Motif ID: SREBF1,2.p2

Z-value: 0.896


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2



Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_48582389 1.826 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr2_+_234333653 1.707 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr2_+_227898163 1.553 MFF
mitochondrial fission factor
chr20_+_37024383 1.479 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr2_+_177785667 1.427 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr14_-_34253473 1.339 NM_138638
CFL2
cofilin 2 (muscle)
chr6_-_84994032 1.250 NM_014895
KIAA1009
KIAA1009
chr2_-_176575171 1.192 NM_030650
KIAA1715
KIAA1715
chr10_+_45542653 1.130 NM_001169106
NM_001169107
NM_015262
FAM21C


FAM21A
family with sequence similarity 21, member C


family with sequence similarity 21, member A
chr17_-_44022595 1.108 HOXB3
homeobox B3
chr11_-_85457469 1.094 PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_35852369 1.094 NM_207409
C6orf126
chromosome 6 open reading frame 126
chr20_-_43953036 1.091 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr6_-_7258351 1.089 NM_003144
SSR1
signal sequence receptor, alpha
chr11_+_85017269 1.050 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr17_-_41018291 1.050


chr14_-_67353046 1.044 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr20_+_43953428 1.037 CTSA
cathepsin A
chr16_+_55580910 1.037 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr10_-_45410197 1.034 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr20_+_43953372 1.008 CTSA
cathepsin A
chr10_+_69314714 0.951 SIRT1
sirtuin 1
chr2_+_187266899 0.946 NM_177454
FAM171B
family with sequence similarity 171, member B
chr2_-_131567458 0.945 NM_001009993
FAM168B
family with sequence similarity 168, member B
chr3_-_20202622 0.938 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
SGOL1





shugoshin-like 1 (S. pombe)





chr6_-_169392771 0.927


chr4_-_23500706 0.925 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_176724583 0.911


chr2_-_27399405 0.908 NM_002437
MPV17
MpV17 mitochondrial inner membrane protein
chr7_-_44496703 0.899 NM_015332
NUDCD3
NudC domain containing 3
chr1_+_224337937 0.883


chr20_+_43953331 0.879 CTSA
cathepsin A
chr6_+_127629677 0.878 NM_030963
RNF146
ring finger protein 146
chr3_-_11736946 0.878 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr13_+_112999590 0.868 LAMP1
lysosomal-associated membrane protein 1
chr2_+_241174803 0.863 NM_023083
NM_023085
CAPN10

calpain 10

chr7_-_134845363 0.860 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr20_+_33506322 0.858 NM_007186
CEP250
centrosomal protein 250kDa
chr16_+_68542126 0.852 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr11_+_125586828 0.850 NM_024556
FAM118B
family with sequence similarity 118, member B
chr2_+_176724358 0.844 NM_014621
HOXD4
homeobox D4
chr22_+_34107087 0.839 HMOX1
heme oxygenase (decycling) 1
chr1_-_152797820 0.839 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_139391511 0.837 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr5_+_41940216 0.831 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr2_+_85676347 0.822 NM_016494
RNF181
ring finger protein 181
chr6_+_160310118 0.811 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr16_+_68542310 0.807 NM_182619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr19_+_10626106 0.803 ILF3
interleukin enhancer binding factor 3, 90kDa
chr1_+_76312962 0.777 NM_001160011
NM_152996
ST6GALNAC3

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

chr13_-_78131259 0.777 NM_024546
RNF219
ring finger protein 219
chr16_-_1465007 0.772 CLCN7
chloride channel 7
chr1_+_159550789 0.761 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr16_-_1465041 0.741 NM_001114331
NM_001287
CLCN7

chloride channel 7

chr6_+_7671267 0.738 BMP6
bone morphogenetic protein 6
chr11_-_85457736 0.730 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_152797707 0.727 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_151815298 0.725 C6orf211
chromosome 6 open reading frame 211
chr5_+_133735004 0.724 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr1_-_152797760 0.719 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr4_+_17225344 0.715 NM_025205
MED28
mediator complex subunit 28
chr16_+_5023672 0.705 LOC100507589
hypothetical LOC100507589
chr1_-_152797767 0.698 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_139391570 0.691 C6orf115
chromosome 6 open reading frame 115
chr16_-_15644465 0.688 NM_001184998
NM_001184999
NM_014647
KIAA0430


