Motif ID: TLX2.p2

Z-value: 1.399


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2



Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_22248630 1.233 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_+_84198015 1.150 NM_006982
ALX1
ALX homeobox 1
chr2_-_200038055 1.123 NM_001172517
SATB2
SATB homeobox 2
chr11_-_8571988 1.076 NM_030906
STK33
serine/threonine kinase 33
chr1_+_205694237 0.971 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr3_+_131547048 0.965 NM_153264
COL6A5
collagen, type VI, alpha 5
chr4_+_114190233 0.946 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr7_+_54577512 0.923 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr7_+_31693155 0.918 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr10_-_50066386 0.903 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr11_-_13474101 0.854 NM_000315
PTH
parathyroid hormone
chr6_-_32742265 0.829 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_+_124166767 0.809 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr14_-_20807346 0.806 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr15_+_46285789 0.796 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr20_+_43283423 0.792 NM_003008
SEMG2
semenogelin II
chr20_+_36867708 0.790 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr2_-_233060774 0.790 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr3_-_114176401 0.770 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr10_-_32707549 0.753 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr14_-_47213906 0.752 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr8_-_120033240 0.747 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr2_-_104834344 0.737 LOC100506421
hypothetical LOC100506421
chr3_-_171786468 0.733 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr2_-_227737009 0.727 COL4A4
collagen, type IV, alpha 4
chr3_-_185578621 0.727 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr10_-_90702490 0.715 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr2_-_40593074 0.706 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_+_93373755 0.680 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr11_-_128217550 0.669 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr14_-_56342097 0.669 NM_172337
OTX2
orthodenticle homeobox 2
chr2_+_231968578 0.660 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr16_+_1979959 0.660 NM_004209
SYNGR3
synaptogyrin 3
chr20_-_14266200 0.656 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr3_-_148607096 0.643 NM_032153
ZIC4
Zic family member 4
chr2_+_219141761 0.641 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr3_+_63403792 0.638 NM_144642
SYNPR
synaptoporin
chr11_-_8572277 0.636 STK33
serine/threonine kinase 33
chr9_+_70509925 0.626 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr3_-_22389126 0.622 ZNF385D
zinc finger protein 385D
chr7_-_11838260 0.616 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr9_-_32563057 0.616 NM_002493
NM_182739
NDUFB6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa

chr11_+_98396789 0.615 NM_014361
NM_175566
CNTN5

contactin 5

chr4_-_35922288 0.612 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_35859545 0.610 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr4_-_105635499 0.601 CXXC4
CXXC finger protein 4
chr6_+_152168500 0.600 NM_001122741
ESR1
estrogen receptor 1
chr14_+_34521854 0.596 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr6_+_55300225 0.592 NM_207410
GFRAL
GDNF family receptor alpha like
chr14_-_87863003 0.587 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr14_+_34521945 0.585 SRP54
signal recognition particle 54kDa
chr5_+_177473071 0.573 NM_015111
N4BP3
NEDD4 binding protein 3
chr11_+_13940715 0.572 SPON1
spondin 1, extracellular matrix protein
chr14_-_23878871 0.572 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr5_+_146594718 0.571 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr20_-_604443 0.568


