Motif ID: POU5F1.p2

Z-value: 1.622


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1



Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_16649211 4.105 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_110443247 3.354 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr10_+_68355797 2.738 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr2_+_5750229 2.646 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr15_+_26832300 2.569 LOC100289656
Dexi homolog (mouse) pseudogene
chr17_-_33178987 2.534 HNF1B
HNF1 homeobox B
chr13_-_52320774 2.500 NM_002590
NM_032949
PCDH8

protocadherin 8

chrX_-_6156655 2.461 NM_181332
NLGN4X
neuroligin 4, X-linked
chr11_-_3620060 2.457 NM_053017
NM_001079536
ART5

ADP-ribosyltransferase 5

chr13_-_101852028 2.411 NM_175929
FGF14
fibroblast growth factor 14
chr13_-_60887210 2.307 PCDH20
protocadherin 20
chr17_+_7494964 2.303 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr17_+_7495140 2.213 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr17_-_33179118 2.095 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr4_+_158361185 2.059 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr4_-_41445479 2.025 PHOX2B
paired-like homeobox 2b
chrX_-_33267646 2.022 NM_000109
DMD
dystrophin
chr4_+_41395493 1.932 LIMCH1
LIM and calponin homology domains 1
chr6_+_105511615 1.905 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr15_-_86600658 1.809 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr1_-_214963279 1.798 NM_001438
ESRRG
estrogen-related receptor gamma
chr10_+_124897627 1.692 NM_005519
HMX2
H6 family homeobox 2
chr1_-_215329569 1.685 NM_206594
NM_206595
ESRRG

estrogen-related receptor gamma

chr17_-_44047299 1.671 NM_024016
HOXB8
homeobox B8
chr11_-_31789360 1.651 PAX6
paired box 6
chr1_-_147665783 1.591 HIST2H2BF
histone cluster 2, H2bf
chr6_+_50789215 1.586 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr8_-_25958556 1.572 EBF2
early B-cell factor 2
chr1_-_175400573 1.555 NM_004319
NM_207108
ASTN1

astrotactin 1

chr3_+_174598937 1.468 NM_014932
NLGN1
neuroligin 1
chr11_-_31789334 1.460 PAX6
paired box 6
chr17_+_7495436 1.457 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr3_+_129124591 1.457 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_-_16650697 1.438 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_61532293 1.430 NM_031914
SYT16
synaptotagmin XVI
chr14_-_56342097 1.425 NM_172337
OTX2
orthodenticle homeobox 2
chrX_-_24575146 1.384 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_-_31789431 1.382 NM_000280
NM_001604
PAX6

paired box 6

chr15_+_58083737 1.373


chr7_+_27248688 1.355 NM_001989
EVX1
even-skipped homeobox 1
chr6_-_49712483 1.351 NM_000324
RHAG
Rh-associated glycoprotein
chr1_-_194844061 1.348 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr4_-_174774368 1.324 NM_006792
MORF4
mortality factor 4
chr8_-_23768242 1.313 NM_003155
STC1
stanniocalcin 1
chr3_+_46370228 1.302 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr17_+_14145051 1.299 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr15_+_58083712 1.295 NM_012182
FOXB1
forkhead box B1
chr10_-_64248932 1.285 NM_001136178
EGR2
early growth response 2
chr12_-_14024187 1.281 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr1_-_226712140 1.279 NM_033445
HIST3H2A
histone cluster 3, H2a
chr3_-_62334229 1.278 NM_018008
FEZF2
FEZ family zinc finger 2
chr5_-_146237826 1.274 PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr11_+_62813947 1.267 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr1_+_226712430 1.265 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr12_+_109956210 1.262 NM_015267
CUX2
cut-like homeobox 2
chr11_-_114880275 1.260 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr4_+_174688183 1.237 NBLA00301
Nbla00301
chr20_+_34019942 1.231 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr19_-_48815572 1.223 ZNF428
zinc finger protein 428
chr5_-_134899537 1.221 NM_006161
NEUROG1
neurogenin 1
chr10_+_83625049 1.220 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr2_-_50428395 1.217 NM_138735
NRXN1
neurexin 1
chr15_-_56145140 1.209 NM_003888
NM_170696
ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr18_-_28606839 1.196 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr11_-_26700121 1.195 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr9_+_134843918 1.174 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr4_-_163304567 1.159 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr4_+_134289893 1.146 NM_020815
NM_032961
PCDH10

