Motif ID: SOX2.p2

Z-value: 1.430


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27186400 2.200 NM_153715
HOXA10
homeobox A10
chr6_+_114285209 2.170 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_-_139654807 2.091 NM_153235
TXLNB
taxilin beta
chr6_+_12398514 1.905 NM_001168319
NM_001955
EDN1

endothelin 1

chr17_+_34114924 1.562 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr1_-_224993498 1.484 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr7_+_128802719 1.434 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr17_-_44006808 1.399 NM_002146
HOXB3
homeobox B3
chr6_-_33028790 1.325 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_+_63252704 1.267 BPTF
bromodomain PHD finger transcription factor
chr1_-_115039614 1.225 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr7_+_153633127 1.225 NM_001936
DPP6
dipeptidyl-peptidase 6
chr11_-_85108030 1.220 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr1_-_7923464 1.080 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr6_+_21701942 1.080 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_-_125956996 1.055 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr11_-_85107569 1.030 NM_206929
SYTL2
synaptotagmin-like 2
chr17_+_63252668 0.999 BPTF
bromodomain PHD finger transcription factor
chr8_-_81155564 0.988 NM_001025252
TPD52
tumor protein D52
chr7_+_20336849 0.980 ITGB8
integrin, beta 8
chr18_-_27594696 0.972 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr5_-_71838875 0.971 NM_152625
ZNF366
zinc finger protein 366
chr10_-_62002672 0.962 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_110665188 0.956 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr1_-_32574185 0.951 NM_023009
MARCKSL1
MARCKS-like 1
chr16_-_71639670 0.925 NM_006885
ZFHX3
zinc finger homeobox 3
chr11_-_14342627 0.917 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr12_-_24606616 0.907 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr2_+_33213111 0.905 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_-_3127057 0.895 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr3_-_150422474 0.891 NM_000096
CP
ceruloplasmin (ferroxidase)
chr15_-_32398220 0.890 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr12_+_14429499 0.884 ATF7IP
activating transcription factor 7 interacting protein
chr4_+_146623405 0.884 NM_001003688
SMAD1
SMAD family member 1
chr3_-_150993299 0.862 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr7_+_27190688 0.859


chr1_+_12757570 0.852 NM_001080830
PRAMEF12
PRAME family member 12
chr10_-_13789628 0.832 FRMD4A
FERM domain containing 4A
chr2_-_1905508 0.824 MYT1L
myelin transcription factor 1-like
chr12_-_68369322 0.794 NM_152439
BEST3
bestrophin 3
chr6_+_155579788 0.790 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_29752909 0.788 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr2_-_70329067 0.769 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr4_+_37655385 0.759 TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr6_+_36752244 0.755 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr6_+_130381408 0.749 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr20_-_45418818 0.742 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr4_-_186969041 0.734 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr7_+_139175420 0.727 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_177106702 0.725 NM_004673
ANGPTL1
angiopoietin-like 1
chr5_-_111119846 0.722 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr13_+_92677012 0.722 NM_005708
GPC6
glypican 6
chr14_+_76298693 0.718 VASH1
vasohibin 1
chr1_+_144152864 0.705 TXNIP
thioredoxin interacting protein
chr9_-_35640852 0.703 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr5_-_160211623 0.699 NM_025153
ATP10B
ATPase, class V, type 10B
chr4_-_186969202 0.693 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr3_+_39484073 0.692 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr2_-_37752272 0.677 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr7_+_134114912 0.672 CALD1
caldesmon 1
chr1_-_26105954 0.668 NM_203399
STMN1
stathmin 1
chr5_+_143171918 0.667 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr3_-_194118321 0.653 MB21D2
Mab-21 domain containing 2
chr1_-_223907283 0.651 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr3_-_194118627 0.647 NM_178496
MB21D2
Mab-21 domain containing 2
chr17_+_55269974 0.646


