Motif ID: Creb3

Z-value: 0.854


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.739.6e-13Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_71546745 13.729 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr7_-_45092130 11.700 ENSMUST00000148175.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr14_-_79301623 10.797 ENSMUST00000022595.7
Rgcc
regulator of cell cycle
chr2_-_105399286 10.546 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chrX_-_60893430 10.447 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr15_+_79516396 10.368 ENSMUST00000010974.7
Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_45091713 10.258 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_+_128523576 9.490 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr3_-_36571952 9.209 ENSMUST00000029270.3
Ccna2
cyclin A2
chr7_-_144939823 9.070 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr11_-_94653964 8.812 ENSMUST00000039949.4
Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr4_-_117182623 8.341 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr18_+_84720019 7.837 ENSMUST00000161429.1
ENSMUST00000052501.1
Fam69c

family with sequence similarity 69, member C

chr2_-_150668198 6.841 ENSMUST00000028944.3
Acss1
acyl-CoA synthetase short-chain family member 1
chr2_-_23155864 6.284 ENSMUST00000028119.6
Mastl
microtubule associated serine/threonine kinase-like
chr5_-_135251209 6.123 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr2_+_119112793 6.088 ENSMUST00000140939.1
ENSMUST00000028795.3
Rad51

RAD51 homolog

chr9_-_20976762 6.000 ENSMUST00000054197.5
S1pr2
sphingosine-1-phosphate receptor 2
chr7_-_25250720 5.862 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr7_-_45092198 5.790 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
Rcn3


reticulocalbin 3, EF-hand calcium binding domain



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.1 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
4.6 13.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.8 12.6 GO:0006621 protein retention in ER lumen(GO:0006621)
2.7 10.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 10.4 GO:0007530 sex determination(GO:0007530)
0.1 9.2 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
1.3 9.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.8 8.8 GO:0072429 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.7 8.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 7.8 GO:0032526 response to retinoic acid(GO:0032526)
0.0 7.2 GO:0043010 camera-type eye development(GO:0043010)
0.4 6.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
2.3 6.8 GO:0006083 acetate metabolic process(GO:0006083)
1.0 6.3 GO:0007135 meiosis II(GO:0007135)
1.5 6.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 6.1 GO:0007405 neuroblast proliferation(GO:0007405)
2.0 6.0 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 6.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.2 5.9 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.8 5.9 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.2 9.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 9.5 GO:0030018 Z disc(GO:0030018)
1.3 9.2 GO:0001940 male pronucleus(GO:0001940)
1.8 8.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 8.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 8.0 GO:0005813 centrosome(GO:0005813)
0.2 7.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 6.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.5 6.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 6.3 GO:0005811 lipid particle(GO:0005811)
0.6 6.1 GO:0000800 lateral element(GO:0000800)
0.3 6.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 4.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 4.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
1.3 3.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 3.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.5 GO:0016604 nuclear body(GO:0016604)
0.5 3.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.5 3.3 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.2 GO:0005509 calcium ion binding(GO:0005509)
0.2 20.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 13.1 GO:0003714 transcription corepressor activity(GO:0003714)
3.2 12.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 10.3 GO:0070412 R-SMAD binding(GO:0070412)
0.3 9.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.6 9.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 9.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 8.8 GO:0004519 endonuclease activity(GO:0004519)
0.6 8.3 GO:0051010 microtubule plus-end binding(GO:0051010)
2.3 6.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 6.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 6.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.9 6.1 GO:0000150 recombinase activity(GO:0000150)
0.3 6.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 6.0 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.4 5.6 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 5.6 GO:0005109 frizzled binding(GO:0005109)
0.1 5.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.4 4.8 GO:0004176 ATP-dependent peptidase activity(GO:0004176)