protocadherin 10

chr2_-_200038055 1.145 NM_001172517
SATB2
SATB homeobox 2
chr3_-_79899748 1.139 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_-_43193614 1.136 DUOX2
dual oxidase 2
chr3_-_173648896 1.132 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr15_-_43193637 1.124 NM_014080
DUOX2
dual oxidase 2
chr4_-_174686918 1.107 HAND2
heart and neural crest derivatives expressed 2
chr18_+_57308754 1.106 NM_031891
CDH20
cadherin 20, type 2
chr13_-_27441423 1.097 CDX2
caudal type homeobox 2
chr6_+_55147029 1.089 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr4_-_41579325 1.087


chr7_+_113513828 1.083 FOXP2
forkhead box P2
chr13_-_27441290 1.076 NM_001265
CDX2
caudal type homeobox 2
chr5_-_146238336 1.074 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr4_+_93444572 1.070 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chrX_-_24575375 1.063 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr1_+_66230977 1.051 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_-_133236447 1.046 NM_130808
CPNE4
copine IV
chr2_+_102456193 1.045 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr6_+_101953581 1.040 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr8_+_19841209 1.030 LPL
lipoprotein lipase
chr11_-_31789168 1.030 PAX6
paired box 6
chr5_-_88004891 1.028 LOC645323
hypothetical LOC645323
chr2_-_200033445 0.993 SATB2
SATB homeobox 2
chr4_+_81325447 0.988 NM_020226
PRDM8
PR domain containing 8
chr15_+_58083798 0.987 FOXB1
forkhead box B1
chr2_-_210726539 0.986 C2orf67
chromosome 2 open reading frame 67
chr18_+_61568467 0.980 NM_033646
CDH7
cadherin 7, type 2
chrX_+_9391314 0.971 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr20_+_17155669 0.960 PCSK2
proprotein convertase subtilisin/kexin type 2
chr5_+_149526533 0.958 NM_001804
CDX1
caudal type homeobox 1
chr3_-_24511180 0.957 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr8_+_19841120 0.943 LPL
lipoprotein lipase
chr20_+_17155680 0.941 PCSK2
proprotein convertase subtilisin/kexin type 2
chr6_+_32003380 0.936 C2
complement component 2
chr11_+_119616112 0.935 NM_014352
POU2F3
POU class 2 homeobox 3
chrX_-_109570113 0.929 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_+_168381811 0.927 NM_001136107
METTL11B
methyltransferase like 11B
chr3_+_182912769 0.925 SOX2
SRY (sex determining region Y)-box 2
chr7_+_113513726 0.916 FOXP2
forkhead box P2
chr1_-_175400665 0.914 ASTN1
astrotactin 1
chr13_-_27441143 0.912 CDX2
caudal type homeobox 2
chr22_+_29848923 0.912 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_-_175400441 0.911 ASTN1
astrotactin 1
chr8_+_19841010 0.905 LPL
lipoprotein lipase
chr12_+_54231249 0.900 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chrX_+_99726445 0.899 NM_022144
TNMD
tenomodulin
chr12_-_80676562 0.898 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr3_+_182912405 0.891 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr13_+_57103789 0.891 NM_001040429
PCDH17
protocadherin 17
chr10_-_97190885 0.886 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr12_-_10846435 0.886 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_+_50488352 0.879 NM_003055
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3
chr4_+_2013517 0.873 NM_001168243
NM_001141936
C4orf48

chromosome 4 open reading frame 48

chr3_-_195601283 0.870 NM_004488
GP5
glycoprotein V (platelet)
chr8_-_21701616 0.866 GFRA2
GDNF family receptor alpha 2
chr7_+_94377145 0.863 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr18_-_29412148 0.856


chr4_-_154929657 0.852 NM_003013
SFRP2
secreted frizzled-related protein 2
chr7_-_50103335 0.847 NM_001159878
NM_007009
ZPBP

zona pellucida binding protein

chr18_+_59374372 0.844 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr3_-_152173475 0.843 NM_001195794
NM_174878
CLRN1

