Motif ID: NR3C1.p2

Z-value: 1.627


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)



Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_202726068 3.283 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr22_+_21042091 2.560 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_105390892 2.475 NM_152750
CDHR3
cadherin-related family member 3
chr1_-_144426918 2.422 NM_007053
CD160
CD160 molecule
chr7_-_16811131 2.251 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr22_+_21053972 2.174


chr6_+_36752244 2.081 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr10_+_77212524 2.072 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr15_-_68781662 1.984 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_116182676 1.961


chr10_+_114033403 1.694 NM_058222
TECTB
tectorin beta
chr16_+_8722068 1.578 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr1_-_181889070 1.571 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_-_89984214 1.526 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr1_-_156800017 1.512 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr11_-_123414917 1.503 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chr11_+_124294355 1.442 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr7_+_117651947 1.398 NM_019644
ANKRD7
ankyrin repeat domain 7
chr7_-_143587653 1.382 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr11_+_4799126 1.350 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr1_-_94359266 1.333 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr21_+_43024936 1.306 PDE9A
phosphodiesterase 9A
chr1_-_177106702 1.301 NM_004673
ANGPTL1
angiopoietin-like 1
chr7_-_99312591 1.278 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr10_+_685887 1.265 C10orf108
chromosome 10 open reading frame 108
chr6_+_150731720 1.240 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr11_-_8695974 1.169 ST5
suppression of tumorigenicity 5
chr3_+_125586241 1.157 KALRN
kalirin, RhoGEF kinase
chr19_+_14913298 1.150 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr11_+_73036241 1.140 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_-_6468108 1.089 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_20837001 1.084


chr11_+_59804634 1.014 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr15_-_31999815 1.004


chr10_-_7699192 0.983 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_-_4924905 0.978 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr22_-_15453440 0.971 NM_014406
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr7_-_124192265 0.966 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr11_+_44742551 0.960 NM_130783
TSPAN18
tetraspanin 18
chr1_+_84646621 0.955 NM_058248
DNASE2B
deoxyribonuclease II beta
chr5_+_169749068 0.955


chr16_-_70591377 0.954 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr16_+_4485859 0.954 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr7_-_98643024 0.952 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr5_+_149867866 0.938 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr16_+_70654625 0.913 NM_020995
HPR
haptoglobin-related protein
chr19_-_56841819 0.868 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr12_+_91654395 0.865 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_+_246468853 0.848 NM_017504
OR2M4
olfactory receptor, family 2, subfamily M, member 4
chrX_-_100434700 0.846 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr7_-_7541974 0.845 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr21_+_29322100 0.841 USP16
ubiquitin specific peptidase 16
chr6_-_152681171 0.822 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_-_20610078 0.785 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr1_+_111571803 0.781 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr6_-_132064233 0.772 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr7_-_132131742 0.772 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr18_+_30652223 0.772 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr19_+_62844143 0.771 ZNF211
zinc finger protein 211
chr6_-_76027286 0.769 TMEM30A
transmembrane protein 30A
chr7_+_94377145 0.761 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr1_-_157950898 0.750 NM_000567
CRP
C-reactive protein, pentraxin-related
chr11_-_33678861 0.750 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr1_-_54256390 0.747 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr1_-_117554999 0.743 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_+_43539239 0.741 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr7_+_128795280 0.738 AHCYL2
adenosylhomocysteinase-like 2
chr1_-_10779291 0.733 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr8_-_110724594 0.719 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_+_24795446 0.717 KIAA1217
KIAA1217
chrX_+_46825179 0.708 RGN
regucalcin (senescence marker protein-30)
chr1_-_11111387 0.701


chr3_-_188935363 0.699 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chrX_+_49223101 0.683 NM_001098405
GAGE12F
GAGE3
GAGE4
GAGE5
GAGE7
G antigen 12F
G antigen 3
G antigen 4
G antigen 5
G antigen 7
chr1_+_190394214 0.683 NM_130782
RGS18
regulator of G-protein signaling 18
chr8_-_62764839 0.668 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr15_+_40481879 0.665 NM_173088
CAPN3
calpain 3, (p94)
chr2_+_231569082 0.665 NM_139073
SPATA3
spermatogenesis associated 3
chr10_+_24795465 0.654 KIAA1217
KIAA1217
chr6_+_31746706 0.630 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr2_-_85749374 0.627 NM_000542
NM_198843
SFTPB

