Motif ID: UCAAGUA

Z-value: 1.959


Mature miRNA associated with seed UCAAGUA:

NamemiRBase Accession
hsa-miR-1297 MIMAT0005886
hsa-miR-26a MIMAT0000082
hsa-miR-26b MIMAT0000083
hsa-miR-4465 MIMAT0018992



Activity profile for motif UCAAGUA.

activity profile for motif UCAAGUA


Sorted Z-values histogram for motif UCAAGUA

Sorted Z-values for motif UCAAGUA



Network of associatons between targets according to the STRING database.



First level regulatory network of UCAAGUA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_24522116 3.686 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr3_-_11736946 3.460 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr6_-_10523424 3.426 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10527772 3.239 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_24518501 2.874 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr20_+_54637714 2.846 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr9_-_111300350 2.504 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_158636987 2.476 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr4_-_40326603 2.452 NM_001098634
RBM47
RNA binding motif protein 47
chr1_-_206484258 2.447 NM_025179
PLXNA2
plexin A2
chr12_+_52680143 2.350 NM_006897
HOXC9
homeobox C9
chr6_-_108252200 2.190 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_+_67069668 2.187 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr5_-_112852425 2.139 NM_001085377
MCC
mutated in colorectal cancers
chr6_-_10520592 2.056 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_-_17986520 1.901 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr11_+_10283171 1.859 NM_001124
ADM
adrenomedullin
chr12_+_4253143 1.825 NM_001759
CCND2
cyclin D2
chr1_-_184916044 1.819 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_168812132 1.700 NM_013233
STK39
serine threonine kinase 39
chr6_-_136913649 1.657 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr6_-_136888771 1.642 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr6_-_136829705 1.615 NM_001198615
MAP7
microtubule-associated protein 7
chr6_-_99904251 1.568 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr5_-_112658456 1.544 NM_002387
MCC
mutated in colorectal cancers
chr4_+_146622154 1.523 NM_005900
SMAD1
SMAD family member 1
chr6_-_138935359 1.493 NM_020464
NHSL1
NHS-like 1
chr6_-_136889436 1.468 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr6_+_150962691 1.457 NM_001029884
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr11_+_32808045 1.449 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr21_+_17807167 1.423 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr3_+_155321826 1.421 NM_015595
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr2_+_190981257 1.394 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr8_-_81246215 1.384 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_-_85131439 1.309 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr4_+_146623405 1.283 NM_001003688
SMAD1
SMAD family member 1
chr4_+_87734489 1.274 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr1_+_24518398 1.273 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr3_-_69518119 1.271 NM_015123
FRMD4B
FERM domain containing 4B
chr22_-_45311730 1.267 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr12_+_62524778 1.239 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr15_-_47042932 1.239 NM_203349
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr10_+_73393998 1.233 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr11_+_36354110 1.226 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr3_+_115099007 1.223 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr9_-_73573121 1.221 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr1_+_218768170 1.219 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr6_+_34964999 1.212 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr7_-_92303865 1.192 NM_001145306
CDK6
cyclin-dependent kinase 6
chr5_+_174838119 1.184 NM_022754
SFXN1
sideroflexin 1
chr6_-_132314004 1.151 NM_001901
CTGF
connective tissue growth factor
chr4_+_152549776 1.146 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr3_-_55496370 1.121 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr16_+_18902756 1.106 NM_024847
TMC7
transmembrane channel-like 7
chr7_+_20337249 1.097 NM_002214
ITGB8
integrin, beta 8
chr16_-_30705707 1.095 NM_001080417
ZNF629
zinc finger protein 629
chr2_+_223433919 1.090 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr4_+_174326464 1.075 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr14_-_70345485 1.070 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr2_+_173000552 1.063 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr8_-_18915443 1.058 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_26239755 1.046 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_+_115040369 1.025 NM_017577
GRAMD1C
GRAM domain containing 1C
chr14_+_70443864 1.024 NM_014982
PCNX
pecanex homolog (Drosophila)
chr11_+_33520348 1.018 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr9_-_76692082 1.015 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr1_+_161308318 1.000 NM_001113380
RGS4
regulator of G-protein signaling 4
chr2_+_14690260 0.988 NM_145175
FAM84A
family with sequence similarity 84, member A
chr6_-_42527760 0.979 NM_033502
TRERF1
transcriptional regulating factor 1
chr10_+_18589589 0.970 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr9_+_108665168 0.958 NM_021224
ZNF462
zinc finger protein 462
chr7_-_150960086 0.957 NM_024429
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr8_-_139995417 0.942 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr1_-_203557379 0.936 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr3_-_147361912 0.921 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr8_-_82186832 0.914 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr3_+_184453547 0.911 NM_032047
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr20_-_10602429 0.889 NM_000214
JAG1
jagged 1
chr12_+_52733927 0.887 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr10_+_18669619 0.883 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_-_56283672 0.878 NM_152622
MIER3
mesoderm induction early response 1, family member 3
chr11_+_119586879 0.866 NM_178507
OAF
OAF homolog (Drosophila)
chr5_+_142130475 0.853 NM_001135608
NM_015071
ARHGAP26