KIAA0430


chr20_+_33823318 0.684 NM_016436
PHF20
PHD finger protein 20
chr20_-_32877029 0.684 NM_014071
NCOA6
nuclear receptor coactivator 6
chr10_+_69314347 0.676 NM_012238
SIRT1
sirtuin 1
chr16_-_1464927 0.668 CLCN7
chloride channel 7
chr16_-_5023562 0.663 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr15_-_71712605 0.658 NPTN
neuroplastin
chr7_+_27190688 0.657


chr20_+_46971618 0.648 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr20_+_18066473 0.642 NM_001164811
PET117
cytochrome c oxidase assembly factor-like
chr6_-_21631992 0.639


chr7_-_135083906 0.638 NM_205855
FAM180A
family with sequence similarity 180, member A
chr14_-_23981493 0.635 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr16_+_80370426 0.627 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr6_-_163754903 0.626 LOC100526820
hypothetical LOC100526820
chr8_-_54918099 0.626 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr6_-_26767892 0.623 NM_024639
ZNF322A
zinc finger protein 322A
chr16_-_1465021 0.623 CLCN7
chloride channel 7
chr3_+_87359088 0.618 NM_014043
CHMP2B
chromatin modifying protein 2B
chr11_-_85457753 0.618 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr17_-_27210330 0.604 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr1_+_10015736 0.603 UBE4B
ubiquitination factor E4B (UFD2 homolog, yeast)
chr1_+_109221271 0.594 GPSM2
G-protein signaling modulator 2
chr8_+_98725505 0.589 NM_178812
MTDH
metadherin
chr1_-_201162991 0.588 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr17_-_43977273 0.587 NM_002145
HOXB2
homeobox B2
chr13_-_32757835 0.584 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr14_-_23752507 0.581 CHMP4A
chromatin modifying protein 4A
chr1_+_234372454 0.579 NM_003272
GPR137B
G protein-coupled receptor 137B
chr16_+_22124870 0.576 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr14_+_30161267 0.562 NM_016106
NM_182835
SCFD1

sec1 family domain containing 1

chr8_-_95343716 0.562 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr3_+_150330060 0.561 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr2_+_46779827 0.559 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr14_-_23752476 0.555 CHMP4A
chromatin modifying protein 4A
chr14_-_23752498 0.554 CHMP4A
chromatin modifying protein 4A
chr9_-_130749604 0.552 NM_014908
DOLK
dolichol kinase
chr1_+_109963982 0.550 AMPD2
adenosine monophosphate deaminase 2
chr2_-_200424140 0.547 LOC348751
hypothetical LOC348751
chr19_-_15436333 0.546 NM_022904
RASAL3
RAS protein activator like 3
chr16_+_83618804 0.545 NM_014732
KIAA0513
KIAA0513
chr22_+_34107051 0.543 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr19_-_13088212 0.541 NM_001142554
NM_017722
NM_001136035
TRMT1


TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)


chr3_-_126257425 0.541 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr17_-_44043361 0.538 NM_004502
HOXB7
homeobox B7
chr17_-_34263487 0.535 NM_000978
SNORA21
RPL23
small nucleolar RNA, H/ACA box 21
ribosomal protein L23
chr17_+_52410466 0.533 NM_021626
SCPEP1
serine carboxypeptidase 1
chr16_+_28893525 0.532 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr20_-_61317891 0.532 NM_017798
YTHDF1
YTH domain family, member 1
chr8_-_81246215 0.529 NM_001025253
NM_005079
TPD52

tumor protein D52

chr6_-_31973418 0.529 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr1_-_201162938 0.526 KLHL12
kelch-like 12 (Drosophila)
chr1_-_77920914 0.520 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr1_+_149750485 0.520 NM_020770
CGN
cingulin
chr17_-_7078304 0.520 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr2_-_105312536 0.518 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr17_-_73636386 0.518 NM_001127198
TMC6
transmembrane channel-like 6
chr6_+_151815114 0.513 NM_024573
C6orf211
chromosome 6 open reading frame 211
chr17_-_44042924 0.513 HOXB7
homeobox B7
chr10_-_120504445 0.513 C10orf46
chromosome 10 open reading frame 46
chr6_-_43305156 0.513 NM_006443
NM_199184
C6orf108

chromosome 6 open reading frame 108

chr2_-_148494732 0.512 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr17_-_40263124 0.512 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_47396724 0.505 NM_001240
CCNT1
cyclin T1
chr4_-_84152985 0.503 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr12_+_54396118 0.501 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr11_-_125586733 0.501 NM_001144827
NM_032795
RPUSD4

