Motif ID: MZF1.p2

Z-value: 3.295


Transcription factors associated with MZF1.p2:

Gene SymbolEntrez IDGene Name
MZF1 7593 myeloid zinc finger 1



Activity profile for motif MZF1.p2.

activity profile for motif MZF1.p2


Sorted Z-values histogram for motif MZF1.p2

Sorted Z-values for motif MZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_159306532 9.362 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr7_+_5289079 6.251 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr3_-_159306214 5.566


chr22_-_28972683 4.989 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr3_+_148610516 4.817 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr1_+_2975590 4.689 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr2_+_45022540 4.652 NM_005413
SIX3
SIX homeobox 3
chr11_+_17714070 4.447 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr8_+_22513043 4.405 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr4_-_1156959 4.120 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr13_+_113574925 4.074 NM_001143945
GAS6
growth arrest-specific 6
chr4_-_1156533 3.961 NM_012445
SPON2
spondin 2, extracellular matrix protein
chr2_-_200030944 3.891 NM_001172509
SATB2
SATB homeobox 2
chr2_+_104837004 3.806


chr4_-_46086528 3.775 NM_000807
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr14_-_60185659 3.729 NM_005982
SIX1
SIX homeobox 1
chr21_+_42946719 3.681 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr4_-_1156378 3.611 SPON2
spondin 2, extracellular matrix protein
chr3_-_148607096 3.537 NM_032153
ZIC4
Zic family member 4
chr6_-_32227645 3.522 PRRT1
proline-rich transmembrane protein 1
chr2_+_5750229 3.424 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr4_-_1156458 3.340 SPON2
spondin 2, extracellular matrix protein
chr2_-_200030412 3.300 SATB2
SATB homeobox 2
chr4_-_1156362 3.295 SPON2
spondin 2, extracellular matrix protein
chr2_+_172658453 3.228 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr6_-_32227695 3.213 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr15_-_77170135 3.204 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr17_-_44047299 3.040 NM_024016
HOXB8
homeobox B8
chr9_+_125813672 2.977 NM_004789
LHX2
LIM homeobox 2
chr9_+_70107602 2.963 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr2_+_104838177 2.942 NM_006236
POU3F3
POU class 3 homeobox 3
chr9_+_125813849 2.913 LHX2
LIM homeobox 2
chr15_-_86600658 2.868 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr2_+_137239583 2.845 THSD7B
thrombospondin, type I, domain containing 7B
chr11_-_27700180 2.696 NM_170731
BDNF
brain-derived neurotrophic factor
chr7_-_19123765 2.695 TWIST1
twist homolog 1 (Drosophila)
chr13_+_99431417 2.665


chr6_+_99389300 2.623 NM_005604
POU3F2
POU class 3 homeobox 2
chr4_+_81406765 2.584 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr4_-_46086218 2.584 GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr20_-_22512893 2.572 FOXA2
forkhead box A2
chr14_-_47213906 2.571 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr19_-_13478037 2.557 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr15_+_65904994 2.550 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr21_+_46226072 2.540 NM_001848
COL6A1
collagen, type VI, alpha 1
chr6_+_99389318 2.524 POU3F2
POU class 3 homeobox 2
chr19_-_55914837 2.517


chr1_-_148155986 2.499 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_-_29321599 2.486 NM_001171868
TMEM200B
transmembrane protein 200B
chr3_+_11009436 2.467 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr4_-_155632317 2.460 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr4_-_109308893 2.457 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr13_+_87122778 2.430 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr19_+_54314292 2.425 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr13_-_113066202 2.407 GRTP1
growth hormone regulated TBC protein 1
chr19_+_12805747 2.387 MAST1
microtubule associated serine/threonine kinase 1
chr5_-_88016397 2.379 LOC645323
hypothetical LOC645323
chr20_-_61755145 2.377 NM_015894
STMN3
stathmin-like 3
chr5_+_92944680 2.373 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_+_60487345 2.287 NM_032430
BRSK1
BR serine/threonine kinase 1
chr5_-_92942680 2.283 FLJ42709
hypothetical LOC441094
chr19_-_53706644 2.221


