Motif ID: PAX5.p2

Z-value: 2.903


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5



Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_22513043 3.576 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr8_-_99906944 3.145 NM_006281
STK3
serine/threonine kinase 3
chr5_+_76047536 2.867 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr2_+_235525355 2.561 NM_014521
SH3BP4
SH3-domain binding protein 4
chr4_+_3264509 2.442 RGS12
regulator of G-protein signaling 12
chr11_-_2907169 2.399 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr1_-_22136263 2.334 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr4_-_809879 2.296 NM_006651
CPLX1
complexin 1
chr20_-_43410437 2.222 NM_002999
SDC4
syndecan 4
chr7_-_525556 2.214 PDGFA
platelet-derived growth factor alpha polypeptide
chr7_+_5289079 2.187 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr1_+_25999245 2.175 NM_020451
NM_206926
SEPN1

selenoprotein N, 1

chr2_+_10101081 2.063 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr14_+_99329198 2.054 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr17_+_77582774 1.961 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr8_+_1699418 1.869 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr22_-_41913076 1.825 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr11_+_359723 1.813 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr16_+_88422354 1.795 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr21_+_46226072 1.755 NM_001848
COL6A1
collagen, type VI, alpha 1
chr19_-_1518875 1.742 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr6_+_12120709 1.740 NM_002114
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chrX_+_43399101 1.737 MAOA
monoamine oxidase A
chr3_-_71857097 1.734 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr22_+_48966480 1.728 NM_025204
TRABD
TraB domain containing
chr22_+_48966394 1.723 TRABD
TraB domain containing
chr22_-_41913002 1.697 TTLL12
tubulin tyrosine ligase-like family, member 12
chr18_-_802268 1.688 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr17_-_39265965 1.687 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr3_-_125085834 1.682 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr22_-_41913075 1.645 TTLL12
tubulin tyrosine ligase-like family, member 12
chr8_+_136538739 1.644 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr6_-_138470160 1.586 NM_022121
PERP
PERP, TP53 apoptosis effector
chr8_+_1699276 1.558 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr13_-_105985313 1.555 NM_004093
EFNB2
ephrin-B2
chr1_+_113734997 1.553 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr11_+_101485946 1.548 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr20_-_38751289 1.546 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr7_-_28186671 1.542 JAZF1
JAZF zinc finger 1
chr10_-_30064600 1.528 NM_003174
SVIL
supervillin
chr7_+_44110470 1.501 NM_001129
AEBP1
AE binding protein 1
chr3_-_51976428 1.501 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr7_-_101906311 1.484 NM_006234
POLR2J2
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr13_+_43845977 1.471 NM_001010897
SERP2
stress-associated endoplasmic reticulum protein family member 2
chr11_+_35922106 1.461 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr8_-_142080169 1.458 NM_005607
NM_153831
PTK2

PTK2 protein tyrosine kinase 2

chr20_-_3336586 1.447 C20orf194
chromosome 20 open reading frame 194
chr1_+_32979930 1.446 NM_020888
KIAA1522
KIAA1522
chr14_+_93710401 1.410 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr15_-_88159061 1.404 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr1_-_223907283 1.394 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr2_-_127694123 1.378 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr14_+_67069668 1.378 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr2_-_36384 1.375 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr8_-_13034873 1.360 DLC1
deleted in liver cancer 1
chr14_-_99842519 1.359 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr18_+_7557313 1.359 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr8_+_25097983 1.357 DOCK5
dedicator of cytokinesis 5
chr14_+_20608179 1.356 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chrX_+_18353623 1.353 NM_003159
CDKL5
cyclin-dependent kinase-like 5
chr21_+_45318861 1.336 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr3_-_127558747 1.335 NM_014079
KLF15
Kruppel-like factor 15
chr2_-_204108151 1.325 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr20_+_55359551 1.324 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr16_+_1604641 1.321 NM_020825
CRAMP1L
Crm, cramped-like (Drosophila)
chr2_-_16710551 1.315 NM_030797
FAM49A
family with sequence similarity 49, member A
chr1_+_43769065 1.314 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr11_+_12652427 1.313 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr20_-_60375695 1.311 NM_005560
LAMA5
laminin, alpha 5
chr2_-_171725150 1.308 TLK1
tousled-like kinase 1
chr2_-_235070431 1.307 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr17_-_78199384 1.305 NM_019613
WDR45L
WDR45-like
chr17_-_39265705 1.297 MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr4_+_152549776 1.296 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr7_+_128257698 1.291 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr5_-_114533448 1.291 TRIM36
tripartite motif containing 36
chr13_+_26029879 1.290 WASF3
WAS protein family, member 3
chr20_+_55359706 1.287 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr6_+_158164269 1.271 NM_016224
SNX9
sorting nexin 9
chr9_+_137511448 1.237 NM_014811
KIAA0649
KIAA0649
chr2_+_159533329 1.235 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr7_+_115926855 1.207 CAV2
caveolin 2
chr14_-_52487558 1.206 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr4_-_7991992 1.202 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr17_-_71386229 1.201 NM_033452
TRIM47
tripartite motif containing 47
chr1_-_93919789 1.200 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr1_+_204049053 1.194