clarin 1

chr5_-_147142249 0.839 JAKMIP2
janus kinase and microtubule interacting protein 2
chr15_-_40537002 0.839 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr12_-_16650687 0.838 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_52713098 0.837 NM_018953
HOXC5
homeobox C5
chr3_-_193928038 0.830 NM_004113
FGF12
fibroblast growth factor 12
chr6_-_128281434 0.829 NM_001164687
THEMIS
thymocyte selection associated
chr6_+_108593907 0.828 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr5_-_111340421 0.826 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr20_+_17155617 0.825 NM_002594
PCSK2
proprotein convertase subtilisin/kexin type 2
chr3_-_166397142 0.824 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr8_-_93181091 0.823 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_192767494 0.819 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_-_76667045 0.819 NM_006682
FGL2
fibrinogen-like 2
chr12_-_94469357 0.818 NM_032147
USP44
ubiquitin specific peptidase 44
chr7_+_45899621 0.804


chr8_+_19840861 0.802 NM_000237
LPL
lipoprotein lipase
chr1_-_151296611 0.800 NM_005988
SPRR2A
small proline-rich protein 2A
chr10_-_64246129 0.798 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr18_+_29412538 0.798 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr10_+_95838801 0.786 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr20_+_9442995 0.784 C20orf103
chromosome 20 open reading frame 103
chr12_+_56290229 0.783 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr12_-_16652202 0.781 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_238813284 0.764 HES6
hairy and enhancer of split 6 (Drosophila)
chr16_+_23754772 0.761 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr14_-_33489708 0.758 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr3_+_135996990 0.758 EPHB1
EPH receptor B1
chr3_+_143824955 0.757 NM_002670
PLS1
plastin 1
chr12_-_10853940 0.756 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr16_+_23754822 0.756 PRKCB
protein kinase C, beta
chr3_-_140879463 0.749 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr13_-_34948758 0.740 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr4_-_164754106 0.737 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr13_-_60887655 0.737 NM_022843
PCDH20
protocadherin 20
chr10_-_64246080 0.737 EGR2
early growth response 2
chr1_-_194844299 0.735 KCNT2
potassium channel, subfamily T, member 2
chr14_-_105623358 0.735 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_177950161 0.734 NM_173465
COL23A1
collagen, type XXIII, alpha 1
chr7_-_36991189 0.733 NM_001039459
ELMO1
engulfment and cell motility 1
chr14_+_64077171 0.726 HSPA2
heat shock 70kDa protein 2
chr6_+_132901119 0.720 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr22_-_43784444 0.719 NM_001135862
PHF21B
PHD finger protein 21B
chr17_-_72045218 0.716 NM_134268
CYGB
cytoglobin
chr20_-_49852353 0.716 NM_020436
SALL4
sal-like 4 (Drosophila)
chr5_+_140767953 0.715 NM_018926
NM_032100
PCDHGB6

protocadherin gamma subfamily B, 6

chr7_-_141320041 0.712 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr4_+_41309690 0.711 LIMCH1
LIM and calponin homology domains 1
chr19_+_40511909 0.709 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr2_+_165860528 0.697 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr8_-_95289945 0.695 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr4_-_100575313 0.692 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr17_-_75427644 0.688 NM_003655
CBX4
chromobox homolog 4
chr8_+_104900591 0.683 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr4_+_41309482 0.677 LIMCH1
LIM and calponin homology domains 1
chr18_+_61569136 0.676 NM_004361
CDH7
cadherin 7, type 2
chr2_-_104834344 0.667 LOC100506421
hypothetical LOC100506421
chr7_+_28441758 0.661 NM_004904
CREB5
cAMP responsive element binding protein 5
chr7_-_92693716 0.658 NM_001039372
HEPACAM2
HEPACAM family member 2
chr12_-_61832856 0.653 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr6_-_26151863 0.653 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr17_-_34635446 0.652 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr11_-_57171554 0.651 YPEL4
yippee-like 4 (Drosophila)
chr3_+_1109619 0.648 NM_014461
CNTN6
contactin 6
chr16_+_23754860 0.647 PRKCB
protein kinase C, beta
chr2_-_89294466 0.646 IGKC
immunoglobulin kappa constant
chr4_-_47534815 0.646 NM_006587
CORIN
corin, serine peptidase
chr1_-_151280201 0.645 NM_006945
SPRR2D
small proline-rich protein 2D
chr4_+_41309668 0.643 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr11_-_84312085 0.643 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr7_-_31347032 0.642 NM_022728
NEUROD6
neurogenic differentiation 6
chr8_+_75899326 0.642 NM_015886
PI15
peptidase inhibitor 15

