Motif ID: NKX3-1.p2

Z-value: 1.364


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1



Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_21399132 3.372 NM_002170
IFNA8
interferon, alpha 8
chr3_+_174598937 3.371 NM_014932
NLGN1
neuroligin 1
chr7_+_94377145 3.028 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr6_+_132000134 3.005 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr22_+_38652555 2.799 GRAP2
GRB2-related adaptor protein 2
chr18_-_29273979 2.645 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chrX_+_99726445 2.091 NM_022144
TNMD
tenomodulin
chr7_+_45899621 2.014


chr4_+_119174947 1.999 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr3_-_121445831 1.752 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr1_-_3556420 1.702 NM_017818
WDR8
WD repeat domain 8
chr5_+_147238466 1.622 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr11_-_13474101 1.615 NM_000315
PTH
parathyroid hormone
chr9_-_21177529 1.607 NM_021068
IFNA4
interferon, alpha 4
chr3_-_99236520 1.604 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr11_+_89507465 1.572 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr12_-_5925658 1.568 NM_020373
ANO2
anoctamin 2
chr2_-_104834344 1.551 LOC100506421
hypothetical LOC100506421
chr11_-_100505667 1.537 NM_000926
PGR
progesterone receptor
chr7_+_86111155 1.510 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr1_-_60312013 1.479 NM_152377
C1orf87
chromosome 1 open reading frame 87
chr3_+_129124591 1.473 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr9_-_21218132 1.421 NM_021268
IFNA17
interferon, alpha 17
chr7_-_123460722 1.387 NM_001136002
TMEM229A
transmembrane protein 229A
chr11_-_56914668 1.358 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr10_+_90336489 1.318 NM_001010939
LIPJ
lipase, family member J
chr7_+_45899080 1.310 IGFBP1
insulin-like growth factor binding protein 1
chr18_-_22696532 1.250 NM_004028
AQP4
aquaporin 4
chr7_+_141457977 1.230 LOC93432
maltase-glucoamylase-like pseudogene
chr5_+_140215778 1.139 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr5_+_127016605 1.112 NM_001127385
CTXN3
cortexin 3
chr10_+_90552466 1.109 NM_001128215
LIPM
lipase, family member M
chr11_+_123625632 1.083 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr12_-_18134319 1.083 NM_024730
RERGL
RERG/RAS-like
chr15_+_57691382 1.071 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr9_-_21375258 1.054 NM_000605
IFNA2
interferon, alpha 2
chrX_-_131089552 1.048 NM_194277
FRMD7
FERM domain containing 7
chrX_-_131401319 1.036 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr11_-_77730573 1.024 NM_012296
GAB2
GRB2-associated binding protein 2
chr10_+_90474280 1.024 NM_001080518
LIPK
lipase, family member K
chr12_-_80676562 1.017 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_83954185 0.998 NM_001100917
TSPAN19
tetraspanin 19
chr6_-_64087806 0.964 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr1_+_50348052 0.961 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_-_60244773 0.961 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr12_+_83954229 0.943 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr5_+_147672181 0.929 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr3_-_139333813 0.921 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr12_+_63510481 0.909


chr9_-_205892 0.907 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr9_+_89302574 0.882 NM_004938
DAPK1
death-associated protein kinase 1
chr10_+_118340460 0.880 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr14_-_74669864 0.870 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr4_-_157006827 0.869 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr8_-_15140162 0.855 NM_139167
SGCZ
sarcoglycan, zeta
chr1_-_103269356 0.855 COL11A1
collagen, type XI, alpha 1
chr8_-_17787342 0.834 FGL1
fibrinogen-like 1
chr4_+_114190233 0.830 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr1_-_177378801 0.828 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr14_-_20098929 0.827 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr11_-_30558495 0.808 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr9_-_21192201 0.806 NM_021057
IFNA7
interferon, alpha 7
chr3_+_120799411 0.800 NM_015900
PLA1A
phospholipase A1 member A
chr11_+_120478584 0.795 NM_005422
TECTA
tectorin alpha
chr1_+_66230977 0.782 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_150353179 0.779 NM_007113
TCHH
trichohyalin
chr15_+_57691272 0.778 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_192413015 0.776 NM_198184
OSTN
osteocrin
chr15_+_92700167 0.742 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chrX_+_107569671 0.741 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_49712483 0.740 NM_000324
RHAG
Rh-associated glycoprotein
chr8_+_24207524 0.739 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr3_-_115380539 0.710 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr6_+_49575629 0.709 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr9_-_21358005 0.707 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr8_+_24354387 0.698 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr12_+_52696908 0.684 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_76470829 0.684


