Motif ID: KLF4.p3

Z-value: 2.278


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)



Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_63965156 4.639 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr6_-_4080700 4.303 NM_001166010
NM_006117
NM_206836
PECI


peroxisomal D3,D2-enoyl-CoA isomerase


chr20_-_39680405 2.823 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr9_-_129573330 2.589 NM_005489
SH2D3C
SH2 domain containing 3C
chr2_-_37752272 2.581 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr20_-_51644187 2.556 ZNF217
zinc finger protein 217
chr17_-_46298671 2.538 TOB1
transducer of ERBB2, 1
chr17_+_58954418 2.537 NM_030779
NM_173092
KCNH6

potassium voltage-gated channel, subfamily H (eag-related), member 6

chr3_-_12983959 2.506 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr6_+_44346457 2.410 NM_001137560
TMEM151B
transmembrane protein 151B
chr22_-_37062114 2.341 CSNK1E
casein kinase 1, epsilon
chr8_-_99906944 2.336 NM_006281
STK3
serine/threonine kinase 3
chr2_-_36678657 2.248 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr22_-_49050847 2.192 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr14_-_104718565 2.159 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr2_-_37752731 2.122 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_+_47498778 2.058 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr7_-_134845363 2.041 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr20_-_32877029 2.018 NM_014071
NCOA6
nuclear receptor coactivator 6
chr2_-_17563186 2.012 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr20_+_36810510 1.949 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr2_-_148494732 1.871 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr2_+_219779737 1.840 NM_138802
ZFAND2B
zinc finger, AN1-type domain 2B
chr20_+_1154763 1.830 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr14_+_34585098 1.825 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr12_-_6852709 1.784 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr20_-_3336586 1.758 C20orf194
chromosome 20 open reading frame 194
chr16_-_8870343 1.751 NM_014316
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr16_-_18845223 1.721 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr16_+_87765661 1.693 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr12_+_56435042 1.683 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr14_-_22658078 1.652 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr7_-_104440707 1.650 LOC100216545
hypothetical LOC100216545
chr6_-_30818198 1.647 NM_005803
FLOT1
flotillin 1
chr20_+_56318415 1.634 RAB22A
RAB22A, member RAS oncogene family
chr19_+_59386915 1.610 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr19_+_5855842 1.602 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr14_+_23610582 1.602 NM_006032
CPNE6
copine VI (neuronal)
chr2_-_122210873 1.596 NM_032390
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein
chr6_-_29708647 1.588 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr14_-_38971370 1.543 NM_203301
FBXO33
F-box protein 33
chr4_-_103968104 1.535 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr19_+_6690697 1.532 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr20_+_17498507 1.523 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr14_-_20975241 1.517 NM_020920
CHD8
chromodomain helicase DNA binding protein 8
chr17_-_73867748 1.516 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr16_-_69030421 1.515 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr14_-_20636337 1.501 ZNF219
zinc finger protein 219
chr16_+_29725311 1.480 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr2_+_220015016 1.415 SPEG
SPEG complex locus
chr2_+_202949289 1.414 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr17_-_15407497 1.397 NM_001135036
NM_145301
FAM18B2-CDRT4
FAM18B2

FAM18B2-CDRT4 read-through transcript
family with sequence similarity 18, member B2

chr2_-_27147995 1.391 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr1_-_9892852 1.359 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr20_-_3336219 1.352 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr16_-_21439195 1.338 SLC7A5P2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 pseudogene 2
chrX_-_1532648 1.308 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr20_-_44426407 1.307 NM_015945
NM_173073
NM_173179
SLC35C2


solute carrier family 35, member C2


chr2_+_42649348 1.288 MTA3
metastasis associated 1 family, member 3
chr4_+_154606900 1.282 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr12_-_56200547 1.263 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr5_-_108773468 1.255 NM_014819
PJA2
praja ring finger 2
chr20_-_472335 1.252 NM_001895
NM_177559
NM_177560
CSNK2A1


