Motif ID: TFAP4.p2

Z-value: 2.049


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)



Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_20068039 3.180 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr2_+_128119908 2.753 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr21_+_36429079 2.478 NM_001236
CBR3
carbonyl reductase 3
chr22_-_20235372 2.390 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr5_+_129268352 2.134 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr7_-_27136876 1.953 NM_002141
HOXA4
homeobox A4
chr17_-_36528113 1.873 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr1_+_43769065 1.848 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_-_93919789 1.805 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr19_-_56841819 1.804 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr6_-_167491305 1.774 NM_005299
GPR31
G protein-coupled receptor 31
chr2_+_159533329 1.759 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr2_+_187266899 1.631 NM_177454
FAM171B
family with sequence similarity 171, member B
chr1_+_208472817 1.460 NM_019605
SERTAD4
SERTA domain containing 4
chr6_-_160599779 1.372 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr5_-_112658200 1.330 MCC
mutated in colorectal cancers
chr18_-_53621277 1.328 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr19_-_55156118 1.326 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11

chr19_-_56825400 1.264 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr7_+_153633127 1.256 NM_001936
DPP6
dipeptidyl-peptidase 6
chr5_+_94981735 1.191 NM_199243
GPR150
G protein-coupled receptor 150
chr17_-_36346240 1.183 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_132890616 1.179 NM_001508
GPR39
G protein-coupled receptor 39
chr9_-_128924706 1.137 ANGPTL2
angiopoietin-like 2
chr6_+_21701942 1.134 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr22_+_17539198 1.128


chr12_-_50871953 1.101 NM_001081492
NM_182507
KRT80

keratin 80

chr9_-_132804243 1.099 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr20_+_31783426 1.088 NM_032819
ZNF341
zinc finger protein 341
chr1_+_181259317 1.084


chr1_+_143920424 1.081 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr3_+_32408346 1.069 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr10_-_30388439 1.064 NM_020848
KIAA1462
KIAA1462
chr17_-_36507900 1.056 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr19_-_59438411 1.049 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr16_-_71650034 1.048 NM_001164766
ZFHX3
zinc finger homeobox 3
chrX_-_46503415 1.046 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr16_-_1215254 1.043 NM_012467
TPSG1
tryptase gamma 1
chr17_+_46067114 1.040 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr9_-_128924782 1.039 ANGPTL2
angiopoietin-like 2
chr4_-_191143017 1.035 NM_020040
TUBB4Q
tubulin, beta polypeptide 4, member Q
chr22_-_19122047 1.034 SCARF2
scavenger receptor class F, member 2
chr18_-_42804291 1.024 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr9_-_128924819 1.002 NM_012098
ANGPTL2
angiopoietin-like 2
chr6_-_154873344 0.997 CNKSR3
CNKSR family member 3
chr6_+_31815703 0.982 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6ORF26
MSH5



MSH5-C6orf26 read-through transcript
mutS homolog 5 (E. coli)



chr6_+_36773605 0.980 RAB44
RAB44, member RAS oncogene family
chr5_-_139402909 0.978 NRG2
neuregulin 2
chr22_-_17303654 0.971 PRODH
proline dehydrogenase (oxidase) 1
chr18_-_42810206 0.970 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr19_+_21056792 0.967 NM_182515
ZNF714
zinc finger protein 714
chr16_-_15742883 0.966 MYH11
myosin, heavy chain 11, smooth muscle
chr16_+_79829794 0.965 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr16_+_68765428 0.965 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr18_-_42798364 0.960 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr21_-_42247007 0.960 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr12_-_4425040 0.959 NM_020996
FGF6
fibroblast growth factor 6
chr17_+_36515166 0.958 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr22_-_19122107 0.956 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr9_-_103397023 0.937 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr6_-_168222645 0.928 NM_024919
FRMD1
FERM domain containing 1
chr22_+_21559959 0.922 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr6_+_37245860 0.919 NM_002648
PIM1
pim-1 oncogene
chr3_-_12983959 0.918 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr1_-_226202210 0.909 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr12_+_62523648 0.909


