Motif ID: E2f4

Z-value: 3.124


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.843.8e-20Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6084983 56.241 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr4_+_134510999 54.648 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr18_-_34751502 49.443 ENSMUST00000060710.7
Cdc25c
cell division cycle 25C
chr4_-_132345686 47.567 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr6_+_124830217 47.389 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr14_-_47418407 46.913 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr4_-_132345715 45.295 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr1_-_169531343 44.827 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_72438534 43.084 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr12_+_117843873 42.757 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr9_+_72438519 40.137 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 39.788 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_53638945 37.041 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr1_-_189688074 36.444 ENSMUST00000171929.1
ENSMUST00000165962.1
Cenpf

centromere protein F

chr2_+_163054682 36.209 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr18_+_34751803 35.963 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr2_-_26503814 35.941 ENSMUST00000028288.4
Notch1
notch 1
chr2_-_172940299 35.508 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr11_-_101551837 33.336 ENSMUST00000017290.4
Brca1
breast cancer 1
chr9_+_44134562 33.145 ENSMUST00000034650.8
ENSMUST00000098852.2
Mcam

melanoma cell adhesion molecule

chr1_+_157412352 32.499 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr4_-_116123618 31.904 ENSMUST00000102704.3
ENSMUST00000102705.3
Rad54l

RAD54 like (S. cerevisiae)

chr17_-_84187939 31.775 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr10_-_88146867 31.195 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr17_-_24251382 31.109 ENSMUST00000115390.3
Ccnf
cyclin F
chr5_+_33721724 29.669 ENSMUST00000067150.7
ENSMUST00000169212.2
ENSMUST00000114411.2
ENSMUST00000164207.3
Fgfr3



fibroblast growth factor receptor 3



chr4_-_58553553 29.377 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1


lysophosphatidic acid receptor 1


chr17_-_25727364 28.825 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr4_-_133967235 27.957 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_58553311 25.941 ENSMUST00000107571.1
ENSMUST00000055018.4
Lpar1

lysophosphatidic acid receptor 1

chr4_-_133967296 25.893 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr7_-_38107490 25.435 ENSMUST00000108023.3
Ccne1
cyclin E1
chr11_+_98907801 24.655 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr9_+_92250039 24.634 ENSMUST00000093801.3
Plscr1
phospholipid scramblase 1
chr17_+_50698525 24.066 ENSMUST00000061681.7
Gm7334
predicted gene 7334
chr1_-_57377476 23.989 ENSMUST00000181949.1
4930558J18Rik
RIKEN cDNA 4930558J18 gene
chr4_+_11558914 23.291 ENSMUST00000178703.1
ENSMUST00000095145.5
ENSMUST00000108306.2
ENSMUST00000070755.6
Rad54b



RAD54 homolog B (S. cerevisiae)



chr5_-_25705791 22.404 ENSMUST00000030773.7
Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr15_+_57912199 21.289 ENSMUST00000022992.6
Tbc1d31
TBC1 domain family, member 31
chr10_+_88147061 19.406 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr13_-_73937761 19.392 ENSMUST00000022053.8
Trip13
thyroid hormone receptor interactor 13
chr16_-_90727329 18.890 ENSMUST00000099554.4
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr15_-_76639840 18.753 ENSMUST00000166974.1
ENSMUST00000168185.1
Tonsl

tonsoku-like, DNA repair protein

chr10_+_88146992 18.508 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr14_-_65953728 17.993 ENSMUST00000042046.3
Scara3
scavenger receptor class A, member 3
chr4_-_133967893 17.925 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2

high mobility group nucleosomal binding domain 2

chr6_-_56704673 17.862 ENSMUST00000170382.2
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_-_28350747 17.640 ENSMUST00000080572.7
ENSMUST00000156862.1
Tead3

