Motif ID: NHLH1,2.p2

Z-value: 2.338


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2



Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_1937711 3.333 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr16_+_155972 3.311 NM_001003938
HBM
hemoglobin, mu
chr8_-_24828134 3.249 NEFM
neurofilament, medium polypeptide
chr5_+_113726203 2.878 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113725914 2.715 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_-_103058568 2.576 CKB
creatine kinase, brain
chr2_-_6923215 2.505 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr3_-_62835601 2.490


chr13_-_71338144 2.396 DACH1
dachshund homolog 1 (Drosophila)
chr7_-_72822471 2.291 NM_001306
CLDN3
claudin 3
chr13_+_48692472 2.250 NM_001507
MLNR
motilin receptor
chr2_+_74595073 2.172 NM_016170
TLX2
T-cell leukemia homeobox 2
chr20_+_20296744 2.090 NM_002196
INSM1
insulinoma-associated 1
chr4_-_13155135 2.077 NM_001189
NKX3-2
NK3 homeobox 2
chr21_+_33364420 2.014 OLIG1
oligodendrocyte transcription factor 1
chrX_+_23262905 2.008 NM_173495
PTCHD1
patched domain containing 1
chr14_+_30413393 1.909 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr17_+_56832492 1.900 TBX2
T-box 2
chr17_-_77512346 1.852 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr8_+_85258007 1.823 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr10_-_15801661 1.815 NM_003638
ITGA8
integrin, alpha 8
chr8_+_56177567 1.807 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr2_+_208979800 1.805 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr3_-_73756668 1.793 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr17_+_7494964 1.779 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr11_-_63440891 1.764 NM_173587
RCOR2
REST corepressor 2
chr8_-_144862266 1.754 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr6_+_133604203 1.682 EYA4
eyes absent homolog 4 (Drosophila)
chr10_+_94823636 1.663 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr3_+_161426322 1.643 LOC401097
hypothetical protein LOC401097
chr2_+_109112428 1.638 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr8_+_85258056 1.629 NM_173848
RALYL
RALY RNA binding protein-like
chr16_+_23754860 1.607 PRKCB
protein kinase C, beta
chr15_+_90738108 1.597 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_-_92724181 1.588 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr11_-_74818685 1.584 KLHL35
kelch-like 35 (Drosophila)
chr22_-_37569679 1.568


chr8_+_24827181 1.554 NEFM
neurofilament, medium polypeptide
chr13_-_71338558 1.535 DACH1
dachshund homolog 1 (Drosophila)
chr17_-_16335809 1.512 C17orf76
chromosome 17 open reading frame 76
chr3_-_62836052 1.495 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr10_+_134893766 1.483 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr14_-_99695684 1.475 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr2_-_47650973 1.473 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr19_+_868285 1.471 NM_032551
KISS1R
KISS1 receptor
chr8_+_24827173 1.469 NM_005382
NEFM
neurofilament, medium polypeptide
chr18_+_74841262 1.456 NM_171999
SALL3
sal-like 3 (Drosophila)
chrX_+_68641802 1.438 NM_015686
FAM155B
family with sequence similarity 155, member B
chr14_+_37748345 1.428 SSTR1
somatostatin receptor 1
chr2_-_72228427 1.426 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_-_83493415 1.408 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr14_-_76807302 1.407 NM_021257
NGB
neuroglobin
chr4_-_168392307 1.399 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr16_+_23754997 1.398 PRKCB
protein kinase C, beta
chr2_-_233060774 1.396 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr6_+_129245978 1.394 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr11_-_74818858 1.393 KLHL35
kelch-like 35 (Drosophila)
chr9_-_110969310 1.390 NM_014334
C9orf4
chromosome 9 open reading frame 4
chr11_-_129803515 1.381 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr3_+_35656012 1.372 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_137239583 1.363 THSD7B
thrombospondin, type I, domain containing 7B
chr17_-_44047299 1.357 NM_024016
HOXB8
homeobox B8
chr20_-_21326046 1.346 NM_033176
NKX2-4
NK2 homeobox 4
chr13_+_87122778 1.338 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr2_-_230287442 1.335 NM_139072
DNER
delta/notch-like EGF repeat containing
chr18_+_65219114 1.334 NM_152721
DOK6
docking protein 6
chr11_-_617172 1.327 NM_021920
SCT
secretin
chr5_+_115326035 1.317 NM_173800
AQPEP
laeverin
chr4_+_115739006 1.311 NM_001128174
UGT8
UDP glycosyltransferase 8
chr4_-_168392266 1.308 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr20_-_9767406 1.298 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr22_+_28206180 1.298 NM_021076
NEFH
neurofilament, heavy polypeptide
chr17_+_56832255 1.285 TBX2
T-box 2
chr14_-_47213906 1.269 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr14_+_37748031 1.264 SSTR1
somatostatin receptor 1
chr16_-_47872880 1.263


