Motif ID: NFE2L1.p2

Z-value: 2.433


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1



Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_71549149 4.095 ZFHX3
zinc finger homeobox 3
chr12_-_121753795 3.338 NM_177551
GPR109A
G protein-coupled receptor 109A
chr7_-_27153892 3.106 NM_024014
HOXA6
homeobox A6
chr12_-_121767272 2.746 NM_006018
GPR109B
G protein-coupled receptor 109B
chrX_-_10495476 2.461 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr6_+_7524691 2.427 DSP
desmoplakin
chr19_+_40895669 2.422 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr11_-_6773589 2.387 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr7_-_99312591 2.304 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr7_+_143331954 2.154 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr11_-_123353607 2.107 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_-_123414917 2.105 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chrX_-_135941498 2.088 NM_054021
GPR101
G protein-coupled receptor 101
chr7_-_27108826 2.019 NM_006735
HOXA2
homeobox A2
chr12_-_10215942 1.999 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr15_-_88143721 1.915 ANPEP
alanyl (membrane) aminopeptidase
chr11_+_7574992 1.888 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_5523328 1.857 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr5_-_34020445 1.849 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr1_-_203657803 1.846 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr6_+_7486891 1.845 DSP
desmoplakin
chrX_-_129347101 1.820 NM_178471
GPR119
G protein-coupled receptor 119
chr17_-_36834183 1.801 NM_003770
KRT37
keratin 37
chr3_-_42892195 1.793 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_4743645 1.728 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr6_+_7486836 1.712 DSP
desmoplakin
chr15_+_99207555 1.655 LOC145757
hypothetical LOC145757
chr11_+_5925152 1.652 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr7_-_142434340 1.642 NM_001001658
OR9A2
olfactory receptor, family 9, subfamily A, member 2
chr7_+_154493478 1.635 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr9_-_135435165 1.619 NM_001080515
FAM163B
family with sequence similarity 163, member B
chr15_-_88150823 1.616 ANPEP
alanyl (membrane) aminopeptidase
chr10_+_86121526 1.600 FAM190B
family with sequence similarity 190, member B
chr6_+_7486862 1.600 NM_001008844
NM_004415
DSP

desmoplakin

chr7_-_99365178 1.586 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr7_+_143287952 1.583 NM_012369
OR2F1
olfactory receptor, family 2, subfamily F, member 1
chr7_+_143378393 1.579 NM_012365
OR2A5
olfactory receptor, family 2, subfamily A, member 5
chrX_+_24290798 1.548 NM_001136234
FAM48B1
family with sequence similarity 48, member B1
chrX_-_39532391 1.543


chr10_+_5556923 1.518 NM_005185
CALML3
calmodulin-like 3
chr4_-_186815116 1.514 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr5_-_16561936 1.512 NM_019000
FAM134B
family with sequence similarity 134, member B
chr1_+_24713396 1.510 RCAN3
RCAN family member 3
chr1_+_156991133 1.506 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr3_+_185580554 1.496 NM_003741
CHRD
chordin
chr5_+_145297490 1.466 SH3RF2
SH3 domain containing ring finger 2
chr12_+_108061584 1.461 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr13_-_107317460 1.460 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr7_+_65056876 1.452 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr11_-_6870306 1.430 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr8_-_134141586 1.414 NM_006748
SLA
Src-like-adaptor
chr11_+_123625632 1.413 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_-_156635879 1.412 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chrX_-_128616594 1.409 NM_017413
APLN
apelin
chr1_-_157772420 1.408 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr7_-_27149750 1.406 NM_019102
HOXA5
homeobox A5
chr12_+_6517600 1.399


