Motif ID: Barhl2

Z-value: 1.036


Transcription factors associated with Barhl2:

Gene SymbolEntrez IDGene Name
Barhl2 ENSMUSG00000034384.10 Barhl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl2mm10_v2_chr5_-_106458440_106458470-0.458.1e-05Click!


Activity profile for motif Barhl2.

activity profile for motif Barhl2


Sorted Z-values histogram for motif Barhl2

Sorted Z-values for motif Barhl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 15.771 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_112782182 14.960 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr18_-_80986578 14.681 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr5_+_110839973 14.482 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr16_-_22439719 13.361 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_+_163225363 11.239 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr17_-_49564262 10.379 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chrX_-_60893430 10.358 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr18_+_61045139 10.332 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr3_-_27153844 10.310 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr3_-_27153782 9.924 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr2_+_59612034 9.703 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr3_-_27153861 9.681 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr19_-_6969746 9.379 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr18_-_78206408 9.166 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chrX_+_71663665 9.023 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr5_-_28467093 8.530 ENSMUST00000002708.3
 Shh
sonic hedgehog
chr19_+_25406661 8.249 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chr2_+_118814237 8.223 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr5_-_37824580 8.204 ENSMUST00000063116.9
 Msx1
msh homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 38.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
4.3 21.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
3.9 15.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
5.0 15.0 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
1.1 14.7 GO:0021891 olfactory bulb interneuron development(GO:0021891)
3.6 14.5 GO:1903463 mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463)
3.8 11.5 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.6 10.4 GO:0007530 sex determination(GO:0007530)
3.4 10.3 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.5 9.7 GO:0097062 dendritic spine maintenance(GO:0097062)
0.3 9.4 GO:0009395 phospholipid catabolic process(GO:0009395)
1.3 9.2 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 9.0 GO:0007368 determination of left/right symmetry(GO:0007368)
2.8 8.5 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
2.7 8.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
2.7 8.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 8.1 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
2.0 8.0 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.9 7.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.8 7.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.0 29.9 GO:0097149 centralspindlin complex(GO:0097149)
2.1 16.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 16.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 15.3 GO:0016605 PML body(GO:0016605)
0.1 15.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 13.4 GO:0031012 extracellular matrix(GO:0031012)
0.1 10.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 9.4 GO:0042383 sarcolemma(GO:0042383)
0.2 8.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 8.2 GO:0032587 ruffle membrane(GO:0032587)
0.9 7.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.2 7.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.5 7.1 GO:0005662 DNA replication factor A complex(GO:0005662)
1.2 7.0 GO:0001674 female germ cell nucleus(GO:0001674)
1.1 6.6 GO:0000796 condensin complex(GO:0000796)
0.2 6.5 GO:0043034 costamere(GO:0043034)
0.1 6.5 GO:0000793 condensed chromosome(GO:0000793)
0.4 5.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.7 5.5 GO:0033269 internode region of axon(GO:0033269)
1.1 5.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 40.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 35.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 19.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 14.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
1.1 12.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
2.9 11.5 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 11.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 10.7 GO:0051015 actin filament binding(GO:0051015)
2.1 10.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 9.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 9.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.5 9.2 GO:0015265 urea channel activity(GO:0015265)
3.0 9.0 GO:0008502 melatonin receptor activity(GO:0008502)
1.7 8.5 GO:0005113 patched binding(GO:0005113)
0.1 8.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 8.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 8.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.7 7.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 7.2 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.1 7.1 GO:0003684 damaged DNA binding(GO:0003684)