Motif ID: NKX3-2.p2

Z-value: 1.571


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2



Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 2.397 VSNL1
visinin-like 1
chr1_+_107484151 1.921 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr12_+_4253143 1.672 NM_001759
CCND2
cyclin D2
chr2_+_17585287 1.610 NM_003385
VSNL1
visinin-like 1
chr20_-_42249631 1.456 NM_020433
NM_175913
JPH2

junctophilin 2

chr20_+_51023159 1.364 TSHZ2
teashirt zinc finger homeobox 2
chr14_+_30098079 1.332 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr18_+_40514772 1.250 NM_015559
SETBP1
SET binding protein 1
chr2_-_70634129 1.191 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr2_-_24123726 1.191 NM_001142319
NM_025203
C2orf44

chromosome 2 open reading frame 44

chr1_+_107485071 1.129 NTNG1
netrin G1
chr5_+_56507029 1.104 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr14_+_22422270 1.079 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr14_-_22840249 1.047


chr2_+_201099093 1.041 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr8_+_120289735 1.024 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr4_-_84475328 0.999 NM_001166498
NM_006665
HPSE

heparanase

chr2_+_61986287 0.975 NM_152516
COMMD1
copper metabolism (Murr1) domain containing 1
chr9_-_205892 0.940 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr2_-_220144254 0.893 OBSL1
obscurin-like 1
chr2_+_63131466 0.892 NM_014562
OTX1
orthodenticle homeobox 1
chr11_-_119499188 0.890 TRIM29
tripartite motif containing 29
chr3_-_137395966 0.885 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr6_+_54819527 0.870 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr2_+_85665041 0.861 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr2_-_220144511 0.854 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr2_-_220144427 0.847 OBSL1
obscurin-like 1
chr6_+_27464461 0.846 NM_001076781
ZNF391
zinc finger protein 391
chr20_-_33793507 0.844 RBM39
RNA binding motif protein 39
chr10_+_96295511 0.835 NM_018063
HELLS
helicase, lymphoid-specific
chr11_+_116520181 0.829 NM_001184746
NM_001184747
NM_001184748
NM_002572
PAFAH1B2



platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)



chr14_-_23878871 0.825 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr2_+_101981888 0.808 NM_173343
IL1R2
interleukin 1 receptor, type II
chr6_+_111409933 0.795 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_-_201082978 0.792 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr20_+_2309553 0.779 NM_198994
TGM6
transglutaminase 6
chr1_+_199519202 0.777 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr1_-_158182006 0.775 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr19_-_6671585 0.770 NM_000064
C3
complement component 3
chr19_-_10489111 0.765 NM_030760
S1PR5
sphingosine-1-phosphate receptor 5
chr6_-_49538810 0.732 NM_000255
MUT
methylmalonyl CoA mutase
chr2_+_218698980 0.727 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr2_+_219141761 0.706 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr11_-_64484184 0.702 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr11_-_101906640 0.696 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr2_-_238861830 0.693 NM_022817
PER2
period homolog 2 (Drosophila)
chr12_+_52618815 0.692 NM_017410
HOXC13
homeobox C13
chr2_+_228386800 0.690 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr8_-_109868945 0.687 NM_153015
TMEM74
transmembrane protein 74
chr20_-_33793591 0.686 RBM39
RNA binding motif protein 39
chr1_+_156417302 0.684 CD1D
CD1d molecule
chr5_-_42847716 0.675 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr6_-_31658044 0.672 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr20_-_42249146 0.668 JPH2
junctophilin 2
chr14_-_20807346 0.666 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr8_+_102573837 0.649 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr14_+_22305570 0.648 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr1_-_154665807 0.645 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr14_-_20636909 0.644 NM_001101672
ZNF219
zinc finger protein 219
chr5_+_148501178 0.635 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr8_-_122722674 0.630 NM_005328
HAS2
hyaluronan synthase 2
chr14_+_20636935 0.629 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr2_+_183697327 0.625 NM_138285
NUP35
nucleoporin 35kDa
chr8_+_102574012 0.613 GRHL2
grainyhead-like 2 (Drosophila)
chr2_-_27399405 0.609 NM_002437
MPV17
MpV17 mitochondrial inner membrane protein
chr4_+_109761170 0.607 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr1_+_234624266 0.607 NM_145861
EDARADD
EDAR-associated death domain
chr10_-_5436781 0.603 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr10_-_123343761 0.600 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr1_+_78243181 0.599 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr2_+_68445936 0.595 PLEK
pleckstrin
chr15_+_56217686 0.594 NM_020980
AQP9
aquaporin 9
chr5_-_180563945 0.594 NM_203294
NM_203295
NM_203296
TRIM7