chr13_-_49597776 2.216 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_154878344 2.215 NM_021948
NM_198427
BCAN

brevican

chr2_+_113973130 2.202 NM_012184
FOXD4L1
forkhead box D4-like 1
chr3_+_98016114 2.197 NM_001080448
EPHA6
EPH receptor A6
chr2_+_176680251 2.186 NM_021192
HOXD11
homeobox D11
chr1_+_26609819 2.185 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr6_-_165995510 2.142 NM_001130690
NM_006661
PDE10A

phosphodiesterase 10A

chr21_-_27261276 2.138 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr8_-_21702273 2.135 NM_001165038
NM_001165039
NM_001495
GFRA2


GDNF family receptor alpha 2


chr9_-_110969310 2.129 NM_014334
C9orf4
chromosome 9 open reading frame 4
chr8_-_144583718 2.121 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr19_+_659766 2.099 NM_001040134
NM_002579
PALM

paralemmin

chr19_-_60350122 2.097 TNNT1
troponin T type 1 (skeletal, slow)
chr12_+_6800950 2.093 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chrX_+_136475979 2.093 NM_003413
ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr19_-_19233370 2.079 HAPLN4
hyaluronan and proteoglycan link protein 4
chr11_-_132318741 2.046 OPCML
opioid binding protein/cell adhesion molecule-like
chr19_+_52215982 2.042 NM_002517
NPAS1
neuronal PAS domain protein 1
chr1_+_20751518 2.020 NM_207334
FAM43B
family with sequence similarity 43, member B
chr14_-_20636909 1.996 NM_001101672
ZNF219
zinc finger protein 219
chr17_+_26742767 1.994 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr20_+_19141282 1.991 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr11_-_31782169 1.972 PAX6
paired box 6
chr8_-_140784416 1.967 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr11_+_61479182 1.962 BEST1
bestrophin 1
chr8_+_1909437 1.958 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr4_+_4912272 1.946 NM_002448
MSX1
msh homeobox 1
chr12_+_101875581 1.928 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr15_+_78483624 1.927 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_-_103346482 1.924 COL11A1
collagen, type XI, alpha 1
chr5_-_63293715 1.914 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr3_-_140148671 1.902 NM_023067
FOXL2
forkhead box L2
chr21_+_33364316 1.895 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr11_-_64268841 1.891 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chrX_-_50230329 1.865 NM_001013742
DGKK
diacylglycerol kinase, kappa
chr19_-_242335 1.864 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr12_+_6807831 1.857 NM_014262
LEPREL2
leprecan-like 2
chr7_-_19123787 1.854 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr3_+_53504070 1.845 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr12_+_56291484 1.833 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chrX_-_74062005 1.815 NM_001008537
KIAA2022
KIAA2022
chr6_+_69401660 1.804 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr1_+_26609893 1.803 LIN28A
lin-28 homolog A (C. elegans)
chr17_-_60986905 1.799 AXIN2
axin 2
chr17_+_35036936 1.799 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chrX_+_71047344 1.794 NM_001013627
NHSL2
NHS-like 2
chr5_-_9599157 1.792 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr22_+_47350781 1.787 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr4_+_93444572 1.786 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chrX_+_12066505 1.783 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr15_+_58083798 1.783 FOXB1
forkhead box B1
chr11_-_27697768 1.777 NM_001143807
BDNF
brain-derived neurotrophic factor
chr11_-_64269501 1.777 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr18_+_53170718 1.776 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr13_+_99432258 1.774 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr10_+_50488352 1.772 NM_003055
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3
chr5_+_82803248 1.771 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr17_+_56884560 1.763 TBX4
T-box 4
chr17_+_38166759 1.762 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr8_-_41624030 1.757 NM_152568
NKX6-3
NK6 homeobox 3
chr8_-_144313293 1.752 NM_001130478
LY6H
lymphocyte antigen 6 complex, locus H
chr2_-_219558517 1.751 NM_017521
FEV
FEV (ETS oncogene family)
chr17_+_7252225 1.743 NM_020795
NLGN2
neuroligin 2
chr16_+_2954217 1.733 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr11_-_44288188 1.729 NM_021926
ALX4
ALX homeobox 4
chr11_-_88436463 1.727 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr10_+_83625049 1.727 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr1_-_103346639 1.717 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr12_+_52618815 1.711 NM_017410
HOXC13
homeobox C13
chr15_+_58083737 1.711


