Motif ID: RUNX1..3.p2

Z-value: 2.179


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3



Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21318779 3.031 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr17_-_3442871 2.508 NM_080706
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr20_-_23915431 2.253 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr7_+_142850667 2.248 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr6_+_30212488 2.239 NM_138700
TRIM40
tripartite motif containing 40
chr1_+_22200735 2.104 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr11_-_31782169 2.023 PAX6
paired box 6
chr1_+_207995999 1.986 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr13_+_112789669 1.974 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_166779825 1.856 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chrX_+_71280758 1.833 NM_207422
FLJ44635
TPT1-like protein
chr6_+_155579788 1.768 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_11490487 1.749 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr14_+_60045621 1.738 NM_007374
SIX6
SIX homeobox 6
chr5_+_156628929 1.729 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr18_+_18989786 1.672 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr18_+_13601664 1.638 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr3_+_101811122 1.625 NM_032787
GPR128
G protein-coupled receptor 128
chr1_+_202000906 1.624 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr1_-_201583989 1.615 FMOD
fibromodulin
chr4_+_37262249 1.607 NM_018302
C4orf19
chromosome 4 open reading frame 19
chr8_+_124032830 1.602 ZHX2
zinc fingers and homeoboxes 2
chr1_-_25164061 1.599 NM_001031680
RUNX3
runt-related transcription factor 3
chr22_+_20350272 1.579 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr5_-_76970129 1.538 OTP
orthopedia homeobox
chr19_+_3659358 1.527 TJP3
tight junction protein 3 (zona occludens 3)
chr9_+_129066576 1.476 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr17_-_45901173 1.470 NM_001267
CHAD
chondroadherin
chr1_+_20489998 1.442 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr16_+_70646008 1.428 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_22176004 1.417 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr5_-_76970264 1.392 NM_032109
OTP
orthopedia homeobox
chr1_-_205012348 1.372 NM_000572
IL10
interleukin 10
chr3_+_46594079 1.372 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr7_-_27149750 1.368 NM_019102
HOXA5
homeobox A5
chr9_-_129557373 1.364 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr22_+_21484240 1.337


chr15_+_72209642 1.316 NM_001130138
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr17_+_77910411 1.312 NM_207459
TEX19
testis expressed 19
chr7_-_44071640 1.310 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr10_+_114144512 1.289 ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_+_21116283 1.286


chr1_+_205068844 1.283 NM_013371
IL19
interleukin 19
chr21_+_43024936 1.272 PDE9A
phosphodiesterase 9A
chrX_-_30505804 1.265 NM_025159
CXorf21
chromosome X open reading frame 21
chr3_+_148609841 1.265 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr2_-_158008763 1.225 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_+_50342814 1.196 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr8_-_19584373 1.180 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr15_-_100280784 1.172 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr8_+_1940282 1.166 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr17_+_23818922 1.151


chr4_+_76700281 1.130 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr19_-_9098625 1.089 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr19_+_61624 1.089 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_+_42922653 1.085 NM_001134656
ZNF662
zinc finger protein 662
chr10_-_74384485 1.085 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr9_+_129893948 1.084 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_+_110074124 1.077 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chrX_+_21960841 1.068 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_+_166812466 1.068 NM_002995
XCL1
chemokine (C motif) ligand 1
chr16_-_66590856 1.067 NM_022355
DPEP2
dipeptidase 2
chrX_-_39921525 1.063 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr12_+_106692291 1.061 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr3_-_148607096 1.059 NM_032153
ZIC4
Zic family member 4
chr5_-_38631263 1.057 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr12_-_101396459 1.057 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_+_156490550 1.050 NM_001763
CD1A
CD1a molecule
chr1_+_32489426 1.046 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr11_-_74120077 1.046 CHRDL2
chordin-like 2
chr6_+_37511383 1.044