chr11_-_123182266 1.386 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr22_+_21318779 1.377 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr7_-_98983924 1.375 FAM200A
family with sequence similarity 200, member A
chr16_+_56219802 1.363 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_42978320 1.340 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr4_-_5881271 1.331 CRMP1
collapsin response mediator protein 1
chr15_+_89570333 1.313 SV2B
synaptic vesicle glycoprotein 2B
chr9_-_128910132 1.313 ANGPTL2
angiopoietin-like 2
chr11_+_123315459 1.300 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr5_+_36644187 1.285 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_150065176 1.268 NM_001001523
RORC
RAR-related orphan receptor C
chr8_-_20156971 1.267 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr12_+_48310593 1.262 NM_001031698
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr18_+_570356 1.261 NM_004066
CETN1
centrin, EF-hand protein, 1
chr19_-_40711034 1.253 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr21_+_33844793 1.252 SON
SON DNA binding protein
chr1_-_150328153 1.245 NM_001008536
TCHHL1
trichohyalin-like 1
chr19_+_15765760 1.235 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr1_-_120189301 1.230 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr11_-_123758448 1.229 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr13_-_32658215 1.225 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_+_124312901 1.222 NM_054107
OR1J2
olfactory receptor, family 1, subfamily J, member 2
chr1_-_156657279 1.222 NM_001004476
OR10K2
olfactory receptor, family 10, subfamily K, member 2
chr2_+_105224631 1.219 NM_007227
GPR45
G protein-coupled receptor 45
chr3_+_10832867 1.216 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr1_-_156800017 1.203 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr11_+_4976788 1.197 NM_001004755
OR51L1
olfactory receptor, family 51, subfamily L, member 1
chr17_-_36475652 1.189 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr1_-_156784518 1.187 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr7_+_128099581 1.182 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chrX_-_24241352 1.172 NM_001136233
FAM48B2
family with sequence similarity 48, member B2
chr6_-_46155937 1.156 NM_001114086
CLIC5
chloride intracellular channel 5
chr11_+_58888460 1.147 NM_001004729
OR5AN1
olfactory receptor, family 5, subfamily AN, member 1
chr1_-_157014048 1.146 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr14_+_76362467 1.143 NM_194287
C14orf166B
chromosome 14 open reading frame 166B
chr1_+_156701895 1.140 NM_001004473
OR10K1
olfactory receptor, family 10, subfamily K, member 1
chr17_-_7047285 1.131 DLG4
discs, large homolog 4 (Drosophila)
chr3_-_152173475 1.116 NM_001195794
NM_174878
CLRN1

clarin 1

chr17_-_36469869 1.114 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr2_+_241456834 1.098 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chrX_+_70360184 1.094 GJB1
gap junction protein, beta 1, 32kDa
chr8_-_107851593 1.083 NM_139166
ABRA
actin-binding Rho activating protein
chr3_-_56784634 1.081 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_+_54316910 1.075 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr6_+_143971009 1.063 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr11_+_34599163 1.060 NM_012153
EHF
ets homologous factor
chr1_+_204390905 1.058 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr18_+_13610866 1.051 NM_004338
NM_181483
C18orf1

chromosome 18 open reading frame 1

chr19_-_9098625 1.051 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chrX_-_10605726 1.044 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_123036312 1.036 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr5_+_34720368 1.035 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr1_-_153107084 1.033


chr4_-_123761615 1.032 NM_021803
IL21
interleukin 21
chr11_+_123945102 1.027 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr1_-_202595666 1.027 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chrX_-_10548458 1.026 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr3_-_158695832 1.022 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr11_+_125781157 1.019 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_-_20682541 1.016


chr12_+_79625538 1.014 NM_002469
MYF6
myogenic factor 6 (herculin)
chr1_+_65503011 1.006 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr7_+_38984133 1.005 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr15_+_60726801 0.999 NM_015059
TLN2
talin 2
chr6_-_29120930 0.997 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chrX_-_32340291 0.996 NM_004011
NM_004012
DMD

dystrophin

chr5_+_52320660 0.996 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr4_-_186814852 0.994 SORBS2
sorbin and SH3 domain containing 2
chr5_+_6799100 0.985 NM_001171806
PAPD7
PAP associated domain containing 7
chr12_+_52665196 0.982 NM_017409
HOXC10
homeobox C10
chr17_+_17339059 0.982


chr11_+_5714253 0.975 NM_001005180
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr6_-_52217185 0.974 NM_052872
IL17F
interleukin 17F
chr21_+_46369911 0.972 COL6A2
collagen, type VI, alpha 2
chrX_-_99778340 0.970 NM_003270
TSPAN6
tetraspanin 6
chr12_-_56447090 0.964 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr15_+_40438989 0.963 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr11_+_5862076 0.956 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr21_+_46370220 0.954 COL6A2
collagen, type VI, alpha 2
chr9_-_35962454 0.954 YBX1
Y box binding protein 1
chr19_-_14944729 0.952 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr12_-_65359019 0.951 GRIP1
glutamate receptor interacting protein 1
chr1_-_68470585 0.950 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_+_71418886 0.949 NM_212557
AMTN
amelotin
chr6_+_37511383 0.945


