Motif ID: E2f2_E2f5

Z-value: 4.385

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.971.6e-44Click!
E2f5mm10_v2_chr3_+_14578609_145786870.901.2e-26Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136172367 99.534 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr2_-_157204483 96.722 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr10_-_69352886 91.222 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr17_+_56304313 81.917 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr3_+_98013503 76.648 ENSMUST00000079812.6
 Notch2
notch 2
chr13_-_24761440 75.752 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr13_-_24761861 73.844 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr4_+_126556935 71.357 ENSMUST00000048391.8
 Clspn
claspin
chr1_-_20820213 69.820 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr12_+_24708241 69.233 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_72476159 67.510 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr2_+_72476225 66.820 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr8_+_75109528 65.299 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr9_+_122951051 64.078 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr10_-_60219260 60.398 ENSMUST00000135158.2
 Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr4_+_126556994 54.261 ENSMUST00000147675.1
 Clspn
claspin
chr13_-_55329723 51.027 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr2_-_113848655 50.644 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr10_+_110745433 50.462 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr13_+_92354783 48.794 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.0 263.5 GO:0006270 DNA replication initiation(GO:0006270)
2.9 171.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
13.2 171.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
11.0 153.5 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
20.4 142.8 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
15.7 125.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
40.1 120.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
10.6 105.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
2.1 93.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
9.3 83.8 GO:0090166 Golgi disassembly(GO:0090166)
10.2 81.7 GO:0033504 floor plate development(GO:0033504)
25.5 76.6 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
9.1 72.5 GO:0019985 translesion synthesis(GO:0019985)
7.6 68.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.4 64.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
5.9 59.0 GO:0015884 positive regulation of platelet activation(GO:0010572) folic acid transport(GO:0015884)
12.2 48.8 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
6.1 48.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
11.5 45.8 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.7 45.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 413.5 GO:0005634 nucleus(GO:0005634)
0.7 307.4 GO:0005667 transcription factor complex(GO:0005667)
18.8 282.7 GO:0042555 MCM complex(GO:0042555)
4.1 218.0 GO:0005657 replication fork(GO:0005657)
23.8 118.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.6 95.3 GO:0005876 spindle microtubule(GO:0005876)
0.7 71.4 GO:0005814 centriole(GO:0005814)
0.2 70.6 GO:0043235 receptor complex(GO:0043235)
1.2 68.0 GO:0005871 kinesin complex(GO:0005871)
11.7 58.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 56.0 GO:0005694 chromosome(GO:0005694)
4.7 47.2 GO:0000800 lateral element(GO:0000800)
5.6 44.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
14.8 44.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
8.7 43.3 GO:0035189 Rb-E2F complex(GO:0035189)
7.1 42.3 GO:0031298 replication fork protection complex(GO:0031298)
0.6 39.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 36.0 GO:0030175 filopodium(GO:0030175)
0.4 35.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
3.5 35.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 248.8 GO:0001047 core promoter binding(GO:0001047)
2.7 162.6 GO:0003678 DNA helicase activity(GO:0003678)
19.4 155.0 GO:0003688 DNA replication origin binding(GO:0003688)
46.7 140.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.8 132.3 GO:0070491 repressing transcription factor binding(GO:0070491)
20.9 125.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
23.8 118.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
6.4 115.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 106.9 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
3.6 96.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
4.9 93.8 GO:0035173 histone kinase activity(GO:0035173)
0.3 86.0 GO:0005096 GTPase activator activity(GO:0005096)
1.9 76.6 GO:0051059 NF-kappaB binding(GO:0051059)
1.0 68.0 GO:0003777 microtubule motor activity(GO:0003777)
0.5 64.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
8.9 62.6 GO:0000150 recombinase activity(GO:0000150)
15.1 60.4 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
6.6 59.0 GO:0008517 folic acid transporter activity(GO:0008517)
16.3 48.8 GO:0051870 methotrexate binding(GO:0051870)
0.4 47.5 GO:0042393 histone binding(GO:0042393)