Motif ID: NFKB1_REL_RELA.p2

Z-value: 1.440


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)



Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_219453487 2.484 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr14_-_34943574 2.189 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr20_-_4743768 1.481 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr6_+_116798791 1.372 NM_013352
DSE
dermatan sulfate epimerase
chr17_+_37694007 1.327 STAT5A
signal transducer and activator of transcription 5A
chr14_-_34253473 1.265 NM_138638
CFL2
cofilin 2 (muscle)
chr6_+_30958672 1.132 DDR1
discoidin domain receptor tyrosine kinase 1
chr2_+_170363573 1.120 NM_003142
SSB
Sjogren syndrome antigen B (autoantigen La)
chr17_+_43328514 1.090 NM_003110
SP2
Sp2 transcription factor
chr19_+_40632456 1.044 NM_005306
FFAR2
free fatty acid receptor 2
chr1_+_45046740 0.960 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr6_-_143307976 0.943 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr2_-_231498184 0.925 NM_005683
GPR55
G protein-coupled receptor 55
chr10_+_104145421 0.924 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr14_-_22825072 0.919 HOMEZ
homeobox and leucine zipper encoding
chr16_+_84490267 0.918 NM_002163
IRF8
interferon regulatory factor 8
chr16_-_73798539 0.907 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr7_-_104440707 0.896 LOC100216545
hypothetical LOC100216545
chr8_-_95343716 0.887 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr18_+_3584056 0.871 FLJ35776
hypothetical LOC649446
chr1_+_110254755 0.869 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr17_+_73054614 0.868


chr5_-_141318810 0.859 NM_016580
PCDH12
protocadherin 12
chr10_-_32707549 0.852 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr6_-_132764257 0.846 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr20_-_24986501 0.844 ACSS1
acyl-CoA synthetase short-chain family member 1
chr6_-_17814596 0.834 NM_005124
NUP153
nucleoporin 153kDa
chr17_+_35277942 0.799 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr10_+_12431477 0.795 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr20_-_55628852 0.794 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr14_+_35365266 0.791 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr20_+_60558369 0.767 C20orf166
chromosome 20 open reading frame 166
chr17_-_46692369 0.763 NM_017643
MBTD1
mbt domain containing 1
chr17_+_19999784 0.740 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr2_+_233093416 0.735 NM_001195129
LOC646960
trypsin serine protease-like
chr20_-_44034194 0.729 NM_022095
ZNF335
zinc finger protein 335
chr5_+_110587546 0.719 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_-_206659140 0.715 NM_017759
INO80D
INO80 complex subunit D
chr16_+_55580910 0.715 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr6_+_130381408 0.705 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr11_+_101693403 0.703 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr6_-_167491305 0.699 NM_005299
GPR31
G protein-coupled receptor 31
chr6_+_31476400 0.696


chr14_-_29466562 0.694 NM_002742
PRKD1
protein kinase D1
chr6_+_35289699 0.679 SCUBE3
signal peptide, CUB domain, EGF-like 3
chr12_+_69046241 0.678 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr20_-_42249146 0.674 JPH2
junctophilin 2
chr6_-_32659958 0.673 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr16_-_65516919 0.672 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr7_+_142723340 0.671 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr2_-_28946631 0.662 NM_017910
TRMT61B
tRNA methyltransferase 61 homolog B (S. cerevisiae)
chr6_+_24511123 0.662 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr2_-_96064389 0.656 NM_207328
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr19_-_6542012 0.639 CD70
CD70 molecule
chr2_-_217248967 0.637 IGFBP5
insulin-like growth factor binding protein 5
chr7_-_134845363 0.636 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr8_-_103737058 0.633 NM_005655
KLF10
Kruppel-like factor 10
chr11_-_95715976 0.625 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr4_-_187713512 0.624 NM_005958
MTNR1A
melatonin receptor 1A
chr2_+_228386800 0.619 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_+_23685935 0.618 RNF31
ring finger protein 31
chr20_-_44034346 0.617 ZNF335
zinc finger protein 335
chr9_-_131555111 0.616 NM_004878
PTGES
prostaglandin E synthase
chr22_+_21543671 0.612 IGLV4-3
immunoglobulin lambda variable 4-3
chr20_+_30410447 0.611 ASXL1
additional sex combs like 1 (Drosophila)
chr22_-_49050847 0.610 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr1_+_40193424 0.608 MFSD2A
major facilitator superfamily domain containing 2A
chr16_+_6009095 0.607 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr6_+_160247962 0.599 NM_002377
MAS1
MAS1 oncogene
chr2_-_152663748 0.599 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr1_+_26896519 0.595 ARID1A
AT rich interactive domain 1A (SWI-like)
chr15_+_74139325 0.593 NM_152335
C15orf27
chromosome 15 open reading frame 27
chr1_+_23990228 0.592 NM_007260
LYPLA2
lysophospholipase II
chr2_-_152663454 0.585 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr10_+_30763056 0.584 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr11_+_18244383 0.581 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr19_+_38556414 0.581 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr2_+_68815416 0.571 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_-_200397300 0.565 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr9_+_4480193 0.564 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr2_-_240634161 0.558 NM_173351
OR6B3
olfactory receptor, family 6, subfamily B, member 3
chr5_+_179092405 0.551 NM_014757
MAML1
mastermind-like 1 (Drosophila)
chr2_-_240618518 0.550 NM_001005853
OR6B2
olfactory receptor, family 6, subfamily B, member 2
chr16_+_67434993 0.549 NM_024562
TMCO7
transmembrane and coiled-coil domains 7
chr2_-_162883062 0.548 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr2_-_201536425 0.547 NM_006190
ORC2
origin recognition complex, subunit 2
chr20_-_697127 0.546 NM_033409
C20orf54
chromosome 20 open reading frame 54
chr11_+_46255737 0.545 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr8_-_9045548 0.543 NM_024607
PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr6_-_167717907 0.543 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr20_+_762355 0.541 NM_001042353
FAM110A
family with sequence similarity 110, member A
chr6_+_111911226 0.540 LOC643749
hypothetical LOC643749
chr6_+_31782618 0.533 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr6_-_20320607 0.531 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr17_-_44037332 0.524 NM_018952
HOXB6
homeobox B6
chr14_+_18623364 0.523 NM_001005356
POTEG
POTE ankyrin domain family, member G
chr16_-_79668304 0.520 NM_001100873
NM_152337
C16orf46

chromosome 16 open reading frame 46

chr20_-_42249631 0.519 NM_020433
NM_175913
JPH2

junctophilin 2

chr4_-_147662318 0.513 NM_001029998
NM_032128
SLC10A7

solute carrier family 10 (sodium/bile acid cotransporter family), member 7

chr2_+_183289205 0.506 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr14_-_22825148 0.506 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr4_-_113656762 0.505 NM_024019
NEUROG2
neurogenin 2
chr15_-_43280664 0.501 NM_138356
SHF
Src homology 2 domain containing F
chr1_+_165865953 0.496 NM_052862
RCSD1
RCSD domain containing 1
chr19_+_2427122 0.495 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr6_+_35290160 0.493 NM_152753
SCUBE3
signal peptide, CUB domain, EGF-like 3
chr8_-_70909754 0.487 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr17_-_50854054 0.487 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr2_+_44442546 0.485 NM_024766
C2orf34
chromosome 2 open reading frame 34
chr1_-_205210567 0.482 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr7_-_21951946 0.481 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chr6_-_150080852 0.480 LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila)
chr4_-_174327377 0.476


chr8_-_95343696 0.475 GEM
GTP binding protein overexpressed in skeletal muscle
chr16_-_14695930 0.474 NM_003561
PLA2G10
phospholipase A2, group X
chr16_+_29942155 0.472 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr12_-_74711642 0.469 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_-_54866126 0.469 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr16_-_73292188 0.468 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr6_+_44352443 0.467 TMEM151B
transmembrane protein 151B
chr1_-_183210155 0.464 FAM129A
family with sequence similarity 129, member A
chr7_+_149042960 0.463 NM_032534
KRBA1
KRAB-A domain containing 1
chr22_+_21094094 0.460


chr1_+_25629968 0.459 NM_018202
TMEM57
transmembrane protein 57
chr14_-_20642214 0.457


chr4_+_609362 0.454 NM_000283
NM_001145291
PDE6B

phosphodiesterase 6B, cGMP-specific, rod, beta

chr6_+_14225932 0.454 CD83
CD83 molecule
chr20_+_28225511 0.454 LOC283788
FRG1B
FSHD region gene 1 pseudogene
FSHD region gene 1 family, member B
chr10_-_21854616 0.453 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr15_+_83724743 0.450 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr18_-_42804291 0.450 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr3_-_130195608 0.448 NM_020741
KIAA1257
KIAA1257
chr11_+_1846478 0.443 NM_001013253
LSP1
lymphocyte-specific protein 1
chr10_-_51293220 0.435 NM_006327
TIMM23
TIMM23B
translocase of inner mitochondrial membrane 23 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr20_-_32163576 0.432 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr8_-_120914233 0.430 NM_003184
TAF2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
chr1_-_202730135 0.430 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr13_+_113369470 0.426 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr2_+_42249896 0.426 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr1_+_16220952 0.425 NM_001042704
NM_004070
CLCNKA

CLCNKB
chloride channel Ka

chloride channel Kb
chr6_+_31648071 0.424 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr14_-_23878871 0.423 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr17_-_17435631 0.423 NM_148172
PEMT
phosphatidylethanolamine N-methyltransferase
chr1_+_144188375 0.423 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr6_+_149109841 0.423 NM_005715
UST
uronyl-2-sulfotransferase
chr17_-_59172897 0.419 NM_001003786
NM_001003787
NM_001003788
NM_001165969
NM_001165970
NM_153335
STRADA





STE20-related kinase adaptor alpha





chr1_-_1667123 0.417 NM_182838
SLC35E2B
SLC35E2
solute carrier family 35, member E2B
solute carrier family 35, member E2
chr1_-_180840016 0.417 NM_002928
RGS16
regulator of G-protein signaling 16
chr19_-_52426055 0.416 NM_014417
BBC3
BCL2 binding component 3
chr2_-_20886293 0.414 NM_021925
C2orf43
chromosome 2 open reading frame 43
chr12_+_92595281 0.413 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr2_-_152664056 0.413 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr2_-_196744546 0.412 NM_004226
STK17B
serine/threonine kinase 17b
chr22_-_14667916 0.411 NM_001136213
POTEH
POTEG
POTE ankyrin domain family, member H
POTE ankyrin domain family, member G
chr2_+_115635982 0.411 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr2_-_88707978 0.410 NM_004836
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr1_-_32574185 0.410 NM_023009
MARCKSL1
MARCKS-like 1
chr17_+_35718948 0.409 NM_000964
RARA
retinoic acid receptor, alpha
chr14_-_19090251 0.409 NM_001145442
POTEG
POTEM
POTE ankyrin domain family, member G
POTE ankyrin domain family, member M
chr14_-_73323629 0.408 NM_001043318
C14orf43
chromosome 14 open reading frame 43
chr6_+_135544138 0.407 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr10_+_12431714 0.406 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr11_+_120828275 0.406 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_+_120496180 0.404 ARHGAP31
Rho GTPase activating protein 31
chr16_+_10945815 0.401 NM_015226
CLEC16A
C-type lectin domain family 16, member A
chr17_-_76720342 0.401 AATK
apoptosis-associated tyrosine kinase
chr20_+_44070946 0.400 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr8_+_38877909 0.396 NM_021623
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr3_-_126576693 0.396 NM_021964
ZNF148
zinc finger protein 148
chr1_+_159959072 0.395 NM_001002901
FCRLB
Fc receptor-like B
chr17_-_59172852 0.394 STRADA
STE20-related kinase adaptor alpha
chr14_-_23685629 0.389 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr15_+_42507123 0.388 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_-_85235210 0.386 NM_153259
MCOLN2
mucolipin 2
chr12_+_68923477 0.385 CNOT2
CCR4-NOT transcription complex, subunit 2
chr17_+_75776193 0.385 NM_052819
CARD14
caspase recruitment domain family, member 14
chr6_+_31647854 0.382 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr14_+_22911857 0.382 NM_172314
NM_022789
IL25

interleukin 25

chr1_+_28752106 0.380 NM_017846
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr14_+_20283938 0.380 NM_006683
EDDM3A
epididymal protein 3A
chr14_-_21074875 0.378 NM_005407
SALL2
sal-like 2 (Drosophila)
chr12_-_55310261 0.378 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr11_-_18226743 0.377 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr2_-_128155829 0.377 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr7_-_110989582 0.373 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr5_-_55326358 0.373 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr10_+_49184658 0.372 MAPK8
mitogen-activated protein kinase 8
chr10_-_61139328 0.370 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr16_+_83239627 0.370 NM_024731
KLHL36
kelch-like 36 (Drosophila)
chr3_+_171558215 0.370 SKIL
SKI-like oncogene
chr20_+_32926452 0.369 ACSS2
acyl-CoA synthetase short-chain family member 2
chr12_+_51948267 0.368 NM_012291
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr1_+_46413335 0.368 NM_005727
TSPAN1
tetraspanin 1
chr2_+_238432925 0.366 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr14_+_70444191 0.362 PCNX
pecanex homolog (Drosophila)
chr15_-_62125562 0.362 NM_014326
DAPK2
death-associated protein kinase 2
chr19_-_56919032 0.361 NM_001523
HAS1
hyaluronan synthase 1
chr8_-_11361594 0.361 NM_053279
FAM167A
family with sequence similarity 167, member A
chr11_-_57054756 0.361 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr17_+_52026058 0.360 NM_005450
NOG
noggin

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
25.74 2.01e-02 GO:0048732 gland development
91.13 2.57e-02 GO:0045638 negative regulation of myeloid cell differentiation
83.75 3.05e-02 GO:0018108 peptidyl-tyrosine phosphorylation
79.46 3.39e-02 GO:0018212 peptidyl-tyrosine modification

Nothing significant found in compartment category.

Nothing significant found in function category.