Motif ID: PAX2.p2

Z-value: 1.831


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2



Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_45542653 2.602 NM_001169106
NM_001169107
NM_015262
FAM21C


FAM21A
family with sequence similarity 21, member C


family with sequence similarity 21, member A
chr6_-_84994032 2.323 NM_014895
KIAA1009
KIAA1009
chr11_+_66915997 1.923 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr14_+_76634323 1.697 NM_033426
KIAA1737
KIAA1737
chr6_+_127629677 1.558 NM_030963
RNF146
ring finger protein 146
chr20_+_46971618 1.552 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr2_-_176575171 1.541 NM_030650
KIAA1715
KIAA1715
chr11_-_85457469 1.532 PICALM
phosphatidylinositol binding clathrin assembly protein
chr17_+_25467948 1.475 NM_032141
CCDC55
coiled-coil domain containing 55
chr10_-_45410197 1.469 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr2_+_177785667 1.359 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr20_+_37024383 1.321 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr17_-_39556483 1.310 HDAC5
histone deacetylase 5
chr2_+_42249896 1.294 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr6_+_160310118 1.269 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr20_+_2744947 1.266 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr2_+_62787534 1.163 NM_001142614
EHBP1
EH domain binding protein 1
chr10_+_70609986 1.119 NM_003171
SUPV3L1
suppressor of var1, 3-like 1 (S. cerevisiae)
chr17_-_39556535 1.093 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr2_-_177836773 1.091 NM_001145412
NM_001145413
NFE2L2

nuclear factor (erythroid-derived 2)-like 2

chr2_+_105320440 1.082 NM_024093
C2orf49
chromosome 2 open reading frame 49
chr2_+_46779827 1.068 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr2_+_234333653 1.064 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr14_-_34943574 1.059 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr5_+_148186348 1.037 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr20_-_2592777 1.036 NM_006899
NM_174855
NM_174856
IDH3B


isocitrate dehydrogenase 3 (NAD+) beta


chr2_+_26840626 1.033 NM_017877
CENPA
C2orf18
centromere protein A
chromosome 2 open reading frame 18
chr1_+_36462625 1.025 THRAP3
thyroid hormone receptor associated protein 3
chr4_-_40327396 1.024 RBM47
RNA binding motif protein 47
chr6_+_34964999 1.010 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr12_+_56374004 0.957 NM_001017956
NM_001017957
NM_001017958
NM_006812
OS9



osteosarcoma amplified 9, endoplasmic reticulum lectin



chr22_-_37425937 0.951 NM_014876
JOSD1
Josephin domain containing 1
chr1_+_159550789 0.921 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr14_+_22860511 0.910 PABPN1
poly(A) binding protein, nuclear 1
chr7_-_6278662 0.910 NM_004227
CYTH3
cytohesin 3
chr11_-_85457736 0.906 PICALM
phosphatidylinositol binding clathrin assembly protein
chr15_+_32304477 0.897 NM_016454
TMEM85
transmembrane protein 85
chr6_+_89848229 0.888 PNRC1
proline-rich nuclear receptor coactivator 1
chr14_-_23680581 0.887 NM_016049
FAM158A
family with sequence similarity 158, member A
chr2_-_179367925 0.876 TTN
titin
chr6_-_144370947 0.874 PLAGL1
pleiomorphic adenoma gene-like 1
chr1_-_197173159 0.872 LOC100131234
familial acute myelogenous leukemia related factor
chr2_-_202811459 0.862 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr16_-_87646856 0.846


chr17_-_44022595 0.844 HOXB3
homeobox B3
chr18_+_9126742 0.841 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr15_-_73719546 0.840 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr6_-_44333002 0.835 NM_178148
SLC35B2
solute carrier family 35, member B2
chr19_-_52426055 0.823 NM_014417
BBC3
BCL2 binding component 3
chr13_+_48582389 0.818 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr4_-_147662318 0.817 NM_001029998
NM_032128
SLC10A7

solute carrier family 10 (sodium/bile acid cotransporter family), member 7

chr22_+_38903825 0.814 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr4_-_84152985 0.808 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr20_+_21231921 0.807 NM_012255
XRN2
5'-3' exoribonuclease 2
chr17_-_44042924 0.802 HOXB7
homeobox B7
chr11_-_125586733 0.797 NM_001144827
NM_032795
RPUSD4

