Motif ID: HSF1,2.p2

Z-value: 1.376


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2



Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_30724442 1.507 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr11_-_118799452 1.316 NM_006288
THY1
Thy-1 cell surface antigen
chr6_+_129245978 1.297 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr5_-_135318420 1.131 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr10_+_95838801 1.121 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr6_+_32817140 1.024 NM_020056
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 2
chr4_+_77575276 1.020 NM_020859
SHROOM3
shroom family member 3
chr1_+_66570683 1.014 PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_102234959 1.014 OLFM3
olfactomedin 3
chr9_-_72926333 0.981 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_21818881 0.950 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr12_+_8557402 0.940 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr19_-_47638890 0.892 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr7_-_27133163 0.839 NM_153631
HOXA3
homeobox A3
chr5_-_42211112 0.815


chr1_-_148155986 0.815 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_-_182273451 0.807 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chr13_+_45174446 0.799 NM_152719
SPERT
spermatid associated
chr6_-_32839244 0.758 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_40003295 0.749 NM_005943
MOCS1
molybdenum cofactor synthesis 1
chr7_-_75876830 0.714 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chrX_+_106050261 0.702 NM_020384
CLDN2
claudin 2
chr3_+_191588354 0.701 NM_006580
CLDN16
claudin 16
chr1_-_102235377 0.701 NM_058170
OLFM3
olfactomedin 3
chr5_+_79366746 0.701 NM_003248
THBS4
thrombospondin 4
chr9_-_90983501 0.689 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr9_+_831689 0.673 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr1_-_163680941 0.673 NM_006917
RXRG
retinoid X receptor, gamma
chr9_-_68492023 0.667 NM_001085476
FOXD4L6
forkhead box D4-like 6
chr15_+_40438989 0.665 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr8_+_87947788 0.665 NM_173538
CNBD1
cyclic nucleotide binding domain containing 1
chr10_-_28611020 0.664 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr18_+_29573152 0.663 ASXL3
additional sex combs like 3 (Drosophila)
chr9_-_90983195 0.656 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr11_+_59806661 0.653 NM_024021
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr8_-_82522175 0.646 NM_002677
PMP2
peripheral myelin protein 2
chr2_-_21084911 0.638 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_217268492 0.636 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr8_-_125649926 0.635 MTSS1
metastasis suppressor 1
chr1_+_114295289 0.628 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr1_-_203657803 0.608 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr5_-_135729062 0.607 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr5_-_135259403 0.606 NM_000590
IL9
interleukin 9
chr2_-_39040981 0.602 LOC375196
hypothetical LOC375196
chr18_+_54013575 0.600 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_173979292 0.599 NM_003285
TNR
tenascin R (restrictin, janusin)
chr1_+_157246305 0.590 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr15_+_74416129 0.588 ISL2
ISL LIM homeobox 2
chr15_+_39739864 0.587 NM_001080541
NM_001164273
MGA