Rho GTPase activating protein 26

chr8_+_95722516 0.853 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr12_+_68418829 0.851 NM_022456
NM_175624
RAB3IP

RAB3A interacting protein (rabin3)

chr10_+_112247614 0.846 NM_004419
DUSP5
dual specificity phosphatase 5
chr15_+_39032927 0.830 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr8_-_18710575 0.829 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr10_-_105604942 0.823 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr4_-_171184003 0.819 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_71307705 0.809 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr2_-_33677798 0.808 NM_015475
FAM98A
family with sequence similarity 98, member A
chr5_+_157103280 0.805 NM_173491
LSM11
LSM11, U7 small nuclear RNA associated
chr12_+_68419446 0.796 NM_175623
NM_175625
RAB3IP

RAB3A interacting protein (rabin3)

chr4_-_152366970 0.795 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr6_+_29732736 0.792 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr12_+_26239535 0.790 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_-_109291866 0.788 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr2_-_161058550 0.787 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr1_+_60053050 0.782 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr6_-_138862271 0.781 NM_001144060
NHSL1
NHS-like 1
chr9_-_111230926 0.776 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_-_88911708 0.775 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr5_+_112224875 0.771 NM_003135
SRP19
signal recognition particle 19kDa
chr22_+_21852551 0.770 NM_004327
NM_021574
BCR

breakpoint cluster region

chr1_+_216585298 0.760 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr1_+_36462583 0.757 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr1_+_242281175 0.751 NM_205768
ZNF238
zinc finger protein 238
chr5_+_156819604 0.751 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr5_-_38631263 0.751 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr17_-_57360091 0.745 NM_020748
INTS2
integrator complex subunit 2
chr20_-_3336219 0.745 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr1_-_51757582 0.744 NM_001981
EPS15
epidermal growth factor receptor pathway substrate 15
chr12_+_70519753 0.740 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr1_+_242283129 0.739 NM_006352
ZNF238
zinc finger protein 238
chr2_+_54638957 0.739 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr6_+_15354278 0.736 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr1_+_70649451 0.731 NM_001190463
NM_001902
NM_153742
CTH


cystathionase (cystathionine gamma-lyase)


chr16_+_18903009 0.722 NM_001160364
TMC7
transmembrane channel-like 7
chr12_-_117026038 0.721 NM_019086
VSIG10
V-set and immunoglobulin domain containing 10
chr9_-_112840064 0.719 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr6_-_3401733 0.717 NM_015482
SLC22A23
solute carrier family 22, member 23
chr2_+_149119029 0.701 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr4_+_106287391 0.699 NM_001127208
NM_017628
TET2

tet oncogene family member 2

chr1_-_51660328 0.699 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr3_+_43707362 0.684 NM_016006
ABHD5
abhydrolase domain containing 5
chr6_-_3390197 0.683 NM_021945
SLC22A23
solute carrier family 22, member 23
chr22_-_16887151 0.681 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr13_+_21143083 0.668 NM_002010
FGF9
fibroblast growth factor 9 (glia-activating factor)
chr8_+_70541412 0.668 NM_001128204
NM_015170
SULF1

sulfatase 1

chr1_+_201711505 0.664 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr20_+_52257800 0.664 NM_002623
PFDN4
prefoldin subunit 4
chr8_-_29263714 0.662 NM_001394
DUSP4
dual specificity phosphatase 4
chr6_+_152053323 0.655 NM_001122742
ESR1
estrogen receptor 1
chr2_+_232359303 0.650 NM_022730
COPS7B
COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
chr6_-_33822659 0.644 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr1_+_15145001 0.641 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr19_+_38556414 0.638 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr12_+_27568311 0.637 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr2_-_47986160 0.631 NM_001190274
FBXO11
F-box protein 11
chr16_-_65287967 0.631 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr3_+_63928459 0.629 NM_001128149
ATXN7
ataxin 7
chrX_-_19815586 0.628 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr16_-_71639670 0.623 NM_006885
ZFHX3
zinc finger homeobox 3
chr15_+_88345612 0.622 NM_198526
ZNF710
zinc finger protein 710
chr1_+_158352143 0.618 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_10779291 0.610 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr1_+_178190493 0.606 NM_014810
CEP350
centrosomal protein 350kDa
chr4_-_139382672 0.603 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr2_-_201082978 0.601 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr20_+_33823318 0.601 NM_016436
PHF20
PHD finger protein 20
chr5_+_72148173 0.595 NM_002270
TNPO1
transportin 1
chr2_-_60633908 0.595 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr10_-_63698463 0.588 NM_145307
RTKN2
rhotekin 2
chr3_-_192063158 0.587 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr5_-_73973004 0.586 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr1_+_116320641 0.584 NM_018420
SLC22A15
solute carrier family 22, member 15
chr11_+_86426518 0.575 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr5_+_72957736 0.574 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr17_+_65677255 0.570 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr7_+_116099648 0.568 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr3_+_42617109 0.565 NM_005385
NKTR
natural killer-tumor recognition sequence
chr16_+_11669736 0.564 NM_003498
SNN
stannin
chr12_-_87498225 0.563 NM_000899
NM_003994
KITLG