TEA domain family member 3

chr6_+_113531675 17.478 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr11_-_106999369 17.355 ENSMUST00000106768.1
ENSMUST00000144834.1
Kpna2

karyopherin (importin) alpha 2

chr11_-_106999482 16.240 ENSMUST00000018506.6
Kpna2
karyopherin (importin) alpha 2
chr4_-_58553184 16.036 ENSMUST00000145361.1
Lpar1
lysophosphatidic acid receptor 1
chr17_-_28350600 15.876 ENSMUST00000114799.1
Tead3
TEA domain family member 3
chr14_-_87141114 15.800 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr18_-_39490649 15.705 ENSMUST00000115567.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr5_+_9100681 15.123 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chrX_+_105079761 14.043 ENSMUST00000119477.1
Pbdc1
polysaccharide biosynthesis domain containing 1
chr14_-_87141206 13.986 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr12_-_4233958 13.873 ENSMUST00000111169.3
ENSMUST00000020981.5
Cenpo

centromere protein O

chr7_+_97371604 13.625 ENSMUST00000098300.4
Alg8
asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
chr2_+_163204483 13.526 ENSMUST00000128999.1
Tox2
TOX high mobility group box family member 2
chrX_+_105079735 13.435 ENSMUST00000033577.4
Pbdc1
polysaccharide biosynthesis domain containing 1
chr9_+_107950952 13.259 ENSMUST00000049348.3
Traip
TRAF-interacting protein
chrX_+_164980592 13.123 ENSMUST00000101082.4
ENSMUST00000167446.1
ENSMUST00000057150.6
Fancb


Fanconi anemia, complementation group B


chr13_+_23535411 12.912 ENSMUST00000080859.5
Hist1h3g
histone cluster 1, H3g
chr1_-_72212249 12.812 ENSMUST00000048860.7
Mreg
melanoregulin
chr13_-_23745511 12.648 ENSMUST00000091752.2
Hist1h3c
histone cluster 1, H3c
chr4_-_43562397 11.831 ENSMUST00000030187.7
Tln1
talin 1
chr9_+_118926453 11.280 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_+_16951371 11.078 ENSMUST00000109635.1
ENSMUST00000061327.1
Fbxo48

F-box protein 48

chr7_-_92874196 11.038 ENSMUST00000032877.9
4632434I11Rik
RIKEN cDNA 4632434I11 gene
chr4_-_133967953 10.436 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr5_-_33652296 10.411 ENSMUST00000151081.1
ENSMUST00000101354.3
Slbp

stem-loop binding protein

chr7_+_58658181 9.565 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr12_-_87147883 9.271 ENSMUST00000037788.4
Pomt2
protein-O-mannosyltransferase 2
chr3_-_107969162 9.213 ENSMUST00000004136.8
ENSMUST00000106678.1
Gstm3

glutathione S-transferase, mu 3

chr17_+_87975044 8.625 ENSMUST00000005503.3
Msh6
mutS homolog 6 (E. coli)
chr17_+_29490812 8.471 ENSMUST00000024811.6
Pim1
proviral integration site 1
chrX_-_78583882 8.165 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr12_+_9029982 8.008 ENSMUST00000085741.1
Ttc32
tetratricopeptide repeat domain 32
chr15_-_98831498 7.730 ENSMUST00000168846.1
Prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr5_-_33652339 7.505 ENSMUST00000075670.6
Slbp
stem-loop binding protein
chrY_-_90754821 7.344 ENSMUST00000177893.1
Gm21860
predicted gene, 21860
chr17_-_12507704 7.229 ENSMUST00000024595.2
Slc22a3
solute carrier family 22 (organic cation transporter), member 3
chr2_+_71786923 7.190 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr2_+_129592914 7.183 ENSMUST00000103203.1
Sirpa
signal-regulatory protein alpha
chr2_+_30286406 7.016 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chrX_-_78583782 6.959 ENSMUST00000177904.1
Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr1_-_33669745 6.934 ENSMUST00000027312.9
Prim2
DNA primase, p58 subunit
chrX_-_8074720 6.920 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr2_+_129593195 6.808 ENSMUST00000099113.3
ENSMUST00000103202.3
Sirpa