MAX gene associated

chr7_+_97199206 0.583 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr6_+_159510416 0.580 NM_032532
FNDC1
fibronectin type III domain containing 1
chr10_+_115501202 0.574 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr4_-_20914626 0.572 NM_147183
KCNIP4
Kv channel interacting protein 4
chr7_-_80386258 0.571 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_+_39739933 0.567 MGA
MAX gene associated
chr11_-_102219450 0.567 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_182273114 0.565 GLT25D2
glycosyltransferase 25 domain containing 2
chr14_+_71468902 0.564 RGS6
regulator of G-protein signaling 6
chr3_+_125586241 0.558 KALRN
kalirin, RhoGEF kinase
chr11_-_35503720 0.557 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr4_+_93444572 0.555 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr18_+_30427279 0.548 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chrX_-_131989963 0.544 NM_031907
USP26
ubiquitin specific peptidase 26
chr21_+_30690165 0.536 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr7_-_131983986 0.534 NM_181775
PLXNA4
plexin A4
chr4_-_85638410 0.533 NM_006168
NKX6-1
NK6 homeobox 1
chr12_-_113326085 0.533 NM_080718
TBX5
T-box 5
chr14_-_59407103 0.531 NM_021136
RTN1
reticulon 1
chr14_-_59167139 0.525 RTN1
reticulon 1
chr14_-_59167284 0.521 RTN1
reticulon 1
chr12_-_43555607 0.521 NM_001145109
NELL2
NEL-like 2 (chicken)
chr11_+_45825244 0.513 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr5_+_140762551 0.512 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr15_+_36014748 0.512 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr5_-_22889487 0.505 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_-_21084077 0.505 APOB
apolipoprotein B (including Ag(x) antigen)
chr18_+_27425727 0.502 NM_000371
TTR
transthyretin
chr7_-_80386602 0.494 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_27700180 0.493 NM_170731
BDNF
brain-derived neurotrophic factor
chr6_-_117193505 0.486 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr5_-_95044415 0.481 NM_031952
SPATA9
spermatogenesis associated 9
chr13_+_23042722 0.480 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_114433551 0.478 ANK2
ankyrin 2, neuronal
chr2_+_113973130 0.476 NM_012184
FOXD4L1
forkhead box D4-like 1
chrX_+_46825179 0.476 RGN
regucalcin (senescence marker protein-30)
chr10_+_82268433 0.476 TSPAN14
tetraspanin 14
chr8_-_13018123 0.474 NM_001164271
DLC1
deleted in liver cancer 1
chr2_+_214984705 0.471 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chrX_-_110542040 0.465 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr7_-_19778928 0.462 NM_152774
TMEM196
transmembrane protein 196
chr8_-_93181091 0.462 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_59167193 0.460 NM_206852
RTN1
reticulon 1
chr19_+_13066956 0.458 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_+_17339059 0.452


chr7_-_4867963 0.445 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr7_-_96489884 0.444


chr4_+_22303645 0.441 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr3_-_124893875 0.438 MYLK
myosin light chain kinase
chr14_-_56346849 0.437 NM_021728
OTX2
orthodenticle homeobox 2
chr4_-_101658094 0.435 NM_001159694
NM_016242
EMCN

endomucin

chr3_+_134978615 0.425 TF
transferrin
chr3_+_149930656 0.421 NM_032049
AGTR1
angiotensin II receptor, type 1
chr10_-_90601655 0.420 NM_144590
ANKRD22
ankyrin repeat domain 22
chr5_-_22889192 0.415 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr19_-_53941835 0.414 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr3_+_12367993 0.413 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr4_-_15686838 0.412 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr12_+_1596482 0.412 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr19_+_56049982 0.411 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr1_+_26220852 0.410 NM_004455
EXTL1
exostoses (multiple)-like 1
chr1_+_179164195 0.409


chr15_+_94670160 0.408 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_-_22248630 0.407 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_-_48607596 0.407 NM_000094
COL7A1
collagen, type VII, alpha 1
chr14_+_88130482 0.406 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr11_-_113971607 0.404 FAM55D
family with sequence similarity 55, member D
chr12_-_14612057 0.402 NM_024829
PLBD1
phospholipase B domain containing 1
chr10_-_104587069 0.402 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chrX_-_54841397 0.401 NM_198510
ITIH5L
inter-alpha (globulin) inhibitor H5-like
chr12_-_24628348 0.399 C12orf67
chromosome 12 open reading frame 67
chr18_-_30057512 0.399 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr6_-_127822227 0.397 NM_014702
KIAA0408
KIAA0408
chrX_-_52700674 0.395 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr18_-_28606839 0.388 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr11_-_123685871 0.388 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr9_-_69468634 0.388 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr6_+_29382381 0.387 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr6_-_127882192 0.386 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr7_-_11643113 0.385 THSD7A
thrombospondin, type I, domain containing 7A
chr15_+_45263517 0.385 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr12_-_14611820 0.382 PLBD1
phospholipase B domain containing 1
chr2_+_143603368 0.382 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr4_-_122304925 0.378 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr17_+_11726943 0.376 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr7_+_30927439 0.375 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr12_-_11230809 0.374 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr4_-_123092358 0.373 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr3_-_152144712 0.373 NM_052995
CLRN1
clarin 1
chr15_+_90815910 0.373 NM_153040
C15orf32
chromosome 15 open reading frame 32
chr19_-_60383280 0.373 NM_003180
SYT5
synaptotagmin V
chr1_+_117098579 0.370 NM_001767
CD2
CD2 molecule
chrX_-_31436335 0.370 NM_004014
DMD
dystrophin
chr3_+_160269734 0.368 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr14_-_69616616 0.367 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr2_+_143603439 0.365 ARHGAP15
Rho GTPase activating protein 15
chr11_-_113971681 0.365 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr6_+_106640903 0.364 PRDM1
PR domain containing 1, with ZNF domain
chr2_+_108604111 0.363 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_+_123405506 0.363 NM_001004464
OR10G8
olfactory receptor, family 10, subfamily G, member 8
chr8_-_23768242 0.363 NM_003155
STC1
stanniocalcin 1
chr17_-_25685175 0.361 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr4_+_96980261 0.358 NM_005390
PDHA2
pyruvate dehydrogenase (lipoamide) alpha 2
chr7_+_18296569 0.353 HDAC9
histone deacetylase 9
chr1_+_153232685 0.353 NM_018655
LENEP
lens epithelial protein
chr2_+_207512522 0.351 NM_173077
CPO
carboxypeptidase O
chr9_-_108416 0.351 NM_207305
FOXD4
forkhead box D4
chr12_+_54106304 0.350 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr4_+_5577783 0.350 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr10_+_90474280 0.349 NM_001080518
LIPK
lipase, family member K
chr14_-_80934523 0.349 NM_033104
STON2
stonin 2
chr15_+_60838053 0.348 TLN2
talin 2
chr15_-_72804763 0.346 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr3_-_9895471 0.344 CIDEC
cell death-inducing DFFA-like effector c
chr22_+_44059491 0.343 NM_001167574
NM_006953
UPK3A