chr11_+_36274300 0.639 NM_001160167
PRR5L
proline rich 5 like
chr2_-_218551786 0.630 TNS1
tensin 1
chr1_+_242281199 0.624 ZNF238
zinc finger protein 238
chr17_+_74542066 0.617 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr15_+_50098730 0.610 MAPK6
mitogen-activated protein kinase 6
chr12_+_47498778 0.606 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr8_-_28403652 0.605 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr18_+_27281729 0.598 NM_001944
DSG3
desmoglein 3
chr16_-_83703496 0.597 NM_198491
FAM92B
family with sequence similarity 92, member B
chr17_-_30783631 0.595 NM_018042
SLFN12
schlafen family member 12
chr4_-_187114407 0.592 SORBS2
sorbin and SH3 domain containing 2
chr21_+_36429079 0.592 NM_001236
CBR3
carbonyl reductase 3
chr7_+_134114957 0.583 CALD1
caldesmon 1
chr12_-_109842736 0.581 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr7_-_27190882 0.577 HOXA11
homeobox A11
chr22_-_20419975 0.570 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr17_-_39094787 0.567 NM_001040002
MEOX1
mesenchyme homeobox 1
chr11_+_61005160 0.567 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr6_-_116973465 0.561 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr16_-_15742883 0.560 MYH11
myosin, heavy chain 11, smooth muscle
chr8_-_18710575 0.558 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_93144039 0.558


chr5_-_88235624 0.558 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr1_+_66570363 0.556 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr15_+_50098724 0.555 MAPK6
mitogen-activated protein kinase 6
chr10_-_32707549 0.551 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr6_-_56816403 0.551 DST
dystonin
chr2_+_101874809 0.550 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr16_-_69876262 0.550 FTSJD1
FtsJ methyltransferase domain containing 1
chr7_-_111633428 0.549 DOCK4
dedicator of cytokinesis 4
chr4_+_120029426 0.548 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr2_+_120233676 0.547 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr8_-_124622434 0.536 NM_058229
FBXO32
F-box protein 32
chr3_-_69254226 0.527 NM_198271
LMOD3
leiomodin 3 (fetal)
chr5_+_138706029 0.525 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr7_-_130891861 0.520 NM_001018111
NM_005397
PODXL

podocalyxin-like

chrX_-_76928334 0.519 NM_000489
NM_138270
ATRX

alpha thalassemia/mental retardation syndrome X-linked

chr8_-_38444398 0.518 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr1_+_154120170 0.516 SYT11
synaptotagmin XI
chr14_-_88953059 0.512 NM_005197
FOXN3
forkhead box N3
chr6_+_121798443 0.509 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_-_7541974 0.507 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr4_-_72868598 0.506 NM_000583
GC
group-specific component (vitamin D binding protein)
chr6_-_159386007 0.500 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr6_+_168161401 0.498 NM_005355
NM_030615
KIF25