signal-regulatory protein alpha

chr9_+_119937606 6.796 ENSMUST00000035100.5
Ttc21a
tetratricopeptide repeat domain 21A
chr3_-_142881942 6.756 ENSMUST00000043812.8
Pkn2
protein kinase N2
chr7_-_127260677 6.638 ENSMUST00000035276.4
Dctpp1
dCTP pyrophosphatase 1
chr10_+_127677064 6.430 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr16_-_59632520 6.359 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr17_+_34982099 6.334 ENSMUST00000007266.7
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_+_34982154 6.334 ENSMUST00000173004.1
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_129593528 6.125 ENSMUST00000049262.7
ENSMUST00000163034.1
ENSMUST00000160276.1
Sirpa


signal-regulatory protein alpha


chr18_+_56707725 5.865 ENSMUST00000025486.8
Lmnb1
lamin B1
chr9_-_82975475 5.800 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chr1_+_9798123 5.771 ENSMUST00000168907.1
ENSMUST00000166384.1
Sgk3

serum/glucocorticoid regulated kinase 3

chr15_+_102406143 5.586 ENSMUST00000170884.1
ENSMUST00000165924.1
ENSMUST00000163709.1
ENSMUST00000001326.6
Sp1



trans-acting transcription factor 1



chr2_+_181319714 5.465 ENSMUST00000098971.4
ENSMUST00000054622.8
ENSMUST00000108814.1
ENSMUST00000048608.9
ENSMUST00000108815.1
Rtel1




regulator of telomere elongation helicase 1




chrX_+_36112110 5.255 ENSMUST00000033418.7
Il13ra1
interleukin 13 receptor, alpha 1
chr2_+_153649617 5.213 ENSMUST00000109771.1
Dnmt3b
DNA methyltransferase 3B
chr1_-_191397026 5.097 ENSMUST00000067976.3
Ppp2r5a
protein phosphatase 2, regulatory subunit B (B56), alpha isoform
chr19_+_5366764 5.091 ENSMUST00000025759.7
Eif1ad
eukaryotic translation initiation factor 1A domain containing
chr8_+_18595131 4.960 ENSMUST00000039412.8
Mcph1
microcephaly, primary autosomal recessive 1
chr10_-_19907645 4.952 ENSMUST00000166511.1
ENSMUST00000020182.8
Pex7

peroxisomal biogenesis factor 7

chr2_+_101678403 4.860 ENSMUST00000004949.7
Traf6
TNF receptor-associated factor 6
chr1_+_134415414 4.830 ENSMUST00000112237.1
Adipor1
adiponectin receptor 1
chr12_+_99884498 4.601 ENSMUST00000153627.1
Tdp1
tyrosyl-DNA phosphodiesterase 1
chr17_-_87025353 4.597 ENSMUST00000024957.6
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr2_+_106695594 4.583 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr2_+_181319806 4.294 ENSMUST00000153112.1
Rtel1
regulator of telomere elongation helicase 1
chr8_+_18595526 3.999 ENSMUST00000146819.1
Mcph1
microcephaly, primary autosomal recessive 1
chr5_+_88764983 3.520 ENSMUST00000031311.9
Dck
deoxycytidine kinase
chr15_-_37791993 3.475 ENSMUST00000168992.1
ENSMUST00000148652.1
Ncald

neurocalcin delta

chr17_+_34981847 3.468 ENSMUST00000114011.4
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_+_88553716 3.280 ENSMUST00000008748.6
Ubqln4
ubiquilin 4
chr5_-_112228934 3.022 ENSMUST00000181535.2
Miat
myocardial infarction associated transcript (non-protein coding)
chr9_-_103365769 2.999 ENSMUST00000035484.4
ENSMUST00000072249.6
Cdv3

carnitine deficiency-associated gene expressed in ventricle 3

chr19_-_4397052 2.822 ENSMUST00000075856.4
Kdm2a
lysine (K)-specific demethylase 2A
chr9_-_65580040 2.795 ENSMUST00000068944.7
Plekho2
pleckstrin homology domain containing, family O member 2
chr5_-_138172383 2.739 ENSMUST00000000505.9
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_-_179803625 2.618 ENSMUST00000027768.7
Ahctf1
AT hook containing transcription factor 1
chr12_+_4234023 2.573 ENSMUST00000179139.1
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chr11_+_108425192 2.517 ENSMUST00000150863.2
ENSMUST00000061287.5
ENSMUST00000149683.2
Cep112


centrosomal protein 112


chr4_+_84884276 2.205 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr12_+_106010263 2.095 ENSMUST00000021539.8
ENSMUST00000085026.4
ENSMUST00000072040.5
Vrk1


vaccinia related kinase 1


chr17_-_66101466 1.780 ENSMUST00000024909.8
ENSMUST00000147484.1
ENSMUST00000143987.1
Ndufv2


