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• Activity deltas table
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Motif ID: PRDM1.p3

Z-value: 1.311

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_-_142795269	4.136	NM_001018074 NM_001018075 NM_001018077	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr16_+_55580910	3.423	NM_032206	NLRC5	NLR family, CARD domain containing 5
chr21_+_42807052	3.140		SLC37A1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr5_+_73145098	2.784		RGNEF	190 kDa guanine nucleotide exchange factor
chr6_+_167445284	2.712	NM_004367	CCR6	chemokine (C-C motif) receptor 6
chr6_+_37081387	2.600	NM_173558	FGD2	FYVE, RhoGEF and PH domain containing 2
chr4_+_187227302	2.220	NM_003265	TLR3	toll-like receptor 3
chr20_-_5048443	2.006	NM_182649	PCNA	proliferating cell nuclear antigen
chr12_+_25096472	1.791	NM_006152	LRMP	lymphoid-restricted membrane protein
chr11_+_28088406	1.716		METTL15	methyltransferase like 15
chr17_+_53602013	1.712	NM_001004707	OR4D2	olfactory receptor, family 4, subfamily D, member 2
chr17_-_45626364	1.562
chr2_-_230792844	1.523	NM_004509 NM_004510 NM_080424	SP110	SP110 nuclear body protein
chr10_+_63478974	1.507		ARID5B	AT rich interactive domain 5B (MRF1-like)
chr11_-_85015961	1.374	NM_001142699	DLG2	discs, large homolog 2 (Drosophila)
chr1_+_220884257	1.363		MIA3	melanoma inhibitory activity family, member 3
chr10_-_35143900	1.356	NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619	PARD3	par-3 partitioning defective 3 homolog (C. elegans)
chr14_+_23771464	1.353	NM_001002000 NM_001002001	GMPR2	guanosine monophosphate reductase 2
chr3_+_186529376	1.298		MAP3K13	mitogen-activated protein kinase kinase kinase 13
chr14_-_23771312	1.294		NEDD8	neural precursor cell expressed, developmentally down-regulated 8
chr14_-_23771399	1.271		NEDD8	neural precursor cell expressed, developmentally down-regulated 8
chr14_-_23685629	1.211	NM_002818	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_110254755	1.188	NM_000757 NM_172210 NM_172211 NM_172212	CSF1	colony stimulating factor 1 (macrophage)
chr1_-_142536082	1.124
chr14_-_23771401	1.093	NM_006156	NEDD8	neural precursor cell expressed, developmentally down-regulated 8
chr14_+_23675206	1.079	NM_006263 NM_176783	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_+_3326045	1.073	NM_000049	ASPA	aspartoacylase
chr14_+_23982017	1.062
chr1_-_146398501	1.059		LOC100286793 FLJ39739	hypothetical LOC100286793 hypothetical FLJ39739
chr6_+_32929902	1.042	NM_002800	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr8_-_29176490	1.036	NM_015254	KIF13B	kinesin family member 13B
chr14_+_23675233	1.026		PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr16_-_71650034	1.010	NM_001164766	ZFHX3	zinc finger homeobox 3
chr15_+_82945223	0.984	NM_001007072 NM_017894 NM_181877	ZSCAN2	zinc finger and SCAN domain containing 2
chr11_-_85107569	0.940	NM_206929	SYTL2	synaptotagmin-like 2
chr10_+_92970487	0.931		PCGF5	polycomb group ring finger 5
chr14_-_68329407	0.930	NM_004926	ZFP36L1	zinc finger protein 36, C3H type-like 1
chr12_+_6431437	0.924	NM_018009	TAPBPL	TAP binding protein-like
chr5_-_37220702	0.924		C5orf42	chromosome 5 open reading frame 42
chr3_-_115825742	0.901	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr6_-_112682401	0.898		LAMA4	laminin, alpha 4
chr10_+_69539255	0.888	NM_032578	MYPN	myopalladin
chr6_-_99904251	0.880	NM_032511	C6orf168	chromosome 6 open reading frame 168
