Motif ID: TP53.p2

Z-value: 1.195


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_36752244 3.999 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_+_3597092 1.783 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr6_-_138470160 1.550 NM_022121
PERP
PERP, TP53 apoptosis effector
chr16_-_66558197 1.423 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr6_+_24511123 1.265 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr6_+_116798791 1.124 NM_013352
DSE
dermatan sulfate epimerase
chr15_-_50608296 1.114 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr1_-_2447848 1.084 NM_018216
PANK4
pantothenate kinase 4
chr22_-_18687511 1.070 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr11_-_72986738 1.018 NM_015159
FAM168A
family with sequence similarity 168, member A
chr7_-_74705276 1.013 NM_001145064
GATSL2
GATS protein-like 2
chr10_-_30388439 0.996 NM_020848
KIAA1462
KIAA1462
chr6_-_167491305 0.892 NM_005299
GPR31
G protein-coupled receptor 31
chr2_-_26058941 0.873 NM_002254
KIF3C
kinesin family member 3C
chr1_+_153799637 0.862 LOC645676
hypothetical LOC645676
chr20_-_32354736 0.855 NM_000687
AHCY
adenosylhomocysteinase
chr1_+_32443822 0.855 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr14_-_30959487 0.814 HEATR5A
HEAT repeat containing 5A
chr5_+_52320660 0.723 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr22_+_35777561 0.715 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr4_+_148872902 0.703 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr7_+_116099648 0.703 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr16_-_14695930 0.699 NM_003561
PLA2G10
phospholipase A2, group X
chr9_+_129962292 0.682 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr7_+_65307816 0.673 TPST1
tyrosylprotein sulfotransferase 1
chr19_+_5855842 0.667 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr8_+_23016271 0.635 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr19_+_2736464 0.632 NM_003249
THOP1
thimet oligopeptidase 1
chr2_+_47021866 0.622 TTC7A
tetratricopeptide repeat domain 7A
chr6_+_117910472 0.620 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr12_+_122652572 0.620 NM_020936
DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr2_+_169021001 0.618 LASS6
LAG1 homolog, ceramide synthase 6
chr2_-_26058831 0.614 KIF3C
kinesin family member 3C
chr21_+_42807052 0.558 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr3_+_184898234 0.548 NM_018023
YEATS2
YEATS domain containing 2
chr15_+_86965526 0.538 NM_022767
AEN
apoptosis enhancing nuclease
chr19_-_47438583 0.537 GSK3A
glycogen synthase kinase 3 alpha
chr2_-_201536425 0.525 NM_006190
ORC2
origin recognition complex, subunit 2
chr9_-_94936319 0.517 NM_004148
NINJ1
ninjurin 1
chr2_+_169021039 0.508 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr14_+_99273751 0.507 EML1
echinoderm microtubule associated protein like 1
chr19_+_61344501 0.507 ZNF444
zinc finger protein 444
chr7_+_72206961 0.501 GTF2IP1
general transcription factor IIi, pseudogene 1
chr1_-_52936573 0.491 C1orf163
chromosome 1 open reading frame 163
chr20_+_47862782 0.489 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr1_+_15957832 0.487 NM_017556
FBLIM1
filamin binding LIM protein 1
chr10_-_105202139 0.487 NM_015916
CALHM2
calcium homeostasis modulator 2
chr19_-_47438384 0.486 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_47438563 0.485 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr8_+_98950453 0.477 NM_002380
NM_030583
MATN2

matrilin 2

chr12_+_54832470 0.475 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr16_-_4243762 0.471 LOC100507501
hypothetical LOC100507501
chr10_+_124124196 0.470 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_-_153799186 0.470 ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_-_23376860 0.466 LUZP1
leucine zipper protein 1
chr14_-_35859545 0.465 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr3_-_46012303 0.463 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr14_+_35365266 0.459 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr2_+_47021816 0.457 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr19_-_47438518 0.454 GSK3A
glycogen synthase kinase 3 alpha
chr11_-_1026654 0.454 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr1_+_13782838 0.449 NM_006474
NM_198389
PDPN

podoplanin

chr6_-_48186868 0.445 C6orf138
chromosome 6 open reading frame 138
chr2_-_151826504 0.444 NM_198557
RBM43
RNA binding motif protein 43
chr10_+_11824361 0.440 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr16_+_2593351 0.440 LOC652276
hypothetical LOC652276
chr1_+_117711575 0.439 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chr20_+_47862656 0.439 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr4_+_153676857 0.433 DKFZP434I0714
hypothetical protein DKFZP434I0714
chr20_-_47238082 0.432 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr19_-_47438548 0.428 GSK3A
glycogen synthase kinase 3 alpha
chr1_-_52936602 0.420 C1orf163
chromosome 1 open reading frame 163
chr5_-_167938875 0.414 PANK3
pantothenate kinase 3
chr8_-_22982435 0.413 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr21_+_43186428 0.406 NM_001001503
NM_021075
NDUFV3

