Motif ID: Dlx1

Z-value: 0.954


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71529085_715291100.473.8e-05Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 11.621 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 10.745 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_84069325 8.236 ENSMUST00000046422.4
ENSMUST00000072505.4
Acot5

acyl-CoA thioesterase 5

chr15_-_37458523 7.149 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr8_+_94172618 6.552 ENSMUST00000034214.6
Mt2
metallothionein 2
chr5_-_70842617 6.309 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr8_+_94152607 6.182 ENSMUST00000034211.8
Mt3
metallothionein 3
chr6_-_36811361 6.117 ENSMUST00000101534.1
Ptn
pleiotrophin
chr5_-_92278155 5.625 ENSMUST00000159345.1
ENSMUST00000113102.3
Naaa

N-acylethanolamine acid amidase

chr19_-_19001099 5.443 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr14_-_48665098 5.396 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr4_+_102570065 4.851 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr14_+_118787894 4.848 ENSMUST00000047761.6
ENSMUST00000071546.7
Cldn10

claudin 10

chr18_-_10706688 4.843 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr15_-_37459327 4.792 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chrX_+_99042581 4.776 ENSMUST00000036606.7
Stard8
START domain containing 8
chr3_+_66219909 4.745 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr18_+_23415400 4.699 ENSMUST00000115832.2
ENSMUST00000047954.7
Dtna

dystrobrevin alpha

chr6_-_124779686 4.674 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr5_-_62765618 4.666 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 22.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 11.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 9.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.2 8.4 GO:0019532 oxalate transport(GO:0019532)
2.1 8.2 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.3 8.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.9 7.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 7.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 6.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
2.1 6.2 GO:0097212 lysosomal membrane organization(GO:0097212)
2.0 6.1 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 5.4 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2 5.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
1.6 4.8 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 4.8 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
1.6 4.7 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
1.5 4.6 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 4.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 4.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.8 4.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 22.4 GO:0043205 fibril(GO:0043205)
0.0 17.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 12.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 11.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 9.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.5 8.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 8.4 GO:0005615 extracellular space(GO:0005615)
0.5 8.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 7.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 7.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 6.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 3.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.7 GO:0030027 lamellipodium(GO:0030027)
0.1 3.3 GO:0043034 costamere(GO:0043034)
0.0 3.3 GO:0005576 extracellular region(GO:0005576)
0.8 3.2 GO:0019815 B cell receptor complex(GO:0019815)
0.1 3.1 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 23.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 11.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 10.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 9.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 8.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 8.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.5 8.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 7.8 GO:0005096 GTPase activator activity(GO:0005096)
0.3 7.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 6.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
2.0 6.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 5.9 GO:0030165 PDZ domain binding(GO:0030165)
0.3 5.6 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
1.8 5.4 GO:0008502 melatonin receptor activity(GO:0008502)
1.6 4.8 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.9 4.7 GO:0001849 complement component C1q binding(GO:0001849)
0.0 4.5 GO:0008168 methyltransferase activity(GO:0008168)
0.3 4.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 4.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
1.3 4.0 GO:0019770 IgG receptor activity(GO:0019770)