Motif ID: Bbx

Z-value: 0.346


Transcription factors associated with Bbx:

Gene SymbolEntrez IDGene Name
Bbx ENSMUSG00000022641.9 Bbx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50330987_50331017-0.371.8e-03Click!


Activity profile for motif Bbx.

activity profile for motif Bbx


Sorted Z-values histogram for motif Bbx

Sorted Z-values for motif Bbx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bbx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_21111452 5.798 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr5_-_146585239 3.851 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr13_-_52530827 3.608 ENSMUST00000057442.6
 Diras2
DIRAS family, GTP-binding RAS-like 2
chr18_+_37421418 3.328 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr10_+_86021961 2.108 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chrX_+_159708593 1.803 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr16_+_20693263 1.750 ENSMUST00000149543.1
ENSMUST00000118919.1
 Fam131a

family with sequence similarity 131, member A

chrX_-_150814265 1.267 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr2_+_136892168 1.209 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr1_+_180111339 1.152 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chrX_+_140367494 1.015 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr8_-_41054771 0.978 ENSMUST00000093534.4
 Mtus1
mitochondrial tumor suppressor 1
chr8_+_45658666 0.924 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr12_+_103388656 0.910 ENSMUST00000101094.2
ENSMUST00000021620.6
 Otub2

OTU domain, ubiquitin aldehyde binding 2

chr17_+_57358682 0.875 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chrX_-_107816238 0.835 ENSMUST00000120722.1
 2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr6_+_124304646 0.832 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr8_+_45658731 0.831 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr10_-_86022325 0.760 ENSMUST00000181665.1
 A230060F14Rik
RIKEN cDNA A230060F14 gene
chr11_+_105146893 0.562 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr8_+_70616816 0.557 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr8_+_45658273 0.554 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr2_-_152830615 0.505 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
 Bcl2l1



BCL2-like 1



chr10_+_84622365 0.495 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr2_-_152830266 0.236 ENSMUST00000140436.1
 Bcl2l1
BCL2-like 1
chr7_-_127708738 0.152 ENSMUST00000106282.1
 Bcl7c
B cell CLL/lymphoma 7C
chr13_+_49608030 0.006 ENSMUST00000021822.5
 Ogn
osteoglycin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.9 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.1 1.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.8 GO:0006953 acute-phase response(GO:0006953)
0.0 1.6 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 3.9 GO:0006874 cellular calcium ion homeostasis(GO:0006874)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.8 GO:0030139 endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 0.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 5.8 GO:0005509 calcium ion binding(GO:0005509)