NADH dehydrogenase (ubiquinone) flavoprotein 2


chr2_-_145935014 1.687 ENSMUST00000001818.4
Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr15_-_38078842 1.666 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr4_-_132463873 1.622 ENSMUST00000102567.3
Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr18_-_60848911 1.585 ENSMUST00000177172.1
ENSMUST00000175934.1
ENSMUST00000176630.1
Tcof1


Treacher Collins Franceschetti syndrome 1, homolog


chr17_+_86753900 1.532 ENSMUST00000024954.9
Epas1
endothelial PAS domain protein 1
chr19_-_5366626 1.380 ENSMUST00000025762.8
Banf1
barrier to autointegration factor 1
chr7_-_16286010 1.326 ENSMUST00000145519.2
Ccdc9
coiled-coil domain containing 9
chr10_-_91123955 1.299 ENSMUST00000164505.1
ENSMUST00000170810.1
ENSMUST00000076694.6
Slc25a3


solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3


chr8_-_69974367 1.283 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chr8_+_124023394 1.271 ENSMUST00000034457.8
Urb2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr5_+_113772748 1.265 ENSMUST00000026937.5
ENSMUST00000112311.1
ENSMUST00000112312.1
Iscu


IscU iron-sulfur cluster scaffold homolog (E. coli)


chr6_-_148831395 1.190 ENSMUST00000145960.1
Ipo8
importin 8
chr14_+_31019125 1.149 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
Pbrm1



polybromo 1



chr15_+_55307743 1.139 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
Col14a1


collagen, type XIV, alpha 1


chr10_-_117792663 1.037 ENSMUST00000167943.1
ENSMUST00000064848.5
Nup107

nucleoporin 107

chr14_-_54517353 1.011 ENSMUST00000023873.5
Prmt5
protein arginine N-methyltransferase 5
chr1_+_132007606 0.754 ENSMUST00000086556.5
Elk4
ELK4, member of ETS oncogene family
chr7_+_126781483 0.592 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr1_+_74601548 0.542 ENSMUST00000087186.4
Stk36
serine/threonine kinase 36
chr2_+_103970221 0.528 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr4_+_84884418 0.525 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr4_-_59783800 0.499 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chrX_-_164980310 0.497 ENSMUST00000004715.1
ENSMUST00000112248.2
Mospd2

motile sperm domain containing 2

chr7_-_127208423 0.377 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr2_-_62646146 0.264 ENSMUST00000112459.3
ENSMUST00000028259.5
Ifih1

interferon induced with helicase C domain 1

chr9_+_57708534 0.253 ENSMUST00000043990.7
ENSMUST00000142807.1
Edc3

enhancer of mRNA decapping 3 homolog (S. cerevisiae)

chr10_-_81427114 0.211 ENSMUST00000078185.7
ENSMUST00000020461.8
ENSMUST00000105321.3
Nfic


