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• Activity deltas table
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Motif ID: REST.p3

Z-value: 4.186

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_+_134447795	22.796	NM_020064	BARHL1	BarH-like homeobox 1
chr2_-_27384617	17.528	NM_003353	UCN	urocortin
chr3_+_9720509	15.924	NM_153635	CPNE9	copine family member IX
chr6_+_110406890	13.685	NM_005284	GPR6	G protein-coupled receptor 6
chr8_-_145530639	13.147	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr5_-_151284515	12.666	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr4_+_158361185	12.590	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr15_+_65904994	12.104	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr5_+_71050745	11.766	NM_004291	CARTPT	CART prepropeptide
chr7_+_154943466	10.774	NM_001427	EN2	engrailed homeobox 2
chr7_-_19778928	10.700	NM_152774	TMEM196	transmembrane protein 196
chr10_+_26545599	10.335		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_57521065	10.321	NM_006211	PENK	proenkephalin
chr19_-_60383280	9.662	NM_003180	SYT5	synaptotagmin V
chr12_-_3472245	8.794		LOC100129223	hypothetical LOC100129223
chr14_-_50631407	8.758		TRIM9	tripartite motif containing 9
chr20_+_30019465	8.745	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr5_+_33972247	8.660	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr8_+_57520915	8.655
chr9_-_138236775	8.266	NM_178138	LHX3	LIM homeobox 3
chr20_+_44091265	8.221		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr3_-_48675321	8.084	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr11_-_27698800	8.026	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr20_+_44091219	7.995	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr3_-_133236447	7.907	NM_130808	CPNE4	copine IV
chr8_-_91164100	7.758	NM_004929	CALB1	calbindin 1, 28kDa
chr11_-_74818858	7.655		KLHL35	kelch-like 35 (Drosophila)
chr11_-_74819165	7.629	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr11_+_627268	7.559	NM_000797	DRD4	dopamine receptor D4
chr2_+_207215386	7.470	NM_001102659	LOC200726	hCG1657980
chr11_+_22316242	7.335	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr3_+_122109716	7.103	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr1_-_149955870	7.066	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr11_-_74818685	6.942		KLHL35	kelch-like 35 (Drosophila)
chr11_-_122357545	6.737	NM_001098169	BSX	brain-specific homeobox
chr17_+_1120607	6.675	NM_001164405	BHLHA9	basic helix-loop-helix family, member a9
chr20_-_10148137	6.509		LOC100131208	similar to hCG2045825
chr14_-_73962557	6.249	NM_001105579	TMEM90A	transmembrane protein 90A
chr17_-_24357014	6.240	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr1_+_208178160	6.141	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr14_+_92459197	6.108	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr14_-_50631794	5.784		TRIM9	tripartite motif containing 9
chr10_+_26545241	5.683	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_208178198	5.659		SYT14	synaptotagmin XIV
chr9_+_139153409	5.659	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr14_+_92459244	5.416		CHGA	chromogranin A (parathyroid secretory protein 1)
chr4_-_175986952	5.397	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr19_-_45416043	5.346		TTC9B	tetratricopeptide repeat domain 9B
chr14_-_104142125	5.191	NM_207379	TMEM179	transmembrane protein 179
chr19_-_45416112	4.950	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr6_+_154402135	4.505	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145285 NM_001145286 NM_001145284	OPRM1	opioid receptor, mu 1
chr7_+_8440541	4.409		NXPH1	neurexophilin 1
chr7_-_100595552	4.409	NM_003378	VGF	VGF nerve growth factor inducible
chr15_-_70399181	4.373		CELF6	CUGBP, Elav-like family member 6
chr3_-_188870799	4.298	NM_001048	SST	somatostatin
chr11_+_45863774	4.120	NM_005456	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr15_+_73074882	4.015	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr4_+_8633116	3.993	NM_080819	GPR78	G protein-coupled receptor 78
chr1_+_33124658	3.972	NM_002143	HPCA	hippocalcin
chr2_-_51112743	3.950		NRXN1	neurexin 1
chr12_+_111714096	3.881		RPH3A	rabphilin 3A homolog (mouse)
chr1_-_102234959	3.864		OLFM3	olfactomedin 3
chr7_+_8440109	3.766	NM_152745	NXPH1	neurexophilin 1