chr4_+_152240182	0.876	NM_001006	RPS3A	ribosomal protein S3A
chr6_-_112682038	0.857		LAMA4	laminin, alpha 4
chr2_+_230900121	0.838	NM_138402	SP140L	SP140 nuclear body protein-like
chr2_-_19421852	0.825	NM_145260	OSR1	odd-skipped related 1 (Drosophila)
chr1_-_143232464	0.823
chr3_-_102888090	0.803	NM_000986	RPL24	ribosomal protein L24
chr19_+_35555158	0.787	NM_014717	ZNF536	zinc finger protein 536
chr1_-_181540631	0.772	NM_170706	NMNAT2	nicotinamide nucleotide adenylyltransferase 2
chr1_-_203867402	0.764		ELK4	ELK4, ETS-domain protein (SRF accessory protein 1)
chr11_-_104344473	0.762	NM_001225	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr17_+_6600080	0.735		XAF1	XIAP associated factor 1
chr4_+_142777172	0.720	NM_000585 NM_172174	IL15	interleukin 15
chr1_-_146543016	0.707
chr1_+_166172420	0.706	NM_001017977 NM_001198956 NM_001198957 NM_018442	DCAF6	DDB1 and CUL4 associated factor 6
chr1_-_166171838	0.696	NM_015415	BRP44	brain protein 44
chr4_+_146623405	0.678	NM_001003688	SMAD1	SMAD family member 1
chr6_-_33389768	0.666		TAPBP	TAP binding protein (tapasin)
chr6_-_10520264	0.656		TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr16_-_83703496	0.655	NM_198491	FAM92B	family with sequence similarity 92, member B
chr6_+_3204133	0.652	NM_001128591 NM_001128592 NM_001135750	PSMG4	proteasome (prosome, macropain) assembly chaperone 4
chr6_-_10520592	0.635	NM_001032280	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_149638633	0.627	NM_002796	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4
chr1_+_166172545	0.619		DCAF6	DDB1 and CUL4 associated factor 6
chr6_-_112682573	0.616		LAMA4	laminin, alpha 4
chr12_-_56111054	0.616		R3HDM2	R3H domain containing 2
chr1_-_166171702	0.603		BRP44	brain protein 44
chr20_+_13924263	0.602		MACROD2	MACRO domain containing 2
chr9_-_14858974	0.587		FREM1	FRAS1 related extracellular matrix 1
chr21_-_34820916	0.586	NM_203418	RCAN1	regulator of calcineurin 1
chr2_+_205118801	0.572		PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)
chr1_-_146543102	0.569
chr11_+_32069183	0.565		RCN1	reticulocalbin 1, EF-hand calcium binding domain
chr1_-_143232526	0.562		FAM91A2	family with sequence similarity 91, member A2
chr6_+_126282078	0.562		NCOA7	nuclear receptor coactivator 7
chr16_-_46738061	0.556	NM_033226	ABCC12	ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr7_-_42938255	0.553		PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2
chr5_+_49998528	0.549	NM_001178056 NM_024615	PARP8	poly (ADP-ribose) polymerase family, member 8
chr7_-_42938304	0.539	NM_002787	PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2
chr7_+_42938463	0.520	NM_031903	MRPL32	mitochondrial ribosomal protein L32
chr15_+_67393795	0.513	NM_001104554	PAQR5	progestin and adipoQ receptor family member V
chr2_+_234191029	0.509	NM_019076	UGT1A8	UDP glucuronosyltransferase 1 family, polypeptide A8
chr18_+_18989786	0.506	NM_138375	CABLES1	Cdk5 and Abl enzyme substrate 1
chr10_-_13789628	0.506		FRMD4A	FERM domain containing 4A
chr11_+_5602782	0.498	NM_021616	TRIM34	tripartite motif containing 34
chr11_-_4371463	0.494	NM_003141	TRIM21	tripartite motif containing 21
chr6_+_3204184	0.484		PSMG4	proteasome (prosome, macropain) assembly chaperone 4
chr6_-_33389825	0.478		TAPBP	TAP binding protein (tapasin)
chr12_+_25096755	0.470		LRMP	lymphoid-restricted membrane protein
chr2_+_234209838	0.460	NM_019075	UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10
chr7_+_128367961	0.458	NM_001098627	IRF5	interferon regulatory factor 5
