Motif ID: SPIB.p2

Z-value: 1.493


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)



Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_64922420 1.996 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_-_159386007 1.451 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr17_+_37693090 1.087 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr6_-_32742265 1.063 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr12_+_4253143 1.020 NM_001759
CCND2
cyclin D2
chr6_+_130381408 1.019 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr14_+_22915772 1.012 NM_001037288
NM_138460
CMTM5

CKLF-like MARVEL transmembrane domain containing 5

chr2_+_183651531 0.996 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr2_+_102401580 0.982 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_-_53847937 0.976 RNF43
ring finger protein 43
chr14_-_22658078 0.950 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr2_-_175207521 0.901 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr14_-_22127902 0.836 DAD1
defender against cell death 1
chr16_-_30841938 0.821 NCRNA00095
non-protein coding RNA 95
chr7_-_104440707 0.813 LOC100216545
hypothetical LOC100216545
chr2_-_55349818 0.791 NM_001005369
MTIF2
mitochondrial translational initiation factor 2
chr17_+_44643067 0.779 ABI3
ABI family, member 3
chr17_+_35046843 0.777 NM_001165937
NM_001165938
NM_006804
STARD3


StAR-related lipid transfer (START) domain containing 3


chr11_+_65026382 0.751


chr16_-_83703496 0.744 NM_198491
FAM92B
family with sequence similarity 92, member B
chr14_-_21074875 0.734 NM_005407
SALL2
sal-like 2 (Drosophila)
chr6_-_56816403 0.700 DST
dystonin
chr12_+_97513644 0.695 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr5_-_138822475 0.689 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr12_-_120725210 0.672 LOC338799
hypothetical LOC338799
chr2_+_138438277 0.669 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr2_+_217071764 0.668 NM_000998
RPL37A
ribosomal protein L37a
chr17_-_44642934 0.666 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr2_-_55349851 0.654 NM_002453
MTIF2
mitochondrial translational initiation factor 2
chr2_+_220170804 0.645 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr6_+_12398514 0.635 NM_001168319
NM_001955
EDN1

endothelin 1

chr12_+_118590039 0.631 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr4_+_109761170 0.624 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr5_+_132237253 0.623 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr20_-_48980858 0.622 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr6_+_31651319 0.621 NM_000594
TNF
tumor necrosis factor
chr20_-_48686832 0.620 NM_080829
FAM65C
family with sequence similarity 65, member C
chr5_-_71838875 0.613 NM_152625
ZNF366
zinc finger protein 366
chr11_-_95715976 0.610 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr17_-_70901303 0.602 GRB2
growth factor receptor-bound protein 2
chr6_+_114285209 0.579 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_213723298 0.569 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_-_47030492 0.569 NM_015234
GPR116
G protein-coupled receptor 116
chr17_+_55269974 0.566


chr20_-_50241581 0.564 ZFP64
zinc finger protein 64 homolog (mouse)
chr2_+_149118791 0.564 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_48521411 0.556 NM_001135629
NM_001193475
NM_152994
KLRAQ1


KLRAQ motif containing 1


chr17_-_53282376 0.555 NM_016070
MRPS23
mitochondrial ribosomal protein S23
chr15_+_79376295 0.547 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr16_+_28413421 0.545 NM_018690
APOBR
apolipoprotein B receptor
chr2_+_217206450 0.543 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr8_-_92122219 0.534 NM_018710
TMEM55A
transmembrane protein 55A
chr20_-_13567529 0.531 NM_017714
TASP1
taspase, threonine aspartase, 1
chr14_-_22891865 0.530 NM_016609
SLC22A17
solute carrier family 22, member 17
chr6_+_57290357 0.529 NM_000947
PRIM2
primase, DNA, polypeptide 2 (58kDa)
chr16_+_11978002 0.525 NM_032167
RUNDC2A
RUN domain containing 2A
chr2_+_149119029 0.519 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr8_-_120914233 0.519 NM_003184
TAF2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
chr14_+_23937766 0.517 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr7_+_128651976 0.517 NM_001130720
NM_015328
AHCYL2