chrX_+_100241453 0.681 NM_006733
CENPI
centromere protein I
chr5_-_177140071 0.680 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr18_-_50776276 0.677 NM_001143829
CCDC68
coiled-coil domain containing 68
chr12_+_61645361 0.673 RPL14
ribosomal protein L14
chr9_+_99303282 0.672 NM_001166116
TMOD1
tropomodulin 1
chr9_-_21207303 0.666 NM_002173
IFNA16
interferon, alpha 16
chr7_+_80069439 0.665 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr5_+_32824701 0.664 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr4_+_74520796 0.663 NM_001134
AFP
alpha-fetoprotein
chrX_-_107569256 0.662 NM_001847
COL4A6
collagen, type IV, alpha 6
chr18_-_21184824 0.661


chr3_-_57209319 0.654 NM_003865
HESX1
HESX homeobox 1
chr1_-_118123033 0.648


chr12_+_130004404 0.647 NM_198827
GPR133
G protein-coupled receptor 133
chr4_+_88748704 0.638 NM_014208
DSPP
dentin sialophosphoprotein
chr4_-_163304567 0.637 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr12_-_242255 0.628 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr4_-_155531898 0.621 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr2_+_234490781 0.605 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_-_30910074 0.603 NM_020869
DCDC5
doublecortin domain containing 5
chr12_+_40117751 0.600 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr14_+_87541220 0.595 NM_003608
GPR65
G protein-coupled receptor 65
chrX_-_21686079 0.587 NM_014332
SMPX
small muscle protein, X-linked
chr4_+_141484046 0.587 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr11_-_57883117 0.584 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr4_-_70861301 0.580 NM_001891
CSN2
casein beta
chr1_+_115373937 0.579 NM_000549
TSHB
thyroid stimulating hormone, beta
chr1_-_68688219 0.579 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr17_-_7434113 0.574 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_+_56772391 0.565 LOC550643
hypothetical LOC550643
chr4_-_100575313 0.563 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr4_-_10295412 0.559 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr2_-_131073329 0.555 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr9_+_89302239 0.550 DAPK1
death-associated protein kinase 1
chr4_+_74498042 0.549 ALB
albumin
chrX_-_131989963 0.541 NM_031907
USP26
ubiquitin specific peptidase 26
chr20_-_52120710 0.535 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr1_+_58899 0.533 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr6_+_55147029 0.532 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr15_-_100280784 0.525 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_-_152541129 0.518 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr9_-_23811842 0.515 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr11_-_40271086 0.513 LRRC4C
leucine rich repeat containing 4C
chr9_-_23811808 0.512 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr13_+_52500830 0.511 NM_006418
OLFM4
olfactomedin 4
chr12_-_10850845 0.501 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr7_-_93027057 0.499 NM_001164738
CALCR
calcitonin receptor
chr11_+_58888460 0.491 NM_001004729
OR5AN1
olfactory receptor, family 5, subfamily AN, member 1
chr6_+_32003180 0.489 NM_000063
NM_001145903
C2

complement component 2

chr4_-_138673078 0.487 NM_019035
PCDH18
protocadherin 18
chr17_+_23818922 0.486


chr8_+_23157094 0.484 NM_152272
CHMP7
CHMP family, member 7
chr4_+_9055357 0.483 NM_001040448
DEFB131
defensin, beta 131
chr18_+_59571256 0.483 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_+_74493918 0.481 ALB
albumin
chrX_+_66705407 0.480 NM_001011645
AR
androgen receptor
chr8_+_120148604 0.479 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr15_+_46285789 0.474 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr3_+_152934393 0.474 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr12_-_29828958 0.473 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr11_-_5099422 0.472 NM_001005222
OR52A4
olfactory receptor, family 52, subfamily A, member 4
chr11_+_56512922 0.469 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr4_+_157044296 0.463 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr2_-_73350103 0.461 NM_001080410
FBXO41
F-box protein 41
chr13_+_51334117 0.460 NM_031290
CCDC70
coiled-coil domain containing 70
chr1_-_158815850 0.460 CD84
CD84 molecule
chr4_+_47403107 0.459