chr3_-_115380539	3.724	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr5_-_135729062	3.642	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr16_+_66244314	3.608		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr20_-_60228665	3.417	NM_007232	HRH3	histamine receptor H3
chr1_+_152806874	3.382	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr6_+_158877640	3.364		TMEM181	transmembrane protein 181
chr12_+_117903682	3.353	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr12_-_29828958	3.333	NM_175861	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr12_+_111713931	3.321	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr12_-_97812633	3.312		ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr17_+_77925441	3.217	NM_018949	UTS2R	urotensin 2 receptor
chr15_-_70399301	3.166	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr15_-_24570010	3.015	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr18_-_39111243	3.012	NM_020783	SYT4	synaptotagmin IV
chr19_-_44427446	2.991	NM_172139	IL28B	interleukin 28B (interferon, lambda 3)
chr11_-_125278296	2.984	NM_031307	PUS3	pseudouridylate synthase 3
chr20_-_61755145	2.893	NM_015894	STMN3	stathmin-like 3
chr1_-_102235377	2.853	NM_058170	OLFM3	olfactomedin 3
chr17_+_70178850	2.790	NM_175738	RAB37	RAB37, member RAS oncogene family
chr10_+_69990050	2.787	NM_030625	TET1	tet oncogene 1
chr12_-_29827952	2.713	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr17_+_70178911	2.626		RAB37	RAB37, member RAS oncogene family
chr15_-_70399551	2.440	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr19_+_4720144	2.314		C19orf30	chromosome 19 open reading frame 30
chr15_-_70399523	2.296		CELF6	CUGBP, Elav-like family member 6
chr6_+_158877455	2.287	NM_020823	TMEM181	transmembrane protein 181
chr10_-_44200458	2.202	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr7_+_145444385	2.146	NM_014141	CNTNAP2	contactin associated protein-like 2
chr19_+_45728270	1.974		SPTBN4	spectrin, beta, non-erythrocytic 4
chr12_+_46133	1.970	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr1_-_239587090	1.887	NM_002924	RGS7	regulator of G-protein signaling 7
chr9_-_73251639	1.833		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr17_-_3248453	1.831	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr2_+_114916368	1.826	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr5_+_175231098	1.784	NM_001008220	CPLX2	complexin 2
chr8_-_145723209	1.775	NM_001024678	LRRC24	leucine rich repeat containing 24
chr10_+_60607232	1.730	NM_001143774	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chr6_+_25760352	1.729	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr5_+_175231170	1.655
chr3_+_62279707	1.601		C3orf14	chromosome 3 open reading frame 14
chrX_-_47364039	1.599
chr5_+_175231210	1.594		CPLX2	complexin 2
chr11_-_1725924	1.525	NM_001170820	LOC402778	CD225 family protein FLJ76511
chrX_-_47364173	1.452	NM_006950 NM_133499	SYN1	synapsin I
chr10_-_50640327	1.427	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr7_+_8439762	1.425		NXPH1	neurexophilin 1
chr16_+_2959362	1.399		PAQR4	progestin and adipoQ receptor family member IV
chr16_+_2959342	1.320	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr18_-_5187240	1.319	NM_001145194	LOC642597	hypothetical protein LOC642597
chr10_-_102780840	1.284		PDZD7	PDZ domain containing 7
chr19_+_45728207	1.279	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr10_-_102780867	1.250	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr2_-_51113040	1.162	NM_001135659 NM_004801	NRXN1	neurexin 1
chr5_-_175969697	1.156	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr15_+_67009892	1.150	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr3_+_52787478	1.077	NM_001166434	ITIH1	inter-alpha (globulin) inhibitor H1
chr6_+_153113624	1.061	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr11_-_6633427	0.971	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr10_+_102780974	0.930	NM_030971	SFXN3	sideroflexin 3
chr11_-_1725662	0.902		LOC402778	CD225 family protein FLJ76511
chr2_+_131230252	0.898	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr1_+_152806924	0.898		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_-_239587007	0.897		RGS7	regulator of G-protein signaling 7