adenosylhomocysteinase-like 2

chr3_+_139200347 0.514 NM_001002026
CLDN18
claudin 18
chr14_-_22127954 0.513 NM_001344
DAD1
defender against cell death 1
chr2_+_113601616 0.504 IL1RN
interleukin 1 receptor antagonist
chr6_+_21701942 0.503 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr2_-_175754366 0.501 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr2_+_113601608 0.497 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr6_-_31007905 0.497 NM_205854
SFTA2
surfactant associated 2
chr12_+_91620749 0.490 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr11_+_63864263 0.489 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr6_-_117096594 0.489 NM_145062
ZUFSP
zinc finger with UFM1-specific peptidase domain
chr9_-_129580732 0.487 NM_170600
SH2D3C
SH2 domain containing 3C
chr12_-_6615348 0.487 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr4_-_174557191 0.486 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr11_+_8660913 0.486 RPL27A
ribosomal protein L27a
chr1_+_9634368 0.486 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr12_+_92595281 0.486 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr14_-_21049204 0.484 NM_019852
METTL3
methyltransferase like 3
chr20_+_30160952 0.479 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr20_+_29598848 0.478 HM13
histocompatibility (minor) 13
chr8_+_82807218 0.473 NM_152284
CHMP4C
chromatin modifying protein 4C
chr14_-_22549168 0.466 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr12_+_56374004 0.466 NM_001017956
NM_001017957
NM_001017958
NM_006812
OS9



osteosarcoma amplified 9, endoplasmic reticulum lectin



chr2_+_85619802 0.463 MAT2A
methionine adenosyltransferase II, alpha
chr2_+_29057667 0.461 NM_199280
FAM179A
family with sequence similarity 179, member A
chr8_-_92151363 0.460


chr11_-_33847507 0.452 LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_31662454 0.450 NM_205837
LST1
leukocyte specific transcript 1
chr2_-_202811459 0.446 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr17_+_63252704 0.439 BPTF
bromodomain PHD finger transcription factor
chr6_+_31661934 0.439 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr17_-_41625921 0.437 NM_001193466
KIAA1267
KIAA1267
chr8_+_64243741 0.433 YTHDF3
YTH domain family, member 3
chr20_-_49008445 0.433 NM_003859
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr7_+_104959767 0.433 NM_021930
RINT1
RAD50 interactor 1
chr16_+_24696069 0.433 TNRC6A
trinucleotide repeat containing 6A
chr1_-_205210567 0.432 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr11_+_101693403 0.431 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr2_-_74259308 0.431 NM_018221
MOBKL1B
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr5_+_61910318 0.431 NM_181506
LRRC70
leucine rich repeat containing 70
chr12_-_15005761 0.427 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_56824371 0.427 DST
dystonin
chr16_-_29781842 0.425 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr1_+_154390939 0.423 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr8_-_57149588 0.423 NM_001023
NM_001146227
RPS20

ribosomal protein S20

chr7_+_141084591 0.419 NM_003143
SSBP1
single-stranded DNA binding protein 1
chr14_+_28311740 0.417 C14orf23
chromosome 14 open reading frame 23
chr14_-_21172837 0.416 NM_001005466
OR10G2
olfactory receptor, family 10, subfamily G, member 2
chr16_-_15644465 0.416 NM_001184998
NM_001184999
NM_014647
KIAA0430


KIAA0430


chr16_-_3246587 0.414 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr12_-_56157898 0.412 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr7_+_139175420 0.410 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr16_+_15644624 0.410 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr18_+_30875297 0.406 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_-_103968104 0.405 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr14_-_20969706 0.404 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr6_-_119137923 0.404 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr2_-_190893015 0.403 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr6_-_116488458 0.401 NM_002031
FRK
fyn-related kinase
chr1_+_159462456 0.400 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr11_+_74788200 0.400 NM_001005
RPS3
ribosomal protein S3
chr1_-_171441234 0.398 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_-_47623340 0.394 NM_005357
LIPE
lipase, hormone-sensitive
chr17_+_35718948 0.392 NM_000964
RARA
retinoic acid receptor, alpha
chr16_-_87460514 0.392 NM_001080487
PABPN1L
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr20_+_30161173 0.392 TM9SF4
transmembrane 9 superfamily protein member 4
chr6_-_32265489 0.392 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr20_-_50241930 0.389 NM_018197
NM_022088
NM_199426
NM_199427
ZFP64



zinc finger protein 64 homolog (mouse)



chr2_-_27147995 0.389 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr5_+_139485703 0.387 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr7_+_102775309 0.386 NM_002803
PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
chr11_+_65027721 0.385