chr14_+_30098079 0.565 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr14_-_87862676 0.562 KCNK10
potassium channel, subfamily K, member 10
chr4_-_111777584 0.557 PITX2
paired-like homeodomain 2
chr19_+_55614006 0.551 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr8_+_50147455 0.540 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr12_-_97812633 0.539 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_131190237 0.538 NM_001195597
LOC285733
hypothetical LOC285733
chr20_-_49852353 0.537 NM_020436
SALL4
sal-like 4 (Drosophila)
chr18_-_29273979 0.526 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr8_+_1940282 0.525 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr11_-_8572321 0.520 STK33
serine/threonine kinase 33
chr17_-_46140015 0.519 NM_052855
ANKRD40
ankyrin repeat domain 40
chr12_+_12829807 0.518 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr6_+_32713160 0.518 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chrX_-_108611940 0.511 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr5_+_7449030 0.504 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr20_+_9442995 0.502 C20orf103
chromosome 20 open reading frame 103
chr20_+_2743613 0.501 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr15_-_24569201 0.498 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr17_+_43165608 0.497 NM_013351
TBX21
T-box 21
chr18_+_59733724 0.492 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr9_-_124733599 0.492 NM_020924
ZBTB26
zinc finger and BTB domain containing 26
chr3_-_166397142 0.490 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chrX_+_144707022 0.487 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr5_+_5193442 0.486 NM_139056
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr11_-_19180092 0.485 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr11_+_122901689 0.483 NM_020716
GRAMD1B
GRAM domain containing 1B
chr8_+_55210333 0.477 NM_014175
MRPL15
mitochondrial ribosomal protein L15
chr10_-_115923874 0.476 C10orf118
chromosome 10 open reading frame 118
chr1_-_68688219 0.475 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr12_-_21985433 0.474 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr9_-_19778590 0.471 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr17_-_44010543 0.470 NM_024015
HOXB4
homeobox B4
chr18_-_59185330 0.469 NM_002035
KDSR
3-ketodihydrosphingosine reductase
chr2_-_122210873 0.466 NM_032390
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein
chr21_-_38955487 0.465 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr3_+_87359088 0.453 NM_014043
CHMP2B
chromatin modifying protein 2B
chr1_+_57093030 0.451 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_-_111777651 0.448 PITX2
paired-like homeodomain 2
chr2_-_74424041 0.447 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chrX_+_151557292 0.446 NM_018558
GABRQ
gamma-aminobutyric acid (GABA) receptor, theta
chr6_-_32665409 0.445 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr16_+_73810383 0.444 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr12_+_79995927 0.442 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr3_+_88114415 0.440 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr17_-_39375327 0.437 NM_002722
PPY
pancreatic polypeptide
chr21_-_36870736 0.432 NM_001146077
CLDN14
claudin 14
chrX_+_23262905 0.429 NM_173495
PTCHD1
patched domain containing 1
chr10_+_88506320 0.427 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr14_+_34585098 0.426 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr3_+_123279439 0.426 NM_006889
CD86
CD86 molecule
chr14_-_36059084 0.425 NM_001079668
NKX2-1
NK2 homeobox 1
chr22_+_40286957 0.420 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr19_-_6671585 0.420 NM_000064
C3
complement component 3
chr6_+_54819527 0.419 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr21_+_33320080 0.417 NM_005806
OLIG2
oligodendrocyte lineage transcription factor 2
chr13_+_87122778 0.415 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr10_-_134449467 0.415 NM_177400
NKX6-2
NK6 homeobox 2
chr20_+_5839973 0.414 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr3_-_99236520 0.413 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr11_-_127962662 0.412 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr6_-_52736231 0.410 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr3_-_53900888 0.409 NM_021237
SELK
selenoprotein K
chr1_+_195123766 0.408 NM_006684
CFHR4
complement factor H-related 4
chr10_+_118295417 0.407 NM_000936
PNLIP
pancreatic lipase
chr7_-_32076985 0.407 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr18_+_27332024 0.406 NM_001943
DSG2
desmoglein 2
chr15_+_56511466 0.406 NM_000236
LIPC
lipase, hepatic
chr20_+_43269051 0.405 NM_003007
SEMG1
semenogelin I
chr10_+_96295511 0.405 NM_018063
HELLS
helicase, lymphoid-specific
chr20_-_13713509 0.405 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr17_+_55269974 0.405


chr18_+_48121067 0.401 DCC
deleted in colorectal carcinoma
chr11_-_95715976 0.401 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr17_-_63798851 0.400 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr2_-_210798232 0.397 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr9_-_78710698 0.397 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr20_-_61462960 0.396 NM_000744
CHRNA4
cholinergic receptor, nicotinic, alpha 4
chr1_-_79244948 0.396 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr3_-_114898003 0.393 NM_001009899
KIAA2018
KIAA2018
chr3_-_120236118 0.393 IGSF11
immunoglobulin superfamily, member 11
chr5_-_27074407 0.392 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr8_-_93144039 0.390