chr9_+_128128913 0.905 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr1_-_8008934 0.905 ERRFI1
ERBB receptor feedback inhibitor 1
chr14_+_23937766 0.902 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr14_+_92049396 0.901 NM_024832
RIN3
Ras and Rab interactor 3
chr7_+_100515439 0.898 NM_030961
TRIM56
tripartite motif containing 56
chr1_+_203503214 0.891 TMCC2
transmembrane and coiled-coil domain family 2
chr6_-_35804337 0.891 NM_001145775
FKBP5
FK506 binding protein 5
chr2_-_216944911 0.890 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr1_-_6585268 0.888 KLHL21
kelch-like 21 (Drosophila)
chr1_-_8008979 0.884 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr5_+_61637701 0.883 NM_001098511
NM_004520
KIF2A

kinesin heavy chain member 2A

chr14_-_22354457 0.883 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chrX_-_19815586 0.880 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_17817397 0.871 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_-_36444626 0.864 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr6_+_36754433 0.862 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_+_199975563 0.861 NM_001167738
NAV1
neuron navigator 1
chr6_+_31799099 0.861 NM_025260
NM_138272
NM_138273
NM_138274
NM_138275
NM_138277
C6orf25





chromosome 6 open reading frame 25





chr6_+_138524717 0.854 NM_020340
KIAA1244
KIAA1244
chr19_-_8118367 0.854 NM_032447
FBN3
fibrillin 3
chr14_-_22354389 0.851 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr2_+_152900076 0.849 FMNL2
formin-like 2
chr17_-_36587965 0.847 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr1_-_6474346 0.842 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_-_154873480 0.836 CNKSR3
CNKSR family member 3
chrX_-_19815370 0.835 SH3KBP1
SH3-domain kinase binding protein 1
chr11_-_118693021 0.831 NM_006500
MCAM
melanoma cell adhesion molecule
chr17_-_74432671 0.829 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_132764257 0.828 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr1_+_113734997 0.828 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr17_+_36636404 0.821 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr16_-_83703496 0.820 NM_198491
FAM92B
family with sequence similarity 92, member B
chr10_-_76831430 0.812 NM_032772
ZNF503
zinc finger protein 503
chr1_+_225124864 0.804 NM_000447
NM_012486
PSEN2

presenilin 2 (Alzheimer disease 4)

chr6_-_143307976 0.802 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr2_-_219404755 0.802 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr5_+_61637822 0.800 KIF2A
kinesin heavy chain member 2A
chr16_+_15435825 0.800 NM_033201
C16orf45
chromosome 16 open reading frame 45
chrX_-_19815526 0.800 SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_199704773 0.799 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr1_+_181258952 0.798 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr16_-_87405817 0.797 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr5_-_73972055 0.792 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr6_+_43151922 0.791 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr6_+_36754467 0.782 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr19_+_18543613 0.782 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr9_+_123544884 0.779 NM_138709
DAB2IP
DAB2 interacting protein
chr4_-_24523605 0.774 NM_001130726
CCDC149
coiled-coil domain containing 149
chr7_-_16427471 0.766 NM_001101417
NM_001101426
ISPD

isoprenoid synthase domain containing

chr17_+_36665161 0.758 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr10_+_129735796 0.754 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr9_-_71476917 0.750 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr19_-_50355247 0.749 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr1_+_1104939 0.749 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr11_-_6397207 0.746 NM_145689
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr1_-_16843764 0.745 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr6_+_32230172 0.742 PPT2
palmitoyl-protein thioesterase 2
chr1_-_20122638 0.730 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr16_+_87021379 0.725 NM_001127464
ZNF469
zinc finger protein 469
chr6_+_11646472 0.724 NM_001100829
TMEM170B
transmembrane protein 170B
chr15_-_68933481 0.723 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr1_+_68070573 0.721


chr14_+_99273751 0.720 EML1
echinoderm microtubule associated protein like 1
chr17_-_27210330 0.716 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr1_-_16843744 0.714 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr2_+_56265260 0.714


