Motif ID: LHX3,4.p2

Z-value: 1.075


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4



Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60962318 1.798 NM_001145014
RFPL4A
ret finger protein-like 4A
chr5_+_6799100 1.421 NM_001171806
PAPD7
PAP associated domain containing 7
chr3_-_69254226 1.404 NM_198271
LMOD3
leiomodin 3 (fetal)
chr15_+_32048380 1.151 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr8_-_131483395 1.118 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr6_+_73133152 1.106 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr15_+_100175888 1.086 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr8_+_124032830 1.048 ZHX2
zinc fingers and homeoboxes 2
chr12_-_7547552 0.995 NM_004244
NM_203416
CD163

CD163 molecule

chr6_+_155579788 0.937 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr8_+_17440664 0.920 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr12_-_41269679 0.901 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr1_+_156991133 0.885 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr1_-_93919789 0.870 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr5_-_16795336 0.869 MYO10
myosin X
chr7_+_129771865 0.860 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chrX_+_7147471 0.823 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr7_+_128802719 0.817 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr9_-_111230926 0.804 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_242281199 0.797 ZNF238
zinc finger protein 238
chr2_-_99238001 0.788 NM_175735
LYG2
lysozyme G-like 2
chr6_-_25679197 0.786


chr5_-_88155360 0.778 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_-_150398327 0.776 NM_001122965
RPTN
repetin
chr16_-_70168449 0.766 NM_000353
TAT
tyrosine aminotransferase
chr1_+_242281175 0.730 NM_205768
ZNF238
zinc finger protein 238
chrX_-_55074125 0.714 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr20_-_49747397 0.708 ATP9A
ATPase, class II, type 9A
chr6_+_29663661 0.691 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr3_+_196933422 0.673 NM_152673
MUC20
mucin 20, cell surface associated
chr6_-_50045296 0.668 NM_001037729
DEFB113
defensin, beta 113
chr7_-_27133163 0.668 NM_153631
HOXA3
homeobox A3
chr1_-_159191184 0.665 NM_080878
ITLN2
intelectin 2
chr1_+_242283129 0.646 NM_006352
ZNF238
zinc finger protein 238
chr4_-_170314382 0.635 SH3RF1
SH3 domain containing ring finger 1
chrX_-_110542040 0.634 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_+_46386636 0.624 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr11_-_111636792 0.623 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr14_+_69307914 0.622 SRSF5
serine/arginine-rich splicing factor 5
chr9_+_674193 0.615


chr10_+_685887 0.609 C10orf108
chromosome 10 open reading frame 108
chr1_-_195818927 0.603 DENND1B
DENN/MADD domain containing 1B
chr7_-_86433139 0.602 NM_152748
KIAA1324L
KIAA1324-like
chr11_+_33306652 0.592 HIPK3
homeodomain interacting protein kinase 3
chr22_+_21817512 0.580 NM_004914
RAB36
RAB36, member RAS oncogene family
chr5_-_137502975 0.575 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr21_-_34820916 0.574 NM_203418
RCAN1
regulator of calcineurin 1
chr2_-_166638376 0.557 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr11_-_114593838 0.554 CADM1
cell adhesion molecule 1
chrX_-_43717864 0.553 NM_000266
NDP
Norrie disease (pseudoglioma)
chr2_-_224574860 0.552 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr10_+_21924265 0.548 MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr9_+_27099138 0.536 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr6_+_161043214 0.532 NM_000301
NM_001168338
PLG