RNA pseudouridylate synthase domain containing 4

chr9_-_129573330 0.795 NM_005489
SH2D3C
SH2 domain containing 3C
chr2_+_219453487 0.790 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr6_-_17814596 0.790 NM_005124
NUP153
nucleoporin 153kDa
chr20_-_34102250 0.788 LOC647979
hypothetical LOC647979
chr14_-_67353046 0.779 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr11_-_17186027 0.777 PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr17_+_45778381 0.775 NM_022167
XYLT2
xylosyltransferase II
chr17_+_7416780 0.770 NM_001416
EIF4A1
eukaryotic translation initiation factor 4A1
chr17_+_44325127 0.758 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr5_-_167938875 0.753 PANK3
pantothenate kinase 3
chr19_+_12709281 0.753 NM_004317
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr2_-_238861830 0.746 NM_022817
PER2
period homolog 2 (Drosophila)
chr2_+_105320247 0.743 C2orf49
chromosome 2 open reading frame 49
chr6_-_169392771 0.741


chr10_-_3817205 0.739 KLF6
Kruppel-like factor 6
chr2_-_148494732 0.739 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr14_+_22860547 0.733 PABPN1
poly(A) binding protein, nuclear 1
chr10_+_75211810 0.732 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr1_-_77920914 0.730 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr20_-_43974092 0.727 NM_006227
NM_182676
PLTP

phospholipid transfer protein

chr4_-_23500706 0.719 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_106287391 0.715 NM_001127208
NM_017628
TET2

tet oncogene family member 2

chr3_+_12573513 0.714 NM_014160
MKRN2
makorin ring finger protein 2
chr12_-_121316907 0.710 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr6_-_119712596 0.708 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr5_-_167938991 0.707 NM_024594
PANK3
pantothenate kinase 3
chr17_-_75735354 0.707 NM_014740
EIF4A3
eukaryotic translation initiation factor 4A3
chr13_-_32757835 0.698 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_85457753 0.698 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr11_+_118460779 0.696 NM_000190
HMBS
hydroxymethylbilane synthase
chr2_+_223625105 0.694 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr11_+_63463009 0.694 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr2_-_105312536 0.685 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr5_-_156525756 0.684 NM_130899
FAM71B
family with sequence similarity 71, member B
chr2_+_46779553 0.684 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr17_+_34162525 0.681 NM_002795
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr11_+_125586828 0.678 NM_024556
FAM118B
family with sequence similarity 118, member B
chr5_-_55564942 0.675 NM_024669
ANKRD55
ankyrin repeat domain 55
chr12_-_122415327 0.674 SBNO1
strawberry notch homolog 1 (Drosophila)
chr1_-_16843764 0.667 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr11_+_60858611 0.667 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr6_-_144371035 0.666 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr4_+_144654005 0.662 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr1_-_234834410 0.659 NM_018072
HEATR1
HEAT repeat containing 1
chr20_+_33823318 0.658 NM_016436
PHF20
PHD finger protein 20
chr4_+_144325533 0.657 USP38
ubiquitin specific peptidase 38
chr20_+_57948803 0.656 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr6_+_43135346 0.650 NM_138343
NM_201521
KLC4

kinesin light chain 4

chr1_-_184916044 0.648 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_128285136 0.646 WDR33
WD repeat domain 33
chr2_-_8895129 0.646 NM_020738
KIDINS220
kinase D-interacting substrate, 220kDa
chr1_+_100276238 0.640 HIAT1
hippocampus abundant transcript 1
chr2_-_128285214 0.635 NM_001006622
NM_001006623
NM_018383
WDR33


WD repeat domain 33


chr3_-_198509276 0.635 DLG1
discs, large homolog 1 (Drosophila)
chr1_-_16843744 0.635 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr9_+_130749812 0.631 NUP188
nucleoporin 188kDa
chr2_-_207738858 0.631 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_-_4300821 0.631 NM_032927
TMEM128
transmembrane protein 128
chr2_+_241174803 0.630 NM_023083
NM_023085
CAPN10

calpain 10

chr6_+_33276580 0.630 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr6_-_112515329 0.627 NM_016262
TUBE1
tubulin, epsilon 1
chr20_-_5539487 0.626 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr20_+_51023159 0.624 TSHZ2
teashirt zinc finger homeobox 2
chr6_-_43135092 0.623 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr20_+_32755778 0.620 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr3_+_144203061 0.619 NM_001080415
U2SURP
U2 snRNP-associated SURP domain containing
chr2_-_136590210 0.617 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr16_+_55580910 0.617 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr3_+_101462375 0.616 NM_018309
TBC1D23
TBC1 domain family, member 23
chr17_-_44043278 0.616 HOXB7
homeobox B7
chr2_-_196744546 0.612 NM_004226
STK17B
serine/threonine kinase 17b
chr18_+_30875297 0.611 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr6_-_10802823 0.611 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr6_+_7535404 0.611 NM_152551
SNRNP48
small nuclear ribonucleoprotein 48kDa (U11/U12)
chr20_+_42972081 0.610 NM_001124756
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr12_+_28234657 0.610


chr12_+_27568311 0.610 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr14_-_35347791 0.609 RALGAPA1
Ral GTPase activating protein, alpha subunit 1 (catalytic)
chr20_-_5879036 0.609 NM_015939
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr5_-_64813459 0.609 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_-_77921681 0.609 ZZZ3
zinc finger, ZZ-type containing 3
chr5_+_52131686 0.608 PELO
pelota homolog (Drosophila)
chr1_+_100276242 0.607 NM_033055
HIAT1
hippocampus abundant transcript 1
chr14_-_35348086 0.596 NM_014990
NM_194301
RALGAPA1

