Motif ID: LMO2.p2

Z-value: 1.355


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)



Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_3556420 4.008 NM_017818
WDR8
WD repeat domain 8
chr1_+_1062137 2.838 LOC254099
hypothetical protein LOC254099
chr9_+_967386 2.557 DMRT3
doublesex and mab-3 related transcription factor 3
chr2_+_171280944 2.449 SP5
Sp5 transcription factor
chr14_+_73775927 2.343 NM_182894
VSX2
visual system homeobox 2
chr10_+_94823221 2.288 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr20_-_3097070 2.248 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr18_-_45975163 2.042 NM_001080467
MYO5B
myosin VB
chr8_+_11599119 1.985 NM_002052
GATA4
GATA binding protein 4
chr19_-_7845325 1.975 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr8_-_144862266 1.952 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr5_-_95794416 1.950 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr18_-_55091596 1.935 NM_013435
RAX
retina and anterior neural fold homeobox
chr9_+_966963 1.928 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr7_-_72822471 1.765 NM_001306
CLDN3
claudin 3
chr3_+_138965844 1.762 SOX14
SRY (sex determining region Y)-box 14
chr3_+_54131613 1.756 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr10_+_22674379 1.741 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr9_-_96441409 1.741 FBP1
fructose-1,6-bisphosphatase 1
chr3_+_54131731 1.717 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_+_76284435 1.716 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr1_+_229365296 1.712 NM_001004342
TRIM67
tripartite motif containing 67
chrX_-_13866451 1.657 GPM6B
glycoprotein M6B
chr12_+_131705438 1.650 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr2_+_208979800 1.642 NM_005048
PTH2R
parathyroid hormone 2 receptor
chrX_+_152562013 1.628 DUSP9
dual specificity phosphatase 9
chr8_-_17315171 1.619 MTMR7
myotubularin related protein 7
chr1_-_114497994 1.583 NM_205848
SYT6
synaptotagmin VI
chr18_+_65219114 1.580 NM_152721
DOK6
docking protein 6
chrX_-_13866565 1.573 NM_001001994
GPM6B
glycoprotein M6B
chr8_-_140784416 1.559 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr4_-_165523856 1.555 NM_001166373
MARCH1
membrane-associated ring finger (C3HC4) 1
chr3_+_129117007 1.537 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr1_-_40555413 1.532 COL9A2
collagen, type IX, alpha 2
chr13_-_77390907 1.515 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr2_-_198359182 1.507 NM_197970
BOLL
bol, boule-like (Drosophila)
chr1_-_40555511 1.492 NM_001852
COL9A2
collagen, type IX, alpha 2
chr10_-_98935369 1.487 SLIT1
slit homolog 1 (Drosophila)
chr7_+_156491223 1.481 MNX1
motor neuron and pancreas homeobox 1
chr2_-_73350103 1.472 NM_001080410
FBXO41
F-box protein 41
chr12_-_33483847 1.458 NM_198992
SYT10
synaptotagmin X
chr15_+_48261649 1.452 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr5_-_132976121 1.451 NM_015082
FSTL4
follistatin-like 4
chr17_+_5913149 1.451 WSCD1
WSC domain containing 1
chr7_-_44331544 1.440 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr17_-_8809656 1.425 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr9_-_96441567 1.404 FBP1
fructose-1,6-bisphosphatase 1
chr2_-_133144094 1.386 LYPD1
LY6/PLAUR domain containing 1
chr14_+_71468902 1.384 RGS6
regulator of G-protein signaling 6
chr21_-_38954433 1.384 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr22_+_38720881 1.374 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_-_92724181 1.367 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr19_-_40325194 1.350 LGI4
leucine-rich repeat LGI family, member 4
chr16_-_2186465 1.333 NM_020764
CASKIN1
CASK interacting protein 1
chr4_-_15694407 1.332 PROM1
prominin 1
chr17_+_7495140 1.326 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr13_+_112681626 1.312 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_74912009 1.302 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr2_-_241408296 1.299 NM_004321
KIF1A
kinesin family member 1A
chr1_+_237616457 1.298 CHRM3
cholinergic receptor, muscarinic 3
chr3_+_120904555 1.280 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr1_+_1971762 1.279 NM_002744
PRKCZ
protein kinase C, zeta
chr19_-_45424403 1.262 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr21_+_33364316 1.259 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr17_+_36647795 1.257 NM_031963
KRTAP9-8
keratin associated protein 9-8
chrX_-_13866366 1.252


