Motif ID: Atf4

Z-value: 1.008


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.235.9e-02Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 13.307 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_71653162 11.992 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr7_+_144896523 9.074 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr19_-_12501996 7.618 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr11_-_75422586 7.607 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr11_-_75422524 6.637 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr13_-_53473074 6.621 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr4_+_46450892 5.499 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_+_49682191 5.038 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr8_+_75093591 4.920 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr4_-_129189600 4.755 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr4_+_43957678 4.539 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr5_-_148399901 4.451 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr19_+_53140430 4.257 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr4_+_117835387 4.175 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_191183244 3.910 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr4_-_129189512 3.667 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr12_-_104865076 3.454 ENSMUST00000109937.1
ENSMUST00000109936.1
 Clmn

calmin

chr13_+_49682100 3.432 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr4_-_129189646 3.431 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chrX_+_106187100 3.251 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr9_-_71771535 3.114 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
 Cgnl1


cingulin-like 1


chr12_+_85599047 3.094 ENSMUST00000177587.1
 Jdp2
Jun dimerization protein 2
chr11_-_120643643 2.844 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
 Pycr1




pyrroline-5-carboxylate reductase 1




chr12_+_85599388 2.753 ENSMUST00000050687.6
 Jdp2
Jun dimerization protein 2
chrX_+_103422010 2.598 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr14_-_54870913 2.548 ENSMUST00000146642.1
 Homez
homeodomain leucine zipper-encoding gene
chr11_+_100320596 2.476 ENSMUST00000152521.1
 Eif1
eukaryotic translation initiation factor 1
chr2_+_163995503 2.422 ENSMUST00000131288.1
 Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr6_-_83317589 2.304 ENSMUST00000005810.6
 Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr6_+_55037988 2.192 ENSMUST00000003572.8
 Gars
glycyl-tRNA synthetase
chr7_-_143600049 2.179 ENSMUST00000105909.3
ENSMUST00000010899.7
 Cars

cysteinyl-tRNA synthetase

chr3_-_138143352 2.062 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr19_-_15924928 2.034 ENSMUST00000025542.3
 Psat1
phosphoserine aminotransferase 1
chr18_-_42262053 1.996 ENSMUST00000097590.3
 Lars
leucyl-tRNA synthetase
chr4_+_129189760 1.995 ENSMUST00000106054.2
ENSMUST00000001365.2
 Yars

tyrosyl-tRNA synthetase

chr8_+_111033890 1.931 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr13_-_118387224 1.804 ENSMUST00000022245.8
 Mrps30
mitochondrial ribosomal protein S30
chr5_+_42067960 1.786 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr14_-_69284982 1.764 ENSMUST00000183882.1
ENSMUST00000037064.4
 Slc25a37

solute carrier family 25, member 37

chr18_-_64516547 1.754 ENSMUST00000025483.9
 Nars
asparaginyl-tRNA synthetase
chr7_-_126625676 1.730 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr2_-_3512746 1.723 ENSMUST00000027961.5
ENSMUST00000056700.7
 Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr5_-_31179901 1.664 ENSMUST00000101411.2
ENSMUST00000140793.1
 Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr12_-_108893197 1.660 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_-_121626316 1.647 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr8_-_92356103 1.601 ENSMUST00000034183.3
 4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr19_-_40588374 1.558 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
 Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr7_-_126566364 1.467 ENSMUST00000032992.5
 Eif3c
eukaryotic translation initiation factor 3, subunit C
chr4_+_42735545 1.449 ENSMUST00000068158.3
 4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr5_-_145140238 1.431 ENSMUST00000031627.8
 Pdap1
PDGFA associated protein 1
chr1_+_156838915 1.408 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr1_+_133131143 1.387 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr19_-_43524462 1.386 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr3_+_138143888 1.383 ENSMUST00000161141.1
 Trmt10a
tRNA methyltransferase 10A
chr5_-_31180110 1.350 ENSMUST00000043161.6
ENSMUST00000088010.5
 Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr10_-_127311740 1.349 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr19_-_40588338 1.330 ENSMUST00000176939.1
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr1_-_78488846 1.317 ENSMUST00000068333.7
ENSMUST00000170217.1
 Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr1_-_170110491 1.200 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr8_+_117157972 1.193 ENSMUST00000064488.4
ENSMUST00000162997.1
 Gan

giant axonal neuropathy

chr9_-_44344159 1.158 ENSMUST00000077353.7
 Hmbs
hydroxymethylbilane synthase
chr15_+_82147238 1.143 ENSMUST00000023100.6
 Srebf2
sterol regulatory element binding factor 2
chr3_+_138143429 1.140 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr3_-_89998656 1.139 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr13_-_30545254 1.107 ENSMUST00000042834.3
 Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr10_+_102158858 1.093 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr10_+_96616998 1.075 ENSMUST00000038377.7
 Btg1
B cell translocation gene 1, anti-proliferative
chr17_-_34187219 1.052 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr15_+_99393219 1.035 ENSMUST00000159209.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr7_+_138846579 1.029 ENSMUST00000155672.1
 Ppp2r2d
protein phosphatase 2, regulatory subunit B, delta isoform
chr19_-_40588453 0.993 ENSMUST00000025979.6
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr11_-_118290167 0.972 ENSMUST00000144153.1
 Usp36
ubiquitin specific peptidase 36
chr17_+_34187545 0.945 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_126502094 0.937 ENSMUST00000179818.1
 Atxn2l
ataxin 2-like
chr5_+_145140362 0.937 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
 Bud31