surfactant protein B

chr2_-_121964373 0.625 CLASP1
cytoplasmic linker associated protein 1
chr1_-_35692668 0.615 KIAA0319L
KIAA0319-like
chr4_+_35962038 0.607 NM_001170700
DTHD1
death domain containing 1
chr7_+_143263191 0.605 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr7_+_20008870 0.597 RPL21
ribosomal protein L21
chr5_-_156705250 0.597 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr7_-_11643113 0.596 THSD7A
thrombospondin, type I, domain containing 7A
chr11_-_123918759 0.595 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr1_+_22852268 0.595 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr10_+_170423 0.592 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr6_-_47117951 0.588 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr2_+_64540843 0.588 HSPC159
galectin-related protein
chr2_-_74460933 0.588 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr7_-_107558021 0.587 NM_007356
LAMB4
laminin, beta 4
chr21_+_37713076 0.577 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr11_+_19328846 0.576 NM_001111018
NAV2
neuron navigator 2
chr10_-_123343320 0.571 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr22_-_35835548 0.570 TMPRSS6
transmembrane protease, serine 6
chr1_-_240228987 0.567 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr11_+_123398929 0.566 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chr1_-_60164912 0.565 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr3_-_152659186 0.564 NM_178822
IGSF10
immunoglobulin superfamily, member 10
chr1_-_7998265 0.561 ERRFI1
ERBB receptor feedback inhibitor 1
chr19_-_59568222 0.560 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr1_-_23393808 0.559 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr8_-_7297296 0.552 NM_058206
NM_058207
SPAG11B

sperm associated antigen 11B

chr5_-_169749215 0.551 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr20_-_54534387 0.549 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr1_+_32777556 0.549 ZBTB8A
zinc finger and BTB domain containing 8A
chr10_-_123343761 0.548 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr7_+_120752656 0.540 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr21_+_45396903 0.535 ADARB1
adenosine deaminase, RNA-specific, B1
chr3_+_16949585 0.534 NM_015184
PLCL2
phospholipase C-like 2
chrX_+_49104714 0.528 NM_001098405
GAGE12F
GAGE1
GAGE4
GAGE5
GAGE7
G antigen 12F
G antigen 1
G antigen 4
G antigen 5
G antigen 7
chr7_+_127020924 0.523 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr1_-_54861656 0.523 NM_176782
FAM151A
family with sequence similarity 151, member A
chr8_-_53484753 0.522 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr12_+_52126131 0.517 PRR13
proline rich 13
chr11_-_47467094 0.502 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr11_-_36576352 0.502 NM_000536
RAG2
recombination activating gene 2
chr20_-_44612619 0.496 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr20_+_30831298 0.487 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr18_+_18989786 0.485 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr19_-_59568483 0.481 NM_002287
NM_021706
LAIR1

leukocyte-associated immunoglobulin-like receptor 1

chr1_-_109957195 0.476 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_-_26717713 0.473 NM_001029881
CIB4
calcium and integrin binding family member 4
chr8_+_128497038 0.472 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr17_+_11726943 0.471 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr15_+_64787983 0.466 NM_001142861
SMAD6
SMAD family member 6
chr11_-_121492010 0.466 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr6_-_31756119 0.461 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr9_-_103237851 0.460 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr16_-_67039874 0.457 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr17_-_24491521 0.457 MYO18A
myosin XVIIIA
chr14_+_62740878 0.455 NM_020663
RHOJ
ras homolog gene family, member J
chr16_-_66075216 0.452 NM_001138
AGRP
agouti related protein homolog (mouse)
chr19_+_59705824 0.447 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr1_-_158190585 0.443 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr14_+_19365447 0.439 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr1_+_89602023 0.438 NM_198460
GBP6
guanylate binding protein family, member 6
chr7_+_128142661 0.438 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr19_-_59568340 0.437 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr6_+_37511383 0.435