RNA pseudouridylate synthase domain containing 4

chr14_+_37746937 0.500 NM_001049
SSTR1
somatostatin receptor 1
chr16_+_80036275 0.499 NM_198390
CMIP
c-Maf-inducing protein
chr8_-_95343696 0.498 GEM
GTP binding protein overexpressed in skeletal muscle
chr8_+_98725604 0.497 MTDH
metadherin
chr20_+_18496068 0.497 LOC388789
hypothetical LOC388789
chr5_-_55564942 0.487 NM_024669
ANKRD55
ankyrin repeat domain 55
chr20_-_4743768 0.486 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr11_-_1741680 0.482 CTSD
cathepsin D
chr17_-_33043514 0.481 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr17_-_7078446 0.480 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr2_-_210743622 0.480 C2orf67
chromosome 2 open reading frame 67
chr14_-_38971370 0.478 NM_203301
FBXO33
F-box protein 33
chr1_+_181871830 0.477 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr1_+_109963950 0.476 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr22_+_38903825 0.476 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr17_+_63252704 0.474 BPTF
bromodomain PHD finger transcription factor
chr2_-_196744546 0.474 NM_004226
STK17B
serine/threonine kinase 17b
chr17_-_73636362 0.474 TMC6
transmembrane channel-like 6
chr10_+_101532544 0.472 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_-_93512818 0.470 ASB2
ankyrin repeat and SOCS box containing 2
chr4_-_152901542 0.470 NM_004564
PET112L
PET112-like (yeast)
chr6_-_31973434 0.470 NM_006709
NM_025256
EHMT2

euchromatic histone-lysine N-methyltransferase 2

chr2_+_223625105 0.467 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr20_+_43952997 0.467 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr16_+_80370400 0.466 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_-_7078399 0.466 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_-_44043278 0.465 HOXB7
homeobox B7
chr9_-_139128777 0.464 DPP7
dipeptidyl-peptidase 7
chr14_-_34661190 0.463 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr14_+_22860511 0.462 PABPN1
poly(A) binding protein, nuclear 1
chr6_-_44333002 0.462 NM_178148
SLC35B2
solute carrier family 35, member B2
chr5_+_122138636 0.461 NM_003100
SNX2
sorting nexin 2
chr16_+_15644624 0.457 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr5_-_172130766 0.456 NM_004417
DUSP1
dual specificity phosphatase 1
chr7_+_97574054 0.456 NM_014916
LMTK2
lemur tyrosine kinase 2
chr2_-_215605054 0.453 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_119826073 0.452 SPPL3
signal peptide peptidase 3
chr18_-_20231709 0.449 OSBPL1A
oxysterol binding protein-like 1A
chr9_-_124707314 0.449 NM_001100588
NM_018835
RC3H2

ring finger and CCCH-type domains 2

chr6_-_80713589 0.448 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr6_-_152664906 0.442 SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_46779553 0.441 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr14_-_34661156 0.441 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr10_+_101532450 0.439 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr17_+_63252087 0.438 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chr16_-_57276108 0.438 NM_018231
SLC38A7
solute carrier family 38, member 7
chr16_+_11669736 0.437 NM_003498
SNN
stannin
chr20_-_34102250 0.437 LOC647979
hypothetical LOC647979
chr5_+_122138661 0.436 SNX2
sorting nexin 2
chr6_-_33822659 0.435 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr1_+_36462583 0.434 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr16_-_87450734 0.433 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr2_-_175741096 0.432 NM_001880
ATF2
activating transcription factor 2
chr11_-_8849485 0.431 ST5
suppression of tumorigenicity 5
chr5_+_122138677 0.430 SNX2
sorting nexin 2
chr11_-_6597220 0.429 TPP1
tripeptidyl peptidase I
chr11_+_120828275 0.428 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr10_-_120504267 0.428


chr1_-_154532019 0.427 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr17_-_71362971 0.424 NM_012478
WBP2
WW domain binding protein 2
chr1_+_36462625 0.424 THRAP3
thyroid hormone receptor associated protein 3
chr7_-_27190882 0.423 HOXA11
homeobox A11
chr11_+_66915997 0.423 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr2_+_68238490 0.422 NM_020143
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr16_+_4837912 0.421 NM_001079514
UBN1
ubinuclein 1
chr8_+_98725670 0.419 MTDH
metadherin
chr11_-_1741663 0.418 CTSD
cathepsin D
chr9_-_135379888 0.415 NM_001080483
TMEM8C
transmembrane protein 8C
chr17_+_46599081 0.415 NM_001018138
NME2
non-metastatic cells 2, protein (NM23B) expressed in

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
44.27 2.36e-03 GO:0031901 early endosome membrane
147.45 4.80e-03 GO:0071203 WASH complex
16.94 4.09e-02 GO:0005769 early endosome

Nothing significant found in function category.