casein kinase 2, alpha 1 polypeptide


chr1_+_172104115 1.226 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr1_-_113059396 1.213 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr14_-_38642165 1.208 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr16_+_29724926 1.207 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_3063860 1.206 NM_004332
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr2_+_148495043 1.206 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr14_+_23937766 1.203 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr6_-_31658044 1.200 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr14_-_22596522 1.194 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr20_+_43531806 1.191 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr5_+_150612805 1.186 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr17_-_70380663 1.186 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr7_-_33068699 1.185 NM_001002010
NT5C3
5'-nucleotidase, cytosolic III
chr6_-_7258351 1.185 NM_003144
SSR1
signal sequence receptor, alpha
chr22_+_18081968 1.183 NM_002688
SEPT5
septin 5
chr6_+_2945025 1.182 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr3_-_48105287 1.178 MAP4
microtubule-associated protein 4
chr20_+_13924263 1.169 MACROD2
MACRO domain containing 2
chr17_-_39265965 1.161 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr20_+_44083667 1.157 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr15_+_61356801 1.156 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr20_+_37024383 1.153 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr11_+_85017269 1.151 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr12_+_120635021 1.144 NM_001080825
TMEM120B
transmembrane protein 120B
chr2_+_220200530 1.142 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr19_+_45807909 1.141


chr12_-_3852655 1.131 NM_020367
PARP11
poly (ADP-ribose) polymerase family, member 11
chr1_-_203985701 1.131 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr6_-_158985727 1.130 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr17_+_39990124 1.125 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr22_-_29015452 1.125 NM_001037666
GATSL3
GATS protein-like 3
chr17_-_60401967 1.118 AMZ2P1
archaelysin family metallopeptidase 2 pseudogene 1
chr2_+_48521411 1.111 NM_001135629
NM_001193475
NM_152994
KLRAQ1


KLRAQ motif containing 1


chr20_+_254205 1.108 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr2_+_96790298 1.103 NM_020184
CNNM4
cyclin M4
chr9_-_138277467 1.103 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr8_+_124498145 1.103 NM_018024
WDYHV1
WDYHV motif containing 1
chr11_+_64838882 1.098 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr7_+_64136078 1.096 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_+_72789086 1.093 NM_001113491
SEPT9
septin 9
chr10_+_75427853 1.092 NM_003373
NM_014000
VCL

vinculin

chr2_+_27504987 1.091 NRBP1
nuclear receptor binding protein 1
chr10_+_92970487 1.090 PCGF5
polycomb group ring finger 5
chr20_-_39379533 1.084 ZHX3
zinc fingers and homeoboxes 3
chr10_+_49184658 1.084 MAPK8
mitogen-activated protein kinase 8
chr12_+_115455579 1.080 NCRNA00173
non-protein coding RNA 173
chr2_-_201082978 1.077 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr2_-_175741096 1.072 NM_001880
ATF2
activating transcription factor 2
chr2_+_219141761 1.072 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr14_-_34168911 1.068 SNX6
sorting nexin 6
chr2_-_33677798 1.067 NM_015475
FAM98A
family with sequence similarity 98, member A
chr13_+_97426713 1.061 IPO5
importin 5
chr20_+_56318245 1.059 RAB22A
RAB22A, member RAS oncogene family
chr16_-_85974810 1.057 NM_024735
FBXO31
F-box protein 31
chr20_-_3102169 1.053 ProSAPiP1
ProSAPiP1 protein
chr17_-_39632845 1.050 ATXN7L3
ataxin 7-like 3
chr10_+_112247614 1.048 NM_004419
DUSP5
dual specificity phosphatase 5
chr11_-_85457469 1.045 PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_44203335 1.043 NM_018426
TMEM63B
transmembrane protein 63B
chr2_-_175060001 1.042 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr2_+_63922488 1.035 NM_006759
UGP2
UDP-glucose pyrophosphorylase 2
chr10_-_131799051 1.033 LOC387723
hypothetical LOC387723
chr17_-_7323528 1.031 ZBTB4
zinc finger and BTB domain containing 4
chr17_-_46553083 1.031 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr17_-_50854054 1.028 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr2_-_97646758 1.026 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr2_+_42249896 1.025 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr1_+_110554836 1.024 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr1_-_203985752 1.020 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_-_13441294 1.019 NM_032320
BTBD10
BTB (POZ) domain containing 10
chr20_+_48781457 1.019 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr8_+_26204997 1.010 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr6_-_42527760 1.004 NM_033502
TRERF1
transcriptional regulating factor 1
chr1_-_109386112 1.001 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr14_-_104705753 0.991 JAG2
jagged 2
chr16_-_11257539 0.989 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr17_-_53946899 0.989 MTMR4
myotubularin related protein 4
chr17_+_45488356 0.984 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr6_-_45453552 0.983 NM_003599
NM_181356
SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr6_+_114285209 0.974 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr17_+_52688842 0.974 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr16_+_29725597 0.973


