Motif ID: IRF1,2,7.p3

Z-value: 2.504


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_34521945 4.696 SRP54
signal recognition particle 54kDa
chr12_+_111900650 4.014 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr9_-_32516164 3.867 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_46997579 3.539 NM_001098518
GPR116
G protein-coupled receptor 116
chr14_+_34521854 3.357 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr6_+_26473376 3.272 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr13_-_42464301 3.170 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr14_+_31100330 3.121 NM_025152
NUBPL
nucleotide binding protein-like
chr20_+_1194959 3.117 NM_014723
SNPH
syntaphilin
chr6_+_26510443 3.045 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr6_+_26548678 2.961 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr20_-_55628852 2.811 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr2_-_1905508 2.707 MYT1L
myelin transcription factor 1-like
chr2_-_70329067 2.697 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr2_+_122229590 2.649 NM_004622
TSN
translin
chr20_-_5048443 2.596 NM_182649
PCNA
proliferating cell nuclear antigen
chr7_+_154351087 2.583 LOC100132707
hypothetical LOC100132707
chr16_+_55580910 2.574 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr12_+_27568311 2.533 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr7_-_92615593 2.481 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_+_101532544 2.457 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_142605739 2.449 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr16_+_10878539 2.420 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_+_44263370 2.394 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr17_+_38719371 2.352 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr10_+_101532450 2.344 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_37081387 2.295 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr1_+_234624266 2.284 NM_145861
EDARADD
EDAR-associated death domain
chr2_-_230792844 2.272 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr4_-_169476391 2.218 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr6_-_30289092 2.121 NM_003449
TRIM26
tripartite motif containing 26
chr12_+_4628521 2.059 NM_005002
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_-_68143618 2.053 C1D
C1D nuclear receptor corepressor
chr10_+_63478974 2.007 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_41018291 1.918


chr12_+_25096472 1.918 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_+_187227302 1.898 NM_003265
TLR3
toll-like receptor 3
chr2_-_112358204 1.842 NM_022662
ANAPC1
anaphase promoting complex subunit 1
chr8_+_101232014 1.840 NM_005034
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr4_+_144654526 1.791


chr12_+_25096755 1.753 LRMP
lymphoid-restricted membrane protein
chr10_+_92970487 1.735 PCGF5
polycomb group ring finger 5
chr13_-_33148899 1.721 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_178986617 1.718


chr2_+_6935246 1.707 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr9_-_122852356 1.707 NM_001735
C5
complement component 5
chr17_+_18320822 1.691 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr2_+_169637255 1.668 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr14_-_34252695 1.657 NM_021914
CFL2
cofilin 2 (muscle)
chr7_-_134845363 1.656 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr14_-_34253473 1.652 NM_138638
CFL2
cofilin 2 (muscle)
chrX_+_77041612 1.643 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr6_+_29902734 1.632 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr4_+_88147107 1.615 NM_005935
AFF1
AF4/FMR2 family, member 1
chr16_+_22011362 1.605 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr12_-_9913199 1.568 CLEC2B
C-type lectin domain family 2, member B
chr2_-_68143662 1.567 NM_001190263
NM_001190265
NM_006333
NM_173177
C1D



C1D nuclear receptor corepressor



chr12_+_38905053 1.559 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr2_+_33555182 1.547 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr22_+_34374358 1.535 NM_030641
APOL6
apolipoprotein L, 6
chr21_+_42807052 1.532 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr8_+_79740813 1.521 NM_016010
FAM164A
family with sequence similarity 164, member A
chr19_+_35555158 1.511 NM_014717
ZNF536
zinc finger protein 536
chr17_-_44022595 1.508 HOXB3
homeobox B3
chr5_+_36642424 1.505 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_100359353 1.496 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr6_-_138231006 1.496