chr6_+_87703742 1.702 NM_000865
HTR1E
5-hydroxytryptamine (serotonin) receptor 1E
chr16_+_85101734 1.701 FOXF1
forkhead box F1
chr2_-_219881937 1.700 PTPRN
protein tyrosine phosphatase, receptor type, N
chr6_+_133604181 1.698 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr10_+_22650145 1.696 BMI1
BMI1 polycomb ring finger oncogene
chr6_+_133604203 1.694 EYA4
eyes absent homolog 4 (Drosophila)
chr4_-_13158391 1.693 LOC285548
hypothetical LOC285548
chr2_+_70981233 1.689 VAX2
ventral anterior homeobox 2
chr3_+_140148765 1.670 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr10_+_102495327 1.668 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr14_-_62581656 1.662 NM_139318
NM_172375
KCNH5

potassium voltage-gated channel, subfamily H (eag-related), member 5

chr9_-_121171400 1.660 NM_014618
DBC1
deleted in bladder cancer 1
chr17_-_72045218 1.660 NM_134268
CYGB
cytoglobin
chr22_-_49348193 1.643 NM_001123225
C22orf41
chromosome 22 open reading frame 41
chr12_+_52665196 1.638 NM_017409
HOXC10
homeobox C10
chr17_+_8865547 1.638 NM_004822
NTN1
netrin 1
chr1_+_154878498 1.634 BCAN
brevican
chr19_-_11452439 1.630 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr19_-_52667056 1.627 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_+_171280046 1.625 NM_001003845
SP5
Sp5 transcription factor
chr10_+_119291945 1.622 NM_001165924
NM_004098
EMX2

empty spiracles homeobox 2

chr1_+_47654330 1.620 NM_012186
FOXE3
forkhead box E3
chr11_+_56984702 1.618 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr18_-_28606839 1.615 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chrX_-_6155887 1.615 NM_020742
NLGN4X
neuroligin 4, X-linked
chr17_-_29930431 1.614 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr4_-_168392307 1.597 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr22_+_28206180 1.595 NM_021076
NEFH
neurofilament, heavy polypeptide
chr10_-_103525646 1.592 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr10_-_103593529 1.585 NM_014591
NM_173191
NM_173192
NM_173193
NM_173195
NM_173197
KCNIP2





Kv channel interacting protein 2





chr19_+_56506907 1.578 NM_001101372
IGLON5
IgLON family member 5
chr14_-_36058648 1.578 NM_003317
NKX2-1
NK2 homeobox 1
chr6_-_165996031 1.578 LOC100132188
LP7097
chr12_-_56312696 1.576 B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr19_+_54361216 1.571 TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr4_+_41057600 1.566


chr17_-_69151821 1.559 NM_001144952
SDK2
sidekick homolog 2 (chicken)
chrX_+_152565849 1.552 DUSP9
dual specificity phosphatase 9
chr14_-_98807307 1.550 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr2_+_233448739 1.549 C2orf82
chromosome 2 open reading frame 82
chr19_+_4229597 1.549 NM_020209
SHD
Src homology 2 domain containing transforming protein D
chr11_-_68537243 1.545 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr4_-_5940893 1.544 CRMP1
collapsin response mediator protein 1
chr4_-_11039600 1.543 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr12_+_52689062 1.519 NM_022658
HOXC8
homeobox C8
chr9_+_2612134 1.519 VLDLR
very low density lipoprotein receptor
chr16_-_52877868 1.512 NM_024336
IRX3
iroquois homeobox 3
chr17_+_45993338 1.511 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr11_-_57171554 1.505 YPEL4
yippee-like 4 (Drosophila)
chr12_-_6668680 1.502 ZNF384
zinc finger protein 384
chr5_-_63293301 1.497 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr14_-_23117614 1.494 JPH4
junctophilin 4
chr19_+_60487578 1.494 BRSK1
BR serine/threonine kinase 1
chr11_+_66939720 1.488 NM_001166222
NM_020811
CARNS1

