Motif ID: KLF12.p2

Z-value: 3.030


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12



Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27180398 2.649 NM_018951
HOXA10
homeobox A10
chr10_+_94439658 2.553 NM_002729
HHEX
hematopoietically expressed homeobox
chr2_+_176702667 2.378 NM_019558
HOXD8
homeobox D8
chr3_-_193609531 2.220 NM_021032
FGF12
fibroblast growth factor 12
chr13_-_27967215 2.204 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chrX_+_67965517 2.182 NM_004429
EFNB1
ephrin-B1
chr3_-_173648896 2.097 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr10_+_106390848 2.084 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr1_-_90955365 1.934 NM_020063
BARHL2
BarH-like homeobox 2
chrX_-_71268475 1.862 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chrX_-_111953009 1.838 NM_001113490
AMOT
angiomotin
chr17_+_23723220 1.834 SARM1
sterile alpha and TIR motif containing 1
chr1_+_63561632 1.829 FOXD3
forkhead box D3
chr12_+_79625538 1.772 NM_002469
MYF6
myogenic factor 6 (herculin)
chr1_+_152741318 1.730 NM_001098475
NM_182499
TDRD10

tudor domain containing 10

chr16_-_47873183 1.724 NM_004352
CBLN1
cerebellin 1 precursor
chr12_+_52665196 1.622 NM_017409
HOXC10
homeobox C10
chr1_+_16247870 1.622 NM_001165945
CLCNKB
chloride channel Kb
chr8_-_140784416 1.599 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr6_-_33268177 1.590 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr4_-_111763356 1.579 PITX2
paired-like homeodomain 2
chr1_+_157441824 1.569 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr17_+_23723180 1.545 SARM1
sterile alpha and TIR motif containing 1
chr1_+_235272324 1.535 NM_001035
RYR2
ryanodine receptor 2 (cardiac)
chr3_-_130761967 1.521 PLXND1
plexin D1
chr18_+_30810889 1.518 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_-_44945025 1.504 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr1_+_150852910 1.497 NM_178433
LCE3B
late cornified envelope 3B
chr1_+_63561317 1.488 NM_012183
FOXD3
forkhead box D3
chr2_-_192767494 1.477 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_+_77925441 1.465 NM_018949
UTS2R
urotensin 2 receptor
chr11_-_118716244 1.397 MFRP
membrane frizzled-related protein
chr15_+_39573363 1.341 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr20_-_33705244 1.337 NM_003915
CPNE1
copine I
chr3_-_129690056 1.322 NM_001145661
GATA2
GATA binding protein 2
chr12_-_79855580 1.313 LIN7A
lin-7 homolog A (C. elegans)
chr1_-_86394695 1.294 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr1_-_110414756 1.294 NM_006492
ALX3
ALX homeobox 3
chr6_+_137285071 1.293 NM_001008783
SLC35D3
solute carrier family 35, member D3
chrX_+_136475979 1.291 NM_003413
ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr16_-_47872880 1.280


chrX_-_53367246 1.274 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chrX_-_131918905 1.265 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr10_-_105604942 1.264 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr16_-_47872973 1.261 CBLN1
cerebellin 1 precursor
chr15_-_80123935 1.258 MEX3B
mex-3 homolog B (C. elegans)
chr7_-_27191287 1.251 NM_005523
HOXA11
homeobox A11
chr15_-_70288071 1.250 PKM2
pyruvate kinase, muscle
chr21_+_44530148 1.249 NM_000383
AIRE
autoimmune regulator
chr22_-_37970902 1.241 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr8_+_56177567 1.240 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr11_-_56846246 1.239 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr11_-_1006736 1.234 MUC6
mucin 6, oligomeric mucus/gel-forming
chr8_-_145609737 1.228 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_-_128138435 1.220 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr2_+_112372671 1.212 MERTK
c-mer proto-oncogene tyrosine kinase
chr12_-_79855618 1.190 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr11_-_2108035 1.183 IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_-_44386731 1.180 NM_001080468
SYCN
syncollin
chr8_-_132122016 1.175 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr10_+_106391032 1.173 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr11_+_65164963 1.173


chr2_+_112372651 1.170 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr11_+_65164767 1.165 SIPA1
signal-induced proliferation-associated 1
chr3_-_129689394 1.159 NM_001145662
GATA2
GATA binding protein 2
chr1_-_202387532 1.159 ETNK2
ethanolamine kinase 2
chr4_+_2031036 1.154 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr10_+_24023680 1.149 NM_001098500
KIAA1217
KIAA1217
chr19_+_54886160 1.145 NM_001136052
NM_152359
CPT1C

carnitine palmitoyltransferase 1C

chr16_+_88169612 1.134 NM_014427
NM_153636
CPNE7

copine VII

chr17_-_34084682 1.133 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr2_+_42128521 1.132 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr14_+_103675194 1.130 KIF26A
kinesin family member 26A
chr4_-_155631861 1.127 DCHS2
dachsous 2 (Drosophila)
chr16_+_86194075 1.120 JPH3
junctophilin 3
chr2_-_42573980 1.101 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr17_+_23723113 1.097 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr16_-_3783475 1.093 CREBBP
CREB binding protein
chr5_-_140663615 1.089 NM_031947
SLC25A2
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2
chrX_-_69396241 1.089 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr2_-_228754585 1.086 NM_001142644
NM_030623
SPHKAP

