Motif ID: Cux1

Z-value: 0.708


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136567242_1365672870.687.5e-11Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_117841839 5.346 ENSMUST00000142742.2
Nos1
nitric oxide synthase 1, neuronal
chr7_-_103827922 5.006 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr11_+_78499087 4.791 ENSMUST00000017488.4
Vtn
vitronectin
chr7_-_19166119 4.455 ENSMUST00000094790.3
Gipr
gastric inhibitory polypeptide receptor
chr11_-_42182924 4.074 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr4_+_119814495 4.001 ENSMUST00000106307.2
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr9_-_112232449 3.936 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr5_-_145201829 3.647 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr7_-_140154712 3.560 ENSMUST00000059241.7
Sprn
shadow of prion protein
chr5_-_122050102 3.548 ENSMUST00000154139.1
Cux2
cut-like homeobox 2
chr9_-_112185726 3.488 ENSMUST00000160240.1
ENSMUST00000162065.1
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr5_+_66968559 3.392 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr9_-_112185939 3.265 ENSMUST00000070218.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr1_-_83408190 3.183 ENSMUST00000160953.1
Sphkap
SPHK1 interactor, AKAP domain containing
chr5_+_110544326 3.143 ENSMUST00000040001.7
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr15_+_21111452 3.067 ENSMUST00000075132.6
Cdh12
cadherin 12
chr5_+_66968961 3.052 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr7_+_96210107 2.944 ENSMUST00000138760.1
Tenm4
teneurin transmembrane protein 4
chr7_+_44384098 2.906 ENSMUST00000118962.1
ENSMUST00000118831.1
Syt3

synaptotagmin III

chr7_-_74013676 2.891 ENSMUST00000026896.4
St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.7 GO:0034605 cellular response to heat(GO:0034605)
0.4 8.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 6.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 6.1 GO:0031032 actomyosin structure organization(GO:0031032)
1.3 5.3 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.3 5.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.4 4.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 4.2 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.5 4.1 GO:0071420 cellular response to histamine(GO:0071420)
0.4 4.0 GO:0071569 protein ufmylation(GO:0071569)
0.1 4.0 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.2 3.5 GO:0007614 short-term memory(GO:0007614)
0.1 3.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 3.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 3.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.7 2.9 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 2.9 GO:0019835 cytolysis(GO:0019835)
0.5 2.8 GO:0001927 exocyst assembly(GO:0001927)
0.2 2.7 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 2.6 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 5.8 GO:0070382 exocytic vesicle(GO:0070382)
0.5 5.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.3 5.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 4.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.4 GO:0055037 recycling endosome(GO:0055037)
0.0 3.3 GO:0044306 neuron projection terminus(GO:0044306)
0.1 3.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 2.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 2.8 GO:0000145 exocyst(GO:0000145)
0.1 2.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 2.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.4 2.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 2.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 1.8 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.2 1.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.8 GO:0071565 nBAF complex(GO:0071565)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 GO:0005516 calmodulin binding(GO:0005516)
0.3 8.7 GO:0001786 phosphatidylserine binding(GO:0001786)
1.8 5.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.3 5.0 GO:0031720 haptoglobin binding(GO:0031720)
0.3 4.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 4.8 GO:0031489 myosin V binding(GO:0031489)
0.2 4.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.1 GO:0017046 peptide hormone binding(GO:0017046)
0.2 3.9 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 3.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 3.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.1 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.5 2.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.5 GO:0043274 phospholipase binding(GO:0043274)
0.3 2.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 2.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)