chr12_+_27511009	0.456	NM_001145010	C12orf70	chromosome 12 open reading frame 70
chr2_-_202216451	0.449	NM_001044385	ALS2CR4	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr8_-_38324809	0.442		WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1
chr14_-_23981493	0.438	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr2_-_224611568	0.437	NM_001136530	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr11_+_63060848	0.437	NM_004585	RARRES3	retinoic acid receptor responder (tazarotene induced) 3
chr4_-_100359353	0.425	NM_000672 NM_001102470	ADH6	alcohol dehydrogenase 6 (class V)
chr6_-_130072971	0.414	NM_033515	ARHGAP18	Rho GTPase activating protein 18
chr2_+_178893216	0.410	NM_145739	OSBPL6	oxysterol binding protein-like 6
chr2_+_205118710	0.394	NM_057177 NM_152526 NM_205863	PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)
chr14_-_22549168	0.393	NM_001130706 NM_001130708 NM_021944	C14orf93	chromosome 14 open reading frame 93
chr5_+_139869819	0.382
chr1_-_142535878	0.376		LOC100286793 FLJ39739	hypothetical LOC100286793 hypothetical FLJ39739
chr3_+_115099007	0.373	NM_001172105	GRAMD1C	GRAM domain containing 1C
chr6_-_105691675	0.370		BVES	blood vessel epicardial substance
chr17_+_6599879	0.366	NM_017523 NM_199139	XAF1	XIAP associated factor 1
chr8_-_42184350	0.363	NM_000930 NM_033011	PLAT	plasminogen activator, tissue
chr10_+_92970302	0.362	NM_032373	PCGF5	polycomb group ring finger 5
chr1_-_44269719	0.360	NM_001024845	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_-_32919751	0.360	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr1_-_242073094	0.356	NM_005465 NM_181690	AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr10_-_82039158	0.355	NM_000429	MAT1A	methionine adenosyltransferase I, alpha
chr11_+_28086373	0.354	NM_001113528 NM_152636	METTL15	methyltransferase like 15
chr2_+_205118961	0.348		PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)
chr3_+_120495906	0.345	NM_020754	ARHGAP31	Rho GTPase activating protein 31
chr4_-_48477021	0.343		FRYL	FRY-like
chr6_-_112682459	0.342	NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290	LAMA4	laminin, alpha 4
chr4_+_88075176	0.341	NM_001166693	AFF1	AF4/FMR2 family, member 1
chr20_-_34102250	0.341		LOC647979	hypothetical LOC647979
chr20_+_44070946	0.338	NM_004994	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr4_+_14985272	0.338	NM_001135171	C1QTNF7	C1q and tumor necrosis factor related protein 7
chr1_-_7998265	0.334		ERRFI1	ERBB receptor feedback inhibitor 1
chr21_-_42219849	0.333	NM_199050	C2CD2	C2 calcium-dependent domain containing 2
chr20_+_18396030	0.330	NM_006466	POLR3F	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr22_+_37766554	0.320	NM_001006666 NM_145298	APOBEC3F	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
chr11_-_85108030	0.317	NM_001162952 NM_206930	SYTL2	synaptotagmin-like 2
chr1_-_219982081	0.314	NM_007207 NM_144729	DUSP10	dual specificity phosphatase 10
chr2_+_17585287	0.313	NM_003385	VSNL1	visinin-like 1
chr16_-_28425632	0.308	NM_145659	IL27	interleukin 27
chr12_-_54995923	0.308		CNPY2	canopy 2 homolog (zebrafish)
chr1_-_44269615	0.304		SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_92301147	0.296	NM_001259	CDK6	cyclin-dependent kinase 6
chr5_-_75044001	0.291	NM_152408	POC5	POC5 centriolar protein homolog (Chlamydomonas)
chr1_-_143232275	0.288		LOC728855	hypothetical LOC728855
chr19_-_23370066	0.288	NM_003430	ZNF91	zinc finger protein 91
chr22_+_20880112	0.288