chr11_-_65841077 1.257 NM_020404
CD248
CD248 molecule, endosialin
chr12_-_61615124 1.253 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr4_-_2390050 1.237 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr12_+_101876151 1.231 ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr17_-_16336204 1.229 NM_001113567
NM_207387
C17orf76

chromosome 17 open reading frame 76

chr11_-_32413486 1.224 WT1
Wilms tumor 1
chr11_-_32413635 1.223 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr2_+_155263338 1.217 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr17_+_14145051 1.216 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr9_-_90983195 1.213 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr8_-_144583718 1.212 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr9_-_85342868 1.197 NM_174938
FRMD3
FERM domain containing 3
chr16_-_47873183 1.195 NM_004352
CBLN1
cerebellin 1 precursor
chr3_+_125786195 1.186 NM_007064
KALRN
kalirin, RhoGEF kinase
chr4_+_156349230 1.186 NM_000910
NPY2R
neuropeptide Y receptor Y2
chr20_+_34357604 1.178 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr4_-_154929657 1.155 NM_003013
SFRP2
secreted frizzled-related protein 2
chr17_-_29930431 1.152 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr11_-_74819165 1.147 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr8_-_17315386 1.146 NM_004686
MTMR7
myotubularin related protein 7
chr16_+_23754772 1.143 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr2_+_5750229 1.142 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr8_-_139578246 1.141 NM_015912
FAM135B
family with sequence similarity 135, member B
chr8_-_140784416 1.139 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr1_+_63561632 1.132 FOXD3
forkhead box D3
chr3_-_135097111 1.132 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr16_+_23754822 1.127 PRKCB
protein kinase C, beta
chr10_-_120345148 1.119 NM_004248
PRLHR
prolactin releasing hormone receptor
chr4_+_61749540 1.115 LPHN3
latrophilin 3
chr3_-_10724715 1.113 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr7_+_98084531 1.112 NM_002523
NPTX2
neuronal pentraxin II
chr1_-_21868380 1.110 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr9_-_139183675 1.098


