Motif ID: SP1.p2

Z-value: 2.588


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor



Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_57492236 3.767 NM_144684
ZNF480
zinc finger protein 480
chr8_-_99906944 3.748 NM_006281
STK3
serine/threonine kinase 3
chr16_-_3225360 3.218 NM_001145448
NM_198088
NM_001145446
NM_198087
ZNF200



zinc finger protein 200



chr19_+_54786723 3.180 NM_020719
PRR12
proline rich 12
chr16_+_80036275 3.170 NM_198390
CMIP
c-Maf-inducing protein
chr12_+_47498778 3.027 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr20_+_17498507 2.953 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr17_+_77582774 2.769 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr19_-_1966628 2.765 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr8_+_22513043 2.724 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr17_-_46298671 2.638 TOB1
transducer of ERBB2, 1
chr22_-_41913075 2.565 TTLL12
tubulin tyrosine ligase-like family, member 12
chr6_+_37895570 2.471 ZFAND3
zinc finger, AN1-type domain 3
chr22_-_41913002 2.465 TTLL12
tubulin tyrosine ligase-like family, member 12
chr22_-_41913076 2.420 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr2_-_61551403 2.332 USP34
ubiquitin specific peptidase 34
chr17_-_39265965 2.314 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr4_-_809879 2.265 NM_006651
CPLX1
complexin 1
chr8_+_1699276 2.261 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr6_+_167970334 2.221 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr6_-_30818198 2.209 NM_005803
FLOT1
flotillin 1
chr7_+_73506333 2.188 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr8_-_96350575 2.175 NM_177965
C8orf37
chromosome 8 open reading frame 37
chrX_-_152853402 2.159 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr6_-_4080700 2.151 NM_001166010
NM_006117
NM_206836
PECI


peroxisomal D3,D2-enoyl-CoA isomerase


chr6_+_44346457 2.125 NM_001137560
TMEM151B
transmembrane protein 151B
chr14_+_23937766 2.112 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr17_+_34114924 2.081 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr16_+_48744310 2.074 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr20_+_1154763 2.052 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr1_+_945331 2.023 NM_198576
AGRN
agrin
chr6_+_44203335 2.017 NM_018426
TMEM63B
transmembrane protein 63B
chr4_+_85723080 1.928 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr4_+_3046034 1.914 NM_002111
HTT
huntingtin
chr2_-_47986160 1.887 NM_001190274
FBXO11
F-box protein 11
chr16_-_18845223 1.878 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr10_-_15250616 1.850 NM_004808
NMT2
N-myristoyltransferase 2
chr12_-_48508411 1.846 NM_001037806
NCKAP5L
NCK-associated protein 5-like
chr12_-_56200547 1.821 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chrX_-_1291526 1.801 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr19_-_51168396 1.787 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr20_-_39379533 1.774 ZHX3
zinc fingers and homeoboxes 3
chr20_-_51644187 1.765 ZNF217
zinc finger protein 217
chr17_-_77129802 1.752 NM_025161
C17orf70
chromosome 17 open reading frame 70
chr20_+_55359706 1.750 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr7_+_73506172 1.739 GTF2IRD1
GTF2I repeat domain containing 1
chr20_+_55359551 1.729 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr20_-_32877029 1.722 NM_014071
NCOA6
nuclear receptor coactivator 6
chr19_-_15351523 1.703 NM_005858
AKAP8
A kinase (PRKA) anchor protein 8
chr9_-_111300350 1.702 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr19_+_4423149 1.691 NM_001001520
NM_032631
HDGFRP2