nuclear factor I/C


chr1_+_74601441 0.005 ENSMUST00000087183.4
ENSMUST00000148456.1
ENSMUST00000113694.1
Stk36


serine/threonine kinase 36



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
18.7 56.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
17.8 71.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
16.5 49.4 GO:0000087 mitotic M phase(GO:0000087)
12.0 35.9 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
11.8 35.5 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
11.1 33.3 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
9.9 29.7 GO:0061144 alveolar secondary septum development(GO:0061144)
8.2 24.6 GO:0010911 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
6.3 44.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
5.6 79.0 GO:0070986 left/right axis specification(GO:0070986)
5.6 22.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
4.4 31.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
3.8 18.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
3.7 33.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
3.6 28.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
3.5 6.9 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
3.3 82.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
3.2 19.4 GO:0007144 female meiosis I(GO:0007144)
3.1 15.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
2.9 8.6 GO:0000710 meiotic mismatch repair(GO:0000710)
2.6 84.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
2.5 55.2 GO:0008340 determination of adult lifespan(GO:0008340)
2.5 17.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
2.4 9.8 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
2.3 9.3 GO:0070589 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule metabolic process(GO:0044036) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589) cell wall organization or biogenesis(GO:0071554)
2.2 17.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.9 24.7 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
1.8 7.2 GO:0035878 nail development(GO:0035878)
1.7 5.2 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
1.7 13.3 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
1.7 36.4 GO:0051310 metaphase plate congression(GO:0051310)
1.6 4.9 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
1.6 31.8 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
1.5 9.0 GO:0060623 regulation of chromosome condensation(GO:0060623)
1.5 11.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.5 5.9 GO:1904008 response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009)
1.5 33.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.5 129.1 GO:0007052 mitotic spindle organization(GO:0007052)
1.4 13.6 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
1.3 16.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.1 3.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
1.1 6.4 GO:0046909 intermembrane transport(GO:0046909)
1.0 18.8 GO:0031297 replication fork processing(GO:0031297)
1.0 54.6 GO:0007051 spindle organization(GO:0007051)
1.0 6.8 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.9 5.6 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.9 37.0 GO:0006284 base-excision repair(GO:0006284)
0.9 13.9 GO:0034508 centromere complex assembly(GO:0034508)
0.9 12.8 GO:0042640 anagen(GO:0042640)
0.9 3.5 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.9 27.9 GO:0006270 DNA replication initiation(GO:0006270)
0.8 5.0 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.7 33.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7 7.2 GO:0051608 organic cation transport(GO:0015695) histamine transport(GO:0051608)
0.7 18.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.7 2.1 GO:0043987 histone-serine phosphorylation(GO:0035404) histone H3-S10 phosphorylation(GO:0043987)
0.7 6.9 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.6 5.1 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.6 5.8 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.6 1.7 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.6 6.6 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.5 6.8 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.5 4.6 GO:0000012 single strand break repair(GO:0000012)
0.4 12.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 6.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.4 2.8 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.4 4.8 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.4 1.5 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.3 1.0 GO:0060161 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.3 1.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.3 2.9 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 1.3 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.3 1.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 0.9 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 5.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.3 3.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 11.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 69.5 GO:0007067 mitotic nuclear division(GO:0007067)
0.2 0.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 0.5 GO:0007227 signal transduction downstream of smoothened(GO:0007227) positive regulation of hh target transcription factor activity(GO:0007228)
0.2 1.4 GO:0015074 DNA integration(GO:0015074)
0.2 9.2 GO:0035690 cellular response to drug(GO:0035690)
0.1 1.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 11.8 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.1 8.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 5.4 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.1 4.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.1 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.1 0.3 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.1 4.4 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.8 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 2.5 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 5.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 5.3 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 3.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 22.9 GO:0007049 cell cycle(GO:0007049)
0.0 12.8 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 1.7 GO:0098792 xenophagy(GO:0098792)
0.0 0.5 GO:0010212 response to ionizing radiation(GO:0010212)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 84.6 GO:0031262 Ndc80 complex(GO:0031262)
7.2 36.2 GO:0031523 Myb complex(GO:0031523)
7.2 35.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
6.2 56.2 GO:0008278 cohesin complex(GO:0008278)