uroplakin 3A

chr19_-_295778 0.343 NM_017550
MIER2
mesoderm induction early response 1, family member 2
chr3_-_13032130 0.341


chr13_+_52500830 0.340 NM_006418
OLFM4
olfactomedin 4
chrX_-_134798808 0.339 NM_001017438
CT45A3
CT45A4
CT45A5
CT45A6
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A5
cancer/testis antigen family 45, member A6
cancer/testis antigen family 45, member A1
chr1_+_66570363 0.339 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr14_-_59166976 0.338 RTN1
reticulon 1
chr2_+_222871109 0.337 NM_153038
CCDC140
coiled-coil domain containing 140
chr4_-_122357104 0.332 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_-_91346054 0.330 NM_001025232
CLLU1OS
chronic lymphocytic leukemia up-regulated 1 opposite strand
chr15_+_87540238 0.329 ABHD2
abhydrolase domain containing 2
chr15_-_79403494 0.328 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr10_-_62002672 0.325 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_+_42707229 0.324 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr10_+_18280773 0.323 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr1_+_109450116 0.322


chr5_+_127012611 0.322 NM_001048252
CTXN3
cortexin 3
chr7_+_137411717 0.320 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_+_92456160 0.319 NM_001012425
C1orf146
chromosome 1 open reading frame 146
chr10_-_75080784 0.317 NM_024875
SYNPO2L
synaptopodin 2-like
chr11_-_65070625 0.317 LTBP3
latent transforming growth factor beta binding protein 3
chr3_+_160269836 0.316 IQCJ
IQ motif containing J
chr4_-_108176901 0.315 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr12_+_5473558 0.315 NM_002527
NTF3
neurotrophin 3
chr2_+_166137091 0.313 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr9_+_110664366 0.313 NM_006687
ACTL7A
actin-like 7A
chr11_-_100959868 0.311 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr1_+_144004589 0.310 NM_001039703
NBPF10
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 8
chr9_+_70107602 0.310 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr3_+_98016114 0.310 NM_001080448
EPHA6
EPH receptor A6
chr8_-_17787342 0.309 FGL1
fibrinogen-like 1
chr3_-_42427026 0.309 NM_144634
LYZL4
lysozyme-like 4
chr5_-_44424423 0.308 NM_004465
FGF10
fibroblast growth factor 10
chr16_+_68516401 0.308 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr9_-_106401514 0.308 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr11_-_62753574 0.308 NM_199352
SLC22A25
solute carrier family 22, member 25
chr3_+_46386636 0.308 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
200.39 3.82e-03 GO:0042462 eye photoreceptor cell development
179.31 4.80e-03 GO:0042461 photoreceptor cell development
154.87 6.48e-03 GO:0001754 eye photoreceptor cell differentiation
141.97 7.74e-03 GO:0046530 photoreceptor cell differentiation

Nothing significant found in compartment category.

Nothing significant found in function category.