carnosine synthase 1

chr10_+_119292699 1.483


chrX_-_139414890 1.472 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr19_-_56260135 1.470 NM_015596
KLK13
kallikrein-related peptidase 13
chr9_-_34579679 1.467 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr16_-_10184111 1.458 NM_000833
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr7_-_122961808 1.452 NM_178827
IQUB
IQ motif and ubiquitin domain containing
chr16_-_2776606 1.447 NM_152891
PRSS33
protease, serine, 33
chr17_-_7138590 1.441 NM_015982
YBX2
Y box binding protein 2
chr7_+_116907252 1.431 NM_000492
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr17_-_7138535 1.429 YBX2
Y box binding protein 2
chr20_+_19141364 1.426 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr6_-_48144344 1.423 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr5_+_152850276 1.419 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr12_+_56140184 1.418 NM_001160045
NM_001167609
NM_005269
GLI1


GLI family zinc finger 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.50 3.99e-36 GO:0007399 nervous system development
3.03 3.20e-31 GO:0048731 system development
2.81 4.98e-29 GO:0048856 anatomical structure development
2.65 1.22e-27 GO:0007275 multicellular organismal development
3.39 3.27e-27 GO:0030154 cell differentiation
2.16 1.65e-26 GO:0032501 multicellular organismal process
3.29 3.36e-26 GO:0048869 cellular developmental process
2.48 8.98e-26 GO:0032502 developmental process
4.74 5.51e-23 GO:0022008 neurogenesis
3.49 6.08e-20 GO:0009653 anatomical structure morphogenesis
4.56 1.26e-19 GO:0048699 generation of neurons
5.50 1.37e-19 GO:0009887 organ morphogenesis
7.32 6.30e-19 GO:0007389 pattern specification process
4.94 2.06e-18 GO:0030182 neuron differentiation
4.25 3.95e-18 GO:0048468 cell development
2.98 2.34e-17 GO:0048513 organ development
1.67 2.57e-14 GO:0050794 regulation of cellular process
1.59 7.80e-14 GO:0065007 biological regulation
2.38 1.31e-13 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.66 1.83e-13 GO:0006357 regulation of transcription from RNA polymerase II promoter
5.00 3.10e-13 GO:0007417 central nervous system development
1.61 3.36e-13 GO:0050789 regulation of biological process
4.27 4.00e-13 GO:0009790 embryo development
2.31 9.14e-13 GO:0051171 regulation of nitrogen compound metabolic process
5.07 1.35e-12 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
3.76 2.24e-12 GO:0009888 tissue development
7.12 5.51e-12 GO:0003002 regionalization
2.45 5.60e-12 GO:0051252 regulation of RNA metabolic process
4.32 6.89e-12 GO:0045893 positive regulation of transcription, DNA-dependent
4.46 1.36e-11 GO:0048666 neuron development
5.53 1.42e-11 GO:0048598 embryonic morphogenesis
4.09 2.00e-11 GO:0010628 positive regulation of gene expression
2.45 2.08e-11 GO:0006355 regulation of transcription, DNA-dependent
3.89 2.50e-11 GO:0010557 positive regulation of macromolecule biosynthetic process
2.26 3.47e-11 GO:0031326 regulation of cellular biosynthetic process
3.82 4.61e-11 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.23 6.74e-11 GO:0009889 regulation of biosynthetic process
4.03 7.04e-11 GO:0051254 positive regulation of RNA metabolic process
2.32 7.42e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.71 1.31e-10 GO:0051173 positive regulation of nitrogen compound metabolic process
6.82 1.72e-10 GO:0002009 morphogenesis of an epithelium
6.11 2.21e-10 GO:0035295 tube development
1.99 3.20e-10 GO:0080090 regulation of primary metabolic process