chr19_-_11452439 1.250 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr15_-_50375143 1.239 NM_018728
MYO5C
myosin VC
chr9_-_96441654 1.213 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr4_-_15694691 1.213 NM_001145847
NM_001145848
PROM1

prominin 1

chr10_-_98935652 1.203 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr2_+_222997529 1.192 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr4_+_82171142 1.188 NM_001201
BMP3
bone morphogenetic protein 3
chr11_+_627268 1.177 NM_000797
DRD4
dopamine receptor D4
chr21_+_36993860 1.160 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr9_+_134447795 1.152 NM_020064
BARHL1
BarH-like homeobox 1
chrX_+_82649924 1.151 NM_000307
POU3F4
POU class 3 homeobox 4
chr5_-_59225377 1.141 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_-_98470164 1.141 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr13_+_77170470 1.136 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr13_-_78075683 1.126 NM_006237
POU4F1
POU class 4 homeobox 1
chr12_-_61614930 1.124 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_+_120944174 1.124 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr5_-_95793618 1.111 NM_001177875
PCSK1
proprotein convertase subtilisin/kexin type 1
chr17_+_40089270 1.107 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr5_-_146238336 1.105 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr2_-_219633481 1.104 NM_002181
IHH
Indian hedgehog
chr4_-_2390050 1.101 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr4_+_3738093 1.095 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr9_+_86475130 1.072 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr5_-_114543632 1.069 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr11_-_1563056 1.068 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr14_+_61653827 1.066 FLJ43390
hypothetical LOC646113
chr17_-_7106497 1.063 CLDN7
claudin 7
chr13_+_30378311 1.058 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr19_+_59618416 1.052 NM_001005367
NM_020659
TTYH1

tweety homolog 1 (Drosophila)

chr14_+_30413393 1.047 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr8_+_21937533 1.044 NPM2
nucleophosmin/nucleoplasmin 2
chr3_-_47595190 1.044 NM_006574
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chr13_-_71338144 1.041 DACH1
dachshund homolog 1 (Drosophila)
chr11_+_45900731 1.040 GYLTL1B
glycosyltransferase-like 1B
chr8_-_17315386 1.040 NM_004686
MTMR7
myotubularin related protein 7
chr12_-_61615124 1.039 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_-_132976094 1.036 FSTL4
follistatin-like 4
chr8_+_1937711 1.031 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr20_-_42872295 1.031 NM_182970
RIMS4
regulating synaptic membrane exocytosis 4
chr10_+_94823636 1.027 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr20_-_26137755 1.026 LOC284801
hypothetical protein LOC284801
chr11_+_817584 1.025 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr2_+_222997456 1.006 SGPP2
sphingosine-1-phosphate phosphatase 2
chr16_+_972064 1.005 SOX8
SRY (sex determining region Y)-box 8
chr16_+_66022551 1.004 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr11_-_129803515 1.003 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chrX_+_23262905 1.001 NM_173495
PTCHD1
patched domain containing 1
chr10_-_135088065 0.999 NM_001012508
SPRN
shadow of prion protein homolog (zebrafish)
chr5_-_1348103 0.997 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr10_-_132999798 0.995 TCERG1L
transcription elongation regulator 1-like
chr18_+_73090913 0.993 NM_001480
GALR1
galanin receptor 1
chr17_+_45405128 0.992 NM_001934
DLX4
distal-less homeobox 4
chr19_+_868285 0.990 NM_032551
KISS1R
KISS1 receptor
chr1_+_12149637 0.990 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr16_+_66022520 0.987 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_-_14177980 0.985 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr15_+_45263517 0.983 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_-_92721943 0.981 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr13_-_50315832 0.979 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr10_-_98935570 0.979 SLIT1
slit homolog 1 (Drosophila)
chr1_+_60053050 0.977 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr2_-_192767494 0.976 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr14_+_28306633 0.969 FOXG1
forkhead box G1
chr2_+_73282893 0.967 NM_001134462
NOTO
notochord homeobox
chr9_-_92444886 0.967 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr4_-_144841277 0.961 NM_001168235
FREM3
FRAS1 related extracellular matrix 3
chr14_-_103058568 0.961 CKB
creatine kinase, brain
chr4_+_2390469 0.958 NM_001193282
LOC402160
hypothetical protein LOC402160
chr14_+_104402626 0.956 NM_001112726
NM_015005
KIAA0284

