Motif ID: Chd1_Pml

Z-value: 5.324

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pmlmm10_v2_chr9_-_58249660_58249672-0.581.6e-07Click!
Chd1mm10_v2_chr17_+_15704963_15704994-0.142.5e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 146.612 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr15_-_66286224 124.100 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr8_-_84800344 119.941 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr6_+_99692679 115.549 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr2_+_155775333 87.755 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr6_-_32588192 81.230 ENSMUST00000115096.2
 Plxna4
plexin A4
chr4_-_120287349 77.621 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr10_-_43174521 74.369 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr11_-_6065737 73.827 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr1_+_167001417 71.645 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr4_+_124657646 70.493 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr12_-_5375682 70.113 ENSMUST00000020958.8
 Klhl29
kelch-like 29
chr6_-_114042020 70.023 ENSMUST00000101045.3
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chrX_+_69360294 69.889 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chrX_+_170009659 69.329 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr1_-_56972437 69.033 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr6_+_54816906 65.474 ENSMUST00000079869.6
 Znrf2
zinc and ring finger 2
chr11_-_6065538 64.428 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr7_+_123982799 62.197 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr14_-_39472825 60.732 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 935 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 330.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
23.6 330.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
14.9 238.6 GO:0060081 membrane hyperpolarization(GO:0060081)
3.3 238.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
10.2 235.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
14.2 226.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.5 225.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
10.7 181.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
6.3 156.9 GO:0060074 synapse maturation(GO:0060074)
1.6 147.7 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
5.0 143.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
47.7 143.0 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
8.9 124.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
41.0 123.1 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
40.0 120.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
4.1 110.6 GO:2001222 regulation of neuron migration(GO:2001222)
3.1 110.1 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
5.5 109.8 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
7.7 107.4 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
8.4 101.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 311 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1058.2 GO:0016021 integral component of membrane(GO:0016021)
3.6 692.5 GO:0045211 postsynaptic membrane(GO:0045211)
1.0 344.1 GO:0005768 endosome(GO:0005768)
2.7 332.6 GO:0070382 exocytic vesicle(GO:0070382)
3.6 302.4 GO:0043195 terminal bouton(GO:0043195)
7.1 296.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
8.2 294.5 GO:0032809 neuronal cell body membrane(GO:0032809)
4.6 280.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
8.4 276.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
8.7 242.9 GO:0043194 axon initial segment(GO:0043194)
3.7 234.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
2.0 213.8 GO:0055037 recycling endosome(GO:0055037)
5.5 196.9 GO:0048786 presynaptic active zone(GO:0048786)
2.0 179.6 GO:0031225 anchored component of membrane(GO:0031225)
1.5 167.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
16.7 166.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
3.0 162.6 GO:0043198 dendritic shaft(GO:0043198)
0.9 158.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
2.2 156.7 GO:0043204 perikaryon(GO:0043204)
2.9 155.8 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 518 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 612.5 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
13.7 384.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.3 277.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.3 240.0 GO:0008017 microtubule binding(GO:0008017)
4.8 227.4 GO:0045499 chemorepellent activity(GO:0045499)
4.8 219.5 GO:0045296 cadherin binding(GO:0045296)
2.1 218.7 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
8.5 205.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.7 192.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
7.2 171.9 GO:0043274 phospholipase binding(GO:0043274)
1.2 168.1 GO:0003714 transcription corepressor activity(GO:0003714)
1.4 162.6 GO:0017137 Rab GTPase binding(GO:0017137)
6.8 162.1 GO:0017075 syntaxin-1 binding(GO:0017075)
11.5 161.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
2.1 158.6 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
4.0 153.0 GO:0001540 beta-amyloid binding(GO:0001540)
3.4 148.3 GO:0030507 spectrin binding(GO:0030507)
10.8 140.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
4.3 137.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
3.7 129.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)