5.7 34.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
4.5 22.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
3.8 41.6 GO:0031080 nuclear pore outer ring(GO:0031080)
3.6 28.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
3.3 33.3 GO:0070531 BRCA1-A complex(GO:0070531)
3.3 36.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.9 46.9 GO:0031616 spindle pole centrosome(GO:0031616)
2.6 17.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
2.3 9.3 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
1.7 8.6 GO:0032300 mismatch repair complex(GO:0032300)
1.6 19.3 GO:0001673 male germ cell nucleus(GO:0001673)
1.5 90.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
1.4 21.2 GO:0042555 MCM complex(GO:0042555)
1.4 7.0 GO:0044611 nuclear pore inner ring(GO:0044611)
1.4 6.9 GO:0033553 rDNA heterochromatin(GO:0033553)
1.3 89.1 GO:0005882 intermediate filament(GO:0005882)
1.0 13.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.9 7.2 GO:0030056 hemidesmosome(GO:0030056)
0.9 24.7 GO:0051233 spindle midzone(GO:0051233)
0.8 6.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.7 54.6 GO:0000922 spindle pole(GO:0000922)
0.6 12.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.6 60.2 GO:0043198 dendritic shaft(GO:0043198)
0.5 25.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 33.6 GO:0005643 nuclear pore(GO:0005643)
0.5 7.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.5 31.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 18.9 GO:0000793 condensed chromosome(GO:0000793)
0.4 12.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 3.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.3 4.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 44.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 12.6 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.3 6.9 GO:0030894 replisome(GO:0030894)
0.3 11.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 1.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.2 16.5 GO:0005581 collagen trimer(GO:0005581)
0.2 5.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 26.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 42.4 GO:0031012 extracellular matrix(GO:0031012)
0.1 5.6 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.0 GO:0034709 methylosome(GO:0034709)
0.1 0.5 GO:0070876 SOSS complex(GO:0070876)
0.1 12.4 GO:0043197 dendritic spine(GO:0043197)
0.1 2.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 30.1 GO:0005925 focal adhesion(GO:0005925)
0.1 40.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 26.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.3 GO:0016235 aggresome(GO:0016235)
0.1 17.1 GO:0000785 chromatin(GO:0000785)
0.0 1.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 25.6 GO:0005730 nucleolus(GO:0005730)
0.0 7.6 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.3 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
13.3 92.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
11.9 71.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
7.4 37.0 GO:0000405 bubble DNA binding(GO:0000405)
6.0 17.9 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
5.2 36.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
3.9 15.7 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
3.6 35.5 GO:0070700 BMP receptor binding(GO:0070700)
3.3 23.3 GO:0015616 DNA translocase activity(GO:0015616)
3.3 29.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
3.2 22.4 GO:0000150 recombinase activity(GO:0000150)
3.2 31.9 GO:0036310 annealing helicase activity(GO:0036310)
3.1 24.6 GO:0042609 CD4 receptor binding(GO:0042609)
2.9 8.6 GO:0032137 guanine/thymine mispair binding(GO:0032137) single guanine insertion binding(GO:0032142)
2.6 31.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
2.6 28.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.4 7.2 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.8 27.2 GO:0070182 DNA polymerase binding(GO:0070182)
1.4 7.2 GO:0038132 neuregulin binding(GO:0038132)
1.3 49.4 GO:0050699 WW domain binding(GO:0050699)
1.3 9.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.2 4.8 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
1.2 35.9 GO:0005112 Notch binding(GO:0005112)
1.2 11.8 GO:0030274 LIM domain binding(GO:0030274)
1.2 33.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.2 6.9 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.9 3.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.9 6.9 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.8 36.4 GO:0045502 dynein binding(GO:0045502)
0.7 8.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.7 16.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.7 2.1 GO:0035175 histone kinase activity (H3-S10 specific)(GO:0035175)
0.7 5.2 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.6 5.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.5 33.2 GO:0003684 damaged DNA binding(GO:0003684)
0.5 25.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 2.6 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.5 20.1 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.5 2.8 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 9.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 6.6 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.4 4.9 GO:0031996 thioesterase binding(GO:0031996)
0.4 8.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 7.7 GO:0016208 AMP binding(GO:0016208)
0.4 5.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.3 1.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 49.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.3 5.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.3 5.9 GO:0043274 phospholipase binding(GO:0043274)
0.2 9.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 45.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 6.8 GO:0004697 protein kinase C activity(GO:0004697)
0.2 36.3 GO:0042393 histone binding(GO:0042393)
0.1 65.1 GO:0003682 chromatin binding(GO:0003682)
0.1 1.5 GO:0050897 cobalt ion binding(GO:0050897)
0.1 3.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 3.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 4.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.1 7.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 5.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 14.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 57.2 GO:0042802 identical protein binding(GO:0042802)
0.0 10.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.9 GO:0042281 alpha-1,3-mannosyltransferase activity(GO:0000033) dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042281)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)