chr8_+_69027143	0.837	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_69026895	0.812		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_39741306	0.804	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr19_-_50429306	0.802	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr15_-_29950070	0.795		OTUD7A	OTU domain containing 7A
chr8_+_69027277	0.779		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_80685859	0.771		STMN2	stathmin-like 2
chr16_+_24175173	0.744		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr5_+_175231144	0.719		CPLX2	complexin 2
chr18_+_55718171	0.711	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr17_-_3283884	0.587	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr1_-_151390050	0.586	NM_001014291	SPRR2G	small proline-rich protein 2G
chr15_-_29950188	0.566		OTUD7A	OTU domain containing 7A
chr3_+_62280435	0.532	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr5_+_141283550	0.531	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr16_+_24174975	0.520		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr12_+_112280757	0.504		PLBD2	phospholipase B domain containing 2
chr1_-_33108876	0.496	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chrX_-_152794478	0.404		L1CAM	L1 cell adhesion molecule
chr20_+_35445350	0.373		SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr11_-_123030091	0.363		SCN3B	sodium channel, voltage-gated, type III, beta
chr17_-_3546236	0.348	NM_002561 NM_175080 NM_175081	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 read-through transcript purinergic receptor P2X, ligand-gated ion channel, 5
chr6_+_35881048	0.345	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr20_+_5839973	0.309	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr5_+_141283647	0.275		KIAA0141	KIAA0141
chr11_-_27677755	0.265	NM_170734	BDNF	brain-derived neurotrophic factor
chr12_+_112280753	0.261	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chrX_-_48943582	0.248	NM_003179	SYP	synaptophysin
chr17_-_7095622	0.222	NM_001143775	CTDNEP1	CTD nuclear envelope phosphatase 1
chr6_-_32121784	0.168	NM_032470	TNXB	tenascin XB
chr19_+_51804260	0.167		CALM3	calmodulin 3 (phosphorylase kinase, delta)
chr1_+_100777044	0.128		GPR88	G protein-coupled receptor 88
chrX_-_152794592	0.111	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr1_-_20707103	0.107		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chrX_+_152891184	0.090	NM_003492	TMEM187	transmembrane protein 187
chr8_-_94046891	0.087	NM_001191036	C8orf83	chromosome 8 open reading frame 83
chr1_-_20707196	0.074	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr22_-_16636748	0.072	NM_197966	BID	BH3 interacting domain death agonist
chr2_-_96174502	0.042		DUSP2	dual specificity phosphatase 2
chr10_+_73225533	0.004	NM_001171933 NM_001171934	CDH23	cadherin-related 23

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
9.30	9.88e-12	GO:0019226	transmission of nerve impulse
9.30	9.88e-12	GO:0035637	multicellular organismal signaling
9.92	1.53e-11	GO:0007268	synaptic transmission
3.90	2.24e-08	GO:0003008	system process
6.05	2.73e-08	GO:0007267	cell-cell signaling
4.37	2.77e-08	GO:0050877	neurological system process
10.04	4.63e-08	GO:0007610	behavior
7.74	3.48e-07	GO:0046903	secretion
4.78	6.16e-07	GO:0007154	cell communication
6.64	8.07e-07	GO:0007186	G-protein coupled receptor protein signaling pathway
13.65	9.37e-06	GO:0031644	regulation of neurological system process
6.61	3.46e-05	GO:0055082	cellular chemical homeostasis
13.41	6.98e-05	GO:0051969	regulation of transmission of nerve impulse
15.64	1.54e-04	GO:0007626	locomotory behavior
6.32	1.88e-04	GO:0006873	cellular ion homeostasis
5.21	1.92e-04	GO:0048878	chemical homeostasis
1.94	2.88e-04	GO:0032501	multicellular organismal process
5.45	3.15e-04	GO:0019725	cellular homeostasis
13.72	3.77e-04	GO:0003001	generation of a signal involved in cell-cell signaling
13.72	3.77e-04	GO:0023061	signal release
28.07	4.38e-04	GO:0051952	regulation of amine transport
5.83	4.41e-04	GO:0050801	ion homeostasis
7.15	6.36e-04	GO:0032940	secretion by cell
6.71	1.12e-03	GO:0044057	regulation of system process
8.94	1.52e-03	GO:0055074	calcium ion homeostasis
37.76	1.70e-03	GO:0014073	response to tropane
37.76	1.70e-03	GO:0042220	response to cocaine
14.33	1.89e-03	GO:0001505	regulation of neurotransmitter levels