chr17_+_70092651 1.493 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr14_-_69953433 1.490 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr2_+_190014432 1.489 WDR75
WD repeat domain 75
chr6_-_133161318 1.488 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr8_-_17797127 1.458 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr2_-_112358013 1.458 ANAPC1
anaphase promoting complex subunit 1
chr4_+_89597257 1.445 NM_016323
HERC5
hect domain and RLD 5
chr17_-_30783631 1.444 NM_018042
SLFN12
schlafen family member 12
chr1_+_110254755 1.420 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr11_+_18244383 1.419 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr5_-_95184121 1.398 GLRX
glutaredoxin (thioltransferase)
chr1_+_87368044 1.381 LOC339524
hypothetical LOC339524
chr1_-_180824967 1.373 RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr1_+_149165438 1.371 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr3_+_114733907 1.368 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr22_+_25155220 1.368 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr22_+_34374421 1.360 APOL6
apolipoprotein L, 6
chr6_-_133126278 1.359 NM_078488
VNN2
vanin 2
chr2_-_101134146 1.357 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr11_-_18226743 1.355 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr3_-_102888090 1.352 NM_000986
RPL24
ribosomal protein L24
chr6_-_31432543 1.340 HLA-B
major histocompatibility complex, class I, B
chr2_-_151826504 1.337 NM_198557
RBM43
RNA binding motif protein 43
chr3_-_69381995 1.332 FRMD4B
FERM domain containing 4B
chr6_-_24827265 1.331 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr17_-_57295451 1.313 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr8_-_143864933 1.305 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr22_-_21204597 1.304 NM_080740
ZNF280A
zinc finger protein 280A
chr19_-_51909416 1.304 NM_001079882
PRKD2
protein kinase D2
chr11_-_62363551 1.304 WDR74
WD repeat domain 74
chr2_-_55774451 1.298 NM_033109
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr2_+_190014403 1.282 NM_032168
WDR75
WD repeat domain 75
chr12_+_111860384 1.276 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_+_49361054 1.269 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr10_+_92970302 1.262 NM_032373
PCGF5
polycomb group ring finger 5
chr11_+_7463175 1.242 NM_198474
OLFML1
olfactomedin-like 1
chr6_+_20642665 1.240 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr3_-_150993299 1.237 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr11_-_104344473 1.236 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr17_+_76988134 1.230 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr1_-_247086686 1.225 NM_030645
SH3BP5L
SH3-binding domain protein 5-like
chr11_+_28088406 1.214 METTL15
methyltransferase like 15
chr2_+_201806410 1.214 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr16_-_18845223 1.213 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr6_+_26195426 1.208 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr8_+_22075112 1.207 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr16_-_11257539 1.196 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr6_+_17501589 1.189 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr14_+_93646831 1.189 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr19_+_17377502 1.184 LOC100507535
hypothetical LOC100507535
chr5_+_36642213 1.179 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr12_-_4628436 1.174 AKAP3
A kinase (PRKA) anchor protein 3
chr6_-_48186868 1.170 C6orf138
chromosome 6 open reading frame 138
chr2_+_85665041 1.168 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr5_-_95184221 1.168 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr20_+_13924263 1.165 MACROD2
MACRO domain containing 2
chr3_+_139388770 1.164 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr5_-_159730196 1.133 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr8_-_95343696 1.124 GEM
GTP binding protein overexpressed in skeletal muscle
chr6_+_37509028 1.119 FTSJD2
FtsJ methyltransferase domain containing 2
chr6_-_121697305 1.111 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr16_+_48616593 1.105 NM_153261
TMEM188
transmembrane protein 188
chr14_-_22549168 1.095 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr5_+_56507029 1.095 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr2_-_162883062 1.080 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr10_+_82290554 1.079 NM_001145719
SH2D4B
SH2 domain containing 4B
chr13_-_40533072 1.078 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_13546097 1.070 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr6_+_37508830 1.058 NM_015050
FTSJD2
FtsJ methyltransferase domain containing 2
chr14_+_72595055 1.058 RBM25
RNA binding motif protein 25
chr15_+_67094087 1.054 NM_001184779
NM_024505
NOX5

NADPH oxidase, EF-hand calcium binding domain 5

chr6_+_6533932 1.053 NM_004271
LY86
lymphocyte antigen 86
chr6_-_170704251 1.051 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr15_+_82945223 1.033 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr14_-_34168911 1.027 SNX6
sorting nexin 6
chr12_+_106236281 1.023 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr6_+_32929902 1.020 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr12_-_8584658 1.018 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr14_-_34169047 1.017 NM_021249
NM_152233
SNX6