chr1_+_22224571 0.713 HSPC157
hypothetical LOC29092
chr5_-_139402989 0.713 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr2_+_43919606 0.708 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr3_-_18441763 0.706 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr1_-_120413542 0.705 NOTCH2
notch 2
chr1_-_56817568 0.704 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_26310854 0.700 NM_152835
PDIK1L
PDLIM1 interacting kinase 1 like
chr8_-_7427584 0.699 NM_001136572
FAM90A7
family with sequence similarity 90, member A7
chr21_-_29286982 0.699 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr17_+_36493927 0.698 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr1_-_32176475 0.695 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr6_+_7671267 0.691 BMP6
bone morphogenetic protein 6
chr6_+_31910623 0.690 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr10_+_124210980 0.688 NM_002775
HTRA1
HtrA serine peptidase 1
chr16_-_20323533 0.688 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr1_-_23376860 0.685 LUZP1
leucine zipper protein 1
chr11_-_5494391 0.681 NM_145053
UBQLNL
ubiquilin-like
chr15_+_72253940 0.678 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_43919392 0.673 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_20075929 0.666 NM_002381
MATN3
matrilin 3
chr13_+_56639331 0.666 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr14_+_30161267 0.665 NM_016106
NM_182835
SCFD1

sec1 family domain containing 1

chr11_+_7965442 0.664 NM_003754
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr15_-_53822468 0.662 NM_173814
PRTG
protogenin
chr16_-_73798539 0.662 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr4_+_169989680 0.660 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr16_-_23515104 0.658 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr22_+_21359175 0.652 IGLV3-25
immunoglobulin lambda variable 3-25
chr19_+_61379200 0.652 NM_001145546
NM_033106
GALP

galanin-like peptide

chr22_-_18687511 0.648 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr15_-_62854749 0.647 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr16_+_68542310 0.645 NM_182619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr20_+_21231921 0.645 NM_012255
XRN2
5'-3' exoribonuclease 2
chr3_-_196787563 0.641 APOD
apolipoprotein D
chr5_+_148186348 0.640 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr16_+_55199978 0.640 NM_005953
MT2A
metallothionein 2A
chr1_+_20788027 0.638 NM_001785
CDA
cytidine deaminase
chr7_-_127833231 0.636 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr3_-_38666122 0.636 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr18_+_32131628 0.636 NM_025135
FHOD3
formin homology 2 domain containing 3
chr16_+_73810383 0.635 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr9_-_122679283 0.635 PHF19
PHD finger protein 19
chr15_+_39032927 0.634 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr14_+_30161285 0.633 SCFD1
sec1 family domain containing 1
chr12_+_50981915 0.630 NM_002284
KRT86
keratin 86
chr20_-_42373151 0.630 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr9_-_122679387 0.630 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr1_+_77520315 0.628 NM_174858
AK5
adenylate kinase 5
chr3_-_10027770 0.628 NM_001008737
LOC401052
hypothetical LOC401052
chr1_-_16272523 0.625 NM_182623
FAM131C
family with sequence similarity 131, member C
chr12_-_51528983 0.621 NM_173352
KRT78
keratin 78
chr22_+_21393107 0.617 IGLJ3
immunoglobulin lambda joining 3
chr16_-_23559978 0.616 NM_024675
PALB2
partner and localizer of BRCA2
chr1_-_6402467 0.613 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr2_+_136005423 0.612 NM_015361
R3HDM1
R3H domain containing 1
chr7_+_45894480 0.610 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr10_-_116382089 0.606 ABLIM1
actin binding LIM protein 1
chr19_-_10305186 0.603 NM_133452
RAVER1
ribonucleoprotein, PTB-binding 1
chr7_-_95063738 0.598 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr1_+_32251988 0.597 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chrX_-_70755023 0.586 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr6_-_153494076 0.584 NM_012419
RGS17
regulator of G-protein signaling 17
chr19_+_56337368 0.582 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr7_+_2525922 0.581 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr14_-_22521544 0.578 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr4_+_39376058 0.578 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr8_+_7101835 0.578 NM_001164456
NM_001164452
FAM90A13
FAM90A14
family with sequence similarity 90, member A13
family with sequence similarity 90, member A14
chr7_-_138316393 0.576 NM_001164665
NM_020910
KIAA1549

KIAA1549


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.07 3.59e-02 GO:0045111 intermediate filament cytoskeleton
3.35 3.97e-02 GO:0031226 intrinsic to plasma membrane
1.72 4.65e-02 GO:0044425 membrane part

Nothing significant found in function category.