tripartite motif containing 7


chr4_-_84475023 0.589 HPSE
heparanase
chr12_-_52980914 0.588 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_56447090 0.587 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr6_-_134680888 0.587 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr17_-_57497380 0.583 NM_005121
MED13
mediator complex subunit 13
chr16_+_11978002 0.581 NM_032167
RUNDC2A
RUN domain containing 2A
chr3_-_192063158 0.581 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr18_+_50646616 0.580 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr5_+_174084137 0.576 NM_002449
MSX2
msh homeobox 2
chr2_+_220033777 0.575 NM_001173476
SPEG
SPEG complex locus
chr17_-_58237742 0.574 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr4_-_84474919 0.571 HPSE
heparanase
chr2_+_54638957 0.570 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_216585298 0.567 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr3_+_46894239 0.566 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr20_+_30161173 0.565 TM9SF4
transmembrane 9 superfamily protein member 4
chr12_-_49708279 0.564 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr14_-_20642214 0.561


chr20_-_60435983 0.559 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr2_-_3360467 0.555 NM_003310
TSSC1
tumor suppressing subtransferable candidate 1
chr4_+_169789327 0.554 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr6_+_122973240 0.553 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr2_-_37752731 0.551 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr22_+_35586950 0.550 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr16_-_80602546 0.546 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr2_+_148495043 0.545 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr16_-_14695930 0.539 NM_003561
PLA2G10
phospholipase A2, group X
chr10_-_116154212 0.538 AFAP1L2
actin filament associated protein 1-like 2
chr5_+_66160359 0.536 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_216586199 0.535 TGFB2
transforming growth factor, beta 2
chr12_-_52980984 0.529 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_+_146961828 0.527 NM_024694
C6orf103
chromosome 6 open reading frame 103
chr18_+_27332024 0.527 NM_001943
DSG2
desmoglein 2
chr3_+_120375053 0.524 NM_006952
UPK1B
uroplakin 1B
chr4_+_169654742 0.522 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr11_+_129823667 0.517 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr17_+_19999784 0.515 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr8_+_22075112 0.515 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr4_+_8935987 0.514 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr16_-_31054563 0.512 NM_002773
PRSS8
protease, serine, 8
chr6_-_46997579 0.512 NM_001098518
GPR116
G protein-coupled receptor 116
chr2_-_148495642 0.511 NM_181742
ORC4
origin recognition complex, subunit 4
chr14_-_23781328 0.510 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr20_-_33793593 0.509 NM_004902
NM_184234
RBM39