SPHK1 interactor, AKAP domain containing

chr5_+_60663842 1.083 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr22_+_23153529 1.082 NM_000675
ADORA2A
adenosine A2a receptor
chr4_-_165523856 1.080 NM_001166373
MARCH1
membrane-associated ring finger (C3HC4) 1
chr19_+_2200112 1.076 NM_000479
AMH
anti-Mullerian hormone
chr1_+_31823097 1.075 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr11_-_118716736 1.070 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr20_+_34206070 1.063 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_40089270 1.053 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr2_-_25390266 1.051 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_160618143 1.049 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr9_+_34642125 1.037 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chrX_-_109925941 1.035 NM_001143981
NM_001143982
NM_001143983
CHRDL1


chordin-like 1


chr6_+_108593907 1.029 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr16_+_162845 1.025 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr15_+_65904994 1.025 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr11_-_76059435 1.022 NM_001128922
LRRC32
leucine rich repeat containing 32
chr1_+_34415139 1.018 NM_001134734
C1orf94
chromosome 1 open reading frame 94
chr2_+_24126140 1.016 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr2_+_24126087 1.012 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr2_+_85834111 1.011 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr14_+_94160046 1.010


chr11_-_66092534 1.006 NM_003793
CTSF
cathepsin F
chr1_-_47428190 1.002 PDZK1IP1
PDZK1 interacting protein 1
chr3_-_129694717 0.999 NM_032638
GATA2
GATA binding protein 2
chr16_+_86194170 0.998 JPH3
junctophilin 3
chr1_+_199108705 0.996 NM_005298
GPR25
G protein-coupled receptor 25
chr2_+_104837004 0.993


chr3_-_51971915 0.991 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_20751518 0.989 NM_207334
FAM43B
family with sequence similarity 43, member B
chr1_-_26245031 0.985 NM_001004434
NM_032513
SLC30A2

solute carrier family 30 (zinc transporter), member 2

chr19_-_55912006 0.984 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr9_+_115970599 0.982 COL27A1
collagen, type XXVII, alpha 1
chr1_+_36160375 0.981 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr7_-_27190882 0.974 HOXA11
homeobox A11
chr4_-_108176901 0.969 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr1_+_212228482 0.969 NM_002763
PROX1
prospero homeobox 1
chr20_+_8060762 0.967 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chrX_-_135166306 0.966 NM_001173516
MAP7D3
MAP7 domain containing 3
chrX_-_109925648 0.965 NM_145234
CHRDL1
chordin-like 1
chr1_-_201583989 0.963 FMOD
fibromodulin
chr18_+_48120539 0.961 NM_005215
DCC
deleted in colorectal carcinoma
chr1_-_114156429 0.958 NM_018364
RSBN1
round spermatid basic protein 1
chr3_+_171619346 0.950 NM_005602
CLDN11
claudin 11
chr3_-_130807865 0.945 NM_015103
PLXND1
plexin D1
chrX_+_151837064 0.940 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr1_-_38285033 0.939 NM_002699
POU3F1
POU class 3 homeobox 1
chr4_+_172971149 0.939 NM_001034845
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr21_-_31175722 0.937 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr3_+_213535 0.935 NM_006614
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chrX_-_62921937 0.935 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_-_1840564 0.931 NM_178545
TMEM52
transmembrane protein 52
chr19_-_40673185 0.925 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr1_+_6767968 0.924 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr6_+_19945578 0.921 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chrX_-_106033202 0.908 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr14_-_103058568 0.900 CKB
creatine kinase, brain
chr1_-_201321711 0.900 MYOG
myogenin (myogenic factor 4)
chr11_+_64737886 0.897 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr15_+_76343540 0.896 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr6_+_22677635 0.896 NM_138574
HDGFL1
hepatoma derived growth factor-like 1
chr17_-_32368033 0.892


chr1_+_168899936 0.885 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr13_-_78075683 0.884 NM_006237
POU4F1
POU class 4 homeobox 1
chr1_-_47428310 0.883 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_204179169 0.879 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chrX_-_134013644 0.879 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr5_+_88220846 0.877


