Motif ID: Dlx5_Dlx4

Z-value: 1.197

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.451.0e-04Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 12.990 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr5_-_84417359 12.763 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr3_+_55782500 11.346 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_-_16378231 10.652 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chrM_+_10167 10.386 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_9870 9.043 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_-_24612700 8.159 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr11_+_58948890 7.788 ENSMUST00000078267.3
 Hist3h2ba
histone cluster 3, H2ba
chr16_-_45724600 6.859 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr16_+_52031549 6.253 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chrX_-_143933204 6.146 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr5_+_17574268 5.981 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_+_51621830 5.903 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr9_-_66514567 5.682 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr9_-_55919605 5.608 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chrX_-_143933089 5.500 ENSMUST00000087313.3
 Dcx
doublecortin
chr4_-_20778527 5.402 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr10_+_80264942 5.018 ENSMUST00000105362.1
ENSMUST00000105361.3
 Dazap1

DAZ associated protein 1

chr3_+_75557530 4.956 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr1_+_6487231 4.601 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 14.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.3 12.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.5 11.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.6 11.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 11.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.8 11.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 10.3 GO:0010842 retina layer formation(GO:0010842)
1.3 9.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 6.9 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 6.9 GO:0006334 nucleosome assembly(GO:0006334)
0.1 6.8 GO:0008347 glial cell migration(GO:0008347)
2.1 6.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.3 5.9 GO:0001504 neurotransmitter uptake(GO:0001504)
1.4 5.6 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 5.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.7 5.1 GO:0019085 early viral transcription(GO:0019085)
1.2 5.0 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.5 4.9 GO:0030035 microspike assembly(GO:0030035)
0.4 4.6 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.1 4.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.8 GO:0070469 respiratory chain(GO:0070469)
0.3 10.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 9.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 9.0 GO:0030425 dendrite(GO:0030425)
0.1 8.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 6.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 5.6 GO:0043195 terminal bouton(GO:0043195)
0.2 5.5 GO:0031672 A band(GO:0031672)
0.1 5.3 GO:0005844 polysome(GO:0005844)
0.1 4.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 4.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 4.1 GO:0036064 ciliary basal body(GO:0036064)
0.2 4.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 4.0 GO:1990391 DNA repair complex(GO:1990391)
0.8 3.9 GO:0008623 CHRAC(GO:0008623)
0.1 3.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 3.9 GO:0031941 filamentous actin(GO:0031941)
0.0 3.8 GO:0031225 anchored component of membrane(GO:0031225)
0.7 3.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 22.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 13.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.6 12.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.5 11.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 8.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 7.9 GO:0038191 neuropilin binding(GO:0038191)
0.4 6.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 6.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 6.4 GO:0019208 phosphatase regulator activity(GO:0019208)
0.3 6.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 5.7 GO:0035613 RNA stem-loop binding(GO:0035613)
1.9 5.6 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.3 5.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 5.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 4.8 GO:0031489 myosin V binding(GO:0031489)
0.2 4.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 4.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.0 3.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 3.9 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 3.7 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)