chr21_+_45649429 1.189 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr21_+_32706615 1.189 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr1_-_115433570 1.187 NM_005725
TSPAN2
tetraspanin 2
chr19_-_55914837 1.177


chr5_+_52320660 1.175 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr2_+_10101822 1.172 NM_001177718
KLF11
Kruppel-like factor 11
chr11_-_27679022 1.165 NM_001143812
BDNF
brain-derived neurotrophic factor
chr7_-_526005 1.164 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr3_+_160964574 1.160 SCHIP1
schwannomin interacting protein 1
chr14_-_104515738 1.149 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr3_-_187025501 1.145 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr19_+_50004134 1.141 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr19_+_39664706 1.139 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr16_-_65287967 1.138 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr8_+_22479115 1.124 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr14_-_64638809 1.123 MAX
MYC associated factor X
chr15_-_27901828 1.119 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr22_+_37193961 1.115 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr10_-_105604942 1.115 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr12_+_13044604 1.112 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chrX_+_17665483 1.107 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr19_-_11390948 1.107 NM_001035223
NM_001161616
RGL3

ral guanine nucleotide dissociation stimulator-like 3

chr5_+_172000793 1.099 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr11_-_94603857 1.097 NM_144665
SESN3
sestrin 3
chr11_+_117983515 1.093 NM_001144758
NM_001144759
PHLDB1

pleckstrin homology-like domain, family B, member 1

chr14_-_52487386 1.087 FERMT2
fermitin family member 2
chr2_+_10009242 1.081 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr21_-_39607288 1.080 BRWD1
bromodomain and WD repeat domain containing 1
chr22_+_48951286 1.075 NM_001160300
NM_052839
PANX2

pannexin 2

chrX_-_152853402 1.072 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr9_+_129414287 1.072 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr19_+_40900965 1.069 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr12_-_13044314 1.062 HEBP1
heme binding protein 1
chr11_-_47164514 1.058 NM_001184974
NM_016223
PACSIN3