chrX_+_117992623 1.090 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chrX_-_99551926 1.087 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr1_+_1062137 1.077 LOC254099
hypothetical protein LOC254099
chr19_-_51856129 1.073 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr11_+_13940715 1.073 SPON1
spondin 1, extracellular matrix protein
chr3_-_135096986 1.062 RAB6B
RAB6B, member RAS oncogene family
chr19_-_6453224 1.059 NM_006087
TUBB4
tubulin, beta 4
chr8_+_31616809 1.055 NM_013962
NRG1
neuregulin 1
chr6_+_124166767 1.052 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr12_+_131705438 1.046 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr3_-_124650081 1.045 NM_183357
ADCY5
adenylate cyclase 5
chr16_-_47872973 1.041 CBLN1
cerebellin 1 precursor
chr16_+_270606 1.038 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr22_+_28446288 1.036 NM_182527
CABP7
calcium binding protein 7
chr4_-_155631861 1.034 DCHS2
dachsous 2 (Drosophila)
chr17_-_17340219 1.033 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr12_+_5023345 1.032 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr8_+_35212505 1.029 NM_080872
UNC5D
unc-5 homolog D (C. elegans)
chr3_-_30911156 1.026 NM_207359
GADL1
glutamate decarboxylase-like 1
chr20_+_13150417 1.025 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr1_+_229365296 1.019 NM_001004342
TRIM67
tripartite motif containing 67
chr21_+_18539016 1.018 NM_024944
CHODL
chondrolectin
chr17_-_7106497 1.012 CLDN7
claudin 7
chr22_+_16973399 1.009 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr22_+_42138034 1.002 MPPED1
metallophosphoesterase domain containing 1
chr19_-_14177980 0.995 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr14_-_37795290 0.993 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr14_-_60185659 0.986 NM_005982
SIX1
SIX homeobox 1
chr10_+_23521464 0.984 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr2_-_128792515 0.983 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chrX_+_21302317 0.983 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr5_+_80292313 0.983 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr3_-_69064364 0.981 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr10_-_99521701 0.980 NM_003015
SFRP5
secreted frizzled-related protein 5
chr7_-_30688626 0.970 NM_001883
CRHR2
corticotropin releasing hormone receptor 2
chr4_+_177223978 0.968 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr9_+_94987032 0.967 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr2_+_185171480 0.965 ZNF804A
zinc finger protein 804A
chr11_+_14621972 0.964 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr7_-_45927263 0.955 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr8_-_17315171 0.949 MTMR7
myotubularin related protein 7
chr10_+_105026773 0.947 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr19_-_44386731 0.945 NM_001080468
SYCN
syncollin
chr10_-_135000358 0.941 CALY
calcyon neuron-specific vesicular protein
chr20_+_19141364 0.937 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr4_-_85638410 0.929 NM_006168
NKX6-1
NK6 homeobox 1
chr5_+_170779664 0.927 FGF18
fibroblast growth factor 18
chr17_+_29931880 0.918 NM_207313
TMEM132E
transmembrane protein 132E
chrX_+_12066505 0.914 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr20_-_49852353 0.905 NM_020436
SALL4
sal-like 4 (Drosophila)
chr22_-_29231597 0.904 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr4_+_3738093 0.904 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr3_+_171619346 0.903 NM_005602
CLDN11
claudin 11
chr13_+_95541093 0.903 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr4_+_7245218 0.900 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr3_-_124228999 0.899 SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr10_+_115793795 0.899 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr6_+_72653126 0.895 RIMS1
regulating synaptic membrane exocytosis 1
chr4_+_177224142 0.895 WDR17
WD repeat domain 17
chr18_+_53170718 0.891 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr10_-_135000464 0.890 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr2_-_42573980 0.890 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr19_-_7845325 0.887 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr4_-_66218777 0.881 EPHA5
EPH receptor A5
chr11_-_18769703 0.876 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr4_-_41849333 0.875 BEND4
BEN domain containing 4
chr4_-_5942818 0.873 CRMP1
collapsin response mediator protein 1
chr13_+_27264779 0.871 NM_145657
GSX1
GS homeobox 1
chr14_-_37795001 0.871 CLEC14A
C-type lectin domain family 14, member A
chr4_+_147779492 0.869 NM_004575
POU4F2
POU class 4 homeobox 2
chr7_+_45580704 0.865 ADCY1
adenylate cyclase 1 (brain)
chr17_+_56831951 0.862 NM_005994
TBX2
T-box 2
chr12_-_61614930 0.861 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_-_44288188 0.860 NM_021926
ALX4
ALX homeobox 4
chr2_+_231610438 0.852 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr8_+_21937533 0.852 NPM2
nucleophosmin/nucleoplasmin 2
chr2_-_278181 0.850 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr17_-_64108529 0.850 NM_017565
FAM20A
family with sequence similarity 20, member A
chr4_+_93444572 0.841 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr5_+_80292213 0.834 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr3_+_182912769 0.827 SOX2
SRY (sex determining region Y)-box 2
chr10_-_135088065 0.827 NM_001012508
SPRN
shadow of prion protein homolog (zebrafish)
chr19_-_54267932 0.822 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr14_+_28305922 0.821 NM_005249
FOXG1
forkhead box G1
chr5_-_134397740 0.821 NM_002653
PITX1
paired-like homeodomain 1
chr20_-_42872295 0.820 NM_182970
RIMS4
regulating synaptic membrane exocytosis 4
chr15_-_76700563 0.819 NM_000743
NM_001166694
CHRNA3

cholinergic receptor, nicotinic, alpha 3

chr9_+_967386 0.818 DMRT3
doublesex and mab-3 related transcription factor 3
chrX_-_74062005 0.818 NM_001008537
KIAA2022
KIAA2022
chr10_+_105334704 0.817 NEURL
neuralized homolog (Drosophila)
chr16_+_1143738 0.815 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.00 5.82e-03 GO:0007275 multicellular organismal development
2.11 1.11e-02 GO:0048731 system development
2.01 1.52e-02 GO:0048856 anatomical structure development
2.65 1.72e-02 GO:0007399 nervous system development
1.66 3.15e-02 GO:0032501 multicellular organismal process
1.82 4.97e-02 GO:0032502 developmental process

Nothing significant found in compartment category.

Nothing significant found in function category.