chr11_+_113435640 0.870 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr19_+_40534284 0.863 NM_005303
FFAR1
free fatty acid receptor 1
chr17_-_77512346 0.859 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr1_+_151015471 0.858 NM_178354
LCE1F
late cornified envelope 1F
chr6_+_99389300 0.858 NM_005604
POU3F2
POU class 3 homeobox 2
chrX_+_51091822 0.856 NM_153183
NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr10_-_44200458 0.856 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr5_+_145698779 0.853 NM_002700
POU4F3
POU class 4 homeobox 3
chr1_+_1557419 0.851 NM_006983
MMP23B
matrix metallopeptidase 23B
chr8_-_27171852 0.849 STMN4
stathmin-like 4
chr12_+_52103905 0.848 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr11_+_113435506 0.848 ZBTB16
zinc finger and BTB domain containing 16
chr22_-_42069211 0.848 NM_173050
SCUBE1
signal peptide, CUB domain, EGF-like 1
chr13_+_57105859 0.847 PCDH17
protocadherin 17
chr9_-_138462384 0.843 SEC16A
SEC16 homolog A (S. cerevisiae)
chr7_-_99365178 0.842 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chrX_+_106050261 0.841 NM_020384
CLDN2
claudin 2
chr9_+_94987032 0.840 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr22_-_17892859 0.838 NM_001130861
NM_003277
CLDN5

claudin 5

chr4_-_45820686 0.837 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr10_-_103525646 0.835 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr12_+_77782648 0.833 SYT1
synaptotagmin I
chr1_+_157441133 0.830 NM_002036
DARC
Duffy blood group, chemokine receptor
chr15_-_75694674 0.821 LINGO1
leucine rich repeat and Ig domain containing 1
chr1_-_37991160 0.820 EPHA10
EPH receptor A10
chr15_+_45263517 0.819 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_-_201321999 0.817 NM_002479
MYOG
myogenin (myogenic factor 4)
chrX_-_131181141 0.816 RAP2C
RAP2C, member of RAS oncogene family
chr5_-_132189762 0.816 NM_133456
SHROOM1
shroom family member 1
chr6_-_71069347 0.815 NM_001851
COL9A1
collagen, type IX, alpha 1
chr15_-_76313896 0.815 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr8_+_1936549 0.813 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr5_-_146238336 0.812 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr3_+_213430 0.810 CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr8_-_89408832 0.809 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr15_-_38362078 0.809 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr19_-_60646041 0.808 NM_001145176
SHISA7
shisa homolog 7 (Xenopus laevis)
chrX_-_139414890 0.798 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr11_-_1725924 0.798 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr3_-_117647011 0.795 LSAMP
limbic system-associated membrane protein
chr9_+_132002692 0.791 NM_001128826
NCS1
neuronal calcium sensor 1
chr3_+_185430910 0.788 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr1_-_17318452 0.786 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr5_+_137829077 0.785 NM_001964
EGR1
early growth response 1
chr9_+_138991775 0.785 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chrX_+_111212908 0.784 NM_001004308
ZCCHC16
zinc finger, CCHC domain containing 16
chrX_+_135079461 0.784 NM_001167819
FHL1
four and a half LIM domains 1
chr5_-_148422799 0.783 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr9_+_110664366 0.782 NM_006687
ACTL7A
actin-like 7A
chr21_+_33364420 0.780 OLIG1
oligodendrocyte transcription factor 1
chr1_+_33124658 0.780 NM_002143
HPCA
hippocalcin
chr22_-_37598115 0.776 CBX6
chromobox homolog 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.88 4.76e-06 GO:0007389 pattern specification process
5.20 1.02e-05 GO:0009790 embryo development
2.41 3.15e-04 GO:0048731 system development
2.17 9.16e-04 GO:0007275 multicellular organismal development
1.83 1.55e-03 GO:0032501 multicellular organismal process
2.17 3.53e-03 GO:0048856 anatomical structure development
1.98 8.34e-03 GO:0032502 developmental process
8.71 8.73e-03 GO:0009952 anterior/posterior pattern formation
11.15 9.06e-03 GO:0061138 morphogenesis of a branching epithelium
5.85 1.25e-02 GO:0001501 skeletal system development
191.30 1.59e-02 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
191.30 1.59e-02 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
9.42 2.37e-02 GO:0001763 morphogenesis of a branching structure
3.63 2.89e-02 GO:0007267 cell-cell signaling
3.15 3.62e-02 GO:0007154 cell communication
127.54 4.74e-02 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
127.54 4.74e-02 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
127.54 4.74e-02 GO:0070296 sarcoplasmic reticulum calcium ion transport

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
27.34 1.96e-02 GO:0033017 sarcoplasmic reticulum membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.14 5.80e-04 GO:0043565 sequence-specific DNA binding
3.02 1.06e-02 GO:0030528 transcription regulator activity
76.53 2.88e-02 GO:0005219 ryanodine-sensitive calcium-release channel activity
2.88 3.12e-02 GO:0001071 nucleic acid binding transcription factor activity
2.88 3.12e-02 GO:0003700 sequence-specific DNA binding transcription factor activity