Ral GTPase activating protein, alpha subunit 1 (catalytic)

chr10_+_5396975 0.593 NM_053049
UCN3
urocortin 3 (stresscopin)
chr15_+_39363442 0.592 LOC729082
hypothetical LOC729082
chr6_-_18230829 0.592 NM_198586
NHLRC1
NHL repeat containing 1
chr19_-_50373294 0.590 NM_024108
TRAPPC6A
trafficking protein particle complex 6A
chr17_-_44043361 0.589 NM_004502
HOXB7
homeobox B7
chr19_+_4353658 0.584 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr1_-_159413833 0.584 NM_003779
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr2_+_237143118 0.582 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr20_+_36810510 0.578 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr12_-_121316997 0.578 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr1_+_172104115 0.575 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr16_-_3707450 0.572 NM_016292
TRAP1
TNF receptor-associated protein 1
chrX_+_24077649 0.568 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr9_-_138277467 0.564 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr20_-_4743768 0.564 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr6_-_119137923 0.563 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr10_+_22645370 0.562 COMMD3
COMM domain containing 3
chr12_+_55148567 0.562 NM_207344
SPRYD4
SPRY domain containing 4
chr14_+_59628381 0.559 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr14_+_44622916 0.559 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr1_-_59020875 0.558 JUN
jun proto-oncogene
chr17_-_46692369 0.558 NM_017643
MBTD1
mbt domain containing 1
chr14_-_21049204 0.557 NM_019852
METTL3
methyltransferase like 3
chr16_-_23068010 0.556 NM_020718
USP31
ubiquitin specific peptidase 31
chr6_-_31973418 0.556 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr1_-_58938323 0.554 NM_001085487
MYSM1
Myb-like, SWIRM and MPN domains 1
chr14_-_34253473 0.554 NM_138638
CFL2
cofilin 2 (muscle)
chr16_+_28893525 0.553 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr16_+_51722285 0.553 CHD9
chromodomain helicase DNA binding protein 9
chr14_-_38971370 0.552 NM_203301
FBXO33
F-box protein 33
chr3_-_198509808 0.547 NM_001098424
NM_004087
DLG1

discs, large homolog 1 (Drosophila)

chr3_+_150330060 0.545 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr5_+_172193826 0.545 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr11_-_71429747 0.540 NUMA1
nuclear mitotic apparatus protein 1
chr2_+_30523586 0.538 NM_182551
NM_001002257
LCLAT1

lysocardiolipin acyltransferase 1

chr4_-_186584031 0.538 NM_018359
UFSP2
UFM1-specific peptidase 2
chr17_+_33761234 0.538 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr6_+_112515366 0.531 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr11_-_72530605 0.530 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr18_-_41801237 0.527 NM_020964
EPG5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr15_+_48503860 0.525 NM_001128610
NM_001128611
NM_005154
USP8


ubiquitin specific peptidase 8


chr16_+_55199978 0.524 NM_005953
MT2A
metallothionein 2A
chr2_+_54195913 0.521 NM_138448
ACYP2
acylphosphatase 2, muscle type
chr14_-_36711615 0.520 NM_001171170
NM_030631
SLC25A21

solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

chr2_-_97646758 0.518 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr6_+_170705345 0.518 NM_001172085
NM_003194
TBP

TATA box binding protein

chr6_+_30142910 0.516 NM_021959
PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr1_+_113300507 0.511 LOC100506392
hypothetical LOC100506392
chr11_+_120828275 0.510 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_122415708 0.510 SBNO1
strawberry notch homolog 1 (Drosophila)
chr14_-_22573764 0.510 PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr14_-_64040072 0.509 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr14_+_23654307 0.509 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr14_-_34078532 0.506 NM_018453
EAPP
E2F-associated phosphoprotein
chr12_+_68923477 0.505 CNOT2
CCR4-NOT transcription complex, subunit 2
chr16_-_66072477 0.504 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_+_30594192 0.504 NM_144975
SLFN5
schlafen family member 5
chr17_-_17081217 0.503 NM_144606
NM_144997
FLCN

folliculin

chr6_-_34772495 0.503 C6orf106
chromosome 6 open reading frame 106
chr2_-_97978421 0.503 NM_015348
TMEM131
transmembrane protein 131

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
21.05 7.67e-03 GO:0016197 endosome transport

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.22 1.85e-03 GO:0044446 intracellular organelle part
2.19 2.34e-03 GO:0044422 organelle part
30.99 8.63e-03 GO:0031901 early endosome membrane
103.22 1.19e-02 GO:0071203 WASH complex

Nothing significant found in function category.