2.26 3.20e-10 GO:0010556 regulation of macromolecule biosynthetic process
3.54 3.31e-10 GO:0031328 positive regulation of cellular biosynthetic process
2.22 5.86e-10 GO:0010468 regulation of gene expression
3.48 5.94e-10 GO:0009891 positive regulation of biosynthetic process
5.57 6.92e-10 GO:0001501 skeletal system development
5.69 1.15e-09 GO:0048729 tissue morphogenesis
1.95 2.03e-09 GO:0031323 regulation of cellular metabolic process
4.30 5.30e-09 GO:0000904 cell morphogenesis involved in differentiation
4.91 5.47e-09 GO:0060429 epithelium development
2.19 7.72e-09 GO:0048522 positive regulation of cellular process
3.67 1.08e-08 GO:0031327 negative regulation of cellular biosynthetic process
4.68 1.72e-08 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
3.60 1.99e-08 GO:0009890 negative regulation of biosynthetic process
3.24 2.22e-08 GO:0006351 transcription, DNA-dependent
3.74 2.59e-08 GO:0032989 cellular component morphogenesis
3.83 2.61e-08 GO:0000902 cell morphogenesis
4.76 2.74e-08 GO:0009792 embryo development ending in birth or egg hatching
2.18 2.77e-08 GO:0048519 negative regulation of biological process
4.03 2.86e-08 GO:0045892 negative regulation of transcription, DNA-dependent
7.66 3.04e-08 GO:0060562 epithelial tube morphogenesis
2.08 3.17e-08 GO:0048518 positive regulation of biological process
3.95 4.87e-08 GO:0051253 negative regulation of RNA metabolic process
3.20 5.44e-08 GO:0040011 locomotion
1.82 6.25e-08 GO:0019222 regulation of metabolic process
4.74 7.38e-08 GO:0007420 brain development
3.68 7.68e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.11 7.76e-08 GO:0050793 regulation of developmental process
6.64 1.04e-07 GO:0035239 tube morphogenesis
7.11 1.07e-07 GO:0009952 anterior/posterior pattern formation
4.64 1.17e-07 GO:0043009 chordate embryonic development
3.69 1.40e-07 GO:0010629 negative regulation of gene expression
2.21 1.41e-07 GO:0048523 negative regulation of cellular process
1.90 1.43e-07 GO:0060255 regulation of macromolecule metabolic process
3.32 1.96e-07 GO:2000026 regulation of multicellular organismal development
3.65 1.96e-07 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.47 2.00e-07 GO:0045595 regulation of cell differentiation
3.52 2.57e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
3.60 2.72e-07 GO:0051172 negative regulation of nitrogen compound metabolic process
2.75 3.24e-07 GO:0010604 positive regulation of macromolecule metabolic process
3.94 4.57e-07 GO:0031175 neuron projection development
2.92 5.53e-07 GO:0032774 RNA biosynthetic process
4.12 7.26e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
3.86 7.26e-07 GO:0048858 cell projection morphogenesis
2.67 8.53e-07 GO:0031325 positive regulation of cellular metabolic process
3.83 8.89e-07 GO:0032990 cell part morphogenesis
5.53 8.92e-07 GO:0048568 embryonic organ development
5.22 9.76e-07 GO:0045596 negative regulation of cell differentiation
4.05 1.06e-06 GO:0048812 neuron projection morphogenesis
2.58 1.12e-06 GO:0051239 regulation of multicellular organismal process
4.67 1.34e-06 GO:0051093 negative regulation of developmental process
4.11 1.61e-06 GO:0007409 axonogenesis
2.58 1.80e-06 GO:0009893 positive regulation of metabolic process
6.85 2.10e-06 GO:0045165 cell fate commitment
6.27 2.60e-06 GO:0030900 forebrain development
2.81 2.69e-06 GO:0009892 negative regulation of metabolic process
1.27 2.79e-06 GO:0009987 cellular process
7.30 2.85e-06 GO:0048705 skeletal system morphogenesis
6.53 4.28e-06 GO:0048562 embryonic organ morphogenesis