KIT ligand

chr3_+_113061218 0.559 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_84961749 0.559 NM_001080824
C2orf89
chromosome 2 open reading frame 89
chr1_+_117950029 0.555 NM_017709
FAM46C
family with sequence similarity 46, member C
chr9_-_138126917 0.554 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr3_+_108724472 0.553 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr18_-_55177430 0.543 NM_005570
LMAN1
lectin, mannose-binding, 1
chr14_+_20580224 0.541 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr12_-_47468985 0.540 NM_020983
ADCY6
adenylate cyclase 6
chr8_-_81155564 0.538 NM_001025252
TPD52
tumor protein D52
chr12_+_63290458 0.531 NM_178169
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr10_+_18729518 0.530 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr4_-_152316105 0.529 NM_001128924
SH3D19
SH3 domain containing 19
chr11_-_73787065 0.529 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr9_-_76692455 0.528 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr7_+_128142661 0.525 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr10_+_86078136 0.524 NM_018999
FAM190B
family with sequence similarity 190, member B
chr3_+_137224266 0.523 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr8_-_11361594 0.521 NM_053279
FAM167A
family with sequence similarity 167, member A
chr17_+_57909979 0.520 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr2_+_33213111 0.519 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr1_+_40635058 0.516 NM_001198980
SMAP2
small ArfGAP2
chr2_-_152538694 0.514 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr2_+_209996913 0.511 NM_001039538
MAP2
microtubule-associated protein 2
chr18_-_72336133 0.510 NM_014643
ZNF516
zinc finger protein 516
chr4_-_71924052 0.509 NM_001098477
GRSF1
G-rich RNA sequence binding factor 1
chr15_-_58671929 0.505 NM_134262
RORA
RAR-related orphan receptor A
chr3_+_113060716 0.504 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr12_+_64504408 0.502 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr10_-_79356285 0.501 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr8_-_8788149 0.497 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr2_+_65136989 0.494 NM_015147
CEP68
centrosomal protein 68kDa
chr16_+_30617962 0.489 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr5_-_58607673 0.486 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_-_90957028 0.481 NM_003956
CH25H
cholesterol 25-hydroxylase
chr6_-_116681863 0.477 NM_021648
TSPYL4
TSPY-like 4
chr1_+_176577228 0.476 NM_004841
RASAL2
RAS protein activator like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
46.16 1.59e-06 GO:0014020 primary neural tube formation
27.61 2.85e-06 GO:0021915 neural tube development
38.62 4.85e-06 GO:0001841 neural tube formation
32.08 1.53e-05 GO:0001838 embryonic epithelial tube formation
31.55 1.69e-05 GO:0072175 epithelial tube formation
30.04 2.28e-05 GO:0035148 tube formation
25.58 6.06e-05 GO:0016331 morphogenesis of embryonic epithelium
40.44 7.19e-05 GO:0001843 neural tube closure
39.43 8.20e-05 GO:0060606 tube closure
3.55 2.17e-04 GO:0048513 organ development
9.76 7.22e-04 GO:0035295 tube development
94.60 1.87e-03 GO:0001736 establishment of planar polarity
94.60 1.87e-03 GO:0007164 establishment of tissue polarity
10.05 2.89e-03 GO:0048568 embryonic organ development
13.25 2.96e-03 GO:0060562 epithelial tube morphogenesis
6.74 3.14e-03 GO:0048646 anatomical structure formation involved in morphogenesis
12.71 3.75e-03 GO:0048562 embryonic organ morphogenesis
7.42 5.50e-03 GO:0043009 chordate embryonic development
7.42 5.50e-03 GO:0048598 embryonic morphogenesis
7.33 5.99e-03 GO:0009792 embryo development ending in birth or egg hatching
2.62 6.61e-03 GO:0048731 system development
59.13 8.59e-03 GO:0001738 morphogenesis of a polarized epithelium
10.95 8.81e-03 GO:0014070 response to organic cyclic compound
10.89 9.10e-03 GO:0035239 tube morphogenesis
7.96 1.32e-02 GO:0048729 tissue morphogenesis
6.52 1.40e-02 GO:0008285 negative regulation of cell proliferation
8.86 2.91e-02 GO:0002009 morphogenesis of an epithelium
157.66 3.13e-02 GO:0042249 establishment of planar polarity of embryonic epithelium
2.35 3.53e-02 GO:0048856 anatomical structure development

Nothing significant found in compartment category.

Nothing significant found in function category.