Motif ID: POU1F1.p2

Z-value: 1.730


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_21177529 4.217 NM_021068
IFNA4
interferon, alpha 4
chr1_+_195123766 4.179 NM_006684
CFHR4
complement factor H-related 4
chr3_+_12367993 3.180 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr4_+_141484046 3.061 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr6_-_52736231 2.880 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr11_+_59564323 2.779 NM_173801
PLAC1L
placenta-specific 1-like
chr13_+_45174446 2.200 NM_152719
SPERT
spermatid associated
chr1_+_195010552 2.171 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr1_-_150599105 2.140 NM_001014342
FLG2
filaggrin family member 2
chr9_-_21207303 2.058 NM_002173
IFNA16
interferon, alpha 16
chr1_+_205344200 2.055 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr11_+_30209138 2.032 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr4_-_77547481 1.971 NM_001042784
CCDC158
coiled-coil domain containing 158
chr12_+_70618892 1.929 NM_173353
TPH2
tryptophan hydroxylase 2
chr18_-_38949481 1.927 NM_002930
RIT2
Ras-like without CAAX 2
chr6_-_101018271 1.918 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr5_-_41249270 1.876 NM_000065
C6
complement component 6
chr12_-_43593977 1.825 NM_001145110
NELL2
NEL-like 2 (chicken)
chr12_+_53534565 1.730 NM_058173
MUCL1
mucin-like 1
chr6_+_72979234 1.683 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr11_-_64484184 1.665 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr3_+_99592199 1.653 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr5_+_140207540 1.627 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr3_+_143824955 1.622 NM_002670
PLS1
plastin 1
chr11_+_89507465 1.556 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr11_-_35235325 1.547 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_-_120737466 1.540 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr5_+_57823017 1.538 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr9_-_21132143 1.518 NM_002177
IFNW1
interferon, omega 1
chr10_+_90474280 1.483 NM_001080518
LIPK
lipase, family member K
chr20_+_71230 1.468 NM_030931
DEFB126
defensin, beta 126
chr1_+_195179533 1.456 NM_005666
CFHR2
complement factor H-related 2
chr6_-_52776558 1.369 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr7_+_137411717 1.356 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr12_-_60872814 1.344 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr3_+_109504021 1.334 NM_007072
HHLA2
HERV-H LTR-associating 2
chr11_-_102250876 1.280 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr6_+_105511615 1.276 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr5_-_75954807 1.261 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr4_-_70547962 1.243 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr4_-_100575313 1.224 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr18_+_52575442 1.218 WDR7
WD repeat domain 7
chr3_+_150065732 1.194 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_-_14740694 1.147 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_+_86998248 1.144 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr11_-_123695302 1.143 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr9_+_21399132 1.142 NM_002170
IFNA8
interferon, alpha 8
chr1_-_143075560 1.140 NM_178230
NM_001143883
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4B
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4B
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr9_-_99746923 1.136 NM_018437
HEMGN
hemogen
chr9_-_21358005 1.127 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr2_-_219906142 1.094 NM_001007089
RESP18
regulated endocrine-specific protein 18 homolog (rat)
chr19_+_51343339 1.092 NM_001135113
IGFL2
IGF-like family member 2
chr5_+_140767953 1.055 NM_018926
NM_032100
PCDHGB6