hepatoma-derived growth factor-related protein 2

chr7_-_127833231 1.681 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr19_-_15421761 1.639 NM_021241
WIZ
widely interspaced zinc finger motifs
chr20_+_254205 1.631 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr20_-_39680405 1.625 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr3_+_37878647 1.618 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr19_+_40451842 1.595 USF2
upstream transcription factor 2, c-fos interacting
chr20_+_30410447 1.581 ASXL1
additional sex combs like 1 (Drosophila)
chr4_+_3264509 1.578 RGS12
regulator of G-protein signaling 12
chr1_+_945472 1.572 AGRN
agrin
chr20_+_36810510 1.562 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr6_+_41714171 1.549 NM_005586
MDFI
MyoD family inhibitor
chr17_-_78199384 1.538 NM_019613
WDR45L
WDR45-like
chr17_-_40484329 1.530 NM_001128631
DCAKD
dephospho-CoA kinase domain containing
chr16_-_65287967 1.527 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr5_+_172193826 1.512 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr3_+_160964574 1.507 SCHIP1
schwannomin interacting protein 1
chr9_-_5997891 1.504 NM_001017969
KIAA2026
KIAA2026
chr21_+_17807167 1.503 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr14_+_23908141 1.501 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr9_-_73573121 1.496 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr4_-_125853166 1.489 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr6_-_160034176 1.480 SOD2
superoxide dismutase 2, mitochondrial
chr2_-_61551350 1.469 NM_014709
USP34
ubiquitin specific peptidase 34
chr1_-_201202956 1.465 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr16_+_29724926 1.463 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr14_+_34585098 1.462 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr16_+_29725311 1.449 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr2_+_85051942 1.445 KCMF1
potassium channel modulatory factor 1
chr2_+_42249896 1.437 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr14_-_94855848 1.437 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr2_-_36678657 1.433 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr1_-_223907283 1.423 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr1_+_149750485 1.416 NM_020770
CGN
cingulin
chr8_+_30133354 1.413 NM_006571
DCTN6
dynactin 6
chr11_+_117812282 1.410 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr16_-_29513787 1.409 LOC440354
PI-3-kinase-related kinase SMG-1 pseudogene
chr22_+_49459935 1.394 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr17_-_39632845 1.391 ATXN7L3
ataxin 7-like 3
chr2_+_241944333 1.379 NM_014808
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr1_+_945399 1.378


chr20_-_62071584 1.376 NM_020713
ZNF512B
zinc finger protein 512B
chr7_-_525556 1.364 PDGFA
platelet-derived growth factor alpha polypeptide
chr3_-_187025438 1.362 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_150612805 1.343 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr3_-_116348780 1.341 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr14_+_23675233 1.339 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr18_+_58341637 1.329 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr12_+_110328126 1.328 NM_005475
SH2B3
SH2B adaptor protein 3
chr1_-_154290112 1.326 NM_020131
UBQLN4
ubiquilin 4
chr17_+_582406 1.323 NM_024792
FAM57A
family with sequence similarity 57, member A
chr8_+_1699418 1.309 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr15_-_100082134 1.306 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr6_+_143423723 1.295 AIG1
androgen-induced 1
chr3_-_12983959 1.294 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr17_-_63965156 1.290 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr7_+_5289079 1.278 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr20_+_48781457 1.278 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_+_242289983 1.277 NM_032329
ING5
inhibitor of growth family, member 5
chr1_+_231530136 1.276 NM_032435
KIAA1804
mixed lineage kinase 4
chr2_-_9061193 1.274 NM_138799
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr15_+_83092854 1.271 ZNF592
zinc finger protein 592
chr3_-_15875932 1.269 NM_015199
ANKRD28
ankyrin repeat domain 28
chr6_+_37895244 1.268 NM_021943
ZFAND3
zinc finger, AN1-type domain 3
chr2_-_235070431 1.267 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr19_+_47480445 1.264 NM_015125
CIC
capicua homolog (Drosophila)
chr8_+_146023706 1.254 NM_003416
ZNF7
zinc finger protein 7
chr7_+_43589163 1.249 NM_004760
STK17A
serine/threonine kinase 17a
chr14_+_31616196 1.244 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr1_-_109386112 1.243 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr14_+_23675206 1.240 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr20_+_56397695 1.238 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr6_+_17501589 1.238 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr2_+_8739563 1.236 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr12_+_92295738 1.233 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr2_+_54536780 1.223 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr6_-_160034308 1.220 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr9_-_122679387 1.219 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr11_-_2907169 1.210 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr7_-_100325209 1.209 NM_001015072
UFSP1
UFM1-specific peptidase 1 (non-functional)
chr9_+_129962292 1.204 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr3_-_17759100 1.203 NM_001134380
TBC1D5
TBC1 domain family, member 5
chr1_-_113059396 1.199 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr19_-_4016467 1.194 ZBTB7A
zinc finger and BTB domain containing 7A
chr9_-_129573330 1.193 NM_005489
SH2D3C
SH2 domain containing 3C
chr1_-_52791309 1.189 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr2_+_26768894 1.188 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr6_+_155096494 1.187 SCAF8
SR-related CTD-associated factor 8
chr9_-_137938778 1.184 NM_015447
CAMSAP1
calmodulin regulated spectrin-associated protein 1
chr19_+_6690697 1.181 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr20_+_25176698 1.181 NM_002862
PYGB
phosphorylase, glycogen; brain
chr17_-_17667580 1.179 SREBF1
sterol regulatory element binding transcription factor 1
chr9_+_19398924 1.173 NM_001010887
ACER2
alkaline ceramidase 2
chr14_-_50367513 1.168 NM_016350
NM_020921
NM_182944
NM_182946
NIN