chr22_+_20880159	0.287		IGLV6-57	immunoglobulin lambda variable 6-57
chr16_-_10696285	0.285	NM_144674	TEKT5	tektin 5
chr8_+_39890484	0.285	NM_002164	IDO1	indoleamine 2,3-dioxygenase 1
chr4_-_185632610	0.279	NM_002199	IRF2	interferon regulatory factor 2
chr1_-_219982049	0.274		DUSP10	dual specificity phosphatase 10
chr17_+_75851984	0.270
chr8_-_145132551	0.264		PARP10	poly (ADP-ribose) polymerase family, member 10
chr2_-_151854619	0.250	NM_004688	NMI	N-myc (and STAT) interactor
chr19_+_12966970	0.247	NM_002501	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr8_+_97575196	0.244		SDC2	syndecan 2
chr15_-_39195701	0.242		INO80	INO80 homolog (S. cerevisiae)
chr8_+_144711619	0.242	NM_024736	GSDMD	gasdermin D
chr15_+_72620570	0.240	NM_006465	ARID3B	AT rich interactive domain 3B (BRIGHT-like)
chr4_+_76868850	0.238	NM_003715	USO1	USO1 vesicle docking protein homolog (yeast)
chr6_-_25044156	0.237		FAM65B	family with sequence similarity 65, member B
chr7_-_86686754	0.237	NM_024315	C7orf23	chromosome 7 open reading frame 23
chr20_+_9963696	0.234	NM_022096 NM_198798	ANKRD5	ankyrin repeat domain 5
chr17_+_38412267	0.231	NM_005533	IFI35	interferon-induced protein 35
chr12_-_54996044	0.230		CNPY2	canopy 2 homolog (zebrafish)
chr2_+_121271336	0.219	NM_005270	GLI2	GLI family zinc finger 2
chr1_-_116185215	0.218	NM_005599	NHLH2	nescient helix loop helix 2
chr20_+_56397695	0.216		VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_110254979	0.212		CSF1	colony stimulating factor 1 (macrophage)
chr1_-_2486313	0.210	NM_003820	TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr20_-_18395622	0.208	NM_001099407	C20orf12	chromosome 20 open reading frame 12
chr12_+_68923043	0.208	NM_014515	CNOT2	CCR4-NOT transcription complex, subunit 2
chr9_+_136673464	0.206	NM_000093	COL5A1	collagen, type V, alpha 1
chr11_+_59001421	0.205	NM_001004705	OR4D10	olfactory receptor, family 4, subfamily D, member 10
chr9_+_33785558	0.205	NM_002771	PRSS3	protease, serine, 3
chr14_+_72594985	0.203		RBM25	RNA binding motif protein 25
chr1_+_210848592	0.202	NM_001040619 NM_001674	ATF3	activating transcription factor 3
chr8_-_42184194	0.202		PLAT	plasminogen activator, tissue
chr6_+_26070957	0.202	NM_006355	TRIM38	tripartite motif containing 38
chr2_+_17585462	0.201		VSNL1	visinin-like 1
chr19_-_11500912	0.199	NM_001142464 NM_001142465 NM_016581	ECSIT	ECSIT homolog (Drosophila)
chr8_-_143864933	0.197	NM_003695	LY6D	lymphocyte antigen 6 complex, locus D
chr19_+_61202902	0.195	NM_153447	NLRP5	NLR family, pyrin domain containing 5
chr10_+_122600843	0.191		WDR11	WD repeat domain 11
chr1_+_32438788	0.187	NM_024296	CCDC28B	coiled-coil domain containing 28B
chr14_+_72595020	0.182		RBM25	RNA binding motif protein 25
chr6_+_32919873	0.177
chr3_-_44527083	0.175		ZNF852	zinc finger protein 852
chr3_-_69212192	0.175	NM_003968 NM_198195	UBA3	ubiquitin-like modifier activating enzyme 3
chr8_+_97575244	0.174		SDC2	syndecan 2
chr1_+_17779528	0.172	NM_001011722	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr20_+_337346	0.171		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr16_-_66528235	0.171	NM_002801	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr8_-_145132582	0.170	NM_032789	PARP10	poly (ADP-ribose) polymerase family, member 10
chr8_+_97575052	0.170	NM_002998	SDC2	syndecan 2
chr1_+_210848726	0.170		ATF3	activating transcription factor 3
chr9_+_108665168	0.167	NM_021224	ZNF462	zinc finger protein 462
chr7_+_134114957	0.164		CALD1	caldesmon 1