8.62	2.00e-03	GO:0072507	divalent inorganic cation homeostasis
2.11	2.29e-03	GO:0023052	signaling
34.62	2.46e-03	GO:0060078	regulation of postsynaptic membrane potential
31.95	3.43e-03	GO:0050433	regulation of catecholamine secretion
30.77	4.02e-03	GO:0045776	negative regulation of blood pressure
69.22	4.44e-03	GO:0010155	regulation of proton transport
12.35	4.50e-03	GO:0006836	neurotransmitter transport
12.11	5.04e-03	GO:0008217	regulation of blood pressure
16.76	5.92e-03	GO:0007269	neurotransmitter secretion
6.33	6.03e-03	GO:0051046	regulation of secretion
11.65	6.27e-03	GO:0007611	learning or memory
6.12	7.85e-03	GO:0055080	cation homeostasis
15.74	8.06e-03	GO:0007631	feeding behavior
11.13	8.15e-03	GO:0050804	regulation of synaptic transmission
56.64	8.65e-03	GO:0032225	regulation of synaptic transmission, dopaminergic
15.28	9.33e-03	GO:0030534	adult behavior
10.66	1.04e-02	GO:0050890	cognition
3.65	1.19e-02	GO:0042592	homeostatic process
8.09	1.26e-02	GO:0006874	cellular calcium ion homeostasis
2.47	1.35e-02	GO:0065008	regulation of biological quality
47.92	1.49e-02	GO:0051954	positive regulation of amine transport
7.83	1.55e-02	GO:0072503	cellular divalent inorganic cation homeostasis
7.78	1.61e-02	GO:0003013	circulatory system process
7.78	1.61e-02	GO:0008015	blood circulation
6.35	1.84e-02	GO:0055065	metal ion homeostasis
12.99	2.06e-02	GO:0051048	negative regulation of secretion
41.54	2.35e-02	GO:0042749	regulation of circadian sleep/wake cycle
41.54	2.35e-02	GO:0045187	regulation of circadian sleep/wake cycle, sleep
12.23	2.76e-02	GO:0007218	neuropeptide signaling pathway
5.97	2.87e-02	GO:0030003	cellular cation homeostasis
38.94	2.89e-02	GO:0022410	circadian sleep/wake cycle process
138.43	3.45e-02	GO:0034776	response to histamine
36.65	3.49e-02	GO:0007212	dopamine receptor signaling pathway
36.65	3.49e-02	GO:0042745	circadian sleep/wake cycle
34.62	4.18e-02	GO:0035176	social behavior
34.62	4.18e-02	GO:0048512	circadian behavior
10.83	4.93e-02	GO:0045761	regulation of adenylate cyclase activity
32.79	4.94e-02	GO:0007622	rhythmic behavior

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
10.86	5.80e-10	GO:0044456	synapse part
8.60	3.61e-09	GO:0045202	synapse
21.74	2.87e-08	GO:0008021	synaptic vesicle
8.12	3.51e-08	GO:0043005	neuron projection
32.31	1.74e-07	GO:0030672	synaptic vesicle membrane
5.85	9.73e-07	GO:0030054	cell junction
11.69	7.08e-06	GO:0030136	clathrin-coated vesicle
4.85	1.30e-05	GO:0016023	cytoplasmic membrane-bounded vesicle
17.11	1.63e-05	GO:0030665	clathrin coated vesicle membrane
4.76	1.68e-05	GO:0031988	membrane-bounded vesicle
4.31	2.71e-05	GO:0042995	cell projection
4.57	2.96e-05	GO:0031410	cytoplasmic vesicle
9.55	4.00e-05	GO:0030135	coated vesicle
8.03	4.32e-05	GO:0030659	cytoplasmic vesicle membrane
4.42	4.57e-05	GO:0031982	vesicle
7.76	5.91e-05	GO:0012506	vesicle membrane
12.65	1.29e-04	GO:0030662	coated vesicle membrane
9.73	1.60e-04	GO:0043025	neuronal cell body
9.45	1.98e-04	GO:0044297	cell body
6.67	2.34e-04	GO:0044433	cytoplasmic vesicle part
8.80	3.37e-04	GO:0030425	dendrite
9.83	6.91e-04	GO:0045211	postsynaptic membrane
2.45	1.92e-03	GO:0044459	plasma membrane part
36.65	6.86e-03	GO:0032589	neuron projection membrane
103.82	1.35e-02	GO:0032590	dendrite membrane

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
17.31	1.18e-04	GO:0005230	extracellular ligand-gated ion channel activity
39.56	2.67e-04	GO:0005184	neuropeptide hormone activity
22.10	2.83e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
10.14	2.64e-03	GO:0043176	amine binding
47.92	2.84e-03	GO:0016594	glycine binding
9.98	2.90e-03	GO:0015276	ligand-gated ion channel activity
9.98	2.90e-03	GO:0022834	ligand-gated channel activity
138.43	6.58e-03	GO:0001591	dopamine receptor activity, coupled via Gi/Go
10.50	1.09e-02	GO:0005179	hormone activity
103.82	1.31e-02	GO:0016933	extracellular-glycine-gated ion channel activity
103.82	1.31e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
83.06	2.18e-02	GO:0004952	dopamine receptor activity
83.06	2.18e-02	GO:0022824	transmitter-gated ion channel activity
83.06	2.18e-02	GO:0022835	transmitter-gated channel activity
69.22	3.26e-02	GO:0005237	inhibitory extracellular ligand-gated ion channel activity
21.49	3.43e-02	GO:0043178	alcohol binding
4.37	4.60e-02	GO:0005216	ion channel activity