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa

chr11_+_1897374 0.405 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr6_+_76515608 0.403 NM_004999
MYO6
myosin VI
chr17_-_975809 0.399 ABR
active BCR-related gene
chr13_-_100866706 0.386 NM_052867
NALCN
sodium leak channel, non-selective
chr16_-_74024750 0.384 NM_006324
CFDP1
craniofacial development protein 1
chr3_+_16901455 0.383 NM_001144382
PLCL2
phospholipase C-like 2
chr3_+_32123004 0.383 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr1_-_10455190 0.372 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr10_+_47216925 0.371 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr6_-_30818198 0.369 NM_005803
FLOT1
flotillin 1
chr20_-_5048443 0.368 NM_182649
PCNA
proliferating cell nuclear antigen
chr18_+_19523526 0.367 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr6_+_33486750 0.359 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr11_-_66993211 0.359 NM_001078650
NM_001078651
NM_025124
TMEM134


transmembrane protein 134


chr19_+_61344341 0.353 NM_018337
ZNF444
zinc finger protein 444
chr14_-_22693333 0.349 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr11_+_118544625 0.345 NM_024618
NM_170722
NLRX1

NLR family member X1

chr20_-_47238310 0.344 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr10_+_88404285 0.341 NM_001030015
NM_033282
OPN4

opsin 4

chr10_+_64234486 0.338 NM_032804
ADO
2-aminoethanethiol (cysteamine) dioxygenase
chr2_-_175741096 0.338 NM_001880
ATF2
activating transcription factor 2
chr9_+_103200939 0.337 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr1_-_52936611 0.337 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr21_-_42172476 0.331 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr1_+_42920946 0.328 YBX1
Y box binding protein 1
chr16_-_87244896 0.327 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr1_-_6375949 0.326 ACOT7
acyl-CoA thioesterase 7
chr12_+_47498778 0.326 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr19_-_43406621 0.325 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr17_+_20423628 0.322 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr12_+_27377034 0.320 NM_020183
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr7_+_115953582 0.319 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr2_+_176761552 0.318 NM_024501
HOXD1
homeobox D1
chr3_-_184363126 0.316 LAMP3
lysosomal-associated membrane protein 3
chr19_+_1358664 0.316 DAZAP1
DAZ associated protein 1
chr16_-_30841938 0.314 NCRNA00095
non-protein coding RNA 95
chr3_-_44494108 0.302 ZNF445
zinc finger protein 445
chr1_+_11718798 0.302 AGTRAP
angiotensin II receptor-associated protein
chr11_+_3833495 0.299 NM_003156
STIM1
stromal interaction molecule 1
chr19_+_40183169 0.299 GRAMD1A
GRAM domain containing 1A
chr1_-_201202956 0.294 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr17_-_14080874 0.292 NM_001007530
CDRT15
CMT1A duplicated region transcript 15
chr8_+_95801375 0.288 DPY19L4
dpy-19-like 4 (C. elegans)
chr8_-_57286412 0.288 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr2_+_11213053 0.288 PQLC3
PQ loop repeat containing 3
chr6_+_146177723 0.288 LOC100507557
hypothetical LOC100507557
chr17_-_9870292 0.287 NM_001130831
GAS7
growth arrest-specific 7
chr8_-_23077392 0.286 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr1_+_232107170 0.285 NM_173508
SLC35F3
solute carrier family 35, member F3
chr1_+_36169260 0.285 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr22_+_21852551 0.283 NM_004327
NM_021574
BCR

breakpoint cluster region

chr2_+_197212522 0.282 NM_001080539
CCDC150
coiled-coil domain containing 150
chr19_+_13090101 0.280 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr5_-_137099361 0.280 KLHL3
kelch-like 3 (Drosophila)
chr17_-_40122542 0.276 NM_001099225
NM_144609
CCDC43

