Motif ID: E2f3

Z-value: 1.035


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.541.1e-06Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_46450892 16.122 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr5_+_114568016 9.121 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr2_-_127133909 8.613 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr11_-_101551837 8.210 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr7_-_137314394 7.631 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr15_+_102296256 7.239 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr12_+_24708241 7.123 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr10_+_20347788 6.602 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr7_+_13278778 6.596 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr12_-_69228167 6.525 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr16_-_78376758 6.407 ENSMUST00000023570.7
 Btg3
B cell translocation gene 3
chr2_+_109280738 6.140 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr3_+_69004969 6.116 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr3_+_69004711 5.647 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr18_+_11657349 5.508 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8
chr4_-_133967235 4.958 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr3_-_84155762 4.922 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr4_+_115000156 4.908 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr1_-_134079114 4.858 ENSMUST00000020692.6
 Btg2
B cell translocation gene 2, anti-proliferative
chr11_-_100759942 4.562 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
2.4 11.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.1 8.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
2.7 8.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 7.7 GO:0033504 floor plate development(GO:0033504)
0.8 7.2 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
0.7 7.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.9 6.6 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.2 6.6 GO:0000266 mitochondrial fission(GO:0000266)
1.6 6.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 5.6 GO:0072520 seminiferous tubule development(GO:0072520)
1.1 5.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.5 5.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.3 5.2 GO:0035624 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099)
0.2 5.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 5.0 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 4.9 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
1.5 4.5 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of plasminogen activation(GO:0010757)
0.0 4.4 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 4.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 20.4 GO:0000796 condensin complex(GO:0000796)
0.1 10.1 GO:0005814 centriole(GO:0005814)
0.8 8.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 7.2 GO:0072686 mitotic spindle(GO:0072686)
1.4 7.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 6.6 GO:0000785 chromatin(GO:0000785)
1.3 6.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.9 6.1 GO:0005828 kinetochore microtubule(GO:0005828)
1.0 5.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 5.7 GO:0016592 mediator complex(GO:0016592)
0.1 5.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.2 GO:0032587 ruffle membrane(GO:0032587)
1.5 4.5 GO:0005577 fibrinogen complex(GO:0005577)
1.1 4.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 3.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.4 3.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 3.1 GO:0016580 Sin3 complex(GO:0016580)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 10.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 8.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 8.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 7.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.4 7.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.1 6.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 6.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 6.1 GO:0051010 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) microtubule plus-end binding(GO:0051010)
0.7 5.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 5.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.7 5.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
1.5 4.5 GO:0070052 collagen V binding(GO:0070052)
0.0 4.2 GO:0005178 integrin binding(GO:0005178)
0.2 4.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.3 4.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
1.2 3.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.2 3.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.6 3.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 3.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)