chr11_-_118799058 1.043 THY1
Thy-1 cell surface antigen
chr17_+_31112028 1.041 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr7_-_141048358 1.041 NM_001080392
KIAA1147
KIAA1147
chr17_-_77512346 1.040 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr2_-_233501069 1.032 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr17_+_45900688 1.032 ACSF2
acyl-CoA synthetase family member 2
chrX_-_49008115 1.026 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr21_-_38955487 1.020 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr4_-_1185144 1.013 LOC100130872
hypothetical LOC100130872
chr10_-_7699192 1.010 ITIH5
inter-alpha (globulin) inhibitor H5
chr1_-_171441234 1.009 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_+_19883745 1.002 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr22_+_21042091 0.998 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr8_-_134141586 0.998 NM_006748
SLA
Src-like-adaptor
chr11_+_57123927 0.992 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr10_-_74384569 0.988 PLA2G12B
phospholipase A2, group XIIB
chrX_-_100015783 0.984 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr14_-_93493519 0.983 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr6_+_45404031 0.978 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr7_-_27171600 0.976 HOXA9
homeobox A9
chr1_+_154478574 0.970 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr4_-_174687104 0.970 HAND2
heart and neural crest derivatives expressed 2
chr4_-_113656762 0.965 NM_024019
NEUROG2
neurogenin 2
chr2_-_21084077 0.960 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_24342158 0.956 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr5_-_140875591 0.955 DIAPH1
diaphanous homolog 1 (Drosophila)
chr13_-_36577800 0.948 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr4_-_174686918 0.940 HAND2
heart and neural crest derivatives expressed 2
chr2_-_74610323 0.932 AUP1
ancient ubiquitous protein 1
chr7_+_45033757 0.928 NM_001029835
CCM2
cerebral cavernous malformation 2
chr1_-_233879617 0.923 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr7_+_29200850 0.920 CHN2
chimerin (chimaerin) 2
chr3_+_186563529 0.917 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_159099090 0.916 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr3_+_42922405 0.913 NM_207404
ZNF662
zinc finger protein 662
chr1_-_181654027 0.911


chr22_+_17337970 0.909 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr15_-_41698251 0.898 NM_153700
STRC
stereocilin
chr12_-_66839589 0.897 NM_000619
IFNG
interferon, gamma
chr3_-_15515382 0.894 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr1_-_202432165 0.890 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr11_-_1006736 0.878 MUC6
mucin 6, oligomeric mucus/gel-forming
chr5_+_140733664 0.867 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr16_+_14187965 0.866 MKL2
MKL/myocardin-like 2
chr7_+_29200636 0.864 NM_004067
CHN2
chimerin (chimaerin) 2
chr10_-_62431203 0.860 RHOBTB1
Rho-related BTB domain containing 1
chr1_+_17507276 0.860 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr1_-_92724181 0.857 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr2_-_42573980 0.853 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr11_-_4893468 0.852 NM_001005238
OR51G2
olfactory receptor, family 51, subfamily G, member 2
chr14_+_28305922 0.849 NM_005249
FOXG1
forkhead box G1
chr16_-_70763524 0.847 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr19_-_4131778 0.842 SIRT6
sirtuin 6
chr1_+_199130571 0.841 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr1_+_165225121 0.840 NM_032858
MAEL
maelstrom homolog (Drosophila)
chr2_-_74610331 0.839 AUP1
ancient ubiquitous protein 1
chr1_+_20269239 0.837 NM_000929
PLA2G5
phospholipase A2, group V
chr11_+_8016755 0.834 NM_003320
TUB
tubby homolog (mouse)
chr15_+_36776090 0.834 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr18_-_72820939 0.832 MBP
myelin basic protein
chr1_-_205161821 0.824 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr13_+_112670757 0.822 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_-_74610332 0.821 AUP1
ancient ubiquitous protein 1
chr19_-_46048033 0.820 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr20_+_56919233 0.819 GNAS
GNAS complex locus
chr19_-_52666886 0.817 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr20_-_34707971 0.814 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr7_-_126679540 0.813 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr7_-_44195405 0.811 NM_000162
GCK
glucokinase (hexokinase 4)
chr19_+_59297953 0.810 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr2_-_74610263 0.805 AUP1
ancient ubiquitous protein 1
chr9_-_69669550 0.804 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr15_-_53440069 0.802 CCPG1
cell cycle progression 1
chr1_+_199108705 0.797 NM_005298
GPR25
G protein-coupled receptor 25
chr17_-_4747147 0.796 NM_000080
CHRNE
cholinergic receptor, nicotinic, epsilon
chr8_+_31616809 0.791 NM_013962
NRG1
neuregulin 1
chr5_+_75734759 0.788 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr3_-_42892195 0.783 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr1_+_154386358 0.780 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_-_27604656 0.779 WASF2
WAS protein family, member 2
chr1_+_32703225 0.776 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr5_+_137447479 0.773 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr1_+_153557263 0.772 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr9_-_34700062 0.772 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr1_+_226069968 0.771 NM_183062
PRSS38
protease, serine, 38
chr4_-_111777651 0.771 PITX2
paired-like homeodomain 2
chr11_-_5657947 0.769 TRIM5
tripartite motif containing 5
chr7_-_56128098 0.765 NM_006213
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr2_-_74610325 0.761 AUP1
ancient ubiquitous protein 1
chr12_+_45896511 0.760 FAM113B
family with sequence similarity 113, member B
chr16_-_70763849 0.756 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_+_28134090 0.755 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr1_-_177378801 0.754 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_156701895 0.749 NM_001004473
OR10K1
olfactory receptor, family 10, subfamily K, member 1
chr22_+_21384862 0.748 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr18_+_59726183 0.748 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr2_-_74610346 0.747 AUP1
ancient ubiquitous protein 1
chr1_+_39694849 0.741 MACF1
microtubule-actin crosslinking factor 1
chr1_-_209732881 0.738 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr22_+_20101661 0.737 NM_015094
HIC2
hypermethylated in cancer 2
chr4_-_55686503 0.737 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr15_+_39918302 0.736 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr11_+_92342436 0.730 NM_005959
MTNR1B
melatonin receptor 1B
chr4_-_79322295 0.729