RNA binding motif protein 39

chr3_+_185762233 0.501 NM_004443
EPHB3
EPH receptor B3
chr2_-_197499584 0.500 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr2_-_104834344 0.499 LOC100506421
hypothetical LOC100506421
chr11_-_57054756 0.499 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr14_-_24115268 0.496 NM_001911
CTSG
cathepsin G
chr14_-_23623657 0.496 NM_006177
NRL
neural retina leucine zipper
chr14_+_38714111 0.492 NM_002687
PNN
pinin, desmosome associated protein
chr9_-_33437527 0.488 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr14_+_34831355 0.488 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr20_-_16501911 0.488 NM_024704
KIF16B
kinesin family member 16B
chr3_-_55490401 0.486 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_35020425 0.485 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr20_-_55719946 0.485 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_-_17638797 0.485 NM_018715
RCC2
regulator of chromosome condensation 2
chr15_+_38318528 0.484 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr5_-_159730196 0.481 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr14_+_34831294 0.477 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr22_-_22714230 0.476 NM_000853
GSTT1
glutathione S-transferase theta 1
chr3_+_77171938 0.474 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr17_-_34575939 0.474 NM_001143968
ARL5C
ADP-ribosylation factor-like 5C
chr10_+_124310170 0.470 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr1_+_158636987 0.469 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr10_-_5035967 0.468 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr2_-_223229006 0.464 NM_005687
FARSB
phenylalanyl-tRNA synthetase, beta subunit
chr14_+_36200867 0.464 PAX9
paired box 9
chr2_-_37727472 0.462 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_-_84475024 0.458 HPSE
heparanase
chr7_+_134893185 0.456 NM_015135
NUP205
nucleoporin 205kDa
chr3_+_143797895 0.454 NM_001145319
PLS1
plastin 1
chr11_-_10630408 0.448 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr2_+_32244406 0.448 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_-_127694123 0.448 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr18_+_3584056 0.447 FLJ35776
hypothetical LOC649446
chr2_+_69093641 0.444 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr20_+_43531806 0.442 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr20_+_44083667 0.440 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr18_-_28304392 0.439 NM_022751
FAM59A
family with sequence similarity 59, member A
chr17_-_40674883 0.439


chr2_+_68815416 0.435 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr5_+_118632403 0.433 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118632316 0.433 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_+_52806103 0.432 LOC400043
hypothetical LOC400043
chr19_+_59061422 0.431 NM_001020820
MYADM
myeloid-associated differentiation marker
chr10_-_116154504 0.431 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr2_+_17861266 0.430 NM_001105569
MSGN1
mesogenin 1
chr19_+_56766342 0.430 NM_007147
ZNF175
zinc finger protein 175
chr12_+_112071930 0.429 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr4_-_84475036 0.427 NM_001098540
HPSE
heparanase
chr2_-_156897286 0.425 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_-_157664464 0.424 C6orf35
chromosome 6 open reading frame 35
chr12_-_41269679 0.423 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr17_+_64922420 0.423 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr3_+_122769467 0.423 NM_001012659
ARGFX
arginine-fifty homeobox
chr2_-_113752957 0.422 NM_003466
NM_013952
NM_013953
NM_013992
PAX8



paired box 8



chr6_-_52060327 0.422 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_-_171184003 0.422 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr14_+_36200815 0.418 PAX9
paired box 9
chr19_-_44214972 0.417 NM_178820
FBXO27
F-box protein 27
chr12_+_52689062 0.414 NM_022658
HOXC8
homeobox C8
chr2_+_190753833 0.411 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr14_-_23874083 0.410 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr6_+_49539049 0.407 NM_018132
CENPQ
centromere protein Q
chr1_-_116184846 0.407 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_201462294 0.407 NM_001136039
NM_001142355
NM_021824
NIF3L1


NIF3 NGG1 interacting factor 3-like 1 (S. pombe)


chr7_+_130445394 0.405 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr21_+_42512271 0.405 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr2_-_201461945 0.405 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr6_+_26359805 0.404 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr14_+_22633728 0.404 C14orf119
chromosome 14 open reading frame 119
chr2_+_178986617 0.404


chr2_+_28828332 0.403 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr4_-_56197115 0.403 NM_006681
NMU
neuromedin U
chr2_-_72224696 0.403 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr17_+_78267868 0.402 NM_024619
FN3KRP
fructosamine 3 kinase related protein
chr2_+_187163232 0.402 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr15_+_38332640 0.401 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_+_94861201 0.401 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr2_-_210798232 0.400 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr3_-_172660545 0.397 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr17_-_46140015 0.396 NM_052855
ANKRD40
ankyrin repeat domain 40
chr6_+_26212082 0.395 NM_003542
HIST1H4C
histone cluster 1, H4c
chr11_+_93114365 0.393 NM_014039
C11orf54
chromosome 11 open reading frame 54
chr2_-_86418143 0.393 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.