Motif ID: Atf7_E4f1

Z-value: 1.453

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4f1mm10_v2_chr17_-_24455265_24455345-0.474.7e-05Click!
Atf7mm10_v2_chr15_-_102529025_102529025-0.441.4e-04Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_36571952 22.829 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr8_+_116921735 21.459 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr3_+_135212557 20.803 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr15_+_99074968 18.120 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr17_-_71526819 18.085 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr9_-_20976762 17.135 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr2_+_105668888 16.737 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr4_+_111720187 16.574 ENSMUST00000084354.3
 Spata6
spermatogenesis associated 6
chr3_+_67374116 16.430 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr6_+_113531675 16.345 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr3_+_40800054 15.642 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr3_+_67374091 15.313 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr19_+_59260878 14.838 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr2_+_105668935 14.626 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr3_+_127553462 13.375 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr2_+_109280738 13.054 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr6_-_23248264 12.980 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_144939823 12.944 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_88718223 12.820 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chrX_-_60893430 12.209 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 211 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.8 38.9 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
3.6 32.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
6.3 31.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.1 28.1 GO:0048864 stem cell development(GO:0048864)
0.9 27.5 GO:0034508 centromere complex assembly(GO:0034508)
0.4 25.1 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
4.5 22.6 GO:0046601 positive regulation of centriole replication(GO:0046601)
2.0 21.9 GO:0014883 transition between fast and slow fiber(GO:0014883)
3.0 20.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
5.7 17.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.4 16.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.4 16.6 GO:0044458 motile cilium assembly(GO:0044458)
2.3 16.3 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
3.9 15.5 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 15.5 GO:0006412 translation(GO:0006412)
0.9 15.3 GO:0007530 sex determination(GO:0007530)
2.5 14.8 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.6 14.4 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
3.5 13.8 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.1 13.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 77.2 GO:0005667 transcription factor complex(GO:0005667)
0.5 55.1 GO:0031514 motile cilium(GO:0031514)
0.3 45.7 GO:0000776 kinetochore(GO:0000776)
3.1 33.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 31.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 27.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 23.3 GO:0005844 polysome(GO:0005844)
3.3 22.8 GO:0001940 male pronucleus(GO:0001940)
2.8 22.6 GO:0098536 deuterosome(GO:0098536)
1.3 20.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 20.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
4.5 18.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
2.8 16.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 14.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.5 13.8 GO:0030008 TRAPP complex(GO:0030008)
4.6 13.7 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 13.2 GO:0044815 DNA packaging complex(GO:0044815)
1.3 13.0 GO:0005642 annulate lamellae(GO:0005642)
0.3 12.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.8 11.0 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 31.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 28.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 23.3 GO:0008266 poly(U) RNA binding(GO:0008266)
1.6 21.9 GO:0051010 microtubule plus-end binding(GO:0051010)
5.2 20.8 GO:0043515 kinetochore binding(GO:0043515)
1.4 20.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 18.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 17.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 16.8 GO:0005198 structural molecule activity(GO:0005198)
3.3 16.6 GO:0032027 myosin light chain binding(GO:0032027)
0.7 16.6 GO:0017160 Ral GTPase binding(GO:0017160)
1.1 16.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 16.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
1.1 15.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 15.5 GO:0033613 activating transcription factor binding(GO:0033613)
4.9 14.8 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.8 14.0 GO:0008307 structural constituent of muscle(GO:0008307)
2.3 13.8 GO:1990932 5.8S rRNA binding(GO:1990932)
2.0 13.7 GO:0019788 NEDD8 transferase activity(GO:0019788)
1.7 13.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)