kinesin family member 25

chr22_-_17892859 0.498 NM_001130861
NM_003277
CLDN5

claudin 5

chr4_-_74307637 0.497 ANKRD17
ankyrin repeat domain 17
chr15_-_68128924 0.494 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chrX_-_110542040 0.494 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr12_-_10173947 0.489 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr6_-_71069347 0.488 NM_001851
COL9A1
collagen, type IX, alpha 1
chr10_-_61819493 0.485 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_10393664 0.483 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr16_+_21518633 0.483 METTL9
methyltransferase like 9
chr17_-_1195096 0.482 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr15_+_50098700 0.482 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr17_-_46479127 0.480 SPAG9
sperm associated antigen 9
chr14_-_91483757 0.479 NM_006329
FBLN5
fibulin 5
chr3_-_150533948 0.478 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chrX_+_135079461 0.477 NM_001167819
FHL1
four and a half LIM domains 1
chr2_-_207738858 0.477 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_-_134680888 0.475 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_202730135 0.475 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr13_-_22905822 0.473 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr18_+_7936885 0.473 PTPRM
protein tyrosine phosphatase, receptor type, M
chr1_+_116455898 0.473 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr15_-_29734833 0.469 NM_130901
OTUD7A
OTU domain containing 7A
chr1_+_8928508 0.466 NM_001215
CA6
carbonic anhydrase VI
chr4_+_146622154 0.464 NM_005900
SMAD1
SMAD family member 1
chr12_-_68379331 0.460 NM_032735
BEST3
bestrophin 3
chr21_+_34112456 0.455 ITSN1
intersectin 1 (SH3 domain protein)
chr2_-_56266408 0.455 LOC100129434
hypothetical LOC100129434
chr6_-_11340886 0.454 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr12_+_91620749 0.453 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr2_+_110013297 0.453 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr6_-_42527760 0.452 NM_033502
TRERF1
transcriptional regulating factor 1
chr7_-_142293382 0.451 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr10_+_18280773 0.450 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr2_+_169631777 0.449 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_-_150501393 0.448 NM_001193544
ANXA6
annexin A6
chr22_+_38903825 0.448 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr6_+_21774624 0.448 FLJ22536
hypothetical locus LOC401237
chr1_+_203106600 0.448 NFASC
neurofascin
chr2_-_37752731 0.443 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_+_9634368 0.443 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr7_-_26202626 0.443 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_+_3056307 0.441 NM_175612
CNTN4
contactin 4
chr6_-_11340869 0.441 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_20337249 0.435 NM_002214
ITGB8
integrin, beta 8
chr11_+_101693403 0.434 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr1_-_114215768 0.433 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr9_+_4480193 0.432 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr2_-_39201631 0.431 SOS1
son of sevenless homolog 1 (Drosophila)
chr4_-_52578542 0.431 NM_001024611
LRRC66
leucine rich repeat containing 66
chr2_-_207739815 0.430 KLF7
Kruppel-like factor 7 (ubiquitous)
chr10_-_14686243 0.429 FAM107B
family with sequence similarity 107, member B
chr1_-_180624380 0.428 GLUL
glutamate-ammonia ligase
chr16_+_55373241 0.428 NUP93
nucleoporin 93kDa
chr2_-_198248828 0.425 NM_144629
RFTN2
raftlin family member 2
chr4_+_110968594 0.423 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr7_+_128136347 0.422 FAM71F1
family with sequence similarity 71, member F1
chr17_-_36915329 0.422 NM_002274
NM_153490
KRT13

keratin 13

chr1_+_24158887 0.419 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr10_+_24795465 0.418 KIAA1217
KIAA1217
chr7_-_111633620 0.418 NM_014705
DOCK4
dedicator of cytokinesis 4
chr2_+_203207912 0.417 FAM117B
family with sequence similarity 117, member B
chr10_-_74863303 0.417 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr7_+_116099648 0.416 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr8_+_1436938 0.413 NM_004745
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr1_+_183970093 0.413 NM_031935
HMCN1
hemicentin 1
chr20_+_30831298 0.412 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr16_-_11282595 0.409 NM_002761
PRM1
protamine 1
chr2_+_232281470 0.408 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr20_+_54541672 0.407 NM_001013646
C20orf107
chromosome 20 open reading frame 107
chr7_+_93388951 0.407 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr3_-_121883647 0.406 HGD
homogentisate 1,2-dioxygenase
chr1_+_33494745 0.406 NM_152493
ZNF362
zinc finger protein 362
chr4_-_170314382 0.405 SH3RF1
SH3 domain containing ring finger 1
chrX_-_76928142 0.405 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr12_-_6103945 0.404 NM_000552
VWF
von Willebrand factor
chr22_-_17799177 0.404 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr22_-_17798998 0.403 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr9_+_132700462 0.402 ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr7_+_142270634 0.399 EPHB6
EPH receptor B6
chr17_+_64922420 0.398 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_+_144654565 0.396 NM_007124
UTRN
utrophin
chr5_-_171643247 0.396 UBTD2
ubiquitin domain containing 2
chr20_+_17622319 0.396 NM_001159495
BANF2
barrier to autointegration factor 2
chr9_+_132700567 0.395 NM_005157
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr2_-_197883739 0.394 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr5_-_171643399 0.393 NM_152277
UBTD2
ubiquitin domain containing 2
chr6_-_134415311 0.392 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr5_-_38631263 0.390 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr5_-_39400319 0.388 NM_001737
C9
complement component 9

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.