chr10_+_114144512 0.434 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_11585264 0.433 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr17_-_36418869 0.431 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr5_+_147628567 0.429 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr12_-_69838045 0.427 NM_004616
TSPAN8
tetraspanin 8
chr11_-_114593838 0.426 CADM1
cell adhesion molecule 1
chr5_-_176876224 0.424 DDX41
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
chr9_+_130427988 0.417 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr2_-_113310796 0.415 NM_000576
IL1B
interleukin 1, beta
chrX_+_65300803 0.414 NM_001130860
NM_014799
HEPH

hephaestin

chr1_+_13588674 0.414 NM_001099851
PRAMEF17
PRAME family member 17
chr11_+_57123927 0.407 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_+_181380837 0.406 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr8_-_13018123 0.406 NM_001164271
DLC1
deleted in liver cancer 1
chr1_+_34997928 0.401 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_-_5835507 0.396 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chr14_-_76612286 0.391


chr15_+_72892205 0.381 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr1_-_151630168 0.380 NM_002964
S100A8
S100 calcium binding protein A8
chr7_-_96492064 0.380 NM_005221
DLX5
distal-less homeobox 5
chr12_-_94914133 0.376 NM_002108
HAL
histidine ammonia-lyase
chr5_+_55098469 0.375 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr4_-_146315341 0.372 NM_017493
OTUD4
OTU domain containing 4
chr19_-_40317829 0.372 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr11_-_116692128 0.371 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chrX_-_44945025 0.369 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr2_+_31310383 0.366 NM_014600
EHD3
EH-domain containing 3
chr3_+_45902999 0.360 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr6_+_29515694 0.360 NM_013941
OR10C1
olfactory receptor, family 10, subfamily C, member 1
chr1_+_32777358 0.357 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr3_-_147696411 0.357 NM_020359
PLSCR2
phospholipid scramblase 2
chr12_+_32546243 0.356 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_-_41230003 0.355 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr11_-_102331643 0.355 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_+_112811562 0.351 NM_004185
WNT2B
wingless-type MMTV integration site family, member 2B
chr19_-_5821546 0.349 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr17_-_68100537 0.346 LOC100499467
hypothetical LOC100499467
chr9_+_101628829 0.345 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr21_+_42792810 0.344 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr21_-_31049566 0.344 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr1_-_171442937 0.343 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_-_166779825 0.342 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr15_-_48766275 0.342 NM_017672
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr11_+_61794205 0.340 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr16_+_88616508 0.338 NM_001481
GAS8
growth arrest-specific 8
chrX_-_52752935 0.336 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr1_-_232962369 0.333 PP2672
hypothetical LOC100130249
chr1_-_150065176 0.331 NM_001001523
RORC
RAR-related orphan receptor C
chr10_-_101680645 0.331 DNMBP
dynamin binding protein
chr11_-_117552355 0.327 SCN2B
sodium channel, voltage-gated, type II, beta
chr19_-_57924946 0.326 NM_030972
ZNF611
zinc finger protein 611
chr5_+_73145098 0.325 RGNEF
190 kDa guanine nucleotide exchange factor
chr10_-_92670764 0.324 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_+_5023345 0.324 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr8_+_67787206 0.323 SGK3
serum/glucocorticoid regulated kinase family, member 3
chrX_+_118598325 0.322 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.54 2.53e-04 GO:0007608 sensory perception of smell
9.44 5.27e-04 GO:0007606 sensory perception of chemical stimulus
4.77 1.63e-03 GO:0050877 neurological system process
6.22 2.15e-03 GO:0007600 sensory perception

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.05 7.64e-05 GO:0004984 olfactory receptor activity
3.67 1.04e-03 GO:0004871 signal transducer activity
3.67 1.04e-03 GO:0060089 molecular transducer activity
4.47 3.38e-03 GO:0004888 transmembrane receptor activity
3.74 5.54e-03 GO:0004872 receptor activity
5.26 9.25e-03 GO:0004930 G-protein coupled receptor activity