Motif ID: E2f4

Z-value: 3.124


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.843.8e-20Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_6084983 56.241 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr4_+_134510999 54.648 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr18_-_34751502 49.443 ENSMUST00000060710.7
Cdc25c
cell division cycle 25C
chr4_-_132345686 47.567 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr6_+_124830217 47.389 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr14_-_47418407 46.913 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr4_-_132345715 45.295 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr1_-_169531343 44.827 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_72438534 43.084 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr12_+_117843873 42.757 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr9_+_72438519 40.137 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 39.788 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_53638945 37.041 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr1_-_189688074 36.444 ENSMUST00000171929.1
ENSMUST00000165962.1
Cenpf

centromere protein F

chr2_+_163054682 36.209 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr18_+_34751803 35.963 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr2_-_26503814 35.941 ENSMUST00000028288.4
Notch1
notch 1
chr2_-_172940299 35.508 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr11_-_101551837 33.336 ENSMUST00000017290.4
Brca1
breast cancer 1
chr9_+_44134562 33.145 ENSMUST00000034650.8
ENSMUST00000098852.2
Mcam

melanoma cell adhesion molecule


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 129.1 GO:0007052 mitotic spindle organization(GO:0007052)
2.6 84.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
3.3 82.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
5.6 79.0 GO:0070986 left/right axis specification(GO:0070986)
17.8 71.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 69.5 GO:0007067 mitotic nuclear division(GO:0007067)
18.7 56.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
2.5 55.2 GO:0008340 determination of adult lifespan(GO:0008340)
1.0 54.6 GO:0007051 spindle organization(GO:0007051)
16.5 49.4 GO:0000087 mitotic M phase(GO:0000087)
6.3 44.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.9 37.0 GO:0006284 base-excision repair(GO:0006284)
1.7 36.4 GO:0051310 metaphase plate congression(GO:0051310)
12.0 35.9 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
11.8 35.5 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.5 33.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
3.7 33.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
11.1 33.3 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.7 33.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.6 31.8 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 90.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
1.3 89.1 GO:0005882 intermediate filament(GO:0005882)
14.1 84.6 GO:0031262 Ndc80 complex(GO:0031262)
0.6 60.2 GO:0043198 dendritic shaft(GO:0043198)
6.2 56.2 GO:0008278 cohesin complex(GO:0008278)
0.7 54.6 GO:0000922 spindle pole(GO:0000922)
2.9 46.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 44.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 42.4 GO:0031012 extracellular matrix(GO:0031012)
3.8 41.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 40.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
3.3 36.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
7.2 36.2 GO:0031523 Myb complex(GO:0031523)
7.2 35.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
5.7 34.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.5 33.6 GO:0005643 nuclear pore(GO:0005643)
3.3 33.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.5 31.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 30.1 GO:0005925 focal adhesion(GO:0005925)
3.6 28.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.3 92.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
11.9 71.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 65.1 GO:0003682 chromatin binding(GO:0003682)
0.0 57.2 GO:0042802 identical protein binding(GO:0042802)
0.3 49.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.3 49.4 GO:0050699 WW domain binding(GO:0050699)
0.2 45.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
7.4 37.0 GO:0000405 bubble DNA binding(GO:0000405)
0.8 36.4 GO:0045502 dynein binding(GO:0045502)
0.2 36.3 GO:0042393 histone binding(GO:0042393)
5.2 36.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 35.9 GO:0005112 Notch binding(GO:0005112)
3.6 35.5 GO:0070700 BMP receptor binding(GO:0070700)
1.2 33.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 33.2 GO:0003684 damaged DNA binding(GO:0003684)
3.2 31.9 GO:0036310 annealing helicase activity(GO:0036310)
2.6 31.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
3.3 29.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.6 28.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.8 27.2 GO:0070182 DNA polymerase binding(GO:0070182)