protocadherin gamma subfamily B, 6

chr21_-_30614477 1.046 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr1_-_203657803 1.043 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr3_+_99370233 1.039 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr18_+_57308754 1.037 NM_031891
CDH20
cadherin 20, type 2
chr11_-_16387001 1.023 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr11_-_113971607 1.017 FAM55D
family with sequence similarity 55, member D
chr1_+_170656450 1.017 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr4_+_77575276 1.015 NM_020859
SHROOM3
shroom family member 3
chr4_+_15038726 1.008 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr7_-_83108682 1.006 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_-_107943227 1.002 NM_018711
SVOP
SV2 related protein homolog (rat)
chr1_+_147819626 0.993 NM_178230
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr7_+_29486010 0.992 NM_001039936
CHN2
chimerin (chimaerin) 2
chr15_+_36014748 0.990 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr1_-_156056456 0.977 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr10_+_111755715 0.970 NM_019903
ADD3
adducin 3 (gamma)
chr6_+_47857733 0.968 NM_181744
OPN5
opsin 5
chr9_-_21340885 0.953 NM_021002
IFNA6
interferon, alpha 6
chr2_+_102456193 0.953 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr3_+_123779122 0.937 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr4_+_9055357 0.935 NM_001040448
DEFB131
defensin, beta 131
chr15_-_43457916 0.934 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_169421011 0.932 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr11_-_127962662 0.931 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr9_-_21218132 0.918 NM_021268
IFNA17
interferon, alpha 17
chr10_-_127559841 0.905 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr15_-_48198697 0.897 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr8_-_19504285 0.896 NM_001130518
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr3_-_17716515 0.887 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr1_+_180685878 0.882 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr9_+_21430439 0.880 NM_024013
IFNA1
interferon, alpha 1
chr10_+_89107404 0.872 NM_001009610
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr18_+_50409387 0.858 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr19_-_23733411 0.855 NM_138286
ZNF681
zinc finger protein 681
chr5_+_140200995 0.850 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr2_-_178461710 0.849 NM_001077196
PDE11A
phosphodiesterase 11A
chr7_-_99115454 0.848 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr6_+_123142344 0.846 NM_001446
FABP7
fatty acid binding protein 7, brain
chr2_-_171631728 0.841 NM_001136555
TLK1
tousled-like kinase 1
chr4_+_74500748 0.840 ALB
albumin
chr12_+_8216416 0.821 NM_001004328
ZNF705A
zinc finger protein 705A
chr15_+_92700167 0.819 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr5_-_135318420 0.813 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr6_+_132000134 0.812 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_+_143858428 0.806 NM_001172312
PLS1
plastin 1
chr1_-_146422000 0.798 NM_178230
PPIAL4A
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr1_-_159546348 0.785 NM_000530
MPZ
myelin protein zero
chr12_+_43972732 0.781 NM_001142678
ANO6
anoctamin 6
chr2_-_88066423 0.777 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr18_+_59726183 0.773 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_-_161439487 0.770 NM_003617
RGS5
regulator of G-protein signaling 5
chr9_+_71134060 0.768 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr8_-_7207899 0.763 NM_001164457
ZNF705G
zinc finger protein 705G
chr5_-_177140071 0.758 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr11_+_36546138 0.750 NM_000448
RAG1
recombination activating gene 1
chr10_+_124660206 0.750 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr4_-_70539922 0.750 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr7_+_142629251 0.739 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr8_-_82536312 0.736 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr3_+_88114415 0.734 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr12_-_21980894 0.727 NM_005691
NM_020297
NM_020298
ABCC9


ATP-binding cassette, sub-family C (CFTR/MRP), member 9


chr12_-_21379098 0.725 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr12_-_54150188 0.725 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr1_-_157003095 0.721 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr5_+_40945244 0.712 C7
complement component 7
chr22_-_38619739 0.707 NM_152512
ENTHD1
ENTH domain containing 1
chr6_-_32742265 0.707 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr3_+_149930656 0.697 NM_032049
AGTR1
angiotensin II receptor, type 1
chr9_-_69669550 0.696 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr19_-_10558906 0.692 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr14_+_61532293 0.691 NM_031914
SYT16
synaptotagmin XVI
chrX_+_147608302 0.691 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr11_+_110890719 0.691 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr5_+_156540425 0.690 NM_005546
ITK
IL2-inducible T-cell kinase
chr9_+_42707229 0.685 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr1_+_115373937 0.684 NM_000549
TSHB
thyroid stimulating hormone, beta
chr11_+_26310253 0.681 NM_031418
ANO3
anoctamin 3
chr4_-_77163609 0.679 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_88814225 0.679 NM_030960
SPACA1
sperm acrosome associated 1
chr11_-_113971681 0.678 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr3_+_192413015 0.678 NM_198184
OSTN
osteocrin
chr11_+_122214415 0.677 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr15_+_43036194 0.677 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr19_+_53891039 0.676 NM_000511
NM_001097638
FUT2

fucosyltransferase 2 (secretor status included)

chr4_+_74505710 0.676


chr5_-_93102952 0.668 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr1_-_102235377 0.667 NM_058170
OLFM3
olfactomedin 3
chr12_+_76749199 0.663 NM_014903
NAV3
neuron navigator 3
chr1_-_159191184 0.657 NM_080878
ITLN2
intelectin 2
chr17_-_29714293 0.656 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr6_+_50789215 0.651 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr10_+_88975184 0.649 NM_001099338
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr9_-_5294579 0.649 NM_005059
NM_134441
RLN2

