Motif ID: Ascl2

Z-value: 0.707


Transcription factors associated with Ascl2:

Gene SymbolEntrez IDGene Name
Ascl2 ENSMUSG00000009248.5 Ascl2



Activity profile for motif Ascl2.

activity profile for motif Ascl2


Sorted Z-values histogram for motif Ascl2

Sorted Z-values for motif Ascl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ascl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_45216671 7.863 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr14_+_33923582 6.105 ENSMUST00000168727.1
 Gdf10
growth differentiation factor 10
chr2_-_170406501 6.069 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1
chr9_-_43239816 5.689 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr2_-_122611238 4.972 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_+_65815508 4.524 ENSMUST00000168064.1
 Vgll3
vestigial like 3 (Drosophila)
chrX_-_106485214 4.291 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr10_-_7212222 4.213 ENSMUST00000015346.5
 Cnksr3
Cnksr family member 3
chr11_+_112782182 4.184 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr2_-_172940299 4.010 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr12_+_53248677 3.993 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr6_-_72235559 3.954 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr15_+_34238026 3.918 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr12_-_40038025 3.807 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr19_-_45560508 3.803 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr8_+_105518736 3.771 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr10_+_94514825 3.742 ENSMUST00000065060.5
 Tmcc3
transmembrane and coiled coil domains 3
chr2_-_92370999 3.682 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr7_-_141443314 3.630 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr4_-_43523388 3.505 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.9 GO:0030903 notochord development(GO:0030903)
0.2 7.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 6.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.8 5.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 5.2 GO:0006270 DNA replication initiation(GO:0006270)
1.7 5.0 GO:0006601 creatine biosynthetic process(GO:0006601)
0.7 5.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.3 4.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 4.4 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
1.4 4.2 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.2 4.2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.3 4.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 4.1 GO:0006730 one-carbon metabolic process(GO:0006730)
1.3 4.0 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 4.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.3 4.0 GO:0042711 maternal behavior(GO:0042711)
1.3 3.8 GO:0046544 development of secondary male sexual characteristics(GO:0046544)
0.6 3.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.3 3.8 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.3 3.8 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.0 GO:0070062 extracellular exosome(GO:0070062)
0.0 19.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 15.2 GO:0005615 extracellular space(GO:0005615)
1.4 12.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 6.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.9 5.8 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.4 5.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 4.4 GO:0000791 euchromatin(GO:0000791)
0.2 3.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 3.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.7 GO:0005819 spindle(GO:0005819)
0.4 2.5 GO:0071817 MMXD complex(GO:0071817)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.4 GO:0005925 focal adhesion(GO:0005925)
0.0 2.3 GO:0005801 cis-Golgi network(GO:0005801)
0.7 2.2 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 10.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 9.5 GO:0003924 GTPase activity(GO:0003924)
0.2 9.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 7.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 5.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 5.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 5.3 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 5.3 GO:0005198 structural molecule activity(GO:0005198)
0.0 5.3 GO:0003779 actin binding(GO:0003779)
0.2 5.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.9 4.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
1.5 4.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 4.3 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.4 4.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 4.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.3 3.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)