2.86 7.51e-06 GO:0031324 negative regulation of cellular metabolic process
3.26 1.03e-05 GO:0030030 cell projection organization
2.82 1.05e-05 GO:0010605 negative regulation of macromolecule metabolic process
3.83 2.76e-05 GO:0016477 cell migration
8.11 3.56e-05 GO:0021537 telencephalon development
2.60 6.10e-05 GO:0007154 cell communication
3.66 6.62e-05 GO:0032583 regulation of gene-specific transcription
8.36 9.83e-05 GO:0021915 neural tube development
8.36 9.83e-05 GO:0060485 mesenchyme development
2.83 1.62e-04 GO:0007267 cell-cell signaling
3.48 1.72e-04 GO:0048870 cell motility
3.48 1.72e-04 GO:0051674 localization of cell
9.08 1.75e-04 GO:0009953 dorsal/ventral pattern formation
8.69 2.68e-04 GO:0048762 mesenchymal cell differentiation
9.78 3.88e-04 GO:0021543 pallium development
3.22 4.10e-04 GO:0008284 positive regulation of cell proliferation
4.17 5.04e-04 GO:0007423 sensory organ development
9.44 5.31e-04 GO:0048704 embryonic skeletal system morphogenesis
3.27 5.38e-04 GO:0019226 transmission of nerve impulse
3.27 5.38e-04 GO:0035637 multicellular organismal signaling
2.42 5.72e-04 GO:0010646 regulation of cell communication
3.93 5.76e-04 GO:0060284 regulation of cell development
11.06 6.67e-04 GO:0048663 neuron fate commitment
3.32 7.29e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.63 7.68e-04 GO:0023052 signaling
7.70 8.54e-04 GO:0048706 embryonic skeletal system development
7.60 9.62e-04 GO:0042063 gliogenesis
3.36 1.02e-03 GO:0007268 synaptic transmission
3.77 1.11e-03 GO:0007411 axon guidance
10.35 1.13e-03 GO:0021510 spinal cord development
2.46 1.17e-03 GO:0042127 regulation of cell proliferation
40.54 1.34e-03 GO:0033504 floor plate development
3.01 1.37e-03 GO:0006928 cellular component movement
12.52 1.44e-03 GO:0014032 neural crest cell development
8.42 1.44e-03 GO:0014031 mesenchymal cell development
3.84 1.62e-03 GO:0022603 regulation of anatomical structure morphogenesis
8.17 1.87e-03 GO:0010001 glial cell differentiation
3.99 1.90e-03 GO:0051960 regulation of nervous system development
3.78 2.08e-03 GO:0007610 behavior
4.71 2.41e-03 GO:0048732 gland development
1.41 2.49e-03 GO:0050896 response to stimulus
15.20 2.54e-03 GO:0060078 regulation of postsynaptic membrane potential
4.66 2.74e-03 GO:0032582 negative regulation of gene-specific transcription
11.20 3.19e-03 GO:0014033 neural crest cell differentiation
10.92 3.83e-03 GO:0021987 cerebral cortex development
2.00 3.86e-03 GO:0023051 regulation of signaling
6.54 3.91e-03 GO:0030324 lung development
3.43 4.41e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
10.64 4.58e-03 GO:0021761 limbic system development
10.64 4.58e-03 GO:0051899 membrane depolarization
6.34 5.22e-03 GO:0030323 respiratory tube development
2.93 9.67e-03 GO:0048585 negative regulation of response to stimulus
5.27 1.05e-02 GO:0042391 regulation of membrane potential
16.00 1.44e-02 GO:0048665 neuron fate specification
3.01 1.69e-02 GO:0023057 negative regulation of signaling
3.01 1.75e-02 GO:0010648 negative regulation of cell communication
15.20 1.89e-02 GO:0060425 lung morphogenesis
5.48 1.92e-02 GO:0060541 respiratory system development
2.98 2.02e-02 GO:0051094 positive regulation of developmental process
3.08 2.02e-02 GO:0009968 negative regulation of signal transduction
8.52 2.13e-02 GO:0001764 neuron migration
5.20 3.05e-02 GO:0050890 cognition
13.82 3.13e-02 GO:0032330 regulation of chondrocyte differentiation
1.87 3.50e-02 GO:0034645 cellular macromolecule biosynthetic process
9.86 3.67e-02 GO:0001708 cell fate specification