chr4_+_186587537 0.458 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr18_+_59733724 0.458 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_-_245902965 0.453 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr9_-_103237851 0.453 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_-_25668855 0.448 NM_001004125
TUSC1
tumor suppressor candidate 1
chr10_-_11614279 0.448 NM_001080491
USP6NL
USP6 N-terminal like
chr10_-_99084417 0.447 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr15_+_60146467 0.447 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr15_-_74091817 0.445 NM_138573
NRG4
neuregulin 4
chr4_+_74497998 0.445 ALB
albumin
chr14_+_31868229 0.443 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_+_50698169 0.442 HLF
hepatic leukemia factor
chr20_-_33580861 0.440 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr7_+_48041632 0.439 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr15_-_48345453 0.436 NM_002112
HDC
histidine decarboxylase
chr12_+_52697160 0.436 HOXC5
HOXC6
homeobox C5
homeobox C6
chr2_-_21106291 0.427 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_-_30826074 0.424 NM_031271
TEX15
testis expressed 15
chr5_+_147529488 0.424 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chrX_+_115215985 0.423 NM_000686
AGTR2
angiotensin II receptor, type 2
chr11_-_128399218 0.422 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chrX_+_114734074 0.422 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_+_78651929 0.422 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr3_+_68136056 0.422 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr19_-_14853166 0.419 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr3_-_120761092 0.419 NM_005191
CD80
CD80 molecule
chr7_-_27133163 0.418 NM_153631
HOXA3
homeobox A3
chr3_+_35697432 0.417 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_+_119617060 0.412


chr3_-_168853982 0.412 NM_178824
WDR49
WD repeat domain 49
chr16_-_23632008 0.412 ERN2
endoplasmic reticulum to nucleus signaling 2
chr12_-_86947276 0.411 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr1_-_102234959 0.410 OLFM3
olfactomedin 3
chr12_+_53178834 0.410 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr3_+_99288706 0.409 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr1_-_195302973 0.408 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr18_+_28023984 0.407 NM_005925
MEP1B
meprin A, beta
chr2_+_69974581 0.406 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr13_+_51496679 0.405 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr4_+_71283383 0.405 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr7_-_92693716 0.405 NM_001039372
HEPACAM2
HEPACAM family member 2
chr6_-_76259976 0.404 NM_015687
FILIP1
filamin A interacting protein 1
chr2_-_18634257 0.404 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr3_-_198784590 0.402 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr1_+_205329206 0.398 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr14_+_28311740 0.397 C14orf23
chromosome 14 open reading frame 23
chr7_+_28441758 0.391 NM_004904
CREB5
cAMP responsive element binding protein 5
chr18_-_3835295 0.390 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr11_+_55335418 0.389 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr1_+_157824239 0.387 NM_001639
APCS
amyloid P component, serum
chr1_-_26571812 0.385 NM_001114759
NM_173574
ZNF683

zinc finger protein 683

chr6_+_50894397 0.385 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chrX_-_33139349 0.383 NM_004006
DMD
dystrophin
chr11_-_16953135 0.382 RPL36A
ribosomal protein L36a
chr21_-_31041390 0.380 NM_181617
KRTAP21-2
keratin associated protein 21-2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
63.08 7.99e-05 GO:0060338 regulation of type I interferon-mediated signaling pathway
30.54 1.55e-03 GO:0001959 regulation of cytokine-mediated signaling pathway
30.54 1.55e-03 GO:0060337 type I interferon-mediated signaling pathway
30.54 1.55e-03 GO:0071357 cellular response to type I interferon
30.05 1.66e-03 GO:0034340 response to type I interferon
30.05 1.66e-03 GO:0060759 regulation of response to cytokine stimulus
11.62 1.16e-02 GO:0071345 cellular response to cytokine stimulus
6.90 3.59e-02 GO:0050776 regulation of immune response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
177.37 2.12e-05 GO:0005132 interferon-alpha/beta receptor binding