chr2_-_100087366 0.387 AFF3
AF4/FMR2 family, member 3
chr10_-_12124778 0.385 NM_015542
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr11_+_8660913 0.385 RPL27A
ribosomal protein L27a
chr1_+_50348052 0.384 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_66952462 0.384 NM_003952
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr13_-_46368968 0.383 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr16_-_87535106 0.383 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_+_144377822 0.383


chr15_-_24569253 0.382 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr4_-_145281237 0.381 NM_002099
GYPA
glycophorin A (MNS blood group)
chr12_-_18134319 0.380 NM_024730
RERGL
RERG/RAS-like
chr10_+_102212787 0.380 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr12_-_94135154 0.377 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr6_+_132901119 0.377 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr2_+_223433919 0.374 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr17_-_57497380 0.374 NM_005121
MED13
mediator complex subunit 13
chr15_-_24569309 0.374 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_+_159817752 0.373 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_-_104587069 0.372 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr21_-_38954433 0.370 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr10_-_7748811 0.369 NM_001001851
NM_030569
ITIH5

inter-alpha (globulin) inhibitor H5

chr16_+_1323627 0.369 BAIAP3
BAI1-associated protein 3
chr14_-_19871267 0.367 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr3_+_116824840 0.367 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr3_+_150330060 0.366 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr2_+_231629839 0.364 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_-_32839244 0.364 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr2_+_190753833 0.362 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr14_+_61653827 0.361 FLJ43390
hypothetical LOC646113
chr8_+_57520915 0.361


chr7_-_31347032 0.360 NM_022728
NEUROD6
neurogenic differentiation 6
chr11_-_1026654 0.360 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr4_+_166468266 0.359 NM_001017369
NM_006745
SC4MOL

sterol-C4-methyl oxidase-like

chr11_-_101828563 0.359 NM_052932
TMEM123
transmembrane protein 123
chr16_-_66827449 0.358 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr18_+_61569136 0.358 NM_004361
CDH7
cadherin 7, type 2
chr2_-_218551786 0.358 TNS1
tensin 1
chrX_+_117364444 0.356 WDR44
WD repeat domain 44
chr20_+_59260847 0.356 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr11_-_19038803 0.355 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr7_+_50318801 0.354 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr16_-_27982277 0.353 NM_001109763
GSG1L
GSG1-like
chr5_+_147238466 0.352 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr3_+_142253432 0.351 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr1_+_18306823 0.350 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr10_-_7491204 0.349 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr12_-_16650687 0.348 LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_120737416 0.348 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr3_-_129694717 0.348 NM_032638
GATA2
GATA binding protein 2
chr16_-_3082840 0.348 NM_032805
ZSCAN10
zinc finger and SCAN domain containing 10
chr2_+_201099093 0.347 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr1_+_159899528 0.347 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_-_206659140 0.343 NM_017759
INO80D
INO80 complex subunit D
chr1_+_195179533 0.343 NM_005666
CFHR2
complement factor H-related 2
chr2_-_190153711 0.341 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_-_245237977 0.341 NM_020394
ZNF695
zinc finger protein 695
chr6_-_33085290 0.340 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr4_+_146250978 0.339 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr8_+_18111894 0.338 NM_000662
NM_001160170
NM_001160171
NM_001160172
NM_001160173
NM_001160175
NM_001160176
NAT1






N-acetyltransferase 1 (arylamine N-acetyltransferase)






chr3_-_109730858 0.337 NM_014981
MYH15
myosin, heavy chain 15
chr17_+_51585834 0.334 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
154.97 3.36e-03 GO:0060021 palate development
117.61 5.87e-03 GO:0048704 embryonic skeletal system morphogenesis
86.40 1.09e-02 GO:0048706 embryonic skeletal system development
75.04 1.45e-02 GO:0051216 cartilage development
54.68 2.74e-02 GO:0048705 skeletal system morphogenesis
45.90 3.89e-02 GO:0048562 embryonic organ morphogenesis

Nothing significant found in compartment category.

Nothing significant found in function category.