protein kinase C and casein kinase substrate in neurons 3

chr7_-_117300763 1.058 NM_033427
CTTNBP2
cortactin binding protein 2
chr6_+_158164294 1.051 SNX9
sorting nexin 9
chr2_+_54536780 1.049 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_15957832 1.048 NM_017556
FBLIM1
filamin binding LIM protein 1
chrX_+_51092407 1.047 NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr8_-_10625352 1.036 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr15_+_92575767 1.036 MCTP2
multiple C2 domains, transmembrane 2
chr2_-_101134146 1.032 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_+_945331 1.031 NM_198576
AGRN
agrin
chr11_-_27450808 1.029 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr4_+_77446700 1.026 NM_003943
STBD1
starch binding domain 1
chr17_-_43470134 1.022 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr12_+_2938703 1.017 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr14_+_74815233 1.017 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr3_-_185461768 1.005 NM_033259
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr3_+_161955980 1.005 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr19_-_51168396 0.998 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr4_-_86106567 0.995 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr1_+_945472 0.991 AGRN
agrin
chr2_+_8739563 0.988 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_-_1465602 0.981 NM_001114748
C1orf70
chromosome 1 open reading frame 70
chr1_-_85131439 0.972 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr16_-_265868 0.970 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr1_+_117253882 0.968 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr12_-_13044448 0.966 HEBP1
heme binding protein 1
chr6_-_80713589 0.962 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr11_-_27678551 0.959 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr21_+_41461962 0.959 BACE2
beta-site APP-cleaving enzyme 2
chr19_+_15079141 0.947 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr6_-_105734535 0.947 NM_022361
POPDC3
popeye domain containing 3
chr12_-_13044467 0.945 NM_015987
HEBP1
heme binding protein 1
chr6_+_83130673 0.945 NM_001166392
TPBG
trophoblast glycoprotein
chr1_+_24701886 0.945 NM_013441
RCAN3
RCAN family member 3
chr19_+_38979502 0.944 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr16_+_1143241 0.943 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr14_-_94855848 0.940 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr5_-_171814026 0.939 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr8_-_18915443 0.937 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr5_-_171813960 0.937 SH3PXD2B
SH3 and PX domains 2B
chr2_+_33025872 0.935 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr9_+_139892049 0.924 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr20_+_336941 0.924 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr13_-_76499297 0.923 NM_012158
FBXL3
F-box and leucine-rich repeat protein 3
chr19_-_15421761 0.914 NM_021241
WIZ
widely interspaced zinc finger motifs
chr9_-_76692082 0.911 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr13_+_26029799 0.911 NM_006646
WASF3
WAS protein family, member 3
chr17_-_45562112 0.903 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr4_-_177950658 0.898 NM_005429
VEGFC
vascular endothelial growth factor C
chr12_+_120322226 0.895 NM_025126
NM_194271
RNF34

ring finger protein 34

chr12_+_970613 0.892 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr12_-_103055924 0.890 NM_006166
NFYB
nuclear transcription factor Y, beta
chr9_-_73573121 0.890 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr1_-_3437834 0.882 MEGF6
multiple EGF-like-domains 6
chr1_-_33139425 0.879 NM_033504
TMEM54
transmembrane protein 54
chr12_-_41269679 0.877 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_2939250 0.874 TEAD4
TEA domain family member 4
chr6_-_35572694 0.868 NM_003214
TEAD3
TEA domain family member 3
chr1_-_166372526 0.863 GPR161
G protein-coupled receptor 161
chr1_-_33669190 0.863 PHC2
polyhomeotic homolog 2 (Drosophila)
chr5_-_131591380 0.857 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr9_+_494661 0.853 NM_015158
KANK1
KN motif and ankyrin repeat domains 1
chr7_+_73506172 0.852 GTF2IRD1
GTF2I repeat domain containing 1
chr1_+_64983312 0.850 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr17_+_61729193 0.850 PRKCA
protein kinase C, alpha
chr13_-_43351825 0.843 NM_144974
CCDC122
coiled-coil domain containing 122
chr19_+_61742111 0.843 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr10_-_126839000 0.843 CTBP2
C-terminal binding protein 2
chr10_-_15250616 0.842 NM_004808
NMT2
N-myristoyltransferase 2
chr17_-_6400470 0.841 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr7_+_89678935 0.840 NM_152999
NM_001040665
STEAP2

six transmembrane epithelial antigen of the prostate 2

chr5_-_145195029 0.838 NM_182960
NM_205846
NM_138492
PRELID2


PRELI domain containing 2


chr7_+_139124502 0.838 NM_001130966
NM_001166254
TBXAS1

thromboxane A synthase 1 (platelet)

chr7_+_55054152 0.838 NM_005228
NM_201282
NM_201283
NM_201284
EGFR



epidermal growth factor receptor



chr10_-_62373828 0.837 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr20_-_60074237 0.837 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr2_-_98713862 0.834 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_-_23683214 0.834 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr7_-_117300702 0.833 CTTNBP2
cortactin binding protein 2
chr2_-_8895129 0.831 NM_020738
KIDINS220
kinase D-interacting substrate, 220kDa

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.88 1.95e-06 GO:0070161 anchoring junction
9.94 8.57e-06 GO:0005912 adherens junction
4.17 1.77e-04 GO:0030054 cell junction
10.48 6.20e-04 GO:0005925 focal adhesion
9.97 8.61e-04 GO:0005924 cell-substrate adherens junction
9.60 1.11e-03 GO:0030055 cell-substrate junction
5.18 2.12e-02 GO:0016323 basolateral plasma membrane
2.04 2.21e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.73 5.60e-03 GO:0008092 cytoskeletal protein binding