relaxin 2

chr3_+_46370228 0.646 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr12_+_55443358 0.645 NM_003725
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
chr1_+_151270301 0.641 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_-_93172119 0.640


chr4_+_73123712 0.633 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr1_+_195213289 0.631 NM_030787
CFHR5
complement factor H-related 5
chr4_-_100461530 0.629 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr4_+_74566325 0.628 NM_001133
AFM
afamin
chr9_-_23811842 0.620 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_+_72983183 0.618 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_91341865 0.615 NM_001025233
CLLU1
chronic lymphocytic leukemia up-regulated 1
chr10_-_104587069 0.607 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr12_+_9925354 0.597 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr4_-_87247829 0.592 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_+_74520796 0.579 NM_001134
AFP
alpha-fetoprotein
chr10_-_50012058 0.574 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr21_-_32879617 0.573 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_+_158603480 0.570 NM_005598
NHLH1
nescient helix loop helix 1
chr6_-_26038817 0.567 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr1_+_146910634 0.567 NM_001144032
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4E
chr3_+_131761867 0.557 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr3_+_99484421 0.557 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr13_+_107753764 0.556


chr7_-_92693716 0.555 NM_001039372
HEPACAM2
HEPACAM family member 2
chr9_-_21156609 0.554 NM_002175
IFNA21
interferon, alpha 21
chr3_+_108578877 0.554 NM_032600
CCDC54
coiled-coil domain containing 54
chr12_-_10042956 0.553 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr3_+_191588354 0.545 NM_006580
CLDN16
claudin 16
chr8_-_17797127 0.539 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr7_+_37689903 0.537


chr5_+_40945315 0.532 NM_000587
C7
complement component 7
chr5_+_40945374 0.531 C7
complement component 7
chr4_-_157006827 0.528 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr3_+_99350859 0.526 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr10_-_6144119 0.525 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr3_-_19950675 0.524 NM_144715
EFHB
EF-hand domain family, member B
chr11_+_18150959 0.521 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr8_+_24207524 0.520 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr4_+_100651183 0.520 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr1_+_195055483 0.519 NM_002113
CFHR1
complement factor H-related 1
chrX_+_66705407 0.516 NM_001011645
AR
androgen receptor
chr10_+_114033403 0.516 NM_058222
TECTB
tectorin beta
chr2_+_135312655 0.515 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr18_+_6824431 0.508 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr17_-_15463742 0.508 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr12_-_8656705 0.506 NM_020661
AICDA
activation-induced cytidine deaminase
chr10_-_48426868 0.505 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_146569159 0.499 NM_001164261
NM_001164262
NM_001144032
PPIAL4D
PPIAL4F
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4D
peptidylprolyl isomerase A (cyclophilin A)-like 4F
peptidylprolyl isomerase A (cyclophilin A)-like 4E
chr2_-_207291364 0.496 NM_001093730
DYTN
dystrotelin
chr9_-_70780574 0.493


chr9_-_23811808 0.493 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_-_115380539 0.492 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr15_-_91433165 0.488 NM_020211
RGMA
RGM domain family, member A
chr3_+_192661645 0.487 NM_001083308
PYDC2
pyrin domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.94 9.13e-04 GO:0045087 innate immune response
35.48 1.00e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
3.79 9.34e-03 GO:0070887 cellular response to chemical stimulus
8.69 1.29e-02 GO:0019221 cytokine-mediated signaling pathway
3.95 1.43e-02 GO:0006952 defense response
17.18 1.87e-02 GO:0001959 regulation of cytokine-mediated signaling pathway
17.18 1.87e-02 GO:0060337 type I interferon-mediated signaling pathway
17.18 1.87e-02 GO:0071357 cellular response to type I interferon
16.91 1.99e-02 GO:0034340 response to type I interferon
16.91 1.99e-02 GO:0060759 regulation of response to cytokine stimulus
7.84 2.28e-02 GO:0071345 cellular response to cytokine stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.18 3.42e-06 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
99.77 1.46e-04 GO:0005132 interferon-alpha/beta receptor binding