plasminogen

chr1_-_203592538 0.530 NM_018203
KLHDC8A
kelch domain containing 8A
chr8_-_7207899 0.527 NM_001164457
ZNF705G
zinc finger protein 705G
chr10_-_48426868 0.523 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr8_-_7710547 0.517 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr8_+_22900863 0.514 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr3_+_46628928 0.513 NM_001195442
LOC100132146
hypothetical LOC100132146
chrX_-_15242589 0.513 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr7_-_122627235 0.512 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr3_+_152934393 0.512 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr17_-_36347197 0.498 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_42773146 0.491 NM_001080850
CCDC30
coiled-coil domain containing 30
chr20_+_56919233 0.490 GNAS
GNAS complex locus
chr2_+_178893216 0.486 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_-_36877002 0.478 NM_002278
KRT32
keratin 32
chr6_-_2580296 0.477 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr13_+_52500830 0.467 NM_006418
OLFM4
olfactomedin 4
chr4_-_68511738 0.463 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr11_+_124294355 0.461 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr18_+_28023984 0.458 NM_005925
MEP1B
meprin A, beta
chr11_-_5819702 0.455 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr7_+_147918589 0.450 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr11_+_89403921 0.448 NM_001195234
TRIM49
TRIM49L2
tripartite motif containing 49
tripartite motif containing 49-like 2
chr6_-_31196174 0.447 NM_001264
CDSN
corneodesmosin
chr9_+_129066576 0.444 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr5_-_111121691 0.444 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr4_-_26100986 0.439 NM_000730
CCKAR
cholecystokinin A receptor
chr1_-_67039518 0.439 NM_005478
INSL5
insulin-like 5
chr7_-_38279757 0.438 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr5_+_36642424 0.438 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_136214495 0.435 NM_018945
PDE7B
phosphodiesterase 7B
chr8_+_7340777 0.434 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr6_-_29635680 0.434 NM_006398
UBD
ubiquitin D
chr5_+_36642213 0.431 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr15_+_22832198 0.426 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr10_-_33264491 0.423 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr5_-_160044844 0.423 ATP10B
ATPase, class V, type 10B
chr16_+_2749934 0.422


chr20_-_29441946 0.420 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr2_-_87102453 0.420 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr16_-_71650034 0.419 NM_001164766
ZFHX3
zinc finger homeobox 3
chr6_+_144654565 0.418 NM_007124
UTRN
utrophin
chr6_-_29120930 0.417 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr5_-_37220702 0.416 C5orf42
chromosome 5 open reading frame 42
chr13_-_109600709 0.416 COL4A1
collagen, type IV, alpha 1
chr21_-_30460841 0.416 NM_012131
CLDN17
claudin 17
chr6_-_152681171 0.416 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_169789327 0.415 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chrX_+_135558001 0.415 NM_000074
CD40LG
CD40 ligand
chr3_+_11269384 0.406 NM_000861
HRH1
histamine receptor H1
chrX_-_44945025 0.401 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr12_+_100394787 0.400 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr15_-_31147376 0.397 NM_001103184
FMN1
formin 1
chr2_-_175170674 0.396 WIPF1
WAS/WASL interacting protein family, member 1
chr10_+_63478974 0.393 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_+_127012611 0.387 NM_001048252
CTXN3
cortexin 3
chr2_+_135312655 0.384 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr16_-_3783475 0.383 CREBBP
CREB binding protein
chr9_-_14076901 0.382 NFIB
nuclear factor I/B
chr1_+_166516901 0.376 NM_005149
TBX19
T-box 19
chr6_+_152053323 0.373 NM_001122742
ESR1
estrogen receptor 1
chr3_+_153074118 0.373 NM_033050
SUCNR1
succinate receptor 1
chr10_+_24795446 0.371 KIAA1217
KIAA1217
chr11_-_18913121 0.368 NM_147199
MRGPRX1
MAS-related GPR, member X1
chr7_+_111908143 0.368 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_+_200775864 0.368 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr5_+_95092384 0.367 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr15_+_55298908 0.367 NM_207040
TCF12
transcription factor 12
chr11_+_89032112 0.367 NM_153696
FOLH1B
folate hydrolase 1B
chr5_+_145296313 0.367 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr3_-_11598829 0.366 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr1_-_163680941 0.366 NM_006917
RXRG
retinoid X receptor, gamma
chr4_+_187227302 0.365 NM_003265
TLR3
toll-like receptor 3
chr19_-_40995564 0.365 PRODH2
proline dehydrogenase (oxidase) 2
chr2_-_56266408 0.365 LOC100129434
hypothetical LOC100129434
chrX_-_138875342 0.363 NM_001013403
CXorf66
chromosome X open reading frame 66
chr4_+_166350620 0.360 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr15_+_94670160 0.358 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_-_15538164 0.358 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr6_-_66346417 0.358 NM_198283
EYS
eyes shut homolog (Drosophila)
chr4_-_54119102 0.355 LNX1
ligand of numb-protein X 1
chr12_+_54172413 0.355 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chrX_-_18600108 0.354 NM_000330
RS1
retinoschisin 1
chr11_-_117628211 0.352 NM_198275
MPZL3
myelin protein zero-like 3
chr1_-_157014048 0.348 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr12_-_52281050 0.346 NM_001130059
ATF7
activating transcription factor 7
chr19_+_21116666 0.345 NM_133473
ZNF431
zinc finger protein 431
chr19_-_56612653 0.344 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr1_-_152845399 0.344 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr11_+_59979857 0.342 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_+_61794205 0.341 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr14_-_105997732 0.341 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr13_+_97856148 0.341