BUD31 homolog (yeast)



chr4_+_127021311 0.932 ENSMUST00000030623.7
 Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr15_-_98953541 0.927 ENSMUST00000097014.5
 Tuba1a
tubulin, alpha 1A
chr1_-_36709904 0.918 ENSMUST00000043951.3
 Actr1b
ARP1 actin-related protein 1B, centractin beta
chr8_+_123477859 0.908 ENSMUST00000001520.7
 Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr3_+_138143483 0.856 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr17_+_34187789 0.808 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_-_68278713 0.782 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr5_-_90223923 0.667 ENSMUST00000118816.1
ENSMUST00000048363.7
 Cox18

cytochrome c oxidase assembly protein 18

chr14_+_63436394 0.659 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A
chr11_-_118290188 0.647 ENSMUST00000106296.2
ENSMUST00000092382.3
 Usp36

ubiquitin specific peptidase 36

chr10_+_121739915 0.625 ENSMUST00000065600.7
ENSMUST00000136432.1
 BC048403

cDNA sequence BC048403

chr19_+_44203265 0.609 ENSMUST00000026220.5
 Scd3
stearoyl-coenzyme A desaturase 3
chr11_-_98400453 0.510 ENSMUST00000090827.5
 Pgap3
post-GPI attachment to proteins 3
chr7_-_126502312 0.437 ENSMUST00000166682.2
 Atxn2l
ataxin 2-like
chr3_+_89715016 0.429 ENSMUST00000098924.2
 Adar
adenosine deaminase, RNA-specific
chr5_+_93093428 0.421 ENSMUST00000074733.7
 Sept11
septin 11
chr15_+_99393610 0.349 ENSMUST00000159531.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr11_-_98400393 0.348 ENSMUST00000128897.1
 Pgap3
post-GPI attachment to proteins 3
chr14_-_37135126 0.313 ENSMUST00000042564.9
 Ghitm
growth hormone inducible transmembrane protein
chr15_+_99393574 0.222 ENSMUST00000162624.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr9_+_109931863 0.193 ENSMUST00000165876.1
 Map4
microtubule-associated protein 4
chr11_+_58009064 0.189 ENSMUST00000071487.6
ENSMUST00000178636.1
 Larp1

La ribonucleoprotein domain family, member 1

chr2_-_18048347 0.163 ENSMUST00000066885.5
 Skida1
SKI/DACH domain containing 1
chr10_+_80141457 0.155 ENSMUST00000105367.1
 Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr3_+_138143846 0.141 ENSMUST00000159481.1
 Trmt10a
tRNA methyltransferase 10A
chr4_+_124741844 0.114 ENSMUST00000094782.3
ENSMUST00000153837.1
ENSMUST00000154229.1
 Inpp5b


inositol polyphosphate-5-phosphatase B


chr11_-_20332689 0.076 ENSMUST00000109594.1
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr9_+_109931774 0.036 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr1_+_134455524 0.025 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
 Klhl12


kelch-like 12



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
2.8 8.5 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
2.3 9.1 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
2.2 13.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.2 6.6 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.8 14.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
1.6 4.9 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
1.4 4.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.3 3.9 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.0 3.9 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.7 4.5 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.7 2.2 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.6 1.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.6 1.8 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.6 2.8 GO:0006561 proline biosynthetic process(GO:0006561)
0.6 1.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.5 1.6 GO:0051031 tRNA transport(GO:0051031)
0.5 2.0 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.5 1.4 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.4 1.8 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.4 2.1 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.4 1.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 1.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3 1.6 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 0.9 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.3 1.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.3 5.8 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.2 1.4 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.2 2.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.2 1.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886) regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.2 0.4 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 1.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.7 GO:2000194 regulation of female gonad development(GO:2000194)
0.2 0.9 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 4.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 2.5 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.2 0.6 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 5.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 1.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 3.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 1.2 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 0.7 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.1 4.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.8 GO:0060613 fat pad development(GO:0060613)
0.1 3.0 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 2.4 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 1.6 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 1.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 3.3 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 7.0 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 1.4 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.6 GO:0006413 translational initiation(GO:0006413)
0.0 1.1 GO:0019882 antigen processing and presentation(GO:0019882)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:0005577 fibrinogen complex(GO:0005577)
1.0 14.2 GO:0043203 axon hillock(GO:0043203)
0.4 3.0 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.3 1.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 1.8 GO:0042825 TAP complex(GO:0042825)
0.2 0.9 GO:0005745 m-AAA complex(GO:0005745)
0.2 1.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.9 GO:0005869 dynactin complex(GO:0005869)
0.1 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.1 GO:0016459 myosin complex(GO:0016459)
0.1 4.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 4.9 GO:0005901 caveola(GO:0005901)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 2.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)
0.0 1.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.1 GO:0030136 sarcoplasmic reticulum(GO:0016529) clathrin-coated vesicle(GO:0030136)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.5 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
2.0 12.0 GO:0045340 mercury ion binding(GO:0045340)
1.8 7.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
1.2 4.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.8 2.3 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.7 2.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.7 4.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.6 1.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.6 4.5 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.6 1.8 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.6 1.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.5 2.0 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.5 1.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.4 1.8 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.4 9.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.4 1.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.3 1.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 14.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 2.4 GO:0050815 phosphoserine binding(GO:0050815)
0.3 1.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 7.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.2 1.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.2 0.6 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 31.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 11.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 4.9 GO:0000049 tRNA binding(GO:0000049)
0.1 2.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.9 GO:0008483 transaminase activity(GO:0008483)
0.1 1.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 1.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 3.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.0 1.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 7.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 3.1 GO:0003774 motor activity(GO:0003774)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)