KIAA0284

chrX_+_115481774 0.949 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr19_+_19510098 0.946 CILP2
cartilage intermediate layer protein 2
chr5_+_80292313 0.946 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr9_-_90983195 0.944 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr1_-_92721633 0.937 GFI1
growth factor independent 1 transcription repressor
chr22_-_49317408 0.934 ODF3B
outer dense fiber of sperm tails 3B
chr7_+_140420500 0.934 NM_001195278
LOC100131199
transmembrane protein 178-like
chr4_-_15694764 0.925 PROM1
prominin 1
chr16_+_971808 0.923 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chrX_+_115481848 0.913 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_105027431 0.911 INA
internexin neuronal intermediate filament protein, alpha
chr2_+_137239583 0.911 THSD7B
thrombospondin, type I, domain containing 7B
chr5_+_80292213 0.910 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr1_-_218168404 0.910


chr4_+_156349230 0.909 NM_000910
NPY2R
neuropeptide Y receptor Y2
chr3_+_138966268 0.908 NM_004189
SOX14
SRY (sex determining region Y)-box 14
chr5_+_79366746 0.902 NM_003248
THBS4
thrombospondin 4
chr5_+_126654354 0.899 NM_032446
MEGF10
multiple EGF-like-domains 10
chr4_+_25266532 0.899 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr3_-_69064364 0.897 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr2_-_233501069 0.897 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr6_-_110786167 0.896 NM_001123364
C6orf186
chromosome 6 open reading frame 186
chr7_-_150128331 0.895 NM_001101311
NM_001101312
NM_001101314
TMEM176B


transmembrane protein 176B


chr17_+_26839143 0.893 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr1_+_95355415 0.887 NM_152487
TMEM56
transmembrane protein 56
chr11_-_118739838 0.883 USP2
ubiquitin specific peptidase 2
chr3_+_98016114 0.883 NM_001080448
EPHA6
EPH receptor A6
chr19_+_1022208 0.878 HMHA1
histocompatibility (minor) HA-1
chr9_-_38610579 0.877 ANKRD18A
ankyrin repeat domain 18A
chr19_-_11550765 0.876 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr9_+_17568952 0.874 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr3_+_161426322 0.872 LOC401097
hypothetical protein LOC401097
chr22_-_22511173 0.870 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr3_-_13436802 0.868 NM_024923
NUP210
nucleoporin 210kDa
chr14_+_103674812 0.865 NM_015656
KIF26A
kinesin family member 26A
chr3_-_22389126 0.862 ZNF385D
zinc finger protein 385D
chr14_-_99695684 0.860 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr17_+_19853200 0.859 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_175407153 0.859 NM_021165
FAM5B
family with sequence similarity 5, member B
chr16_-_2330738 0.856 NM_001089
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr8_+_17478214 0.854 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr22_-_42069211 0.852 NM_173050
SCUBE1
signal peptide, CUB domain, EGF-like 1
chr7_-_124192265 0.848 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_116181927 0.846 NHLH2
nescient helix loop helix 2
chr17_+_36599664 0.845 NM_001190460
KRTAP9-1
keratin associated protein 9-1
chr1_-_40027108 0.837 NM_001720
BMP8B
bone morphogenetic protein 8b
chr19_+_659766 0.834 NM_001040134
NM_002579
PALM

paralemmin

chr19_+_6415259 0.832 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr17_-_6887965 0.832 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr10_-_132999973 0.829 NM_174937
TCERG1L
transcription elongation regulator 1-like
chr18_-_42590989 0.828 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr3_-_124650081 0.824 NM_183357
ADCY5
adenylate cyclase 5
chr19_+_44681374 0.823 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr19_+_7834124 0.819 EVI5L
ecotropic viral integration site 5-like
chr19_+_10392128 0.817 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr10_-_134449467 0.817 NM_177400
NKX6-2
NK6 homeobox 2
chrX_-_71442488 0.813 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr13_-_52211836 0.810 LECT1
leukocyte cell derived chemotaxin 1
chrX_+_16874651 0.809 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr1_-_40027097 0.805 BMP8B
bone morphogenetic protein 8b
chr21_+_41610530 0.803 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr9_+_138862212 0.803 PHPT1
phosphohistidine phosphatase 1
chr9_-_138757175 0.802 NM_001001712
LCN10
lipocalin 10
chr17_+_14145051 0.798 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.18 6.36e-04 GO:0007399 nervous system development
2.74 7.68e-04 GO:0030154 cell differentiation
2.67 1.28e-03 GO:0048869 cellular developmental process
46.23 1.48e-02 GO:0003407 neural retina development
3.43 2.20e-02 GO:0022008 neurogenesis
33.39 4.14e-02 GO:0060042 retina morphogenesis in camera-type eye

Nothing significant found in compartment category.

Nothing significant found in function category.