chr11_-_85457736 0.967 PICALM
phosphatidylinositol binding clathrin assembly protein
chr7_+_21434097 0.964 NM_003112
SP4
Sp4 transcription factor
chr12_+_69046241 0.962 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_42274160 0.962


chr9_-_87546620 0.960 NM_015239
AGTPBP1
ATP/GTP binding protein 1
chr18_-_50004770 0.959 MBD2
methyl-CpG binding domain protein 2
chr14_-_37133927 0.958 FOXA1
forkhead box A1
chr4_+_85723080 0.955 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_-_203985780 0.948 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_+_47863724 0.945 NM_000179
MSH6
mutS homolog 6 (E. coli)
chr16_+_4948318 0.944 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr15_-_100082134 0.944 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr16_+_15644624 0.943 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr14_+_35365266 0.941 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr17_-_39556535 0.940 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr20_+_39402834 0.940 NM_022896
LPIN3
lipin 3
chr16_+_76313909 0.939 NM_001105663
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr2_+_23461802 0.929 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr16_-_2125825 0.924 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr12_-_6995988 0.920 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr8_-_96350575 0.920 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr20_+_36534871 0.917 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr16_-_30254189 0.915 LOC595101
PI-3-kinase-related kinase SMG-1 pseudogene
chr1_+_103841155 0.914 NM_017619
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr6_+_37245860 0.914 NM_002648
PIM1
pim-1 oncogene
chr9_-_5997891 0.914 NM_001017969
KIAA2026
KIAA2026
chr17_-_53950191 0.912 NM_004687
MTMR4
myotubularin related protein 4
chr17_-_24302450 0.911 PHF12
PHD finger protein 12
chr6_-_41855564 0.910 NM_006653
FRS3
fibroblast growth factor receptor substrate 3
chr20_+_33823318 0.903 NM_016436
PHF20
PHD finger protein 20
chr21_-_33935883 0.903 NM_145858
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr21_+_16024241 0.898 NM_013396
USP25
ubiquitin specific peptidase 25
chr17_-_39265705 0.897 MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr2_+_178767317 0.897 NM_032523
OSBPL6
oxysterol binding protein-like 6
chr14_-_20636568 0.892 NM_016423
ZNF219
zinc finger protein 219
chr17_+_45488330 0.888 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr2_+_84986273 0.888 NM_021103
TMSB10
thymosin beta 10
chr2_+_190981257 0.884 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr16_+_29725665 0.883


chr9_+_138805581 0.881 NM_032928
TMEM141
transmembrane protein 141
chr19_-_45663463 0.880 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr17_-_2153561 0.879 NM_001170957
SMG6
Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr12_+_121803255 0.876 NM_003677
DENR
density-regulated protein
chr14_-_29466562 0.876 NM_002742
PRKD1
protein kinase D1
chr16_+_67902751 0.873 NM_013245
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_+_1099145 0.871 NM_001130045
TTLL10
tubulin tyrosine ligase-like family, member 10
chr14_+_22410795 0.870 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr10_+_76256305 0.868 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr17_-_17667580 0.867 SREBF1
sterol regulatory element binding transcription factor 1
chr20_+_61841662 0.867 SLC2A4RG
SLC2A4 regulator
chr6_-_34772495 0.867 C6orf106
chromosome 6 open reading frame 106
chr19_+_45996881 0.863 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chr7_+_99919485 0.855 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr3_+_184898234 0.854 NM_018023
YEATS2
YEATS domain containing 2
chr20_+_61841553 0.853 NM_020062
SLC2A4RG
SLC2A4 regulator

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
25.91 2.66e-02 GO:0032589 neuron projection membrane

Nothing significant found in function category.