chr14_+_19285426 0.944 NM_172194
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr2_-_42573980 0.942 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr2_-_192767494 0.938 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr10_-_105604942 0.935 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr2_+_201182187 0.925 AOX1
aldehyde oxidase 1
chr1_+_84636802 0.914 NM_021233
DNASE2B
deoxyribonuclease II beta
chr19_-_14813688 0.914 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr5_-_112798436 0.909 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr18_-_28606839 0.907 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr2_-_160838397 0.906 RBMS1
RNA binding motif, single stranded interacting protein 1
chr12_-_103846186 0.902 NM_032148
SLC41A2
solute carrier family 41, member 2
chr5_-_95774444 0.901 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr15_-_79453472 0.880 NM_001080532
TMC3
transmembrane channel-like 3
chr2_-_166638376 0.878 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chrX_+_64625339 0.874 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr11_-_7917642 0.868 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr18_+_30652223 0.867 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr11_+_58980986 0.864 NM_001004708
OR4D6
olfactory receptor, family 4, subfamily D, member 6
chr21_-_42303517 0.861 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr1_+_156716290 0.846 NM_001004472
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr4_+_3434830 0.845 NM_001164673
NM_173660
DOK7

docking protein 7

chrX_-_135166306 0.839 NM_001173516
MAP7D3
MAP7 domain containing 3
chr14_+_51850754 0.839 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr6_+_158877455 0.837 NM_020823
TMEM181
transmembrane protein 181
chr12_-_121780835 0.833 NM_032554
GPR81
G protein-coupled receptor 81
chr7_+_96473225 0.831 NM_005222
DLX6
distal-less homeobox 6
chr11_-_123918759 0.827 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr1_-_41399632 0.825 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr12_-_65359148 0.821 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr14_+_28306633 0.817 FOXG1
forkhead box G1
chrX_-_9693916 0.816 NM_000273
GPR143
G protein-coupled receptor 143
chr3_-_45242072 0.816 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr1_-_154205675 0.815 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_-_157003095 0.814 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr12_+_5473558 0.811 NM_002527
NTF3
neurotrophin 3
chr11_+_6762823 0.808 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr2_+_134728299 0.807 NM_002410
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr9_-_132759045 0.805 NM_198180
QRFP
pyroglutamylated RFamide peptide
chrX_+_123062143 0.802 STAG2
stromal antigen 2
chr13_+_48692472 0.800 NM_001507
MLNR
motilin receptor
chr11_-_6005546 0.798 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr20_+_19903778 0.796 RIN2
Ras and Rab interactor 2
chr8_-_95289945 0.795 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr11_-_123695302 0.794 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr1_+_144004589 0.791 NM_001039703
NBPF10
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 8
chr8_-_67253234 0.787 NM_000756
CRH
corticotropin releasing hormone
chr1_+_158413824 0.784 NM_001001734
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr21_+_46369606 0.780 COL6A2
collagen, type VI, alpha 2
chr2_-_21081694 0.774 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_-_26937435 0.773 NM_001031689
PLAA
phospholipase A2-activating protein
chrX_+_47114925 0.771 NM_003446
ZNF157
zinc finger protein 157
chr3_+_141879555 0.770 NM_152616
TRIM42
tripartite motif containing 42
chr1_+_61697209 0.764 NFIA
nuclear factor I/A
chr12_-_51173238 0.763 NM_005554
KRT6A
keratin 6A
chr9_+_114671635 0.761 SNX30
sorting nexin family member 30
chr11_-_5819702 0.759 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr17_+_39437439 0.747 NM_153006
NAGS
N-acetylglutamate synthase
chr8_-_30826074 0.747 NM_031271
TEX15
testis expressed 15

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
13.07 4.51e-23 GO:0007608 sensory perception of smell
8.31 3.00e-22 GO:0007600 sensory perception
11.70 1.19e-21 GO:0007606 sensory perception of chemical stimulus
4.63 4.52e-16 GO:0003008 system process
5.23 6.64e-16 GO:0050877 neurological system process
2.09 6.29e-08 GO:0032501 multicellular organismal process
1.71 4.82e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.31 5.16e-09 GO:0071944 cell periphery
2.26 4.24e-08 GO:0005886 plasma membrane
1.99 1.62e-07 GO:0016021 integral to membrane
1.95 3.63e-07 GO:0031224 intrinsic to membrane
1.73 1.67e-05 GO:0044425 membrane part
1.53 5.91e-04 GO:0016020 membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
13.70 2.99e-24 GO:0004984 olfactory receptor activity
8.23 2.17e-23 GO:0004930 G-protein coupled receptor activity
5.58 5.34e-18 GO:0004888 transmembrane receptor activity
4.41 2.14e-15 GO:0004872 receptor activity
3.61 2.40e-12 GO:0004871 signal transducer activity
3.61 2.40e-12 GO:0060089 molecular transducer activity