C20orf103
chromosome 20 open reading frame 103
chr7_-_16811131 1.001 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr8_-_74167886 1.000 NM_153225
C8orf84
chromosome 8 open reading frame 84
chr11_+_6216905 0.990 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr5_-_88004891 0.990 LOC645323
hypothetical LOC645323
chr1_+_111573855 0.988 NM_001025199
CHI3L2
chitinase 3-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
16.31 7.52e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
2.85 1.53e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.24 2.17e-05 GO:0005576 extracellular region
2.81 7.58e-05 GO:0044421 extracellular region part
2.73 3.40e-03 GO:0005615 extracellular space
1.48 4.20e-03 GO:0031224 intrinsic to membrane
1.43 4.52e-03 GO:0044425 membrane part
1.47 7.56e-03 GO:0016021 integral to membrane
1.53 2.61e-02 GO:0005886 plasma membrane
1.50 3.93e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.35 8.40e-05 GO:0004872 receptor activity
2.02 1.69e-03 GO:0004871 signal transducer activity
2.02 1.69e-03 GO:0060089 molecular transducer activity
2.39 1.88e-03 GO:0004888 transmembrane receptor activity
2.74 3.18e-03 GO:0004930 G-protein coupled receptor activity
36.70 1.08e-02 GO:0005132 interferon-alpha/beta receptor binding
4.43 3.93e-02 GO:0005125 cytokine activity