chr4_-_48477038	0.161	NM_015030	FRYL	FRY-like
chr15_-_29181198	0.158	NM_002420	TRPM1	transient receptor potential cation channel, subfamily M, member 1
chr10_-_73167586	0.158	NM_001168390	C10orf105	chromosome 10 open reading frame 105
chr13_+_30207690	0.157		ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr6_+_30018287	0.155	NM_002116	HLA-A	major histocompatibility complex, class I, A
chr11_-_10546654	0.154	NM_006691	LYVE1	lymphatic vessel endothelial hyaluronan receptor 1
chr1_-_143232344	0.154		LOC728855	hypothetical LOC728855
chr2_+_148495043	0.152	NM_018328	MBD5	methyl-CpG binding domain protein 5
chrX_-_118711088	0.151		SEPT6	septin 6

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
6.70	1.49e-04	GO:0050790	regulation of catalytic activity
9.01	3.23e-04	GO:0043085	positive regulation of catalytic activity
5.44	1.01e-03	GO:0065009	regulation of molecular function
7.72	1.03e-03	GO:0044093	positive regulation of molecular function
26.31	3.73e-03	GO:0000084	S phase of mitotic cell cycle
25.84	4.01e-03	GO:0051320	S phase
21.38	8.48e-03	GO:0010565	regulation of cellular ketone metabolic process
6.95	9.69e-03	GO:0031399	regulation of protein modification process
20.46	1.01e-02	GO:0000082	G1/S transition of mitotic cell cycle
3.07	1.13e-02	GO:0007165	signal transduction
40.19	1.45e-02	GO:0006521	regulation of cellular amino acid metabolic process
2.94	1.82e-02	GO:0080090	regulation of primary metabolic process
2.90	2.12e-02	GO:0031323	regulation of cellular metabolic process
34.93	2.21e-02	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
34.93	2.21e-02	GO:0072395	signal transduction involved in cell cycle checkpoint
34.93	2.21e-02	GO:0072401	signal transduction involved in DNA integrity checkpoint
34.93	2.21e-02	GO:0072404	signal transduction involved in G1/S transition checkpoint
34.93	2.21e-02	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
34.93	2.21e-02	GO:0072422	signal transduction involved in DNA damage checkpoint
34.93	2.21e-02	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
34.93	2.21e-02	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
33.29	2.55e-02	GO:0033238	regulation of cellular amine metabolic process
33.29	2.55e-02	GO:0071158	positive regulation of cell cycle arrest
31.80	2.93e-02	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
31.34	3.06e-02	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
2.78	3.33e-02	GO:0023052	signaling
30.44	3.33e-02	GO:0051352	negative regulation of ligase activity
30.44	3.33e-02	GO:0051444	negative regulation of ubiquitin-protein ligase activity
30.02	3.48e-02	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.69	3.91e-02	GO:0035556	intracellular signal transduction
27.68	4.43e-02	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.44	4.58e-02	GO:0032268	regulation of cellular protein metabolic process
27.33	4.60e-02	GO:0000216	M/G1 transition of mitotic cell cycle
27.33	4.60e-02	GO:0031575	mitotic cell cycle G1/S transition checkpoint
27.33	4.60e-02	GO:0051443	positive regulation of ubiquitin-protein ligase activity
27.33	4.60e-02	GO:0071779	G1/S transition checkpoint
3.19	4.68e-02	GO:0051171	regulation of nitrogen compound metabolic process
26.64	4.96e-02	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
472.96	2.55e-04	GO:0008537	proteasome activator complex
33.82	3.97e-03	GO:0000502	proteasome complex
118.27	5.56e-03	GO:0022624	proteasome accessory complex

Nothing significant found in function category.