chrX_-_62697473 0.341 LOC92249
hypothetical LOC92249
chrX_-_138552517 0.341 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr19_-_40995606 0.336 PRODH2
proline dehydrogenase (oxidase) 2
chr6_-_50097606 0.331 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr21_-_30510113 0.330 NM_199328
CLDN8
claudin 8
chr5_-_124108672 0.328 NM_020747
ZNF608
zinc finger protein 608
chr18_+_59767567 0.326 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chr3_-_127810087 0.325 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr3_+_45902999 0.323 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr10_+_24795465 0.321 KIAA1217
KIAA1217
chr4_+_123311207 0.317 NM_015312
KIAA1109
KIAA1109
chr2_+_158559936 0.317 NM_001135098
UPP2
uridine phosphorylase 2
chr7_+_137795387 0.314 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chrX_+_50044279 0.314 NM_033031
NM_033670
CCNB3

cyclin B3

chr11_-_89181390 0.312 NM_020358
TRIM49
tripartite motif containing 49
chr8_+_22266256 0.309 PIWIL2
piwi-like 2 (Drosophila)
chr17_-_36346240 0.308 KRT23
keratin 23 (histone deacetylase inducible)
chr13_+_108046500 0.308 NM_015011
MYO16
myosin XVI
chr4_+_3341521 0.305 NM_198227
RGS12
regulator of G-protein signaling 12
chr5_+_179065282 0.305 CANX
calnexin
chr3_+_150675117 0.304 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr11_-_47472648 0.303 NM_198700
CELF1
CUGBP, Elav-like family member 1
chr9_-_15240113 0.301 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr1_+_119759076 0.298 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr18_+_27210737 0.296 NM_001134453
NM_177986
DSG4

desmoglein 4

chr15_-_64108718 0.292


chrX_+_55666557 0.289 NM_198451
FOXR2
forkhead box R2
chrX_+_70682204 0.289 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr5_+_71538456 0.288 MAP1B
microtubule-associated protein 1B
chr4_-_54119159 0.287 NM_032622
LNX1
ligand of numb-protein X 1
chr1_+_111634996 0.287 NM_021797
NM_201653
CHIA

chitinase, acidic

chrX_+_107174855 0.286 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr20_+_56455866 0.284 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_-_206790871 0.284 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr6_-_38671741 0.281 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr3_+_171022403 0.279 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr9_-_4142182 0.277 NM_152629
GLIS3
GLIS family zinc finger 3
chr11_-_85115105 0.277 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chrX_+_55951280 0.276


chr3_+_115099007 0.275 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_-_37454933 0.275 NM_014800
ELMO1
engulfment and cell motility 1
chr9_+_123369219 0.274 NM_032552
DAB2IP
DAB2 interacting protein
chr21_-_35174742 0.274 RUNX1
runt-related transcription factor 1
chr7_+_18296569 0.274 HDAC9
histone deacetylase 9
chr8_-_62764839 0.273 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr4_+_88748704 0.273 NM_014208
DSPP
dentin sialophosphoprotein
chr7_-_139408808 0.272 PARP12
poly (ADP-ribose) polymerase family, member 12
chr2_+_216695062 0.272 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr9_+_117955890 0.271 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr19_+_9157269 0.271 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr12_-_10870134 0.270 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr1_-_155336223 0.267 NM_001004341
ETV3L
ets variant 3-like
chr5_+_67622242 0.266 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_111616630 0.263 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.