Motif ID: Clock

Z-value: 0.380


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.281.8e-02Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_186705980 2.102 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr12_-_90738438 1.674 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr2_+_164769892 1.299 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chrX_+_36328353 1.200 ENSMUST00000016383.3
 Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr4_-_97778042 1.040 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr19_+_4510472 1.040 ENSMUST00000068004.6
 Pcx
pyruvate carboxylase
chr15_+_39076885 0.941 ENSMUST00000067072.3
 Cthrc1
collagen triple helix repeat containing 1
chr15_+_81811414 0.885 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr12_+_16653470 0.871 ENSMUST00000111064.1
 Ntsr2
neurotensin receptor 2
chr17_-_35000848 0.858 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr2_-_147186389 0.855 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr5_-_74702891 0.812 ENSMUST00000117388.1
 Lnx1
ligand of numb-protein X 1
chr6_+_108660616 0.810 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr7_-_144939823 0.807 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr1_-_153332724 0.783 ENSMUST00000027752.8
 Lamc1
laminin, gamma 1
chr6_+_108660772 0.771 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr16_-_45158566 0.759 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr12_+_59131473 0.757 ENSMUST00000177162.1
 Ctage5
CTAGE family, member 5
chr4_-_57143437 0.756 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr4_-_97584605 0.745 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 2.8 GO:0008643 carbohydrate transport(GO:0008643)
0.7 2.1 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.3 1.7 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.3 1.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.3 1.0 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 1.0 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.9 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.9 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.2 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.7 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 0.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.6 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.6 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 0.5 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1 0.5 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.2 0.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.2 0.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.4 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.4 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.5 2.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.6 GO:0043426 MRF binding(GO:0043426)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 1.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 1.0 GO:0009374 biotin binding(GO:0009374)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)