chr3_-_10522267 0.728 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr11_-_56761250 0.726 NM_005161
APLNR
apelin receptor
chr10_-_72215116 0.724 NM_152710
C10orf27
chromosome 10 open reading frame 27
chr17_-_1478293 0.722 SLC43A2
solute carrier family 43, member 2
chr11_+_122214415 0.722 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr6_-_52217185 0.721 NM_052872
IL17F
interleukin 17F
chr17_-_31441390 0.721 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr8_-_143820825 0.717 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr11_+_36354110 0.717 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr6_-_68655708 0.712


chr5_+_54434230 0.711 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr8_+_143542378 0.708 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr13_-_27572646 0.706 NM_004119
FLT3
fms-related tyrosine kinase 3
chr2_-_73723001 0.704 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr2_+_74610333 0.697 HTRA2
HtrA serine peptidase 2
chr19_+_59657440 0.694


chr3_+_134976965 0.694 TF
transferrin
chr1_-_181654124 0.693 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr22_-_36305883 0.692 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr19_-_50797258 0.690 GPR4
G protein-coupled receptor 4
chr1_+_144124547 0.689 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr16_+_31105579 0.686


chr3_+_157491469 0.685 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr6_+_160247962 0.685 NM_002377
MAS1
MAS1 oncogene
chr11_+_120036237 0.685 NM_014619
GRIK4
glutamate receptor, ionotropic, kainate 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.13 3.29e-03 GO:0050863 regulation of T cell activation
79.94 3.34e-03 GO:0032689 negative regulation of interferon-gamma production
59.96 8.66e-03 GO:0050710 negative regulation of cytokine secretion
239.80 1.01e-02 GO:0002725 negative regulation of T cell cytokine production
24.61 1.18e-02 GO:0050868 negative regulation of T cell activation
8.12 1.38e-02 GO:0051249 regulation of lymphocyte activation
5.06 1.45e-02 GO:0010942 positive regulation of cell death
1.83 1.76e-02 GO:0032501 multicellular organismal process
6.45 1.85e-02 GO:0051050 positive regulation of transport
20.87 2.29e-02 GO:0002700 regulation of production of molecular mediator of immune response
20.87 2.29e-02 GO:0032649 regulation of interferon-gamma production
7.38 2.56e-02 GO:0002694 regulation of leukocyte activation
7.31 2.71e-02 GO:0045321 leukocyte activation
19.59 2.95e-02 GO:0051250 negative regulation of lymphocyte activation
12.37 3.00e-02 GO:0002683 negative regulation of immune system process
159.87 3.01e-02 GO:0002677 negative regulation of chronic inflammatory response
39.98 3.16e-02 GO:0050709 negative regulation of protein secretion
7.10 3.28e-02 GO:0050865 regulation of cell activation

Nothing significant found in compartment category.

Nothing significant found in function category.