Motif ID: E2f1

Z-value: 6.361


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.855.5e-21Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 176.510 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004695 116.434 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 114.207 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr1_-_20820213 90.466 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr14_-_79301623 89.189 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr17_+_56303396 85.122 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56303321 75.792 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_+_98907801 69.525 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr10_-_128704978 67.849 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr10_-_78591945 65.451 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr14_-_103843685 63.453 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr2_+_163054682 60.872 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr10_-_120476469 60.730 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr14_-_47276790 57.492 ENSMUST00000111792.1
ENSMUST00000111791.1
ENSMUST00000111790.1
 Wdhd1


WD repeat and HMG-box DNA binding protein 1


chr5_+_45669907 55.739 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr12_+_24708241 54.625 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr19_+_36409719 54.106 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr7_+_13278778 53.658 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr4_+_126556935 52.559 ENSMUST00000048391.8
 Clspn
claspin
chr4_-_137796350 51.842 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 497 entries
Log-likelihood per target Total log-likelihoodTermDescription
14.0 461.7 GO:0006270 DNA replication initiation(GO:0006270)
24.7 271.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
14.8 221.6 GO:0010216 maintenance of DNA methylation(GO:0010216)
10.2 162.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
9.6 162.5 GO:0007530 sex determination(GO:0007530)
4.0 119.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
5.8 116.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
6.0 114.4 GO:0030261 chromosome condensation(GO:0030261)
8.4 109.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
20.1 100.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
24.6 98.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
32.1 96.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
13.3 92.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
3.2 89.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
7.4 89.2 GO:0019985 translesion synthesis(GO:0019985)
21.6 86.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
12.0 84.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
14.8 74.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
10.6 74.1 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
14.7 73.6 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1041.1 GO:0005634 nucleus(GO:0005634)
19.2 287.7 GO:0042555 MCM complex(GO:0042555)
4.8 265.8 GO:0000791 euchromatin(GO:0000791)
0.7 254.1 GO:0005667 transcription factor complex(GO:0005667)
18.2 236.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.1 207.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.6 152.7 GO:0000228 nuclear chromosome(GO:0000228)
27.9 139.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.3 104.7 GO:0005814 centriole(GO:0005814)
10.0 99.9 GO:0000805 X chromosome(GO:0000805)
11.9 95.4 GO:0098536 deuterosome(GO:0098536)
1.4 88.2 GO:0005844 polysome(GO:0005844)
2.7 86.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
4.0 84.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
2.1 83.8 GO:0048786 presynaptic active zone(GO:0048786)
0.5 81.5 GO:0031965 nuclear membrane(GO:0031965)
0.3 75.8 GO:0031012 extracellular matrix(GO:0031012)
0.4 75.0 GO:0009897 external side of plasma membrane(GO:0009897)
10.7 74.9 GO:0000796 condensin complex(GO:0000796)
2.6 72.4 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 274.6 GO:0042393 histone binding(GO:0042393)
15.4 230.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
3.8 220.5 GO:0003678 DNA helicase activity(GO:0003678)
1.2 205.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 202.6 GO:0003682 chromatin binding(GO:0003682)
62.0 185.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
5.0 176.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
27.9 139.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.1 135.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
4.6 134.2 GO:0070412 R-SMAD binding(GO:0070412)
3.6 131.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
15.6 109.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
8.8 96.4 GO:0003680 AT DNA binding(GO:0003680)
15.6 93.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.6 90.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
21.8 87.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
7.6 83.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.8 81.3 GO:0017025 TBP-class protein binding(GO:0017025)
2.1 78.5 GO:0070063 RNA polymerase binding(GO:0070063)
4.4 69.8 GO:0035173 histone kinase activity(GO:0035173)