coiled-coil domain containing 43

chrX_+_153767803 0.276 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr20_+_4077466 0.273 SMOX
spermine oxidase
chr3_+_9919511 0.273 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr20_+_4077409 0.271 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr20_+_56900116 0.270 NM_001077488
GNAS
GNAS complex locus
chr12_-_74710741 0.268 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr6_+_37895570 0.267 ZFAND3
zinc finger, AN1-type domain 3
chr11_+_85017269 0.266 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr2_+_113546365 0.266 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr2_+_97717300 0.262 NM_207519
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr15_-_40173949 0.261 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr9_+_88953378 0.259 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr7_+_43589163 0.257 NM_004760
STK17A
serine/threonine kinase 17a
chr2_+_171998988 0.256 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr6_+_76515690 0.255 MYO6
myosin VI
chr16_-_1410710 0.254 C16orf91
chromosome 16 open reading frame 91
chr4_-_108860740 0.254 NM_005443
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr21_+_45649429 0.253 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr19_-_52426055 0.253 NM_014417
BBC3
BCL2 binding component 3
chr7_+_65307691 0.252 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr11_+_63758550 0.251 NM_003377
VEGFB
vascular endothelial growth factor B
chr5_-_167938991 0.247 NM_024594
PANK3
pantothenate kinase 3
chrX_+_38548316 0.246 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr13_-_100866839 0.245 NALCN
sodium leak channel, non-selective
chrX_+_129133234 0.244 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr6_+_21774624 0.244 FLJ22536
hypothetical locus LOC401237
chr16_-_56789142 0.243 NM_001896
CSNK2A2
casein kinase 2, alpha prime polypeptide
chr3_+_32123140 0.242 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr22_-_21231421 0.241 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr22_-_22422951 0.241 NM_021916
ZNF70
zinc finger protein 70
chr2_-_24161033 0.239 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr20_+_61760084 0.236 NM_016434
NM_032957
RTEL1

regulator of telomere elongation helicase 1

chr10_-_95231933 0.235 NM_013451
NM_133337
MYOF

myoferlin

chr1_+_11718715 0.234 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr22_-_17846621 0.233 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr16_-_29781842 0.233 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr8_+_95801277 0.232 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr12_+_30970882 0.231 TSPAN11
tetraspanin 11
chr5_-_95323353 0.230 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr20_+_34667624 0.228 C20orf24
chromosome 20 open reading frame 24
chr20_-_33007242 0.226 GSS
glutathione synthetase
chr22_+_39096509 0.225 NM_015705
SGSM3
small G protein signaling modulator 3
chr6_-_30820264 0.224 NM_003897
IER3
immediate early response 3
chr20_+_56899904 0.224 GNAS
GNAS complex locus
chr3_-_44494160 0.224 NM_181489
ZNF445
zinc finger protein 445
chr9_-_5997891 0.223 NM_001017969
KIAA2026
KIAA2026
chr7_-_44496703 0.222 NM_015332
NUDCD3
NudC domain containing 3
chrX_+_151837064 0.219 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr19_+_55985483 0.218 NM_033068
ACPT
acid phosphatase, testicular
chr10_+_124124083 0.217 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_100557098 0.216 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chrX_+_38548373 0.214 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr20_-_33007209 0.213 GSS
glutathione synthetase
chr1_-_207892420 0.212 NM_000228
LAMB3
laminin, beta 3
chr4_-_159863889 0.212 NM_005038
PPID
peptidylprolyl isomerase D
chr4_-_184662604 0.212 LOC389247
hypothetical LOC389247
chr19_+_32976717 0.211


chr13_-_78131259 0.210 NM_024546
RNF219
ring finger protein 219
chr11_-_64327197 0.209 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr1_+_54954082 0.208 NM_004623
TTC4
tetratricopeptide repeat domain 4
chr3_-_8980070 0.207 NM_020165
RAD18
RAD18 homolog (S. cerevisiae)
chr7_-_99707708 0.206 NM_178831
GATS
GATS, stromal antigen 3 opposite strand
chrX_-_153767625 0.204 NM_019863
F8
coagulation factor VIII, procoagulant component
chr19_-_14089362 0.204 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr20_-_60435983 0.204 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr3_+_161601040 0.204 NM_005496
SMC4
structural maintenance of chromosomes 4
chr2_+_187266899 0.202 NM_177454
FAM171B
family with sequence similarity 171, member B
chr2_+_42649105 0.202 NM_020744
MTA3
metastasis associated 1 family, member 3
chr14_+_101853466 0.202 ZNF839
zinc finger protein 839
chr18_+_3584056 0.201 FLJ35776
hypothetical LOC649446

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.