ninein (GSK3B interacting protein)



chr1_+_181259317 1.168


chr20_+_35407872 1.162 NM_198291
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chrX_-_1531733 1.156 NM_001173474
NM_004192
ASMTL

acetylserotonin O-methyltransferase-like

chr4_-_110870414 1.155 NM_030821
PLA2G12A
phospholipase A2, group XIIA
chr20_+_44083667 1.154 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr13_-_76499270 1.152 FBXL3
F-box and leucine-rich repeat protein 3
chr10_+_86078136 1.150 NM_018999
FAM190B
family with sequence similarity 190, member B
chr17_-_34157962 1.146 NM_007144
PCGF2
polycomb group ring finger 2
chr21_+_36614347 1.135 NM_015358
MORC3
MORC family CW-type zinc finger 3
chr3_-_13896618 1.131 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr20_-_60074237 1.130 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr6_+_83130673 1.129 NM_001166392
TPBG
trophoblast glycoprotein
chr16_-_8870343 1.127 NM_014316
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr16_+_86193993 1.127 NM_020655
JPH3
junctophilin 3
chr7_+_44754978 1.126 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr7_+_64136078 1.124 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_-_32632601 1.118 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr16_+_4948318 1.117 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr8_-_103737058 1.115 NM_005655
KLF10
Kruppel-like factor 10
chr20_-_3336586 1.110 C20orf194
chromosome 20 open reading frame 194
chr19_-_60557875 1.110 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr7_-_143230096 1.107 NM_014719
FAM115A
family with sequence similarity 115, member A
chr2_+_218972963 1.107 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr16_-_11744103 1.105 NM_015914
TXNDC11
thioredoxin domain containing 11
chr10_-_35143900 1.103 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr1_-_22136263 1.092 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr14_-_38971049 1.092 FBXO33
F-box protein 33
chr6_+_138767151 1.087 HEBP2
heme binding protein 2
chr2_+_192251105 1.085 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr3_-_48569213 1.082 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr1_+_153366928 1.075 NM_004428
NM_182685
EFNA1

ephrin-A1

chr1_-_11663762 1.072 NM_006341
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr9_+_138805581 1.065 NM_032928
TMEM141
transmembrane protein 141
chr7_-_127837195 1.063 IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr1_+_153366559 1.063 EFNA1
ephrin-A1
chr12_-_123617962 1.061 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr22_-_34754343 1.061 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr19_-_52426055 1.060 NM_014417
BBC3
BCL2 binding component 3
chr14_+_31615922 1.053 ARHGAP5
Rho GTPase activating protein 5
chr19_-_43570503 1.052 NM_152657
GGN
gametogenetin
chr20_-_61574259 1.051 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr21_-_39607415 1.048 NM_001007246
NM_018963
NM_033656
BRWD1


bromodomain and WD repeat domain containing 1


chr9_-_122679283 1.047 PHF19
PHD finger protein 19
chr9_+_130354490 1.045 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr6_-_36272951 1.044


chr12_+_55769153 1.039 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr4_+_152549776 1.038 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr4_-_177950658 1.037 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_-_44203131 1.031 MRPL14
mitochondrial ribosomal protein L14
chr14_+_93710401 1.030 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr3_-_51976428 1.029 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr19_+_40451807 1.026 USF2
upstream transcription factor 2, c-fos interacting
chr17_-_46140015 1.025 NM_052855
ANKRD40
ankyrin repeat domain 40
chr4_-_84152985 1.023 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr3_-_184180985 1.023 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr17_-_46553083 1.023 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.21 7.28e-03 GO:0005622 intracellular
1.22 1.07e-02 GO:0044424 intracellular part
1.42 3.82e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.42 1.41e-03 GO:0005515 protein binding