Motif ID: REST.p3

Z-value: 4.186


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor



Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_134447795 22.796 NM_020064
 BARHL1
BarH-like homeobox 1
chr2_-_27384617 17.528 NM_003353
 UCN
urocortin
chr3_+_9720509 15.924 NM_153635
 CPNE9
copine family member IX
chr6_+_110406890 13.685 NM_005284
 GPR6
G protein-coupled receptor 6
chr8_-_145530639 13.147 NM_031309
 SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr5_-_151284515 12.666 NM_000171
NM_001146040
 GLRA1

glycine receptor, alpha 1

chr4_+_158361185 12.590 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr15_+_65904994 12.104 NM_001031807
 SKOR1
SKI family transcriptional corepressor 1
chr5_+_71050745 11.766 NM_004291
 CARTPT
CART prepropeptide
chr7_+_154943466 10.774 NM_001427
 EN2
engrailed homeobox 2
chr7_-_19778928 10.700 NM_152774
 TMEM196
transmembrane protein 196
chr10_+_26545599 10.335 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_57521065 10.321 NM_006211
 PENK
proenkephalin
chr19_-_60383280 9.662 NM_003180
 SYT5
synaptotagmin V
chr12_-_3472245 8.794 LOC100129223
hypothetical LOC100129223
chr14_-_50631407 8.758 TRIM9
tripartite motif containing 9
chr20_+_30019465 8.745 NM_001011718
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr5_+_33972247 8.660 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr8_+_57520915 8.655


chr9_-_138236775 8.266 NM_178138
 LHX3
LIM homeobox 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 66 entries
Enrichment   P-value GO Accession GO Term
138.43 3.45e-02 GO:0034776 response to histamine
69.22 4.44e-03 GO:0010155 regulation of proton transport
56.64 8.65e-03 GO:0032225 regulation of synaptic transmission, dopaminergic
47.92 1.49e-02 GO:0051954 positive regulation of amine transport
41.54 2.35e-02 GO:0042749 regulation of circadian sleep/wake cycle
41.54 2.35e-02 GO:0045187 regulation of circadian sleep/wake cycle, sleep
38.94 2.89e-02 GO:0022410 circadian sleep/wake cycle process
37.76 1.70e-03 GO:0014073 response to tropane
37.76 1.70e-03 GO:0042220 response to cocaine
36.65 3.49e-02 GO:0007212 dopamine receptor signaling pathway
36.65 3.49e-02 GO:0042745 circadian sleep/wake cycle
34.62 2.46e-03 GO:0060078 regulation of postsynaptic membrane potential
34.62 4.18e-02 GO:0035176 social behavior
34.62 4.18e-02 GO:0048512 circadian behavior
32.79 4.94e-02 GO:0007622 rhythmic behavior
31.95 3.43e-03 GO:0050433 regulation of catecholamine secretion
30.77 4.02e-03 GO:0045776 negative regulation of blood pressure
28.07 4.38e-04 GO:0051952 regulation of amine transport
16.76 5.92e-03 GO:0007269 neurotransmitter secretion
15.74 8.06e-03 GO:0007631 feeding behavior

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
103.82 1.35e-02 GO:0032590 dendrite membrane
36.65 6.86e-03 GO:0032589 neuron projection membrane
32.31 1.74e-07 GO:0030672 synaptic vesicle membrane
21.74 2.87e-08 GO:0008021 synaptic vesicle
17.11 1.63e-05 GO:0030665 clathrin coated vesicle membrane
12.65 1.29e-04 GO:0030662 coated vesicle membrane
11.69 7.08e-06 GO:0030136 clathrin-coated vesicle
10.86 5.80e-10 GO:0044456 synapse part
9.83 6.91e-04 GO:0045211 postsynaptic membrane
9.73 1.60e-04 GO:0043025 neuronal cell body
9.55 4.00e-05 GO:0030135 coated vesicle
9.45 1.98e-04 GO:0044297 cell body
8.80 3.37e-04 GO:0030425 dendrite
8.60 3.61e-09 GO:0045202 synapse
8.12 3.51e-08 GO:0043005 neuron projection
8.03 4.32e-05 GO:0030659 cytoplasmic vesicle membrane
7.76 5.91e-05 GO:0012506 vesicle membrane
6.67 2.34e-04 GO:0044433 cytoplasmic vesicle part
5.85 9.73e-07 GO:0030054 cell junction
4.85 1.30e-05 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
138.43 6.58e-03 GO:0001591 dopamine receptor activity, coupled via Gi/Go
103.82 1.31e-02 GO:0016933 extracellular-glycine-gated ion channel activity
103.82 1.31e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
83.06 2.18e-02 GO:0004952 dopamine receptor activity
83.06 2.18e-02 GO:0022824 transmitter-gated ion channel activity
83.06 2.18e-02 GO:0022835 transmitter-gated channel activity
69.22 3.26e-02 GO:0005237 inhibitory extracellular ligand-gated ion channel activity
47.92 2.84e-03 GO:0016594 glycine binding
39.56 2.67e-04 GO:0005184 neuropeptide hormone activity
22.10 2.83e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
21.49 3.43e-02 GO:0043178 alcohol binding
17.31 1.18e-04 GO:0005230 extracellular ligand-gated ion channel activity
10.50 1.09e-02 GO:0005179 hormone activity
10.14 2.64e-03 GO:0043176 amine binding
9.98 2.90e-03 GO:0015276 ligand-gated ion channel activity
9.98 2.90e-03 GO:0022834 ligand-gated channel activity
4.37 4.60e-02 GO:0005216 ion channel activity