9.86 3.67e-02 GO:0021782 glial cell development
5.70 3.74e-02 GO:0043523 regulation of neuron apoptosis
13.22 3.94e-02 GO:0021885 forebrain cell migration
2.18 3.97e-02 GO:0009605 response to external stimulus
1.85 4.02e-02 GO:0016070 RNA metabolic process
7.74 4.04e-02 GO:0007612 learning
1.96 4.32e-02 GO:0050877 neurological system process
4.99 4.38e-02 GO:0001763 morphogenesis of a branching structure
4.99 4.38e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.73 4.43e-02 GO:0006935 chemotaxis
2.73 4.43e-02 GO:0042330 taxis
4.95 4.70e-02 GO:0022604 regulation of cell morphogenesis
1.85 4.71e-02 GO:0009059 macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.09 2.60e-07 GO:0045202 synapse
3.96 1.04e-06 GO:0043005 neuron projection
1.88 1.00e-04 GO:0044459 plasma membrane part
4.27 1.08e-04 GO:0005667 transcription factor complex
4.83 1.08e-04 GO:0030425 dendrite
3.82 2.60e-04 GO:0044456 synapse part
4.10 1.76e-03 GO:0034702 ion channel complex
2.01 4.83e-03 GO:0031226 intrinsic to plasma membrane
6.40 6.54e-03 GO:0033267 axon part
2.23 7.23e-03 GO:0042995 cell projection
2.00 7.24e-03 GO:0005887 integral to plasma membrane
4.79 8.99e-03 GO:0031225 anchored to membrane
4.51 1.51e-02 GO:0034703 cation channel complex
1.44 1.91e-02 GO:0005886 plasma membrane
3.91 2.39e-02 GO:0043025 neuronal cell body
3.80 3.08e-02 GO:0044297 cell body
1.42 3.28e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.49 2.49e-24 GO:0001071 nucleic acid binding transcription factor activity
4.49 2.49e-24 GO:0003700 sequence-specific DNA binding transcription factor activity
5.35 2.36e-23 GO:0043565 sequence-specific DNA binding
4.34 4.51e-23 GO:0030528 transcription regulator activity
2.23 5.04e-10 GO:0003677 DNA binding
10.46 6.82e-10 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
10.86 1.91e-09 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
6.02 4.36e-08 GO:0000975 regulatory region DNA binding
6.02 4.36e-08 GO:0001067 regulatory region nucleic acid binding
6.02 4.36e-08 GO:0044212 transcription regulatory region DNA binding
4.71 1.05e-07 GO:0016563 transcription activator activity
5.96 1.53e-07 GO:0010843 promoter binding
4.67 2.99e-07 GO:0016564 transcription repressor activity
11.06 5.50e-06 GO:0008301 DNA bending activity
8.11 7.98e-06 GO:0003704 specific RNA polymerase II transcription factor activity
4.25 8.54e-06 GO:0022836 gated channel activity
3.67 2.67e-05 GO:0005216 ion channel activity
3.62 3.53e-05 GO:0022838 substrate-specific channel activity
1.71 3.97e-05 GO:0003676 nucleic acid binding
3.51 6.10e-05 GO:0015267 channel activity
3.50 6.38e-05 GO:0022803 passive transmembrane transporter activity
4.15 1.19e-04 GO:0005261 cation channel activity
5.57 1.89e-04 GO:0022843 voltage-gated cation channel activity
4.56 7.94e-04 GO:0005244 voltage-gated ion channel activity
4.56 7.94e-04 GO:0022832 voltage-gated channel activity
6.27 1.29e-03 GO:0016566 specific transcriptional repressor activity
4.28 3.58e-03 GO:0043566 structure-specific DNA binding
4.96 4.23e-03 GO:0003690 double-stranded DNA binding
3.71 4.29e-03 GO:0003702 RNA polymerase II transcription factor activity
3.37 7.37e-03 GO:0008134 transcription factor binding
4.21 1.92e-02 GO:0008083 growth factor activity
10.86 2.41e-02 GO:0008066 glutamate receptor activity
2.14 3.11e-02 GO:0022891 substrate-specific transmembrane transporter activity
2.24 3.45e-02 GO:0015075 ion transmembrane transporter activity
2.02 3.69e-02 GO:0022892 substrate-specific transporter activity
14.31 4.14e-02 GO:0004970 ionotropic glutamate receptor activity