sorting nexin 6

chr11_-_64520964 1.013 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr10_+_115429622 0.988 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_-_51155073 0.986 NM_018286
TMEM100
transmembrane protein 100
chr6_+_20510019 0.986 NM_001949
E2F3
E2F transcription factor 3
chr6_-_150253729 0.984 NM_139165
RAET1E
retinoic acid early transcript 1E
chr2_+_230900121 0.979 NM_138402
SP140L
SP140 nuclear body protein-like
chr2_-_151854379 0.979 NMI
N-myc (and STAT) interactor
chr6_-_170704304 0.971 NM_002793
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr6_-_110843432 0.970 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr6_-_32929721 0.970 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr22_+_34979118 0.965 APOL1
apolipoprotein L, 1
chr1_+_234625338 0.962 NM_080738
EDARADD
EDAR-associated death domain
chr1_-_27871245 0.956 IFI6
interferon, alpha-inducible protein 6
chr2_+_69822609 0.953 NM_001153
ANXA4
annexin A4
chr16_-_73292188 0.947 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr1_-_27871287 0.947 IFI6
interferon, alpha-inducible protein 6
chr5_-_147191428 0.945 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr14_+_72595020 0.945 RBM25
RNA binding motif protein 25
chr22_+_17012704 0.944 NM_017414
USP18
ubiquitin specific peptidase 18
chr11_+_63060848 0.944 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr15_-_97607108 0.944 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr6_-_32929570 0.939 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_151854619 0.938 NM_004688
NMI
N-myc (and STAT) interactor
chr22_+_38903825 0.932 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr16_-_74239030 0.932 NM_001130089
NM_005548
KARS

lysyl-tRNA synthetase

chr4_+_89519134 0.932 HERC6
hect domain and RLD 6
chr11_-_62364203 0.929 NM_018093
WDR74
WD repeat domain 74
chr20_+_226200 0.929 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr2_-_242449662 0.903 NM_005018
PDCD1
programmed cell death 1
chr18_-_13905534 0.901 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr1_+_161558346 0.898 NM_031423
NM_145697
NUF2

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

chr7_-_76883642 0.890 NM_017439
PION
pigeon homolog (Drosophila)
chr11_-_4585947 0.890 NM_018073
TRIM68
tripartite motif containing 68
chr4_-_40212670 0.884 NM_019027
RBM47
RNA binding motif protein 47
chr14_-_22358752 0.884 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr7_+_100515439 0.884 NM_030961
TRIM56
tripartite motif containing 56
chr11_-_82289006 0.883 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr6_+_112481970 0.879 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr2_+_33554824 0.874 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_159462456 0.873 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr9_-_134271985 0.871 NM_007344
TTF1
transcription termination factor, RNA polymerase I
chr19_-_17377383 0.870 NM_004335
BST2
bone marrow stromal cell antigen 2
chr17_+_53602013 0.868 NM_001004707
OR4D2
olfactory receptor, family 4, subfamily D, member 2
chr7_+_138469029 0.868 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr10_+_91051685 0.862 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr10_+_22765996 0.861 LOC100289455
hypothetical LOC100289455
chr15_-_72775378 0.860 EDC3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr2_+_68855436 0.860 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr14_+_72594985 0.859 RBM25
RNA binding motif protein 25
chr6_+_126282078 0.852 NCOA7
nuclear receptor coactivator 7
chr6_-_138862273 0.848


chr6_-_33389768 0.843 TAPBP
TAP binding protein (tapasin)
chr2_-_88707978 0.843 NM_004836
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr20_-_24986501 0.841 ACSS1
acyl-CoA synthetase short-chain family member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.68 1.05e-06 GO:0045087 innate immune response
3.78 5.91e-04 GO:0006955 immune response
2.96 1.15e-03 GO:0002376 immune system process
13.97 2.37e-03 GO:0060337 type I interferon-mediated signaling pathway
13.97 2.37e-03 GO:0071357 cellular response to type I interferon
13.75 2.60e-03 GO:0034340 response to type I interferon
3.31 7.06e-03 GO:0006952 defense response
10.83 1.05e-02 GO:0034341 response to interferon-gamma
15.04 1.08e-02 GO:0032479 regulation of type I interferon production
5.11 1.45e-02 GO:0034097 response to cytokine stimulus
19.25 2.89e-02 GO:0032480 negative regulation of type I interferon production
11.64 3.80e-02 GO:0060333 interferon-gamma-mediated signaling pathway
5.06 4.01e-02 GO:0001817 regulation of cytokine production

Nothing significant found in compartment category.

Nothing significant found in function category.