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.39 8.20e-08 GO:0007417 central nervous system development
4.49 1.39e-07 GO:0007399 nervous system development
2.68 6.99e-06 GO:0007275 multicellular organismal development
8.99 1.46e-05 GO:0007389 pattern specification process
3.52 1.59e-05 GO:0048513 organ development
2.74 1.63e-05 GO:0048856 anatomical structure development
8.51 2.57e-05 GO:0007420 brain development
2.85 2.67e-05 GO:0048731 system development
5.77 4.19e-05 GO:0009790 embryo development
2.44 7.18e-05 GO:0032502 developmental process
8.91 7.20e-05 GO:0007610 behavior
7.49 3.56e-04 GO:0009792 embryo development ending in birth or egg hatching
51.61 4.51e-04 GO:0060079 regulation of excitatory postsynaptic membrane potential
2.03 4.72e-04 GO:0032501 multicellular organismal process
43.01 9.78e-04 GO:0060078 regulation of postsynaptic membrane potential
9.31 1.01e-03 GO:0003002 regionalization
4.41 1.08e-03 GO:0022008 neurogenesis
2.67 2.26e-03 GO:0010556 regulation of macromolecule biosynthetic process
19.86 2.43e-03 GO:0030902 hindbrain development
6.82 2.88e-03 GO:0043009 chordate embryonic development
3.97 3.72e-03 GO:0007154 cell communication
2.78 3.81e-03 GO:0006355 regulation of transcription, DNA-dependent
2.67 6.89e-03 GO:0051252 regulation of RNA metabolic process
2.48 7.71e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.48 7.71e-03 GO:0031326 regulation of cellular biosynthetic process
25.81 8.03e-03 GO:0051899 membrane depolarization
2.46 9.28e-03 GO:0009889 regulation of biosynthetic process
2.45 9.53e-03 GO:0048518 positive regulation of biological process
8.22 1.03e-02 GO:0048568 embryonic organ development
10.40 1.12e-02 GO:0048562 embryonic organ morphogenesis
23.47 1.18e-02 GO:0048663 neuron fate commitment
3.82 1.23e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.41 1.26e-02 GO:0051171 regulation of nitrogen compound metabolic process
10.07 1.35e-02 GO:0009952 anterior/posterior pattern formation
4.01 1.64e-02 GO:0048699 generation of neurons
5.44 1.75e-02 GO:0050801 ion homeostasis
2.50 1.87e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.69 1.89e-02 GO:0030154 cell differentiation
9.40 1.98e-02 GO:0030900 forebrain development
2.48 2.12e-02 GO:0048522 positive regulation of cellular process
6.07 2.29e-02 GO:0048598 embryonic morphogenesis
4.63 2.46e-02 GO:0048878 chemical homeostasis
4.14 2.76e-02 GO:0007267 cell-cell signaling
2.62 2.77e-02 GO:0048869 cellular developmental process
6.88 3.22e-02 GO:0007423 sensory organ development
2.37 4.32e-02 GO:0010468 regulation of gene expression
6.49 4.66e-02 GO:0016337 cell-cell adhesion
1.56 4.67e-02 GO:0065007 biological regulation
5.43 4.98e-02 GO:0016477 cell migration

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.67 1.33e-03 GO:0044459 plasma membrane part
8.20 7.84e-03 GO:0030425 dendrite
3.13 9.64e-03 GO:0005887 integral to plasma membrane
5.39 9.76e-03 GO:0043005 neuron projection
3.07 1.18e-02 GO:0031226 intrinsic to plasma membrane
8.73 2.37e-02 GO:0045211 postsynaptic membrane
6.41 3.00e-02 GO:0005667 transcription factor complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.98 8.90e-07 GO:0001071 nucleic acid binding transcription factor activity
4.98 8.90e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
4.89 1.20e-06 GO:0030528 transcription regulator activity
5.59 1.36e-05 GO:0043565 sequence-specific DNA binding
2.97 1.99e-05 GO:0003677 DNA binding
45.54 3.76e-03 GO:0004970 ionotropic glutamate receptor activity
43.01 4.50e-03 GO:0005234 extracellular-glutamate-gated ion channel activity
2.09 1.22e-02 GO:0003676 nucleic acid binding
27.65 1.76e-02 GO:0008066 glutamate receptor activity
5.84 1.93e-02 GO:0016563 transcription activator activity
6.89 2.36e-02 GO:0046982 protein heterodimerization activity
73.72 3.20e-02 GO:0042043 neurexin binding
11.11 4.76e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity