Motif ID: Brca1

Z-value: 0.527


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_101551893-0.019.1e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 199 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.033 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_97020322 3.915 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr7_-_102100227 2.885 ENSMUST00000106937.1
 Art5
ADP-ribosyltransferase 5
chr7_-_144939823 2.289 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_70853482 2.264 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chrX_+_150594420 2.230 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_+_44617310 2.112 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr11_-_98625661 2.111 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr7_-_102099932 2.097 ENSMUST00000106934.1
 Art5
ADP-ribosyltransferase 5
chr3_+_87906321 1.693 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor
chr12_-_10900296 1.618 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr4_-_98817537 1.570 ENSMUST00000102790.3
 Kank4
KN motif and ankyrin repeat domains 4
chr11_-_106998483 1.532 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr13_-_107890059 1.515 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr9_-_109082372 1.504 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr5_+_147077050 1.476 ENSMUST00000050970.3
 Polr1d
polymerase (RNA) I polypeptide D
chr12_+_52097737 1.454 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like
chr11_+_59306920 1.382 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr5_-_138187177 1.355 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr17_+_40811089 1.324 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 5.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 3.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.4 3.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 2.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 2.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 2.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 2.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 1.9 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 1.8 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 1.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 1.7 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.2 1.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 1.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.4 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.3 1.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 1.3 GO:0010832 negative regulation of myotube differentiation(GO:0010832)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 2.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.3 GO:0005643 nuclear pore(GO:0005643)
0.2 1.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 1.8 GO:0001739 sex chromatin(GO:0001739)
0.1 1.8 GO:0031512 motile primary cilium(GO:0031512)
0.3 1.7 GO:0000125 PCAF complex(GO:0000125)
0.1 1.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.4 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.2 GO:0005921 gap junction(GO:0005921)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 0.9 GO:0070876 SOSS complex(GO:0070876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.7 5.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 3.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 3.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.5 3.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 3.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.8 GO:0008432 JUN kinase binding(GO:0008432)
0.1 2.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 1.9 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 1.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.5 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 1.2 GO:0031419 cobalamin binding(GO:0031419)