chr2_-_206659140 0.385 NM_017759
INO80D
INO80 complex subunit D
chr2_-_178125680 0.381 NM_152517
TTC30B
tetratricopeptide repeat domain 30B
chr2_-_96174865 0.381 NM_004418
DUSP2
dual specificity phosphatase 2
chr6_-_34963565 0.380 NM_005643
TAF11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
chr5_-_139402909 0.379 NRG2
neuregulin 2
chr17_+_44642587 0.375 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr5_+_180514548 0.375 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr1_-_220829704 0.373 NM_005681
NM_139352
TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

chr6_-_28327980 0.371 NM_019110
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr20_+_47096280 0.370 CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr22_+_29333069 0.370 NM_000355
NM_001184726
TCN2

transcobalamin II

chr5_-_158567411 0.367 NM_144726
RNF145
ring finger protein 145
chr22_+_35586950 0.367 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_182040837 0.363 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr14_-_24047261 0.362 NM_001836
CMA1
chymase 1, mast cell
chr6_+_31647854 0.362 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr12_-_46438447 0.361 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr7_+_99052489 0.359 NM_145115
ZNF498
zinc finger protein 498
chr14_-_20975241 0.358 NM_020920
CHD8
chromodomain helicase DNA binding protein 8
chr6_+_15354278 0.356 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr5_+_143171918 0.356 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr2_+_183651713 0.354 DUSP19
dual specificity phosphatase 19
chr3_+_87359088 0.353 NM_014043
CHMP2B
chromatin modifying protein 2B
chr4_+_39376058 0.350 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr2_-_61551403 0.349 USP34
ubiquitin specific peptidase 34
chr14_+_22410795 0.349 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr17_+_35097851 0.348 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr6_+_43136159 0.348 NM_201522
KLC4
kinesin light chain 4
chr2_-_174537021 0.348 NM_001017371
SP3
Sp3 transcription factor
chr12_-_56111054 0.347 R3HDM2
R3H domain containing 2
chr1_-_116184846 0.346 NM_001111061
NHLH2
nescient helix loop helix 2
chr16_+_51690564 0.344 CHD9
chromodomain helicase DNA binding protein 9
chr12_+_52132353 0.344 PCBP2
poly(rC) binding protein 2
chr16_+_24459173 0.341 RBBP6
retinoblastoma binding protein 6
chr2_-_242449662 0.341 NM_005018
PDCD1
programmed cell death 1
chr2_+_85619797 0.340 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr11_-_14342627 0.340 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr2_-_24995402 0.338 NM_004036
ADCY3
adenylate cyclase 3
chr6_+_31731647 0.338 NM_019101
APOM
apolipoprotein M
chr6_-_31658044 0.337 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr14_+_22859236 0.336 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_-_180580024 0.335 NM_020943
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr22_-_35494019 0.334 NM_001177702
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr17_+_54642152 0.333 NM_018149
C17orf71
chromosome 17 open reading frame 71
chr13_-_47885018 0.332 LPAR6
lysophosphatidic acid receptor 6
chr10_-_98470164 0.332 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr1_-_199348316 0.331 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr6_-_33016561 0.330 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_24518501 0.330 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_100957883 0.330 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr17_-_44058612 0.330 NM_024017
HOXB9
homeobox B9
chr9_-_6005602 0.329 NM_012416
RANBP6
RAN binding protein 6
chr5_+_133870175 0.327


chr6_-_25044156 0.327 FAM65B
family with sequence similarity 65, member B
chr3_+_98966253 0.325 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr14_+_38714111 0.325 NM_002687
PNN
pinin, desmosome associated protein
chr10_+_22580992 0.324


chr1_+_204797516 0.322 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_219404755 0.322 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr17_-_59403932 0.322 NM_000334
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chr10_+_104580420 0.322


chr2_+_112956204 0.321 NM_153712
TTL
tubulin tyrosine ligase
chr10_+_129735796 0.316 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr4_+_84596141 0.315 NM_016067
MRPS18C
mitochondrial ribosomal protein S18C
chr2_-_190892730 0.312 HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr15_+_72620570 0.312 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr2_-_152538694 0.311 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr7_-_30032649 0.310 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr12_+_52689062 0.310 NM_022658
HOXC8
homeobox C8

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.